Drug-Drug Interactions

My current research focuses on determining how targeted and cytotoxic chemotherapy impact the brain and how drug transporters contribute to these effects. Consistent with this research, I am interested in the translational pharmacology of anticancer therapeutics, especially the characterization of preclinical and clinical pharmacokinetics and pharmacodynamics.

Dr. Johnson’s research is focused on understanding genetic and other sources of variability in drug response, building evidence to support translation of research to clinical practice, implementing genomic medicine in practice and documenting clinical outcomes associated with use of genomic medicine in practice. Her discovery research focuses primarily on cardiovascular drugs used in the treatment of hypertension and heart failure and used to prevent blood clots. Her pharmacogenetics implementation work is across a range of therapeutic areas and explores clinical trial approaches for documenting its impact on clinical outcomes. She’s also deeply committed to training the next generation of clinical and translational scientists.

Dr. Wei's area of research expertise is in geriatric pharmacoepidemiology, with specific focus areas on drug safety, drug effectiveness, and quality of medication prescribing in older adults, especially those with pain, neurodegenerative diseases (e.g., Alzheimer’s disease and related dementia [ADRD]), and nursing home stays.