Daniel Binzel

Education

• 2016, PhD, University of Kentucky
• 2010, BS Engineering, Miami University

Publications

• Constructing an active chimeric pRNA ring with a stoichiometry of six and identifying 12 domains of the pRNA ring binding to the 12-subunit channel of phi29 DNA-packaging motor., RNA (New York, N.Y.). 2025 May | journal-article. doi: 10.1261/rna.080383.125.
• Synergistic RNA particles for spontaneous and specific cancer targeting but low toxicity due to motility and deformation., Nanomedicine (London, England). 2025 Apr | journal-article. doi: 10.1080/17435889.2025.2488727.
• Inhibition of Endothelial Cell Tube Formation by Anti-Vascular Endothelial Growth Factor/Anti-Angiopoietin-2 RNA Nanoparticles., Pharmaceutics. 2025 Jan | journal-article. doi: 10.3390/pharmaceutics17010055.
• Sustained Release of RNA Nanoparticles from Reservoir Implant for Ocular Delivery., Journal of Pharmaceutical Sciences. 2024 Dec | journal-article. doi: 10.1016/j.xphs.2024.12.019.
• Engineered extracellular vesicles for combinatorial TNBC therapy: SR-SIM-guided design achieves substantial drug dosage reduction., Molecular Therapy. 2024 Oct | journal-article. doi: 10.1016/j.ymthe.2024.09.034.
• Cracking the Code: Enhancing Molecular Tools for Progress in Nanobiotechnology., ACS Applied Bio Materials. 2024 Jun | journal-article. doi: 10.1021/acsabm.4c00432.
• Posterior eye delivery of angiogenesis-inhibiting RNA nanoparticles via subconjunctival injection., International Journal of Pharmaceutics. 2024 Apr | journal-article. doi: 10.1016/j.ijpharm.2024.124151.
• Conversion of Chemical Drugs into Targeting Ligands on RNA Nanoparticles and Assessing Payload Stoichiometry for Optimal Biodistribution in Cancer Treatment., RNA nanomed. 2024 Jan | journal-article. doi: 10.59566/isrnn.2024.0101109.
• Targeting oncogenic KRAS in non-small cell lung cancer with EGFR aptamer-conjugated multifunctional RNA nanoparticles., Molecular therapy. Nucleic acids. 2023 Jul | journal-article. doi: 10.1016/j.omtn.2023.07.027.
• Ligand-displaying-exosomes using RNA nanotechnology for targeted delivery of multi-specific drugs for liver cancer regression., Nanomedicine : nanotechnology, biology, and medicine. 2023 Mar | journal-article. doi: 10.1016/j.nano.2023.102667.
• Biomotors, viral assembly, and RNA nanobiotechnology: Current achievements and future directions., Computational and structural biotechnology journal. 2022 Nov | journal-article. doi: 10.1016/j.csbj.2022.11.007.
• Targeted delivery of RNAi to cancer cells using RNA-ligand displaying exosome, Acta Pharmaceutica Sinica B. 2022 Nov | journal-article. doi: 10.1016/j.apsb.2022.11.019.
• The dynamic, motile and deformative properties of RNA nanoparticles facilitate the third milestone of drug development, Advanced Drug Delivery Reviews. 2022 Jul | journal-article. doi: 10.1016/j.addr.2022.114316.
• Rational design for controlled release of Dicer-substrate siRNA harbored in phi29 pRNA-based nanoparticles., Molecular therapy. Nucleic acids. 2021 Aug | journal-article. doi: 10.1016/j.omtn.2021.07.021.
• Thermostability, Tunability, and Tenacity of RNA as Rubbery Anionic Polymeric Materials in Nanotechnology and Nanomedicine-Specific Cancer Targeting with Undetectable Toxicity., Chemical reviews. 2021 May | journal-article. doi: 10.1021/acs.chemrev.1c00009.
• Non-Small-Cell Lung Cancer Regression by siRNA Delivered Through Exosomes That Display EGFR RNA Aptamer., Nucleic acid therapeutics. 2021 May | journal-article. doi: 10.1089/nat.2021.0002.
• RNA nanotechnology to build a dodecahedral genome of single-stranded RNA virus., RNA biology. 2021 Apr | journal-article. doi: 10.1080/15476286.2021.1915620.
• One-Pot Production of RNA Nanoparticles via Automated Processing and Self-Assembly., ACS nano. 2019 Mar | journal-article. doi: 10.1021/acsnano.9b00649.
• Photo-controlled release of paclitaxel and model drugs from RNA pyramids., Nano research. 2018 Sep | journal-article. doi: 10.1007/s12274-018-2174-x.
• Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression., Nature nanotechnology. 2017 Dec | journal-article. doi: 10.1038/s41565-017-0012-z.
• Assessment and comparison of thermal stability of phosphorothioate-DNA, DNA, RNA, 2'-F RNA, and LNA in the context of Phi29 pRNA 3WJ., RNA (New York, N.Y.). 2017 Oct | journal-article. doi: 10.1261/rna.063057.117.
• Favorable biodistribution, specific targeting and conditional endosomal escape of RNA nanoparticles in cancer therapy., Cancer letters. 2017 Oct | journal-article. doi: 10.1016/j.canlet.2017.09.043.
• Advancement of the Emerging Field of RNA Nanotechnology., ACS nano. 2017 Feb | journal-article. doi: 10.1021/acsnano.6b05737.
• Mechanism of three-component collision to produce ultrastable pRNA three-way junction of Phi29 DNA-packaging motor by kinetic assessment., RNA (New York, N.Y.). 2016 Sep | journal-article. doi: 10.1261/rna.057646.116.
• Specific Delivery of MiRNA for High Efficient Inhibition of Prostate Cancer by RNA Nanotechnology., Molecular therapy : the journal of the American Society of Gene Therapy. 2016 Apr | journal-article. doi: 10.1038/mt.2016.85.
• Entropy-driven one-step formation of Phi29 pRNA 3WJ from three RNA fragments., Biochemistry. 2014 Apr | journal-article. doi: 10.1021/bi4017022.
• Synthesis, conjugation, and labeling of multifunctional pRNA nanoparticles for specific delivery of siRNA, drugs, and other therapeutics to target cells., Methods in molecular biology (Clifton, N.J.). 2012 Jan | journal-article. doi: 10.1007/978-1-62703-008-3_16.