February 8, 2018
The Ohio State University College of Pharmacy is pleased to present Michel Bouvier, Ph.D., on February 28, 2018 at 11:30 a.m. in 103 Parks Hall. Bouvier’s talk, “Functional Selectivity and Spatio-Temporal propagation of GPCR signaling; from structural determinants to better drugs?” is part of the College of Pharmacy’s Distinguished Lecture Series.
Bouvier is a professor of Biochemistry and Molecular Medicine, the director of the Institute for Research in Immunology and Cancer (IRIC) and associate vice director for research at the Université de Montréal. Following his Ph.D. in Neurological Sciences at the Université de Montréal in 1985, he completed a post-doctoral fellowship at Duke University. He holds the Canada Research Chair in Signal Transduction and Molecular Pharmacology.
The author of 277 scientific papers and 15 patents, Bouvier has delivered more than 400 invited presentations. He is a world-renowned expert in the field of cell signaling and G protein-coupled receptors (GPCRs) and made seminal contributions to our understanding of this major class of drug targets. In addition to work leading to paradigm shifts including the discovery of inverse agonism and biased signaling at GPCRs and of pharmacological chaperones to restore folding of disease-causing genetically mutated GPCRs, his work on bioluminescence resonance energy transfer (BRET) resulted in the development of screening assays that are now used for drug discovery.