Tom Li

Image
Tom Li

Tom Li, PhD

Title
Associate Professor
Unit / Department / Division
Medicinal Chemistry and Pharmacognosy
Address
336 Parks Hall
Email Address
Phone Number

Professional Interests

Professional Interests

The research area of Dr. Li focuses in the design, synthesis and biochemical testing of steroidal and non-steroidal steroid sulfatase inhibitors as potential agents for the treatment of hormone-dependent cancers. Estrogen levels in breast tumors of post-menopausal women are as much as 10 times higher than estrogen levels in plasma, presumably due to in situ formation of estrogen. The major source of estrogen in breast cancer cells may be conversion of estrone sulfate to estrone by the enzyme estrone sulfatase. One of their goals is to develop potent estrone sulfatase inhibitors as potential agents for the treatment of estrogen-dependent breast cancer. They have synthesized both the steroidal and non-steroidal estrone sulfatase inhibitors.

Education

  • 1988, PhD, The Ohio State University, Medicinal Chemistry
  • 1983, BS, University of Wyoming, Pharmacy
  • 1980, Please enter degree name, University of Nevada, Pre-Pharmacy

Honors

  • President's Award for Excellence, 1997
  • School of Pharmacy Award for Excellence in Scholarship, 1997
  • Distinguished Presentation of the 14th annual meeting, Graduate Student Forum, 1988
  • University Graduate Associate Teaching Award, 1987
  • University Fellowship, 1983 - 1984

Journal Articles

  • Bhasin, Deepak; Cisek, Katryna; Pandharkar, Trupti; Regan, Nicholas; Li, Chenglong; Pandit, Bulbul; Lin, Jiayuh; Li, Pui-Kai Design, synthesis, and studies of small molecule Stat3 inhibitors Bioorganic & Medicinal Chemistry Letters. 2008 Jan; 18(1):391-395.
  • Hutzen, Brian; Cen, Ling; Friedman, Lauren; Sobo, Matthew; Ball, Sarah; Li, Pui-Kai; Li, Chenglong; Fuchs, James; Bhasin, Deepak; Pandit, Bulbul; Shibata, Hiroyuki; Iwabuchi, Yoshiharu; Lin, Jiayuh New curcumin analogues with enhanced growth suppressive activity in cancer cells Proceedings of the American Association for Cancer Research Annual Meeting. 2008 Jan; 49 291.
  • Fossey, Stacey; Liao, Albert; Bear, Misty; Lin, Jiayuh; Li, Pui-Kai; Kisseberth, William; London, Cheryl Investigating the role of Stat3 dysregulation in human and canine osteosarcoma Proceedings of the American Association for Cancer Research Annual Meeting. 2008 Jan; 49 889.
  • Selcer, Kyle W.; DiFrancesca, Heidi M.; Chandra, Abhinav B.; Li, Pui-Kai Immunohistochemical analysis of steroid sulfatase in human tissues Journal of Steroid Biochemistry and Molecular Biology. 2007 Jan; 105(1-5):115-123.
  • Gul, Halise I.; Yerdelen, Kadir O.; Gul, Mustafa; Das, Umashankar; Pandit, Bulbul; Li, Pui-Kai; Secen, Hasan; Sahin, Fikrettin Synthesis of 4 '-hydroxy-3 '-piperidinomethylchalcone derivatives and their cytotoxicity against Pc-3 cell lines Archiv der Pharmazie (Weinheim). 2007 Jan; 340(4):195-201.
  • Hackett, John; Xiao, Zili; Zang, Xiao-Ping; Lerner, Megan L.; Brackett, Daniel J.; Brueggemeier, Robert W.; Li, Pui-Kai; Pento, J. Thomas Development of keratinocyte growth factor receptor tyrosine kinase inhibitors for the treatment of cancer Anticancer Research. 2007 Jan; 27(6B):3801-3806.
  • Pento, J. Thomas; Li, Pui-Kai Keratinocyte growth factor receptor tyrosine kinase antagonists for the prevention of metastatic cancer progression Drugs of the Future. 2007 Jan; 32(11):965-972.
  • Ishida, Hiroyuki; Nakata, Taisuke; Suzuki, Masayo; Shiotsu, Yukimasa; Tanaka, Hideyuki; Sato, Natsuko; Terasaki, Yoko; Takebayashi, Miho; Anazawa, Hideharu; Murakata, Chikara; Li, Pui-Kai; Kuwabara, Takashi; Akinaga, Shiro A novel steroidal selective steroid sulfatase inhibitor Kw-2581 inhibits sulfated-estrogen dependent growth of breast cancer cells in vitro and in animal models Breast Cancer Research and Treatment. 2007 Jan; 106(2):215-227.
  • Selcer, Kyle W.; Difrancesca, Heidi M.; Chandra, Abhinav B.; Li, Pui-Kai Immunohistochemical analysis of steroid sulfatase in human tissues. Proceedings of the American Association for Cancer Research Annual Meeting. 2007 Jan; 48 848.
  • Bhasin, Deepak; Cisek, Katryna; Pandharkar, Trupti; Pahdit, Bulbul; Li, Chenglong; Lin, Jiayuh; Li, Pui-Kai Small molecule inhibitors of Stat3 dimerization for prostate cancer. Proceedings of the American Association for Cancer Research Annual Meeting. 2007 Jan; 48 566.
  • Ishida, Hiroyuki; Nakata, Taisuke; Sato, Natsuko; Li, Pui-Kai; Kuwabara, Takashi; Akinaga, Shiro Inhibition of steroid sulfatase activity and cell proliferation in Zr-75-1 and Bt-474 human breast cancer cells by Kw-2581 in vitro and in vivo Breast Cancer Research and Treatment. 2007 Jan; 104(2):211-219.
  • Pandit, Bulbul; Sun, Yanjun; Chen, Ping; Sackett, Dan L.; Hu, Zhigen; Rich, Wendy; Li, Chenglong; Lewis, Andrew; Schaefer, Kevin; Li, Pui-KaI Structure-activity-relationship studies of conformationally restricted analogs of combretastatin A-4 derived from Su5416 Bioorganic & Medicinal Chemistry. 2006 Jan; 14(19):6492-6501.
  • Gul, Halise Inci; Das, Umashankar; Pandit, Bulbul; Li, Pui-Kai Evaluation of the cytotoxicity of some mono-mannich bases and their corresponding azine derivatives against androgen-independent prostate cancer cells Arzneimittel-Forschung. 2006 Jan; 56(12):850-855.
  • Li, Pui-Kai; Pandit, Bulbul; Sackett, Dan L.; Hu, Zhigen; Zink, Jennifer; Zhi, Jiandong; Freeman, Dena; Robey, Robert W.; Werbovetz, Karl; Lewis, Andrew; Li, Chenglong A thalidomide analogue with in vitro antiproliferative, antimitotic, and microtubule-stabilizing activities Molecular Cancer Therapeutics. 2006 Jan; 5(2):450-456.
  • Pandit, Bulbul; Chen, Ping; Sun, Yanjun; Li, Pui-Kai; Hildebrand, April Tri-methoxy benzylidene substituted 1, 3-dihydro-indol-2-one analogs as cytotoxic and anti-microtubule agents. Abstracts of Papers American Chemical Society. 2005 Jan; 229(Part 2):U194.
  • Pandit, Bulbul; Sun, Yanjun; Chen, Ping; Sackett, Dan L.; Hildebrand, April; Lewis, Andrew; Li, Pui-Kai Tri-methoxy benzylidene substituted 1, 3-dihydro-indol-2-one analogs as anti-prolifierative and anti-microtubule agents. Proceedings of the American Association for Cancer Research Annual Meeting. 2005 Jan; 46(Suppl. S):810.
  • Thomas, Michael J.; Mameli, Manuel; Carta, Mario; Valenzuela, C. Fernando; Li, Pui-Kai; Partridge, L. Donald Neurosteroid paradoxical enhancement of paired-pulse inhibition through paired-pulse facilitation of inhibitory circuits in dentate granule cells Neuropharmacology. 2005 Jan; 48(4):584-596.
  • Brueggemeier, Robert W.; Diaz-Cruz, Edgar S.; Li, Pui-Kai; Sugimoto, Yasuro; Lin, Young C.; Shapiro, Charles L. Translational studies on aromatase, cyclooxygenases, and enzyme inhibitors in breast cancer Journal of Steroid Biochemistry and Molecular Biology. 2005 Jan; 95(1-5):129-136.
  • Kyker, Kimberly D.; Ross, Krysten; Clark, Callie; Ihnat, Michael A.; Li, Pui-Kai; Hurst, Robert E. A 3-dimensional model for screening for drugs preferentially active against suppressed bladder cancer cells. Proceedings of the American Association for Cancer Research Annual Meeting. 2005 Jan; 46(Suppl. S):1393.
  • El-Sherif, Yasir; Witt-Enderby, Paula; Li, Pui-Kai; Tesoriero, Jene; Hogan, Michael V.; Wieraszko, Andrzej The actions of a charged melatonin receptor ligand, Tmepi, and an irreversible Mt2 receptor agonist, Bmnep, on mouse hippocampal evoked potentials in vitro (vol 75, pg 3147, 2004) Life Sciences. 2005 Jan; 77(4):480.
  • Li, Pui-Kai; Zili, Xiao; Pandit, Bulbul; Hu, Zhigen; Freeman, Dena; Cheah, Christine; Rich, Wendy; Sackett, Dan L. Anti protiiferative, anti-apoptotic and anti-microtubule activities of 3 substituted indolin-2-one derivatives. Proceedings of the American Association for Cancer Research Annual Meeting. 2004 Jan; 45(Suppl. S):1250.
  • Park, Kah-Young; Liu, Suling; Sugimoto, Yasuro; Chang, Hsiang-Lin; Ye, Weiping; Wang, Li-Shu; Huang, Yi-Wen; Shu, Sherry; Li, Tom; Brueggemeier, Robert W.; Lin, Young C. Effect of inhibiting aromatase activity in estrogen-transformed human breast epithelial cells. Proceedings of the American Association for Cancer Research Annual Meeting. 2004 Jan; 45(Suppl. S):106.
  • Caldeira, Jerri C.; Wu, Yan; Mameli, Manuel; Purdy, Robert H.; Li, Pui-Kai; Akwa, Yvette; Savage, Daniel D.; Engen, John R.; Valenzuela, C. Fernando Fetal alcohol exposure alters neurosteroid levels in the developing rat brain Journal of Neurochemistry. 2004 Jan; 90(6):1530-1539.
  • Li, Pui-Kai; Selcer, Kyle W. Compounds for the treatment of estrogen-dependent illnesses and methods for making and using the same Official Gazette of the United States Patent and Trademark Office Patents. 2004 Jan; 1281(1):.
  • El-Sherif, Yasir; Witt-Enderby, Paula; Li, Pui-Kai; Tesoriero, Jene; Hogan, Michael V.; Wieraszko, Andrzej The actions of a charged melatonin receptor ligand, Tmepi, and an irreversible Mt2 receptor agonist, Bmnep, on mouse hippocampal evoked potentials in vitro Life Sciences. 2004 Jan; 75(26):3147-3156.
  • Chandra, Abhinav B.; Li, Pui-Kai; Selcer, Kyle W. Immunohistochemical analysis of steryl sulfatase activity in human tissues. Biology of Reproduction. 2003 Jan; 68(Supplement 1):357-358.
  • Ino, Yoji; Amishiro, Nobuyoshi; Nakata, Taisuke; Ishida, Hiroyuki; Akinaga, Shiro; Murakata, Chikara; Li, Pui-Kai Estra-1,3,5(10),16-tetraene derivatives Official Gazette of the United States Patent and Trademark Office Patents. 2003 Jan; 1275(4):.
  • Shi, Jiandong; Xiao, Zili; Ihnat, Michael A.; Kamat, Chandrashekhar; Pandit, Bulbul; Hu, Zhigen; Li, Pui-Kai Structure-activity relationships studies of the anti-angiogenic activities of linomide. Bioorganic & Medicinal Chemistry Letters. 2003 Jan; 13(6):1187-1189.
  • Hu, Zhigen; Pandit, Bulbul; Shi, Jiandong; Zink, Jennifer; Sackett, Dan L.; Li, Pui-Kai Thalidomide analogs with antiproliferative and antimicrotubule activities. Abstracts of Papers American Chemical Society. 2003 Jan; 225(1-2):MEDI 126.
  • Chu, Guo-Hua; Witt-Enderby, Paula A.; Jones, Marla; Li, Pui-Kai Synthesis and pharmacological analysis of high affinity melatonin receptor ligands Chemical and Pharmaceutical Bulletin (Tokyo). 2002 Jan; 50(2):272-275.
  • Li, Pui-Kai; Shi, Jiandong; Wu, Min; Marks, Megan; Hu, Zhigen; Ihnat, Michael; Kamat, Chandrashkhar Design and studies of anti-angiogenic thalidomide analogs Proceedings of the American Association for Cancer Research Annual Meeting. 2002 Jan; 43 739.
  • Li, Pui-Kai; Murakata, Chikara; Akinaga, Shiro Steroid sulfatase inhibitors and methods for making and using the same Official Gazette of the United States Patent and Trademark Office Patents. 2002 Jan; 1261(3):.
  • Li, Pui-Kai; Murakata, Chikara; Akinaga, Shiro Steroid sulfatase inhibitors and methods for making and using the same Official Gazette of the United States Patent and Trademark Office Patents. 2002 Jan; 1259(1):.
  • Li, Pui-Kai; Murakata, Chikara; Akinaga, Shiro Steroid sulfatase inhibitors and methods for making and using the same Official Gazette of the United States Patent and Trademark Office Patents. 2002 Jan; 1257(4):.
  • Selcer, Kyle W.; Kabler, Heidi; Sarap, Jennifer; Xiao, Zili; Li, Pui-Kai Inhibition of steryl sulfatase activity in Lncap human prostate cancer cells Steroids. 2002 Jan; 67(10):821-826.
  • Li, Pui-Kai; Selcer, Kyle W. Compounds for the treatment of estrogen-dependent illnesses and methods of making and using the same Official Gazette of the United States Patent and Trademark Office Patents. 2002 Jan; 1261(2):.
  • Xiao, Zili; Schaefer, Kevin; Firestine, Steven; Li, Pui-Kai Solid-phase synthesis of thalidomide and its analogues Journal of Combinatorial Chemistry. 2002 Jan; 4(2):149-153.
  • Marks, Megan G.; Shi, Jiandong; Fry, Michael O.; Xiao, Zili; Trzyna, Michelle; Pokala, Vedavalli; Ihnat, Michael A.; Li, Pui-Kai Effects of putative hydroxylated thalidomide metabolites on blood vessel density in the chorioallantoic membrane (cam) assay and on tumor and endothelial cell proliferation Biological and Pharmaceutical Bulletin. 2002 Jan; 25(5):597-604.
  • Esposito, Emilio Xavier; Wymore, Troy; Li, Pui-Kai; Madura, Jeffry D. Docking of novel melatonin ligands to homology models of Mt1 and Mt2 Abstracts of Papers American Chemical Society. 2002 Jan; 224(1-2):COMP 162.
  • Hackett, John C.; Li, Pui-Kai; Brueggemeier, Robert W. Virtual screening using a Kgfr homology model Proceedings of the American Association for Cancer Research Annual Meeting. 2002 Jan; 43 738.
  • Hu, Zhigen; Zink, Jennifer; Zili, Xiao; Shi, Jiandong; Li, Pui-Kai Anti-angiogenic and anti-proliferative thalidomide analogs Abstracts of Papers American Chemical Society. 2002 Jan; 224(1-2):MEDI 91.
  • Li, Pui-Kai; Selcer, Kyle W. Compounds for the treatment of estrogen-dependent illnesses and methods for making and using the same Official Gazette of the United States Patent and Trademark Office Patents. 2001 Jan; 1250(2):.
  • Li, Pui-Kai; Selcer, Kyle W. Compounds for the treatment of estrogen-dependent illnesses and methods for making and using the same Official Gazette of the United States Patent and Trademark Office Patents. 2001 Jan; 1247(3):.
  • Xiao, Zili; Schaefer, Kevin; Li, Pui-Kai Solid phase synthesis of thalidomide and its analogs Abstracts of Papers American Chemical Society. 2001 Jan; 222(1-2):MEDI119.
  • Bordt, Shannon L.; McKeon, Raelene M.; Li, Pui-Kai; Witt-Enderby, Paula A.; Melan, Melissa A. N1e-115 mouse neuroblastoma cells express mt1 melatonin receptors and produce neurites in response to melatonin Biochimica et Biophysica Acta. 2001 Jan; 1499(3):257-264.
  • Selcer, Kyle W.; Beyer, Amanda R.; Parker, Sarah; Li, Pui-Kai; Clemens, Jeffrey W. Development and characterization of a steryl sulfatase antibody Biology of Reproduction. 2001 Jan; 64(Supplement 1):248.
  • Li, Pui-Kai; Murakata, Chikara; Akinaga, Shiro Steroid sulfatase inhibitors and methods for making and using the same Official Gazette of the United States Patent and Trademark Office Patents. 2001 Jan; 1250(2):.
  • Xiao, Zili; Waters, Norman C.; Woodard, Cassandra L.; Li, Zhiyu; Li, Pui-Kai Design and synthesis of Pfmrk inhibitors as potential antimalarial agents Bioorganic and Medicinal Chemistry Letters. 2001 Jan; 11(21):2875-2878.
  • Ino, Yoji; Amishiro, Nobuyoshi; Nakata, Taisuke; Ishida, Hiroyuki; Akinaga, Shiro; Murakata, Chikara; Li, Pui-Kai Estra-1,3,5(10),16-tetraene derivatives Official Gazette of the United States Patent and Trademark Office Patents. 2001 Jan; 1248(3):.
  • Shi, Jiandong; Xiao, Zili; Marks, Megan; Kamat, Chandrashkhar; Pokala, Vedavalli; Ihnat, Michael A.; Wu, Min; Li, Pui-Kai Development of thalidomide analogs as anti-angiogenic agents Abstracts of Papers American Chemical Society. 2001 Jan; 222(1-2):MEDI81.
  • Chu, Guo-Hua; Li, Pui-Kai Synthesis of (25, 26, 26, 26, 27, 27, 27-d7)-cholesterol Journal of Labelled Compounds and Radiopharmaceuticals. 2000 Jan; 43(8):773-779.
  • Li, Pui-Kai; Witt-Enderby, A. Melatonin receptors as potential targets for drug discovery Drugs of the Future. 2000 Jan; 25(9):945-957.
  • Sane, Rucha; Chu, Guo-Hua; Sarap, Jennifer; Kabler, Heidi; Selcer, Kyle W.; Li, Pui-Kai Design and syntheses of dual-acting inhibitors for breast cancer Abstracts of Papers American Chemical Society. 2000 Jan; 219(1-2):MEDI 32.
  • Selcer, Kyle W.; Kabler, Heidi; Sarap, Jennifer; Li, Pui-Kai Inhibition of steryl sulfatase activity in Lncap human prostate cancer cells Biology of Reproduction. 2000 Jan; 62(Supplement 1):187.
  • Clemens, Jeffrey W.; Kabler, Heidi L.; Sarap, Jennifer L.; Beyer, Amanda R.; Li, Pui-Kai; Selcer, Kyle W. Steroid sulfatase activity in the rat ovary, cultured granulosa cells, and a granulosa cell line Journal of Steroid Biochemistry and Molecular Biology. 2000 Jan; 75(4-5):245-252.
  • Li, Pui-Kai; Sugden, David; Teh, Muy Teck; Chu, Guo-Hua; Witt-Enderby, Paula A. Synthesis and studies of irreversible melatonin receptor ligands Abstracts of Papers American Chemical Society. 1999 Jan; 218(1-2):MEDI 149.
  • Kolli, Aparna; Chu, Guo-Hua; Rhodes, Michael E.; Inoue, Kengo; Selcer, Kyle W.; Li, Pui-Kai Development of (p-o-sulfamoyl)-n-alkanoyl-phenylalkyl amines as non-steroidal estrone sulfatase inhibitors Journal of Steroid Biochemistry and Molecular Biology. 1999 Jan; 68(1-2):31-40.
  • Chu, Guo-Hua; Peters, Amy; Selcer, Kyle W.; Li, Pui-Kai Synthesis and sulfatase inhibitory activities of (e)- and (z)-4-hydroxytamoxifen sulfamates Bioorganic and Medicinal Chemistry Letters. 1999 Jan; 9(2):141-144.
  • Li, Pui-Kai; Sane, Rucha; Chu, Guo-Hua; Peters, Amy; Selcer, K. W. 17-substituted estra-1,3,5(10)-triene-3-o-sulfamates as potent estrone sulfatase inhibitors for breast cancer Abstracts of Papers American Chemical Society. 1999 Jan; 217(1-2):MEDI 68.
  • Li, Pui-Kai; Chu, Guo-Hua; Guo, Jingping; Peters, Amy; Selcer, Kyle W. Development of potent non-estrogenic estrone sulfatase inhibitors Steroids. 1998 Jan; 63(7-8):425-432.
  • Chu, Guo-Hua; Li, Pui-Kai Synthesis of a radiolabeled charged melatonin receptor ligand Journal of Labelled Compounds and Radiopharmaceuticals. 1998 Jan; 41(5):435-441.
  • Chu, Guo-Hua; Jagannathan, Sharada; Li, Pui-Kai Synthesis of 17-oxoandrosta-3,5-dien-3-methyl sulfonate as stable analog of dehydroepiandrosterone sulfate Steroids. 1998 Jan; 63(4):214-217.
  • Rhodes, Michael E.; Li, Pui-Kai; Burke, Alexis M.; Johnson, David A. Enhanced plasma Dheas, brain acetylcholine and memory mediated by steroid sulfatase inhibition Brain Research. 1997 Jan; 773(1-2):28-32.
  • Johnson, David A.; Rhodes, Michael E.; Boni, Riccardo L.; Li, Pui-Kai Chronic steroid sulfatase inhibition by (p-o-sulfamoyl)-n-tetradecanoyl tyramine increases dehydroepiandrosterone sulfate in whole brain Life Sciences. 1997 Jan; 61(24):PL355-PL359.
  • Chu, Guo-Hua; Li, Pui-Kai Synthesis of sodium androst-5-ene-17-one-3-beta-methylene sulfonate Steroids. 1997 Jan; 62(7):543-545.
  • Li, Pui-Kai; Rhodes, Michael E.; Burke, Alexis M.; Johnson, David A. Memory enhancement mediated by the steroid sulfatase inhibitor (p-o-sulfamoyl)-n-tetradecanoyl tyramine Life Sciences. 1997 Jan; 60(3):PL45-PL51.
  • Li, Pui-Kai; Chu, Guo-Hua; Gillen, Megan L.; Witt-Enderby, Paula A. Synthesis and receptor binding studies of quinolinic derivatives as melatonin receptor ligands Bioorganic and Medicinal Chemistry Letters. 1997 Jan; 7(17):2177-2180.
  • Selcer, Kyle W.; Hegde, Priya V.; Li, Pui-Kai Inhibition of estrone sulfatase and proliferation of human breast cancer cells by nonsteroidal (p-o-sulfamoyl)-n-alkanoyl tyramines Cancer Research. 1997 Jan; 57(4):702-707.
  • Witt-Enderby, Paula A.; Chu, Guo-Hua; Gillen, Megan L.; Li, Pui-Kai Development of a high-affinity ligand that binds irreversibly to Mel1b melatonin receptors Journal of Medicinal Chemistry. 1997 Jan; 40(26):4195-4198.
  • Li, Pui-Kai; Chu, Guo-Hua; Gillen, Megan L.; Parekh, Tejal; Witt-Enderby, Paula A. The development of a charged melatonin receptor ligand Bioorganic and Medicinal Chemistry Letters. 1997 Jan; 7(18):2409-2414.
  • Chu, Guo-Hua; Milano, Shawn; Kluth, Lisa; Rhodes, Michael; Boni, Riccardo; Johnson, David A.; Li, Pui-Kai Structure-activity relationship studies of the amide functionality in (p-o-sulfamoyl)-n-alkanoyl tyramines as estrone sulfatase inhibitors Steroids. 1997 Jan; 62(7):530-535.
  • Selcer, Kyle W.; Jagannathan, Sharada; Rhodes, Michael E.; Li, Pui-Kai Inhibition of placental estrone sulfatase activity and Mcf-7 breast cancer cell proliferation by estrone-3-amino derivatives Journal of Steroid Biochemistry and Molecular Biology. 1996 Jan; 59(1):83-91.
  • Li, Pui-Kai; Milano, Shawn; Kluth, Lisa; Rhodes, Michael E. Synthesis and sulfatase inhibitory activities of non-steroidal estrone sulfatase inhibitors Journal of Steroid Biochemistry and Molecular Biology. 1996 Jan; 59(1):41-48.
  • Selcer, Kyle W.; Li, Pui-Kai Estrogenicity, antiestrogenicity and estrone sulfatase inhibition of estrone-3-amine and estrone-3-thiol Journal of Steroid Biochemistry and Molecular Biology. 1995 Jan; 52(3):281-286.
  • Dibbelt, Leif; Li, Pui-Kai; Pillai, Radhakrishnan; Knuppen, Rudolf Inhibition of human placental sterylsulfatase by synthetic analogs of estrone sulfate Journal of Steroid Biochemistry and Molecular Biology. 1994 Jan; 50(5-6):261-266.
  • Krise, Jeffrey P.; Li, Pui-Kai; Drennen, James K. Characterization of insulin adsorption to intravenous infusion systems by near-infrared analysis Pharmaceutical Research (New York). 1993 Jan; 10(10 SUPPL.):S17.
  • Li, Pui-Kai; Pillai, Radhakrishnan; Young, Barry L.; Bender, William H.; Martino, Dino M.; Lin, Fu-Tyan Synthesis and biochemical studies of estrone sulfatase inhibitors Steroids. 1993 Jan; 58(3):106-111.
  • Wang B, Li PK, Ma JX, Chen D. Therapeutic Effects of a Novel Phenylphthalimide Analog for Corneal Neovascularization and Retinal Vascular Leakage. Invest Ophthalmol Vis Sci. 2018 Jul 02;59(8):3630-3642.
  • Arend RC, Londoño-Joshi AI, Gangrade A, Katre AA, Kurpad C, Li Y, Samant RS, Li PK, Landen CN, Yang ES, Hidalgo B, Alvarez RD, Straughn JM, Forero A, Buchsbaum DJ. Correction: Niclosamide and its analogs are potent inhibitors of Wnt/β-catenin, mTOR and STAT3 signaling in ovarian cancer. Oncotarget. 2018 Apr 10;9(27):19459.
  • Tang Z, Acuña UM, Fernandes NF, Chettiar S, Li PK, DE Blanco EC. Structure-Activity Relationship of Niclosamide Derivatives. Anticancer Res. 2017 06;37(6):2839-2843.
  • Sugimoto Y, Sawant DB, Fisk HA, Mao L, Li C, Chettiar S, Li PK, Darby MV, Brueggemeier RW. Novel pyrrolopyrimidines as Mps1/TTK kinase inhibitors for breast cancer. Bioorg Med Chem. 2017 04 01;25(7):2156-2166.
  • Arend RC, Londoño-Joshi AI, Gangrade A, Katre AA, Kurpad C, Li Y, Samant RS, Li PK, Landen CN, Yang ES, Hidalgo B, Alvarez RD, Straughn JM, Forero A, Buchsbaum DJ. Niclosamide and its analogs are potent inhibitors of Wnt/β-catenin, mTOR and STAT3 signaling in ovarian cancer. Oncotarget. 2016 Dec 27;7(52):86803-86815.
  • Lin L, Jou D, Wang Y, Ma H, Liu T, Fuchs J, Li PK, Lü J, Li C, Lin J. STAT3 as a potential therapeutic target in ALDH+ and CD44+/CD24+ stem cell-like pancreatic cancer cells. Int J Oncol. 2016 Dec;49(6):2265-2274.
  • Zhao J, Yu H, Liu Y, Gibson SA, Yan Z, Xu X, Gaggar A, Li PK, Li C, Wei S, Benveniste EN, Qin H. Protective effect of suppressing STAT3 activity in LPS-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2016 11 01;311(5):L868-L880.
  • Walters Haygood CL, Arend RC, Gangrade A, Chettiar S, Regan N, Hassmann CJ, Li PK, Hidalgo B, Straughn JM, Buchsbaum DJ. Niclosamide Analogs for Treatment of Ovarian Cancer. Int J Gynecol Cancer. 2015 Oct;25(8):1377-85.
  • Li Y, Li PK, Roberts MJ, Arend RC, Samant RS, Buchsbaum DJ. Multi-targeted therapy of cancer by niclosamide: A new application for an old drug. Cancer Lett. 2014 Jul 10;349(1):8-14.
  • Kim TD, Fuchs JR, Schwartz E, Abdelhamid D, Etter J, Berry WL, Li C, Ihnat MA, Li PK, Janknecht R. Pro-growth role of the JMJD2C histone demethylase in HCT-116 colon cancer cells and identification of curcuminoids as JMJD2 inhibitors. Am J Transl Res. 2014;6(3):236-47.