Robert Curley

Robert Curley, PhD

Faculty Emeritus
curley.1@osu.edu
(614) 292-7628

Education

  • 1984, Please enter degree name, University of Wisconsin, Biochemistry
  • 1982, PhD, West Virginia University, Pharmaceutical Sciences
  • 1978, BS, University of Connecticut, Pharmacy

Honors

  • AAPS Fellow, 2009
  • Pfeiffer Memorial Fellowship, American Foundation for Pharmaceutical Education, 1993 - 1994
  • National Research Service Fellowship, National Cancer Institute, 1982 - 1984
  • Abe Plough Citation Fellow, American Foundation for Pharmaceutical Education, 1981 - 1982
  • American Foundation for Pharmaceutical Education Fellowships, 1979 - 1981
  • Melvin A. Prawdzik Memorial Scholarships, 1973 - 1975

Patents

  • C-Linked Glucuronide of 4-Hydroxybenzylretinone, Analogs Thereof, and Method of Using the Same to Inhibit Neoplastic Cell Growth (2011, May). US 2011/0212906 A1.
  • 4-[(E)-2-(5,6,7,8-Tetrahydro-5,5,8,8- tetramethyl-2-naphthalenyl)-1-propenyl]benzoic Acid Analogs and Method of Manufacture and Use Thereof (2009, July). U.S. Patent No. 7,968,602.
  • C-Linked Glucuronide of 4-Hydroxybenzylretinone, Analogs Thereof, and Method of Using the Same to Inhibit Neoplastic Cell Growth (2009, January). U.S. Patent No. 8,026,220.
  • 4-[(E)-2-(5,6,7,8-Tetrahydro-5,5,8,8- tetramethyl-2-naphthalenyl)-1-propenyl]benzoic Acid Analogs and Method of Manufacture and Use Thereof (2005, June). U.S. Patent No. 7,585,894.
  • C-Linked Glucuronide of 4-Hydroxybenzylretinone, Analogs Thereof, and Method of Using the Same to Inhibit Neoplastic Cell Growth (2005, May). U.S. Patent No. 7,528,114.
  • Solid-Phase Synthesis of 4-HPR Analogs (2002, July). U.S. Patent No. 6,696,606.
  • Methimazole Derivatives/Tautomeric Cyclic Thiones to Treat Autoimmune Diseases (1999, August). U.S. Patent No. 6,365,616.
  • Stable C-Linked Analog of the Cancer Chemopreventive Retinoid N-(4-Hydroxyphenyl)retinamide (4-HPR) (1999, June). U.S. Patent No. 6,117,845.
  • Stable Acitretinoid Compounds (1997, May). U.S. Patent No. 5,808,111.
  • Arylamide Analogues of N-(4-Hydroxyphenyl)retinamide-O-glucuronide (1995, June). U.S. Patent No. 5,663,377..
  • C-Glycoside Analogues of N-(4-Hydroxyphenyl)retinamide-O-glucuronide (1995, May). U.S. Patent No. 5,599,953..
  • Arylamide Analogues of N-(4-Hydroxyphenyl)retinamide-O-glucuronide (1994, October). U.S. Patent No. 5,574,177.
  • C-Glycoside Analogues of N-(4-Hydroxyphenyl)retinamide-O-glucuronide (1994, September). U.S. Patent No. 5,516,792.

Publications

  • Eroglu, A.; Hruszkewycz, D.P.; dela Sena, C.; Narayanasamy, S.; Riedl, K.M.; Kopec, R.E.; Schwartz, S. J.; Curley, Jr., R.W.; Harrison, E.H. Naturally Occurring Eccentric Cleavage Products of Provitamin A beta-Carotene Function as Antagonists of Retinoic Acid Receptors J. Biol. Chem.. 2012 May; 287(19):15886-15895.
  • Fleshman, M.K.; Lester, G.E.; Riedl, K.M.; Kopec, R.E.; Narayanasamy, S.; Curley, R.W., Jr.; Schwartz, S.J.; Harrison, E.H. Carotene and Novel Apocarotenoid Concentrations in Orange-Fleshed Cucumis melo Melons: Determinations of beta-Carotene Bioaccessibility and Bioavailability J. Agric. Food Chem.. 2011 Jan; 59 4448-4454.
  • Shmarakov, I.; Fleshman, M.K.; D'Ambrosio, D.; Piantedosi, R.; Riedl, K.M.; Schwartz, S.J.; Curley, R.W., Jr.; von Lintig, J.; Rubin, L.P.; Harrison, E.H.; Blaner, W.S. Hepatic Stellate Cells are an Important Cellular Site for beta-Carotene Conversion to Retinoid Arch. Biochem. Biophys.. 2010 Jan; 504 3-10.
  • Eroglu, A.; Hruszkewycz, D.P.; Curley, R.W., Jr.; Harrison, E.H. The Eccentric Cleavage Product of beta-Carotene, beta-apo-13-Carotenone, Functions as an Antagonist of RXRalpha Arch. Biochem. Biophys.. 2010 Jan; 504 11-16.
  • Kopec, R.E.; Riedl, K.M.; Harrison, E.H.; Curley, R. W., Jr.; Hruszkewycz, D.P.; Clinton, S.K.; Schwartz, S.J. Identification and Quantitation of Apo-Lycopenals in Fruits, Vegetables, and Human Plasma J. Agric. Food Chem.. 2010 Jan; 58 3290-3296.
  • Eroglu, A.; Hruszkewycz, D.P.; dela Sena, C.; Narayanasamy, S.; Riedl, K.M.; Kopec, R.E.; Schwartz, S.J.; curley, R.W., Jr.; Harrison, E.H. Naturally-Occurring Eccentric Cleavage Products of Provitamin A beta-Carotene Function as Antagonists of Retinoic Acid Receptors J. Biol. Chem.. Dec .
  • Eroglu, A.; Hruszkewycz, D.P.; Curley, R.W., Jr.; Harrison, E.H. The Eccentric Cleavage Product of beta-Carotene, beta-apo-13-Carotenone, Functions as an Antagonist of RXRalpha Arch. Biochem. Biophys.. Dec .
  • Hartman, D.A.; Curley, R.W., Jr. lodotrimethylsilane Deoxygenation of Carbonyl Conjugated Allylic Ethers Tetrahedron Lett.. 1989 Jan; 30 645-646.
  • Curley, R.W., Jr.; Carson, D.L.; Ryzewski, C.N Analysis of Vitamin A and its Metabolites Using Ultrasil and Ultrasphere C18 Columns Chromatogram. 1987 Jan; 8 7-9.