January 21, 2020
Garima Agarwal, Peter J. Blanco Carcache and Ermias Mekuria Addo recently worked with their advisor, Dr. A. Douglas Kinghorn, to publish a major review article, “Current status and contemporary approaches to the discovery of antitumor agents from higher plants,” in the journal Biotechnology Advances.
According to research published by the American Cancer Society, cancer is the second leading cause of death in the United States. Higher plant constituents have afforded clinically available anticancer drugs.
The group’s article on higher plants:
- Summarizes the small organic molecules obtained from higher plants and their derivatives currently on the market and in clinical trials as single chemical entity cancer agents;
- Demonstrates the constituents of botanical dietary supplements that have shown potential anticancer properties, in particular those from noni and mangosteen;
- Discusses new approaches to the purification of biologically active plant extracts containing thousands of individual compounds and the use of hyphenated analytical techniques and molecular networking in rapid dereplication procedures;
- Demonstrates the application of biotechnological strategies, including different formulations, such as micelles and nanoparticles; and,
- Describes antibody-drug conjugates (ADCs) and their role in enhancing targeted drug delivery using natural product-derived molecules.
Peter Blanco Carcache and Ermias Mekuria Addo are both PhD students in Dr. Kinghorn’s lab in the Division of Medicinal Chemistry and Pharmacognosy. Dr. Garima Agarwal recently graduated and now works in Dr. Craig McElroy’s lab in the college.
Biotechnology Advances has an impact factor of 12.8.
View the full article here.