Navjot Pabla, PhD

Associate Professor

Pharmaceutics and Pharmacology

Outcomes and Translational Sciences

Research Areas: Clinical & Pre-Clinical Pharmacology, The Division of Pharmaceutics & Pharmacology

402 Riffe Building

Professional Interests

Our laboratory is focused on identifying therapeutic targets for kidney diseases. Acute kidney injury and renal cell carcinoma are the two major areas of interest. Our recent work has identified several protein kinases and membrane transporters as therapeutic targets for renal disorders. We utilize high throughput screening assays and functional genomics to identify molecular targets for renal diseases, followed by validation in in vivo animal models. The overall goal of these studies is to identify new therapeutic strategies to treat acute kidney injury and renal cell carcinoma, diseases for which no effective therapies are currently available.

Education

2009, PhD (Biomedical Sciences), Medical College of Georgia
2003, M.Sc. (Biochemistry), Maharaja Sayajirao University of Baroda
2001, B.Sc. (Biotechnology), Sardar Patel University

Publications

Gilteritinib-induced upregulation of S100A9 is mediated through BCL6 in Acute Myeloid Leukemia., Blood advances. 2021 Oct | journal-article. doi: 10.1182/bloodadvances.2021005614.
Kidney toxicity of the BRAF-kinase inhibitor vemurafenib is driven by off-target ferrochelatase inhibition., Kidney international. 2021 Sep | journal-article. doi: 10.1016/j.kint.2021.08.022.
Involvement of the CDKL5-SOX9 signaling axis in rhabdomyolysis-associated acute kidney injury., American journal of physiology. Renal physiology. 2020 Oct | journal-article. doi: 10.1152/ajprenal.00429.2020.
SOX9 promotes stress-responsive transcription of VGF nerve growth factor inducible gene in renal tubular epithelial cells., The Journal of biological chemistry. 2020 Sep | journal-article. doi: 10.1074/jbc.ra120.015110.
Neuronal uptake transporters contribute to oxaliplatin neurotoxicity in mice., The Journal of clinical investigation. 2020 Jun | journal-article. doi: 10.1172/jci136796.
A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury., Nature communications. 2020 Apr | journal-article. doi: 10.1038/s41467-020-15638-6.
Ribociclib mitigates cisplatin-associated kidney injury through retinoblastoma-1 dependent mechanisms., Biochemical pharmacology. 2020 Mar | journal-article. doi: 10.1016/j.bcp.2020.113939.
FoxO1 is a critical regulator of M2-like macrophage activation in allergic asthma., Allergy. 2018 Nov | journal-article. doi: 10.1111/all.13626.
Hypoxia-induced upregulation of BMX kinase mediates therapeutic resistance in acute myeloid leukemia., The Journal of clinical investigation. 2017 Dec | journal-article. doi: 10.1172/jci91893.
Identification of OAT1/OAT3 as Contributors to Cisplatin Toxicity., Clinical and translational science. 2017 Jul | journal-article. doi: 10.1111/cts.12480.
OCTN1 Is a High-Affinity Carrier of Nucleoside Analogues., Cancer research. 2017 Feb | journal-article. doi: 10.1158/0008-5472.can-16-2548.
Role of Passive Diffusion, Transporters, and Membrane Trafficking-Mediated Processes in Cellular Drug Transport., Clinical pharmacology and therapeutics. 2016 Nov | journal-article. doi: 10.1002/cpt.545.
A phosphotyrosine switch regulates organic cation transporters., Nature communications. 2016 Mar | journal-article. doi: 10.1038/ncomms10880.
DNA damage response in cisplatin-induced nephrotoxicity., Archives of toxicology. 2015 Nov | journal-article. doi: 10.1007/s00204-015-1633-3.
Mitigation of acute kidney injury by cell-cycle inhibitors that suppress both CDK4/6 and OCT2 functions., Proceedings of the National Academy of Sciences of the United States of America. 2015 Apr | journal-article. doi: 10.1073/pnas.1424313112.
CCR 20th anniversary commentary: BMS-247550—microtubule stabilization as successful targeted therapy., Clinical cancer research : an official journal of the American Association for Cancer Research. 2015 Mar | journal-article. doi: 10.1158/1078-0432.ccr-14-2551.
MicroRNA-687 Induced by Hypoxia-Inducible Factor-1 Targets Phosphatase and Tensin Homolog in Renal Ischemia-Reperfusion Injury., Journal of the American Society of Nephrology : JASN. 2015 Jan | journal-article. doi: 10.1681/asn.2014050463.
Cisplatin-induced renal injury is independently mediated by OCT2 and p53., Clinical cancer research : an official journal of the American Association for Cancer Research. 2014 Jun | journal-article. doi: 10.1158/1078-0432.ccr-14-0319.
Nek1 interacts with Ku80 to assist chromatin loading of replication factors and S-phase progression., Cell cycle (Georgetown, Tex.). 2013 Jul | journal-article. doi: 10.4161/cc.25624.
Checkpoint kinase 1 in DNA damage response and cell cycle regulation., Cellular and molecular life sciences : CMLS. 2013 Mar | journal-article. doi: 10.1007/s00018-013-1307-3.
Nek1 phosphorylates Von Hippel-Lindau tumor suppressor to promote its proteasomal degradation and ciliary destabilization., Cell cycle (Georgetown, Tex.). 2012 Dec | journal-article. doi: 10.4161/cc.23053.
Sibling rivalry in checkpoint control of cell cycle and DNA damage response., Cell cycle (Georgetown, Tex.). 2012 May | journal-article. doi: 10.4161/cc.20416.
Curtailing side effects in chemotherapy: a tale of PKCδ in cisplatin treatment., Oncotarget. 2012 Jan | journal-article. doi: 10.18632/oncotarget.439.
Checkpoint kinase 1 (Chk1)-short is a splice variant and endogenous inhibitor of Chk1 that regulates cell cycle and DNA damage checkpoints., Proceedings of the National Academy of Sciences of the United States of America. 2011 Dec | journal-article. doi: 10.1073/pnas.1104767109.
Inhibition of PKCδ reduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer., The Journal of clinical investigation. 2011 Jul | journal-article. doi: 10.1172/jci45586.
hMSH2 recruits ATR to DNA damage sites for activation during DNA damage-induced apoptosis., The Journal of biological chemistry. 2011 Feb | journal-article. doi: 10.1074/jbc.m110.210989.
PKC-delta promotes renal tubular cell apoptosis associated with proteinuria., Journal of the American Society of Nephrology : JASN. 2010 Apr | journal-article. doi: 10.1681/asn.2009070760.
The copper transporter Ctr1 contributes to cisplatin uptake by renal tubular cells during cisplatin nephrotoxicity., American journal of physiology. Renal physiology. 2009 Jan | journal-article. doi: 10.1152/ajprenal.90545.2008.
ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis. VOLUME 283 (2008) PAGES 6572-6583, The Journal of biological chemistry. 2008 May | journal-article. .
Cisplatin nephrotoxicity: mechanisms and renoprotective strategies., Kidney international. 2008 Feb | journal-article. doi: 10.1038/sj.ki.5002786.
ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis., The Journal of biological chemistry. 2007 Dec | journal-article. doi: 10.1074/jbc.m707568200.
Effects of targeted Bcl-2 expression in mitochondria or endoplasmic reticulum on renal tubular cell apoptosis., American journal of physiology. Renal physiology. 2007 Dec | journal-article. doi: 10.1152/ajprenal.00415.2007.
Effects of hydroxyl radical scavenging on cisplatin-induced p53 activation, tubular cell apoptosis and nephrotoxicity., Biochemical pharmacology. 2007 Jan | journal-article. doi: 10.1016/j.bcp.2007.01.010.
Expression, subcellular localization, and regulation of sigma receptor in retinal muller cells., Investigative ophthalmology & visual science. 2006 Dec | journal-article. doi: 10.1167/iovs.06-0608.
Nutlin-3 protects kidney cells during cisplatin therapy by suppressing Bax/Bak activation., The Journal of biological chemistry. 2006 Nov | journal-article. doi: 10.1074/jbc.m606928200.
Caspase-mediated cleavage of ATM during cisplatin-induced tubular cell apoptosis: inactivation of its kinase activity toward p53., American journal of physiology. Renal physiology. 2006 Jul | journal-article. doi: 10.1152/ajprenal.00509.2005.