Navjot Pabla, PhD
Professional Interests
Our laboratory is focused on identifying therapeutic targets for kidney diseases. Acute kidney injury and renal cell carcinoma are the two major areas of interest. Our recent work has identified several protein kinases and membrane transporters as therapeutic targets for renal disorders. We utilize high throughput screening assays and functional genomics to identify molecular targets for renal diseases, followed by validation in in vivo animal models. The overall goal of these studies is to identify new therapeutic strategies to treat acute kidney injury and renal cell carcinoma, diseases for which no effective therapies are currently available.
Education
- 2009, PhD (Biomedical Sciences), Medical College of Georgia
- 2003, M.Sc. (Biochemistry), Maharaja Sayajirao University of Baroda
- 2001, B.Sc. (Biotechnology), Sardar Patel University
Journal Articles
Zavorka Thomas ME, Jeon JY, Talebi Z, Buelow DR, Silvaroli J, Campbell MJ, Sparreboom A, Pabla N, Baker SD. Gilteritinib-induced upregulation of S100A9 is mediated through BCL6 in Acute Myeloid Leukemia. Blood Adv. 2021 Oct 6:bloodadvances.2021005614. doi: 10.1182/bloodadvances.2021005614. Epub ahead of print. PMID: 34614509.
Bai Y, Kim JY, Bisunke B, Jayne LA, Silvaroli JA, Balzer MS, Gandhi M, Huang KM, Sander V, Prosek J, Cianciolo RE, Baker SD, Sparreboom A, Jhaveri KD, Susztak K, Bajwa A, Pabla NS. Kidney toxicity of the BRAF-kinase inhibitor vemurafenib is driven by off-target ferrochelatase inhibition. Kidney Int. 2021 Sep 14:S0085-2538(21)00855-3. doi: 10.1016/j.kint.2021.08.022. Epub ahead of print. PMID: 34534550.
Kim JY, Bai Y, Jayne LA, Abdulkader F, Gandhi M, Perreau T, Parikh SV, Gardner DS, Davidson AJ, Sander V, Song MA, Bajwa A, Pabla NS. SOX9 promotes stress-responsive transcription of VGF nerve growth factor inducible gene in renal tubular epithelial cells. J Biol Chem. 2020 Nov 27;295(48):16328-16341. doi: 10.1074/jbc.RA120.015110. Epub 2020 Sep 4. PMID: 32887795; PMCID: PMC7705303.
Kim JY, Bai Y, Jayne LA, Cianciolo RE, Bajwa A, Pabla NS. Involvement of the CDKL5-SOX9 signaling axis in rhabdomyolysis-associated acute kidney injury. Am J Physiol Renal Physiol. 2020 Nov 1;319(5):F920-F929. doi: 10.1152/ajprenal.00429.2020. Epub 2020 Oct 12. PMID: 33044867; PMCID: PMC7789981.
Huang KM, Leblanc AF, Uddin ME, Kim JY, Chen M, Eisenmann ED, Gibson AA, Li Y, Hong KW, DiGiacomo D, Xia SH, Alberti P, Chiorazzi A, Housley SN, Cope TC, Sprowl JA, Wang J, Loprinzi CL, Noonan A, Lustberg MB, Cavaletti G, Pabla N, Hu S, Sparreboom A. Neuronal uptake transporters contribute to oxaliplatin neurotoxicity in mice. J Clin Invest. 2020 Sep 1;130(9):4601-4606. doi: 10.1172/JCI136796. PMID: 32484793; PMCID: PMC7456253.
Kim JY, Jayne LA, Bai Y, Feng MJHH, Clark MA, Chung S, W Christman J, Cianciolo RE, Pabla NS. Ribociclib mitigates cisplatin-associated kidney injury through retinoblastoma-1 dependent mechanisms. Biochem Pharmacol. 2020 Jul;177:113939. doi: 10.1016/j.bcp.2020.113939. Epub 2020 Mar 27. PMID: 32229099; PMCID: PMC7789910.
Kim JY, Bai Y, Jayne LA, Hector RD, Persaud AK, Ong SS, Rojesh S, Raj R, Feng MJHH, Chung S, Cianciolo RE, Christman JW, Campbell MJ, Gardner DS, Baker SD, Sparreboom A, Govindarajan R, Singh H, Chen T, Poi M, Susztak K, Cobb SR, Pabla NS. A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury. Nat Commun. 2020 Apr 21;11(1):1924. doi: 10.1038/s41467-020-15638-6. PMID: 32317630; PMCID: PMC7174303.
Chung S, Kim JY, Song MA, Park GY, Lee YG, Karpurapu M, Englert JA, Ballinger MN, Pabla N, Chung HY, Christman JW. FoxO1 is a critical regulator of M2-like macrophage activation in allergic asthma. Allergy. 2019 Mar;74(3):535-548. doi: 10.1111/all.13626. Epub 2018 Nov 5. PMID: 30288751; PMCID: PMC6393185.
van Oosterwijk JG, Buelow DR, Drenberg CD, Vasilyeva A, Li L, Shi L, Wang YD, Finkelstein D, Shurtleff SA, Janke LJ, Pounds S, Rubnitz JE, Inaba H, Pabla N, Baker SD. Hypoxia-induced upregulation of BMX kinase mediates therapeutic resistance in acute myeloid leukemia. J Clin Invest. 2018 Jan 2;128(1):369-380. doi: 10.1172/JCI91893. Epub 2017 Dec 11. PMID: 29227282; PMCID: PMC5749502.
Drenberg CD, Gibson AA, Pounds SB, Shi L, Rhinehart DP, Li L, Hu S, Du G, Nies AT, Schwab M, Pabla N, Blum W, Gruber TA, Baker SD, Sparreboom A. OCTN1 Is a High-Affinity Carrier of Nucleoside Analogues. Cancer Res. 2017 Apr 15;77(8):2102-2111. doi: 10.1158/0008-5472.CAN-16-2548. Epub 2017 Feb 16. PMID: 28209616; PMCID: PMC5419029.
Sprowl JA, Ong SS, Gibson AA, Hu S, Du G, Lin W, Li L, Bharill S, Ness RA, Stecula A, Offer SM, Diasio RB, Nies AT, Schwab M, Cavaletti G, Schlatter E, Ciarimboli G, Schellens JHM, Isacoff EY, Sali A, Chen T, Baker SD, Sparreboom A, Pabla N. A phosphotyrosine switch regulates organic cation transporters. Nat Commun. 2016 Mar 16;7:10880. doi: 10.1038/ncomms10880. PMID: 26979622; PMCID: PMC4799362.
Zhu S, Pabla N, Tang C, He L, Dong Z. DNA damage response in cisplatin- induced nephrotoxicity. Arch Toxicol. 2015 Dec;89(12):2197-205. doi: 10.1007/s00204-015-1633-3. Epub 2015 Nov 13. PMID: 26564230; PMCID: PMC4734632.