Keli Hu, MD, PhD

Associate Professor

Pharmaceutics and Pharmacology

Research Areas: Cardiovascular Disorders, The Division of Pharmaceutics & Pharmacology

530 Parks Hall

Professional Interests

The long-term research goal in Dr. Hu's laboratory is to understand the mechanisms in myocardial ischemia and cardioprotection. The lab is particularly interested in studying the regulation of ion channels and their signaling molecules in the cardiovascular system, with a special emphasis on subcellular localization, traffic regulation, molecular mechanisms and their physiological relevance, particularly as these processes relate to human cardiovascular diseases. The ultimate goal is to explore the challenges in identifying therapeutic targets and to help developing preventive and therapeutic strategies for cardiovascular diseases.

Education

Postdoctoral Fellow, VA New York Harbor Healthcare System/University of California San Francisco, USA
PhD, Pharmacology, McGill University, Canada
MD, Xiangya College of Medicine, Central South University, China

Publications

TASK-1 regulates mitochondrial function under hypoxia, Biochemical and Biophysical Research Communications. 2021 Jan | journal-article. doi: 10.1016/j.bbrc.2021.09.032.
Functional interaction of the two-pore domain potassium channel TASK-1 and caveolin-3., Biochimica et biophysica acta. Molecular cell research. 2017 Jun | journal-article. doi: 10.1016/j.bbamcr.2017.06.016.
Endurance exercise accelerates myocardial tissue oxygenation recovery and reduces ischemia reperfusion injury in mice, PLoS ONE. 2014 Jan | journal-article. doi: 10.1371/journal.pone.0114205.
MOG1 rescues defective trafficking of Na(v)1.5 mutations in Brugada syndrome and sick sinus syndrome., Circulation. Arrhythmia and electrophysiology. 2013 Feb | journal-article. doi: 10.1161/circep.111.000206.
GLUT12 functions as a basal and insulin-independent glucose transporter in the heart, Biochimica et Biophysica Acta - Molecular Basis of Disease. 2013 Jan | journal-article. doi: 10.1016/j.bbadis.2012.09.013.
Molecular mechanism underlying adenosine receptor-mediated mitochondrial targeting of protein kinase C, Biochimica et Biophysica Acta - Molecular Cell Research. 2012 Jan | journal-article. doi: 10.1016/j.bbamcr.2011.12.012.
Role for SUR2A in coupling cardiac K(ATP) channels to caveolin-3., Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2010 Mar | journal-article. doi: 10.1159/000303045.
Peroxynitrite-mediated oxidative modifications of complex II: Relevance in myocardial infarction, Biochemistry. 2010 Jan | journal-article. doi: 10.1021/bi9018237.
Adenosine A(1) receptors selectively target protein kinase C isoforms to the caveolin-rich plasma membrane in cardiac myocytes., Biochimica et biophysica acta. 2009 Oct | journal-article. doi: 10.1016/j.bbamcr.2009.10.007.
Opening of the mitoKATP channel and decoupling of mitochondrial complex II and III contribute to the suppression of myocardial reperfusion hyperoxygenation., Molecular and cellular biochemistry. 2009 Oct | journal-article. doi: 10.1007/s11010-009-0283-2.
Caveolin-3 negatively regulates recombinant cardiac K(ATP) channels., Biochemical and biophysical research communications. 2009 May | journal-article. doi: 10.1016/j.bbrc.2009.05.100.
Regulation of ATP-sensitive K+ channels by caveolin-enriched microdomains in cardiac myocytes., Cardiovascular research. 2009 Jan | journal-article. doi: 10.1093/cvr/cvp039.
Protein kinase C-epsilon induces caveolin-dependent internalization of vascular adenosine 5'-triphosphate-sensitive K+ channels., Hypertension (Dallas, Tex. : 1979). 2008 Jul | journal-article. doi: 10.1161/hypertensionaha.108.110817.
Novel functional role of heat shock protein 90 in ATP-sensitive K+ channel-mediated hypoxic preconditioning., Cardiovascular research. 2007 Oct | journal-article. doi: 10.1093/cvr/cvm028.
Protein kinase C isoform-dependent modulation of ATP-sensitive K+ channels in mitochondrial inner membrane., American journal of physiology. Heart and circulatory physiology. 2007 Mar | journal-article. doi: 10.1152/ajpheart.01035.2006.
Functional basis of sinus bradycardia in congenital heart block., Circulation research. 2004 Jan | journal-article. doi: 10.1161/01.res.0000121566.01778.06.
ATP-sensitive potassium channel traffic regulation by adenosine and protein kinase C, Neuron. 2003 Jan | journal-article. doi: 10.1016/S0896-6273(03)00256-3.
Cardiac 5-HT(4) serotoninergic receptors, 52kD SSA/Ro and autoimmune-associated congenital heart block., Journal of autoimmunity. 2002 Aug | journal-article. doi: 10.1006/jaut.2002.0594.
Direct inhibition of expressed cardiac L- and T-type calcium channels by IgG from mothers whose children have congenital heart block, Circulation. 2001 Jan | journal-article. doi: 10.1161/01.CIR.103.11.1599.
Down-regulation of L-type calcium channel in pups born to 52 kDa SSA/Ro immunized rabbits, FASEB Journal. 2001 Jan | journal-article. doi: 10.1096/fj.01-0052com.
Evidence for functional role of epsilonPKC isozyme in the regulation of cardiac Ca(2+) channels., American journal of physiology. Heart and circulatory physiology. 2000 Dec | journal-article. doi: 10.1152/ajpheart.2000.279.6.h2658.
Adenosine-induced activation of ATP-sensitive K+ channels in excised membrane patches is mediated by PKC., The American journal of physiology. 1999 Feb | journal-article. doi: 10.1152/ajpheart.1999.276.2.h488.
Protein kinase C activates ATP-sensitive K+ current in human and rabbit ventricular myocytes., Circulation research. 1996 Mar | journal-article. doi: 10.1161/01.res.78.3.492.
Mechanisms of ischemic preconditioning in rat hearts: Involvement of α(1B)-adrenoceptors, pertussis toxin-sensitive G proteins, and protein kinase C, Circulation. 1995 Jan | journal-article. doi: 10.1161/01.CIR.92.8.2259.
Thinking skill of beta-receptor blocking agent discovered by 1988 Nobel Prize Winner Dr. Black, Medicine & Philosophy. 1990 Jan | journal-article. .
Comparative effects of captopril, nitroprusside, dopamine and lanatoside C on a new model of rabbit congestive heart failure., Zhongguo yao li xue bao = Acta pharmacologica Sinica. 1988 Sep | journal-article. .