Keli Hu, MD, PhD
Professional Interests
The long-term research goal in Dr. Hu's laboratory is to understand the mechanisms in myocardial ischemia and cardioprotection. The lab is particularly interested in studying the regulation of ion channels and their signaling molecules in the cardiovascular system, with a special emphasis on subcellular localization, traffic regulation, molecular mechanisms and their physiological relevance, particularly as these processes relate to human cardiovascular diseases. The ultimate goal is to explore the challenges in identifying therapeutic targets and to help developing preventive and therapeutic strategies for cardiovascular diseases.
Education
- MD, Xiangya College of Medicine, Central South University, China
- PhD, Pharmacology, McGill University, Canada
- Postdoctoral Fellow, VA New York Harbor Healthcare System/University of California San Francisco, USA
Journal Articles
Kang C, Hernandez VA, Hu K. Functional interaction of the two-pore domain potassium channel TASK-1 and caveolin-3. Biochim Biophys Acta Mol Cell Res. 2017 Oct;1864(10):1537-1544. doi: 10.1016/j.bbamcr.2017.06.016. Epub 2017 Jun 23. PMID: 28648645.
Kang C, Qin J, Osei W, Hu K. Regulation of protein kinase C-epsilon and its age-dependence. Biochem Biophys Res Commun. 2017 Jan 22;482(4):1201-1206. doi: 10.1016/j.bbrc.2016.12.012. Epub 2016 Dec 3. PMID: 27919679.
Li Y, Cai M, Cao L, Qin X, Zheng T, Xu X, Sandvick TM, Hutchinson K, Wold LE, Hu K, Sun Q, Thomas DP, Ren J, He G. Endurance exercise accelerates myocardial tissue oxygenation recovery and reduces ischemia reperfusion injury in mice. PLoS One. 2014 Dec 4;9(12):e114205. doi: 10.1371/journal.pone.0114205. PMID: 25474642; PMCID: PMC4256403.
Waller AP, George M, Kalyanasundaram A, Kang C, Periasamy M, Hu K, Lacombe VA. GLUT12 functions as a basal and insulin-independent glucose transporter in the heart. Biochim Biophys Acta. 2013 Jan;1832(1):121-7. doi: 10.1016/j.bbadis.2012.09.013. Epub 2012 Oct 4. PMID: 23041416.
Yang Z, Sun W, Hu K. Molecular mechanism underlying adenosine receptor- mediated mitochondrial targeting of protein kinase C. Biochim Biophys Acta. 2012 Apr;1823(4):950-8. doi: 10.1016/j.bbamcr.2011.12.012. Epub 2011 Dec 31. PMID: 22233927.
Liu B, Zhu X, Chen CL, Hu K, Swartz HM, Chen YR, He G. Opening of the mitoKATP channel and decoupling of mitochondrial complex II and III contribute to the suppression of myocardial reperfusion hyperoxygenation. Mol Cell Biochem. 2010 Apr;337(1-2):25-38. doi: 10.1007/s11010-009-0283-2. Epub 2009 Oct 23. PMID: 19851835; PMCID: PMC3738814.
Zhang L, Chen CL, Kang PT, Garg V, Hu K, Green-Church KB, Chen YR. Peroxynitrite-mediated oxidative modifications of complex II: relevance in myocardial infarction. Biochemistry. 2010 Mar 23;49(11):2529-39. doi: 10.1021/bi9018237. PMID: 20143804; PMCID: PMC3754874.
Sun W, Hu K. Role for SUR2A in coupling cardiac K(ATP) channels to caveolin-3. Cell Physiol Biochem. 2010;25(4-5):409-18. doi: 10.1159/000303045. Epub 2010 Mar 23. PMID: 20332621.
Yang Z, Sun W, Hu K. Adenosine A(1) receptors selectively target protein kinase C isoforms to the caveolin-rich plasma membrane in cardiac myocytes. Biochim Biophys Acta. 2009 Dec;1793(12):1868-75. doi: 10.1016/j.bbamcr.2009.10.007. Epub 2009 Oct 30. PMID: 19879903.
Garg V, Sun W, Hu K. Caveolin-3 negatively regulates recombinant cardiac K(ATP) channels. Biochem Biophys Res Commun. 2009 Jul 31;385(3):472-7. doi: 10.1016/j.bbrc.2009.05.100. Epub 2009 May 27. PMID: 19481058.