Kari Hoyt, PhD

Professor

Pharmaceutics and Pharmacology

Research Areas: Central Nervous System Disorders, Clinical & Pre-Clinical Pharmacology, The Division of Pharmaceutics & Pharmacology

412 Riffe

hoyt.31@osu.edu

(614) 292-6636

Professional Website

Professional Interests

Our research team members are engaged in pre-clinical target identification for pharmacologic treatment of neurodegenerative and psychiatric disorders. We use in vivo and in vitro high-resolution fluorescence microscopy and high-content analysis of live neurons to reveal complex interactions between signaling pathways that regulate cell survival/function and circadian clock signaling. This work is designed to identify new avenues of chronotherapeutic target development for CNS disorders. Current work focuses on two related themes: (1) Alzheimer’s Disease and desynchronization of cortico-limbic circadian rhythms and (2) MAPK signaling: gates, oscillators and circadian timing.

Education

PhD, Pharmacology, University of Pittsburgh School of Medicine

Honors

Dean's Innovative Research Award, 2019

Publications

Ribosomal S6 kinase signaling regulates neuronal viability during development and confers resistance to excitotoxic cell death in mature neurons., Neuroscience. 2024 Aug | journal-article. doi: 10.1016/j.neuroscience.2024.08.012.
Ribosomal S6 Kinase Regulates the Timing and Entrainment of the Mammalian Circadian Clock Located in the Suprachiasmatic Nucleus, Neuroscience. 2023 Apr | journal-article. doi: 10.1016/j.neuroscience.2023.02.003.
Zinc finger protein 24-dependent transcription factor SOX9 up-regulation protects tubular epithelial cells during acute kidney injury., Kidney international. 2023 Mar | journal-article. doi: 10.1016/j.kint.2023.02.026.
Circadian clocks, cognition, and Alzheimer's disease: synaptic mechanisms, signaling effectors, and chronotherapeutics., Molecular neurodegeneration. 2022 May | journal-article. doi: 10.1186/s13024-022-00537-9.
Light-induced changes in the suprachiasmatic nucleus transcriptome regulated by the ERK/MAPK pathway, PLOS ONE. 2021 Jun | journal-article. doi: 10.1371/journal.pone.0249430.
SynGAP is expressed in the murine suprachiasmatic nucleus and regulates circadian‐gated locomotor activity and light‐entrainment capacity, European Journal of Neuroscience. 2021 Feb | journal-article. doi: 10.1111/ejn.15043.
Data highlighting the expression of two miR-132/212 target genes-Sirt1 and Pten-after chronic stress., Data in brief. 2018 Nov | journal-article. doi: 10.1016/j.dib.2018.11.042.
miR-132/212 is induced by stress and its dysregulation triggers anxiety-related behavior., Neuropharmacology. 2018 Oct | journal-article. doi: 10.1016/j.neuropharm.2018.10.020.
The Phosphorylation of CREB at Serine 133 Is a Key Event for Circadian Clock Timing and Entrainment in the Suprachiasmatic Nucleus., Journal of biological rhythms. 2018 Sep | journal-article. doi: 10.1177/0748730418791713.
miR-132 couples the circadian clock to daily rhythms of neuronal plasticity and cognition., Learning & memory (Cold Spring Harbor, N.Y.). 2018 Apr | journal-article. doi: 10.1101/lm.047191.117.
Circadian expression and functional characterization of PEA-15 within the mouse suprachiasmatic nucleus, European Journal of Neuroscience. 2018 Jan | journal-article. doi: 10.1111/ejn.13850.
Mitogen- and stress-activated protein kinase 1 regulates status epilepticus- evoked cell death in the hippocampus, ASN Neuro. 2017 Jan | journal-article. doi: 10.1177/1759091417726607.
The miR-132/212 locus: a complex regulator of neuronal plasticity, gene expression and cognition., RNA & disease (Houston, Tex.). 2016 Aug | journal-article. .
Activation of Mitofusin2 by Smad2-RIN1 Complex during Mitochondrial Fusion, Molecular Cell. 2016 Jan | journal-article. doi: 10.1016/j.molcel.2016.04.010.
Modulation of learning and memory by the targeted deletion of the circadian clock gene Bmal1 in forebrain circuits, Behavioural Brain Research. 2016 Jan | journal-article. doi: 10.1016/j.bbr.2016.04.027.
Status epilepticus stimulates NDEL1 expression via the CREB/CRE pathway in the adult mouse brain, Neuroscience. 2016 Jan | journal-article. doi: 10.1016/j.neuroscience.2016.06.010.
Mitogen and stress-activated kinases 1/2 regulate ischemia-induced hippocampal progenitor cell proliferation and neurogenesis, Neuroscience. 2015 Jan | journal-article. doi: 10.1016/j.neuroscience.2014.10.053.
Clock and light regulation of the CREB coactivator CRTC1 in the suprachiasmatic circadian clock, Journal of Neuroscience. 2013 Jan | journal-article. doi: 10.1523/JNEUROSCI.4202-12.2013.
Mitogen- and stress-activated kinases regulate progenitor cell proliferation and neuron development in the adult dentate gyrus, Journal of Neurochemistry. 2012 Jan | journal-article. doi: 10.1111/jnc.12035.
CREB is a key regulator of striatal vulnerability in chemical and genetic models of Huntington's disease, Neurobiology of Disease. 2009 Jan | journal-article. doi: 10.1016/j.nbd.2009.07.014.
The CREB/CRE transcriptional pathway: Protection against oxidative stress-mediated neuronal cell death, Journal of Neurochemistry. 2009 Jan | journal-article. doi: 10.1111/j.1471-4159.2008.05864.x.
IGF-1 receptor-mediated ERK/MAPK signaling couples status epilepticus to progenitor cell proliferation in the subgranular layer of the dentate gyrus, GLIA. 2008 Jan | journal-article. doi: 10.1002/glia.20653.
Bioenergetic and oxidative effects of free 3-nitrotyrosine in culture: Selective vulnerability of dopaminergic neurons and increased sensitivity of non-dopaminergic neurons to dopamine oxidation, Journal of Neurochemistry. 2007 Jan | journal-article. doi: 10.1111/j.1471-4159.2007.04735.x.
Cardiac dysfunction in the R6/2 mouse model of Huntington's disease, Neurobiology of Disease. 2007 Jan | journal-article. doi: 10.1016/j.nbd.2006.09.016.
Metformin therapy in a transgenic mouse model of Huntington's disease, Neuroscience Letters. 2007 Jan | journal-article. doi: 10.1016/j.neulet.2006.10.039.
A sensitive and selective assay of neuronal degeneration in cell culture, Journal of Neuroscience Methods. 2006 Jan | journal-article. doi: 10.1016/j.jneumeth.2005.12.030.
Activity-dependent neuroprotection and cAMP response element-binding protein (CREB): Kinase coupling, stimulus intensity, and temporal regulation of CREB phosphorylation at serine 133, Journal of Neuroscience. 2005 Jan | journal-article. doi: 10.1523/JNEUROSCI.4288-04.2005.
CRE-Mediated Transcription Is Increased in Huntington's Disease Transgenic Mice, Journal of Neuroscience. 2004 Jan | journal-article. doi: 10.1523/JNEUROSCI.3493-03.2004.
The ERK/MAP kinase pathway couples light to immediate-early gene expression in the suprachiasmatic nucleus, European Journal of Neuroscience. 2003 Jan | journal-article. doi: 10.1046/j.1460-9568.2003.02592.x.
Inhibition of glutamate-induced mitochondrial depolarization by tamoxifen in cultured neurons, Journal of Pharmacology and Experimental Therapeutics. 2000 Jan | journal-article. .
Metabolic and glutamatergic disturbances in the Huntington's disease transgenic mouse, Annals of the New York Academy of Sciences. 1999 Jan | book. doi: 10.1111/j.1749-6632.1999.tb07841.x.
Alkalinization prolongs recovery from glutamate-induced increases in intracellular Ca²⁺ concentration by enhancing Ca²⁺ efflux through the mitochondrial Na⁺/Ca²⁺ exchanger in cultured rat forebrain neurons, Journal of Neurochemistry. 1998 Jan | journal-article. .
Reverse Na⁺/Ca²⁺exchange contributes to glutamate-induced intracellular Ca²⁺concentration increases in cultured rat forebrain neurons, Molecular Pharmacology. 1998 Jan | journal-article. doi: 10.1124/mol.53.4.742.
The role of intracellular Na⁺ and mitochondria in buffering of kainate-induced intracellular free Ca²⁺ changes in rat forebrain neurones, Journal of Physiology. 1998 Jan | journal-article. doi: 10.1111/j.1469-7793.1998.103bo.x.
Characterization of hydrogen peroxide toxicity in cultured rat forebrain neurons, Neurochemical Research. 1997 Jan | journal-article. doi: 10.1023/A:1022403224901.
Mechanisms of dopamine-induced cell death in cultured rat forebrain neurons: Interactions with and differences from glutamate-induced cell death, Experimental Neurology. 1997 Jan | journal-article. doi: 10.1006/exnr.1996.6374.
Trifluoperazine and dibucaine-induced inhibition of glutamate-induced mitochondrial depolarization in rat cultured forebrain neurones, British Journal of Pharmacology. 1997 Jan | journal-article. doi: 10.1038/sj.bjp.0701442.
Intracellular Signalling in Glutamate Excitotoxicity, Neurodegenerative Diseases. 1996 Jan | other. doi: 10.1007/978-1-4899-0209-2_1.
Localization of D1dopamine receptors on live cultured striatal neurons by quantitative fluorescence microscopy, Brain Research. 1996 Jan | journal-article. doi: 10.1016/S0006-8993(96)00436-2.
Cyclothiazide Modulates AMPA Receptor‐Mediated Increases in Intracellular Free Ca²⁺ and Mg²⁺ in Cultured Neurons from Rat Brain, Journal of Neurochemistry. 1995 Jan | journal-article. doi: 10.1046/j.1471-4159.1995.64052049.x.
Nitric oxide modulates NMDA-induced increases in intracellular Ca²⁺in cultured rat forebrain neurons, Brain Research. 1992 Jan | journal-article. doi: 10.1016/0006-8993(92)91690-G.
Oxidized glutathione modulates and depolarization-induced increases in intracellular Ca2+ in cultured rat forebrain neurons, Neuroscience Letters. 1991 Nov | journal-article. doi: 10.1016/0304-3940(91)90045-u.