March 21, 2018
The Ohio State University College of Pharmacy and the Infectious Disease Institute are pleased to present distinguished lecturer R. Kip Guy, PhD, on Tuesday, April 10, at 4 p.m., in 103 Parks Hall. Guy’s talk, "SJ733, a novel antimalarial, from discovery to mechanism,” is part of the 2018 Distinguished Lecture series.
Dr. Guy is the dean of the College of Pharmacy at the University of Kentucky and a professor in the Department of Pharmaceutical Sciences. He received his BA in chemistry from Reed College in Portland, Oregon. He received his PhD in organic chemistry based on the total synthesis of taxol from the Scripps Research Institute (TSRI) in La Jolla, California.
Dr. Guy's research is focused on the discovery and development of novel small molecules that target the pathophysiology of orphan pediatric diseases, particularly pediatric oncology and protozoal infectious diseases. Most of his group’s work falls into the areas of chemical validation of novel targets, lead discovery and optimization of novel chemical matter for validated disease targets, and use of non-targeted whole-cell strategies for lead discovery and optimization. He is the author of 173 papers and book chapters, and the inventor on 18 issued patents.
While at TSRI, he held an Office of Naval Research Graduate Research Fellowship, George Hewitt Medical Research Fellowship, and ACS Organic Division Fellowship. In 1995, he carried out additional training in Physiology at the Woods Hole Research Institute. From 1996-1998, he was a Helen Hay Whitney Postdoctoral Fellow in Cellular Biology, focusing on the relationship between hedgehog signaling and sterol homeostasis with Drs. Brown and Goldstein at University of Texas Southwestern Medical Center, Dallas, TX. In 1998, he joined the University of California San Francisco (UCSF) as an assistant professor with joint appointments in Pharmaceutical Chemistry and Cellular and Molecular Pharmacology, where he was promoted to full professor. From 2002-2003, he founded the Center for Chemical Diversity at UCSF, which provided access to high throughput chemistry to the campus, and the Bay Area Screening Center, a joint endeavor between UCSF and the Gallo Institute that provided high throughput screening. These were subsequently merged into the Small Molecule Discovery Center. Later, he was recruited to St Jude Children’s Research Hospital, Memphis, TN, to found and chair the new department of Chemical Biology and Therapeutics where he was the Robert J. Ulrich Chair in Chemical Biology and Therapeutics. He has held adjunct academic positions at UCSF (Adjunct Professor of Pharmaceutical Chemistry), the University of Tennessee (Adjunct Professor of Pharmaceutical Sciences and Pathology), and Vanderbilt University (Adjunct Professor of Biochemistry).