Xiaolin Cheng

photo of Xiaolin Cheng
Professional Website

Xiaolin Cheng, PhD

Associate Professor
Medicinal Chemistry and Pharmacognosy
642 Riffe Building
cheng.1302@osu.edu
(614) 292-3198

Professional Interests

Dr. Cheng’s laboratory aims to develop an interdisciplinary research program centered on Computer Aided Drug Design and Discovery. Closely collaborating with experimental chemists and biologists, our group utilizes a myriad of computational modeling & simulation, and data analytics techniques to understand molecular basis of drug action and to rationally design new drug molecules. Our group also has long-standing interests in: a) developing and applying multiscale computational techniques to investigate the structure, dynamics and function of complex biomolecular (and cellular ) systems; and b) bridge large-scale molecular simulation with systems biology (cellular metabolism and signaling networks) towards a new drug discovery paradigm.

Journal Articles

  • Mostofian B , Johnson QR , Smith JC , Cheng X . Carotenoids promote lateral packing and condensation of lipid membranes. Phys Chem Chem Phys. 2020 Jun 7;22(21):12281-12293.
  • Ren Y, Tan Q, Heath K, Wu S, Wilson JR, Ren J, Shriwas P, Yuan C, Ngoc Ninh T, Chai HB, Chen X, Soejarto DD, Johnson ME, Cheng X, Burdette JE, Kinghorn AD. Cytotoxic and non-cytotoxic cardiac glycosides isolated from the combined flowers, leaves, and twigs of Streblus asper. Bioorg Med Chem. 2020 Feb 15;28(4):115301.
  • Martinez MP, Cheng X, Joseph A, Al-Saleem J, Panfil AR, Palettas M, Dirksen WP, Ratner L, Green PL. HTLV-1 CTCF-binding site is dispensable for in vitro immortalization and persistent infection in vivo. Retrovirology. 2019 Dec 21;16(1):44.
  • Ishita K, Stefanopoulos S, Khalil A, Cheng X, Tjarks W, Rappleye CA. Synthesis and biological evaluation of aminothiazoles against Histoplasma capsulatum and Cryptococcus neoformans. Bioorg Med Chem. 2018 May 15;26(9):2251-2261.
  • Chen Q, Yu HL, Cheng X, Xu JH. Structural investigation of the enantioselectivity and thermostability mechanisms of esterase RhEst1. J Mol Graph Model. 2018 Oct;85:182-189.
  • Dhakal S, Cheng X, Salcido J, Renu S, Bondra K, Lakshmanappa YS, Misch C, Ghimire S, Feliciano-Ruiz N, Hogshead B, Krakowka S, Carson K, McDonough J, Lee CW, Renukaradhya GJ. Liposomal nanoparticle-based conserved peptide influenza vaccine and monosodium urate crystal adjuvant elicit protective immune response in pigs. Int J Nanomedicine. 2018 Oct 24;13:6699-6715.
  • Wu S, Chan C, Zhuang T, Li PK, Cheng X. A computational study of effects on membrane recruitment of the polar linkers in Vitamin E derivatives. Biochim Biophys Acta Gen Subj. 2020 Oct;1864(10):129655.
  • Cheng X, Liu Q, Li H, Kang C, Liu Y, Guo T, Shang K, Yan C, Cheng G, Lee RJ. Lipid Nanoparticles Loaded with an Antisense Oligonucleotide Gapmer Against Bcl-2 for Treatment of Lung Cancer. Pharm Res. 2017 Feb;34(2):310-320.
  • Mian MA, Zhang Y, Wang ZY, Zhang JY, Cheng X, Chen L, Chekhovskiy K, Dai X, Mao C, Cheung F, Zhao X, He J, Scott AD, Town CD, May GD. Analysis of tall fescue ESTs representing different abiotic stresses, tissue types and developmental stages. BMC Plant Biol. 2008 Mar 4;8:27.
  • Sommer M, Sutter M, Gupta S, Kirst H, Turmo A, Lechno-Yossef S, Burton RL, Saechao C, Sloan NB, Cheng X, Chan LG, Petzold CJ, Fuentes-Cabrera M, Ralston CY, Kerfeld CA. Heterohexamers Formed by CcmK3 and CcmK4 Increase the Complexity of Beta Carboxysome Shells. Plant Physiol. 2018 Nov 02.
  • Chen Q, Yu HL, Cheng X, Xu JH. Structural investigation of the enantioselectivity and thermostability mechanisms of esterase RhEst1. J Mol Graph Model. 2018 Oct;85:182-189.
  • Ishita K, Stefanopoulos S, Khalil A, Cheng X, Tjarks W, Rappleye CA. Synthesis and biological evaluation of aminothiazoles against Histoplasma capsulatum and Cryptococcus neoformans. Bioorg Med Chem. 2018 05 15;26(9):2251-2261.
  • Li Z, Zhang Y, Chan C, Zhi C, Cheng X, Fan J. Temperature-Dependent Lipid Extraction from Membranes by Boron Nitride Nanosheets. ACS Nano. 2018 Mar 27;12(3):2764-2772.
  • Cheng X, Lee RJ. The role of helper lipids in lipid nanoparticles (LNPs) designed for oligonucleotide delivery. Adv Drug Deliv Rev. 2016 Apr 1;99(Pt A):129-137.