MicroRNAs (miRNAs) are a family of small nonprotein-coding RNAs that have emerged as important regulators in cardiac developmental and pathological processes. They are genomically encoded and are initially transcribed as part of much longer molecules that become processed into a mature ~22-nucleotide-long form. miRNAs are generally regarded as negative regulators of gene expression that inhibit translation and/or promote messenger RNA (mRNA) degradation by base-pairing to complementary sequences within protein-coding mRNA transcripts. Hundreds of human miRNA genes have been identified and bioinformatic analyses indicate that miRNAs might regulate the expression of more than a third of human protein-coding genes, highlighting the potential magnitude of their influence on gene expression. Given the increasingly important roles of miRNAs in heart development and function, the lab hypothesizes that aberrant regulation of miRNAs may play a role in mediating cardiovascular disease. Therefore, one major focus of Elton’s laboratory investigates miRNA expression and gene regulation in various cardiovascular diseases.
- 1988, Postdoctoral, University of Alabama
- 1987, Postdoctoral, Washington State University
- 1986, PhD, Washington State University, Biochemistry
- 1981, BS, Weber State University, Chemistry
- Clinical Research Award, 1988 - 1988
- Finalist, 1988 - 1988
- Summer Graduate Research Assistantship, 1984 - 1984
- A.C. Glen King Award, 1981 - 1981
- Kanagasabai R, Karmahapatra S, Kientz CA, Yu Y, Hernandez VA, Kania EE, Yalowich JC, Elton TS. The Novel C-terminal Truncated 90-kDa Isoform of Topoisomerase IIα (TOP2α/90) Is a Determinant of Etoposide Resistance in K562 Leukemia Cells via Heterodimerization with the TOP2α/170 Isoform. Mol Pharmacol. 2018 May;93(5):515-525.
- Kanagasabai R, Serdar L, Karmahapatra S, Kientz CA, Ellis J, Ritke MK, Elton TS, Yalowich JC. Alternative RNA Processing of Topoisomerase IIα in Etoposide-Resistant Human Leukemia K562 Cells: Intron Retention Results in a Novel C-Terminal Truncated 90-kDa Isoform. J Pharmacol Exp Ther. 2017 Jan;360(1):152-163.
- Martin MM, Buckenberger JA, Knoell DL, Strauch AR, Elton TS. Retraction notice to "TGF-β1 regulation of human AT1 receptor mRNA splice variants harboring exon 2". Mol Cell Endocrinol. 2016 10 15;434:288.
- Elton TS, Yalowich JC. Experimental procedures to identify and validate specific mRNA targets of miRNAs. EXCLI J. 2015;14:758-90.
- Elton TS, Selemon H, Elton SM, Parinandi NL. Regulation of the MIR155 host gene in physiological and pathological processes. Gene. 2013 Dec 10;532(1):1-12.
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