Terry Elton

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Terry Elton, PhD

Title
Professor
Unit / Department / Division
Pharmacology
Address
555 Parks Parks Hall
Email Address
Phone Number

Professional Interests

Professional Interests

MicroRNAs (miRNAs) are a family of small nonprotein-coding RNAs that have emerged as important regulators in cardiac developmental and pathological processes. They are genomically encoded and are initially transcribed as part of much longer molecules that become processed into a mature ~22-nucleotide-long form. miRNAs are generally regarded as negative regulators of gene expression that inhibit translation and/or promote messenger RNA (mRNA) degradation by base-pairing to complementary sequences within protein-coding mRNA transcripts. Hundreds of human miRNA genes have been identified and bioinformatic analyses indicate that miRNAs might regulate the expression of more than a third of human protein-coding genes, highlighting the potential magnitude of their influence on gene expression. Given the increasingly important roles of miRNAs in heart development and function, the lab hypothesizes that aberrant regulation of miRNAs may play a role in mediating cardiovascular disease. Therefore, one major focus of Elton’s laboratory investigates miRNA expression and gene regulation in various cardiovascular diseases.

Education

  • 1988, Postdoctoral, University of Alabama
  • 1987, Postdoctoral, Washington State University
  • 1986, PhD, Washington State University, Biochemistry
  • 1981, BS, Weber State University, Chemistry

Honors

  • Clinical Research Award, 1988 - 1988
  • Finalist, 1988 - 1988
  • Summer Graduate Research Assistantship, 1984 - 1984
  • A.C. Glen King Award, 1981 - 1981

Journal Articles

  • Kanagasabai R, Karmahapatra S, Kientz CA, Yu Y, Hernandez VA, Kania EE, Yalowich JC, Elton TS. The Novel C-terminal Truncated 90-kDa Isoform of Topoisomerase IIα (TOP2α/90) Is a Determinant of Etoposide Resistance in K562 Leukemia Cells via Heterodimerization with the TOP2α/170 Isoform. Mol Pharmacol. 2018 May;93(5):515-525.
  • Kanagasabai R, Serdar L, Karmahapatra S, Kientz CA, Ellis J, Ritke MK, Elton TS, Yalowich JC. Alternative RNA Processing of Topoisomerase IIα in Etoposide-Resistant Human Leukemia K562 Cells: Intron Retention Results in a Novel C-Terminal Truncated 90-kDa Isoform. J Pharmacol Exp Ther. 2017 Jan;360(1):152-163.
  • Martin MM, Buckenberger JA, Knoell DL, Strauch AR, Elton TS. Retraction notice to "TGF-β1 regulation of human AT1 receptor mRNA splice variants harboring exon 2". Mol Cell Endocrinol. 2016 10 15;434:288.
  • Elton TS, Yalowich JC. Experimental procedures to identify and validate specific mRNA targets of miRNAs. EXCLI J. 2015;14:758-90.
  • Elton TS, Selemon H, Elton SM, Parinandi NL. Regulation of the MIR155 host gene in physiological and pathological processes. Gene. 2013 Dec 10;532(1):1-12.
  • Wu Y, Crawford M, Mao Y, Lee RJ, Davis IC, Elton TS, Lee LJ, Nana-Sinkam SP. Therapeutic Delivery of MicroRNA-29b by Cationic Lipoplexes for Lung Cancer. Mol Ther Nucleic Acids. 2013 Apr 16;2:e84.
  • Pleister A, Selemon H, Elton SM, Elton TS. Circulating miRNAs: novel biomarkers of acute coronary syndrome? 2013 Apr;7(2):287-305.
  • Nishijima Y, Sridhar A, Bonilla I, Velayutham M, Khan M, Terentyeva R, Li C, Kuppusamy P, Elton TS, Terentyev D, Györke S, Zweier JL, Cardounel AJ, Carnes CA. Tetrahydrobiopterin depletion and NOS2 uncoupling contribute to heart failure-induced alterations in atrial electrophysiology. Cardiovasc Res. 2011 Jul 01;91(1):71-9.
  • Belevych AE, Sansom SE, Terentyeva R, Ho HT, Nishijima Y, Martin MM, Jindal HK, Rochira JA, Kunitomo Y, Abdellatif M, Carnes CA, Elton TS, Györke S, Terentyev D. MicroRNA-1 and -133 increase arrhythmogenesis in heart failure by dissociating phosphatase activity from RyR2 complex. PLoS One. 2011;6(12):e28324.