Pui Kai (Tom) Li, PhD
Associate Professor
Medicinal Chemistry and Pharmacognosy
Research Areas:
Division of Medicinal Chemistry & Pharmacognosy,
Cancer,
Infectious Diseases,
Chemical Synthesis
336 Parks Hall
li.27@osu.edu
(614) 688-0253
Professional Interests
Dr. Li’s research interest focuses on the design, syntheses and studies of small molecules for cancers and infectious diseases. In the cancer area, our group focus on prostate and pancreatic cancer. Novel molecules are developed using the strategies of drug repurposing and structure-based drug design (in collaboration with Dr. Xiaolin Cheng). In the research of infectious disease, our focus is on the development of small molecules for the treatment of COVID-19. Novel molecules are generated through computational chemistry, molecular modeling and virtual screening targeting the interface of spike protein and human ACE-2 receptor.
Biography
Dr. Li obtained his BS degree in Pharmacy from the University of Wyoming and his Ph.D. in Medicinal Chemistry from The Ohio State University. He conducted his postdoctoral research in the Department of Veterinary Bioscience at The Ohio State University. His first faculty appointment was at the School of Pharmacy, Duquesne University as an assistant professor and then tenured associate professor. In 2000, he joined the Division of Medicinal Chemistry, College of Pharmacy, as tenured associate professor. He was the chair of the division from 2003 to 2013.
Education
- 1988-1990, Postdoctoral Researcher, Department of Veterinary Biosciences, The Ohio State University
- 1988, PhD Medicinal Chemistry, The Ohio State University, Medicinal Chemistry
- 1983, BS Pharmacy, University of Wyoming
- 1980, University of Nevada, Pre-Pharmacy
Honors
- 1997, Recipient of the Distinguished Research Award, Duquesne University
- 1997, School of Pharmacy Award for Excellence in Scholarship
- 1997, President's Award for Excellence
- 1988, Distinguished Presentation of the 14th annual meeting, Graduate Student Forum, 1988
- 1987, University Graduate Associate Teaching Award
- 1983-1984, University Fellowship
Publications
- BET Bromodomain Inhibitors: Novel Design Strategies and Therapeutic Applications, Molecules. 2023 Jan | journal-article. doi: 10.3390/molecules28073043.
- Computational modeling studies reveal the origin of the binding preference of 3-(3,4-di hydroisoquinolin-2(1H)-ylsulfonyl)benzoic acids for AKR1C3 over its isoforms, Protein Science. 2022 Jan | journal-article. doi: 10.1002/pro.4499.
- Constitutively Active Androgen Receptor in Hepatocellular Carcinoma, International Journal of Molecular Sciences. 2022 Jan | journal-article. doi: 10.3390/ijms232213768.
- ARVib suppresses growth of advanced prostate cancer via inhibition of androgen receptor signaling, Oncogene. 2021 Jan | journal-article. doi: 10.1038/s41388-021-01914-2.
- Development of Murine Leukemia Virus Integrase-Derived Peptides That Bind Brd4 Extra-Terminal Domain as Candidates for Suppression of Acute Myeloid Leukemia, ACS Pharmacology and Translational Science. 2021 Jan | journal-article. doi: 10.1021/acsptsci.1c00159.
- Mechanistic Insights into the Allosteric Inhibition of Androgen Receptors by Binding Function 3 Antagonists from an Integrated Molecular Modeling Study, Journal of Chemical Information and Modeling. 2021 Jan | journal-article. doi: 10.1021/acs.jcim.1c00124.
- Rationally Designed ACE2-Derived Peptides Inhibit SARS-CoV-2, Bioconjugate Chemistry. 2021 Jan | journal-article. doi: 10.1021/acs.bioconjchem.0c00664.
- A computational study of effects on membrane recruitment of the polar linkers in Vitamin E derivatives, Biochimica et Biophysica Acta - General Subjects. 2020 Jan | journal-article. doi: 10.1016/j.bbagen.2020.129655.
- Steroid sulfatase stimulates intracrine androgen synthesis and is a therapeutic target for advanced prostate cancer, Clinical Cancer Research. 2020 Jan | journal-article. doi: 10.1158/1078-0432.CCR-20-1682.
- Correction: Niclosamide and its analogs are potent inhibitors of Wnt/β-catenin, mTOR and STAT3 signaling in ovarian cancer [Oncotarget., 7, (2016) (86803-86815)] 10.18632/oncotarget.13466, Oncotarget. 2018 Jan | journal-article. doi: 10.18632/oncotarget.25151.
- Therapeutic effects of a novel phenylphthalimide analog for corneal neovascularization and retinal vascular leakage, Investigative Ophthalmology and Visual Science. 2018 Jan | journal-article. doi: 10.1167/IOVS.18-24015.
- Novel pyrrolopyrimidines as Mps1/TTK kinase inhibitors for breast cancer, Bioorganic and Medicinal Chemistry. 2017 Jan | journal-article. doi: 10.1016/j.bmc.2017.02.030.
- Structure-activity relationship of niclosamide derivatives, Anticancer Research. 2017 Jan | journal-article. doi: 10.21873/anticanres.11635.
- Niclosamide and its analogs are potent inhibitors of Wnt/ß- catenin, mTOR and STAT3 signaling in ovarian cancer, Oncotarget. 2016 Jan | journal-article. .
- Protective effect of suppressing STAT3 activity in LPS-induced acute lung injury, American Journal of Physiology - Lung Cellular and Molecular Physiology. 2016 Jan | journal-article. doi: 10.1152/ajplung.00281.2016.
- STAT3 as a potential therapeutic target in ALDH+ and CD44+/CD24+ stem cell-like pancreatic cancer cells, International Journal of Oncology. 2016 Jan | journal-article. doi: 10.3892/ijo.2016.3728.
- Niclosamide analogs for treatment of ovarian cancer, International Journal of Gynecological Cancer. 2015 Jan | conference-paper. doi: 10.1097/IGC.0000000000000506.
- Oncolytic potential of a novel KGFR tyrosine kinase inhibitor using a KGFR-selective breast cancer xenograft model, Anticancer Research. 2015 Jan | journal-article. .
- Multi-targeted therapy of cancer by niclosamide: A new application for an old drug, Cancer Letters. 2014 Jan | journal-article. doi: 10.1016/j.canlet.2014.04.003.
- Pro-growth role of the JMJD2C histone demethylase in HCT-116 colon cancer cells and identification of curcuminoids as JMJD2 inhibitors, American Journal of Translational Research. 2014 Jan | journal-article. .
- Tumor-induced STAT3 signaling in myeloid cells impairs dendritic cell generation by decreasing PKCβII abundance, Science Signaling. 2014 Jan | journal-article. doi: 10.1126/scisignal.2004656.
- Anticancer activity and SAR studies of substituted 1,4-naphthoquinones, Bioorganic and Medicinal Chemistry. 2013 Jan | journal-article. doi: 10.1016/j.bmc.2013.05.017.
- Antiproliferative activities and SAR studies of substituted anthraquinones and 1,4-naphthoquinones, Bioorganic and Medicinal Chemistry Letters. 2013 Jan | journal-article. doi: 10.1016/j.bmcl.2013.09.098.
- Design, synthesis and biological studies of Survivin Dimerization Modulators that prolong mitotic cycle, Bioorganic and Medicinal Chemistry Letters. 2013 Jan | journal-article. doi: 10.1016/j.bmcl.2013.07.034.
- Design, synthesis and biological studies of novel tubulin inhibitors, Bioorganic and Medicinal Chemistry Letters. 2013 Jan | journal-article. doi: 10.1016/j.bmcl.2013.04.078.
- Evaluation of STAT3 signaling in ALDH+ and ALDH+/CD44+/CD24- subpopulations of breast cancer cells, PLoS ONE. 2013 Jan | journal-article. doi: 10.1371/journal.pone.0082821.
- Inhibition of human γ -glutamyl transpeptidase: Development of more potent, physiologically relevant, uncompetitive inhibitors, Biochemical Journal. 2013 Jan | journal-article. doi: 10.1042/BJ20121435.
- JAK-STAT blockade inhibits tumor initiation and clonogenic recovery of prostate cancer stem-like cells, Cancer Research. 2013 Jan | journal-article. doi: 10.1158/0008-5472.CAN-13-0874.
- Phosphoproteomic analysis of anaplastic lymphoma kinase (ALK) downstream signaling pathways identifies signal transducer and activator of transcription 3 as a functional target of activated ALK in neuroblastoma cells, FEBS Journal. 2013 Jan | conference-paper. doi: 10.1111/febs.12453.
- Structure-activity relationship studies of thalidomide analogs with a taxol-like mode of action, Bioorganic and Medicinal Chemistry Letters. 2013 Jan | journal-article. doi: 10.1016/j.bmcl.2013.09.084.
- A small molecule, LLL12 inhibits constitutive STAT3 and IL-6-induced STAT3 signaling and exhibits potent growth suppressive activity in human multiple myeloma cells, International Journal of Cancer. 2012 Jan | journal-article. doi: 10.1002/ijc.26152.
- Divergent effects of compounds on the hydrolysis and transpeptidation reactions of γ-glutamyl transpeptidase, Journal of Enzyme Inhibition and Medicinal Chemistry. 2012 Jan | journal-article. doi: 10.3109/14756366.2011.597748.
- First-in-human trial of a STAT3 decoy oligonucleotide in head and neck tumors: Implications for cancer therapy, Cancer Discovery. 2012 Jan | journal-article. doi: 10.1158/2159-8290.CD-12-0191.
- Small molecules, LLL12 and FLLL32, inhibit STAT3 and exhibit potent growth suppressive activity in osteosarcoma cells and tumor growth in mice, Investigational New Drugs. 2012 Jan | journal-article. doi: 10.1007/s10637-011-9645-1.
- Structurally modified curcumin analogs inhibit STAT3 phosphorylation and promote apoptosis of human renal cell carcinoma and melanoma cell lines, PLoS ONE. 2012 Jan | journal-article. doi: 10.1371/journal.pone.0040724.
- The effect of the steroid sulfatase inhibitor (p-O-sulfamoyl)-tetradecanoyl tyramine (DU-14) on learning and memory in rats with selective lesion of septal-hippocampal cholinergic tract, Neurobiology of Learning and Memory. 2012 Jan | journal-article. doi: 10.1016/j.nlm.2012.09.003.
- Creating diverse target-binding surfaces on FKBP12: Synthesis and evaluation of a rapamycin analogue library, ACS Combinatorial Science. 2011 Jan | journal-article. doi: 10.1021/co200057n.
- Glioma cell migration on three-dimensional nanofiber scaffolds is regulated by substrate topography and abolished by inhibition of STAT3 signaling, Neoplasia. 2011 Jan | journal-article. doi: 10.1593/neo.11612.
- LLL12 inhibits endogenous and exogenous interleukin-6-induced STAT3 phosphorylation in human pancreatic cancer cells, Anticancer Research. 2011 Jan | journal-article. .
- STAT3 is necessary for proliferation and survival in colon cancer-initiating cells, Cancer Research. 2011 Jan | journal-article. doi: 10.1158/0008-5472.CAN-10-4660.
- Targeting colon cancer stem cells using a new curcumin analogue, GO-Y030, British Journal of Cancer. 2011 Jan | journal-article. doi: 10.1038/bjc.2011.200.
- The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines, BMC Cancer. 2011 Jan | journal-article. doi: 10.1186/1471-2407-11-112.
- The small molecule, lll12, inhibits stat3 phosphorylation and induces apoptosis in medulloblastoma and glioblastoma cells, PLoS ONE. 2011 Jan | journal-article. doi: 10.1371/journal.pone.0018820.
- Two small molecule compounds, LLL12 and FLLL32, exhibit potent inhibitory activity on STAT3 in human rhabdomyosarcoma cells, International Journal of Oncology. 2011 Jan | journal-article. doi: 10.3892/ijo-00000848.
- A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells, Molecular Cancer. 2010 Jan | journal-article. doi: 10.1186/1476-4598-9-217.
- A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells, Neoplasia. 2010 Jan | journal-article. doi: 10.1593/neo.91196.
- Biological activity of 1-aryl-3-phenethylamino-1-propanone hydrochlorides and 3-aroyl-4-aryl-1-phenethyl-4-piperidinols on pc-3 cells and DNA topoisomerase I enzyme, Zeitschrift fur Naturforschung - Section C Journal of Biosciences. 2010 Jan | journal-article. doi: 10.1515/znc-2010-11-1203.
- Influence of novel KGFR tyrosine kinase inhibitors on KGF-mediated proliferation of breast cancer, Anticancer Research. 2010 Jan | journal-article. .
- Inhibition of STAT3 signaling blocks the anti-apoptotic activity of IL-6 in human liver cancer cells, Journal of Biological Chemistry. 2010 Jan | journal-article. doi: 10.1074/jbc.M110.142752.
- Investigation of the potential utility of a linomide analogue for treatment of choroidal neovascularization, Experimental Eye Research. 2010 Jan | journal-article. doi: 10.1016/j.exer.2010.10.013.
- Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells, Cancer Research. 2010 Jan | journal-article. doi: 10.1158/0008-5472.CAN-09-2468.
- Sorafenib overcomes TRAIL resistance of hepatocellular carcinoma cells through the inhibition of STAT3, Clinical Cancer Research. 2010 Jan | journal-article. doi: 10.1158/1078-0432.CCR-09-3389.
- The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity, Molecular Cancer. 2010 Jan | journal-article. doi: 10.1186/1476-4598-9-165.
- Anti-angiogenic and vascular disrupting effects of C9, a new microtubule-depolymerizing agent, British Journal of Pharmacology. 2009 Jan | journal-article. doi: 10.1111/j.1476-5381.2009.00112.x.
- Characterization of STAT3 activation and expression in canine and human osteosarcoma, BMC Cancer. 2009 Jan | journal-article. doi: 10.1186/1471-2407-9-81.
- Curcumin analogues exhibit enhanced growth suppressive activity in human pancreatic cancer cells, Anti-Cancer Drugs. 2009 Jan | journal-article. doi: 10.1097/CAD.0b013e32832afc04.
- Curcumin is a potent DNA hypomethylation agent, Bioorganic and Medicinal Chemistry Letters. 2009 Jan | journal-article. doi: 10.1016/j.bmcl.2008.12.041.
- LLL-3 inhibits STAT3 activity, suppresses glioblastoma cell growth and prolongs survival in a mouse glioblastoma model, British Journal of Cancer. 2009 Jan | journal-article. doi: 10.1038/sj.bjc.6604793.
- Modulation of DNA methylation by a sesquiterpene lactone parthenolide, Journal of Pharmacology and Experimental Therapeutics. 2009 Jan | journal-article. doi: 10.1124/jpet.108.147934.
- New curcumin analogues exhibit enhanced growth-suppressive activity and inhibit AKT and signal transducer and activator of transcription 3 phosphorylation in breast and prostate cancer cells, Cancer Science. 2009 Jan | journal-article. doi: 10.1111/j.1349-7006.2009.01220.x.
- New structural analogues of curcumin exhibit potent growth suppressive activity in human colorectal carcinoma cells, BMC Cancer. 2009 Jan | journal-article. doi: 10.1186/1471-2407-9-99.
- Structure-activity relationship studies of curcumin analogues, Bioorganic and Medicinal Chemistry Letters. 2009 Jan | journal-article. doi: 10.1016/j.bmcl.2009.01.104.
- Design, synthesis, and studies of small molecule STAT3 inhibitors, Bioorganic and Medicinal Chemistry Letters. 2008 Jan | journal-article. doi: 10.1016/j.bmcl.2007.10.031.
- Synthesis and cytotoxicity of novel 3-aryl-1-(3′-dibenzylaminomethyl- 4′-hydroxyphenyl)-propenones and related compounds, Chemical and Pharmaceutical Bulletin. 2008 Jan | journal-article. doi: 10.1248/cpb.56.1675.
- A novel steroidal selective steroid sulfatase inhibitor KW-2581 inhibits sulfated-estrogen dependent growth of breast cancer cells in vitro and in animal models, Breast Cancer Research and Treatment. 2007 Jan | journal-article. doi: 10.1007/s10549-007-9495-x.
- Development of keratinocyte growth factor receptor tyrosine kinase inhibitors for the treatment of cancer, Anticancer Research. 2007 Jan | journal-article. .
- Immunohistochemical analysis of steroid sulfatase in human tissues, Journal of Steroid Biochemistry and Molecular Biology. 2007 Jan | journal-article. doi: 10.1016/j.jsbmb.2006.12.105.
- Inhibition of steroid sulfatase activity and cell proliferation in ZR-75-1 and BT-474 human breast cancer cells by KW-2581 in vitro and in vivo, Breast Cancer Research and Treatment. 2007 Jan | journal-article. doi: 10.1007/s10549-006-9404-8.
- Inhibitors of NF-κB derived from thalidomide, Bioorganic and Medicinal Chemistry Letters. 2007 Jan | journal-article. doi: 10.1016/j.bmcl.2007.01.088.
- Keratinocyte growth factor receptor tyrosine kinase antagonists for the prevention of metastatic cancer progression, Drugs of the Future. 2007 Jan | journal-article. doi: 10.1358/dof.2007.032.11.1131966.
- Synthesis of 4′-hydroxy-3′-piperidinomethylchalcone derivatives and their cytotoxicity against PC-3 cell lines, Archiv der Pharmazie. 2007 Jan | journal-article. doi: 10.1002/ardp.200600072.
- A thalidomide analogue with in vitro antiproliferative, antimitotic, and microtubule-stabilizing activities, Molecular Cancer Therapeutics. 2006 Jan | journal-article. doi: 10.1158/1535-7163.MCT-05-0254.
- Evaluation of the cytotoxicity of some mono-Mannich bases and their corresponding azine derivatives against androgen-independent prostate cancer cells, Arzneimittel-Forschung/Drug Research. 2006 Jan | journal-article. doi: 10.1055/s-0031-1296797.
- Structure-activity-relationship studies of conformationally restricted analogs of combretastatin A-4 derived from SU5416, Bioorganic and Medicinal Chemistry. 2006 Jan | journal-article. doi: 10.1016/j.bmc.2006.06.017.
- Conformationally restricted analogs of Combretastatin A-4 derived from SU5416, Bioorganic and Medicinal Chemistry Letters. 2005 Jan | journal-article. doi: 10.1016/j.bmcl.2005.09.001.
- Erratum: The actions of a charged melatonin receptor ligand, TMEPI, and an irreversible MT2 receptor agonist, BMNEP, on mouse hippocampal evoked potentials in vitro (Life Sciences (2004) 75 (3147-3156) DOI: 10.1016/j.lfs.2004.06.009), Life Sciences. 2005 Jan | journal-article. doi: 10.1016/j.lfs.2005.01.006.
- Neurosteroid paradoxical enhancement of paired-pulse inhibition through paired-pulse facilitation of inhibitory circuits in dentate granule cells, Neuropharmacology. 2005 Jan | journal-article. doi: 10.1016/j.neuropharm.2004.11.014.
- Translational studies on aromatase, cyclooxygenases, and enzyme inhibitors in breast cancer, Journal of Steroid Biochemistry and Molecular Biology. 2005 Jan | conference-paper. doi: 10.1016/j.jsbmb.2005.04.013.
- Fetal alcohol exposure alters neurosteroid levels in the developing rat brain, Journal of Neurochemistry. 2004 Jan | journal-article. doi: 10.1111/j.1471-4159.2004.02686.x.
- Synthesis of new estrone derivatives using excess oxalyl chloride, Chemistry of Natural Compounds. 2004 Jan | journal-article. doi: 10.1023/B:CONC.0000025465.76505.33.
- The actions of a charged melatonin receptor ligand, TMEPI, and an irreversible MT2 receptor agonist, BMNEP, on mouse hippocampal evoked potentials in vitro, Life Sciences. 2004 Jan | journal-article. doi: 10.1016/j.lfs.2004.06.009.
- Role of steroid sulfatase in local formation of estrogen in post-menopausal breast cancer patients, Journal of Steroid Biochemistry and Molecular Biology. 2003 Jan | conference-paper. doi: 10.1016/S0960-0760(03)00357-1.
- Structure-activity relationships studies of the anti-angiogenic activities of linomide, Bioorganic and Medicinal Chemistry Letters. 2003 Jan | journal-article. doi: 10.1016/S0960-894X(03)00047-7.
- Effects of putative hydroxylated thalidomide metabolites on blood vessel density in the chorioallantoic membrane (CAM) assay and on tumor and endothelial cell proliferation, Biological and Pharmaceutical Bulletin. 2002 Jan | journal-article. doi: 10.1248/bpb.25.597.
- Inhibition of steryl sulfatase activity in LNCaP human prostate cancer cells, Steroids. 2002 Jan | journal-article. doi: 10.1016/S0039-128X(02)00030-2.
- Solid-phase synthesis of thalidomide and its analogues, Journal of Combinatorial Chemistry. 2002 Jan | journal-article. doi: 10.1021/cc010038n.
- Synthesis and pharmacological analysis of high affinity melatonin receptor ligands, Chemical and Pharmaceutical Bulletin. 2002 Jan | journal-article. doi: 10.1248/cpb.50.272.
- Design and synthesis of Pfmrk inhibitors as potential antimalarial agents, Bioorganic and medicinal chemistry letters. 2001 Jan | journal-article. doi: 10.1016/S0960-894X(01)00578-9.
- N1E-115 mouse neuroblastoma cells express mt1 melatonin receptors and produce neurites in response to melatonin, Biochimica et Biophysica Acta - Molecular Cell Research. 2001 Jan | journal-article. doi: 10.1016/S0167-4889(00)00127-0.
- Synthesis of naphthalenic melatonin receptor ligands, Synthetic Communications. 2001 Jan | journal-article. doi: 10.1081/SCC-100000591.
- Melatonin receptors and ligands, Vitamins and Hormones. 2000 Jan | book. doi: 10.1016/s0083-6729(00)58030-3.
- Melatonin receptors as potential targets for drug discovery, Drugs of the Future. 2000 Jan | journal-article. doi: 10.1358/dof.2000.025.09.858694.
- Steroid sulfatase activity in the rat ovary, cultured granulosa cells, and a granulosa cell line, Journal of Steroid Biochemistry and Molecular Biology. 2000 Jan | journal-article. doi: 10.1016/S0960-0760(00)00171-0.
- Steroid sulfatase inhibitor alters blood pressure and steroid profiles in hypertensive rats, Journal of Steroid Biochemistry and Molecular Biology. 2000 Jan | journal-article. doi: 10.1016/S0960-0760(00)00062-5.
- Synthesis of [25,26,26,26,27,27,27-d7]-cholesterol, Journal of Labelled Compounds and Radiopharmaceuticals. 2000 Jan | journal-article. doi: 10.1002/1099-1344(200007)43:8<773::AID-JLCR361>3.0.CO;2-G.
- The effect of steroid sulfatase inhibition on learning and spatial memory, Brain Research. 2000 Jan | journal-article. doi: 10.1016/S0006-8993(00)02372-6.
- Tissue steroid sulfatase levels, testosterone and blood pressure, Journal of Steroid Biochemistry and Molecular Biology. 2000 Jan | journal-article. doi: 10.1016/S0960-0760(00)00075-3.
- Development of (p-O-sulfamoyl)-N-alkanoyl-phenylalkyl amines as non- steroidal estrone sulfatase inhibitors, Journal of Steroid Biochemistry and Molecular Biology. 1999 Jan | journal-article. doi: 10.1016/S0960-0760(98)00159-9.
- Peripheral steroid sulfatase inhibition potentiates improvement of memory retention for hippocampally administered dehydroepiandrosterone sulfate but not pregnenolone sulfate, Psychoneuroendocrinology. 1999 Jan | journal-article. doi: 10.1016/S0306-4530(99)00030-X.
- Synthesis and sulfatase inhibitory activities of (E)- and (Z)-4- hydroxytamoxifen sulfamates, Bioorganic and Medicinal Chemistry Letters. 1999 Jan | journal-article. doi: 10.1016/S0960-894X(98)00707-0.
- Development of potent non-estrogenic estrone sulfatase inhibitors, Steroids. 1998 Jan | journal-article. doi: 10.1016/S0039-128X(98)00044-0.
- Synthesis of 17-oxoandrosta-3,5-dien-3-methyl sulfonate as stable analog of dehydroepiandrosterone sulfate, Steroids. 1998 Jan | journal-article. doi: 10.1016/S0039-128X(98)00006-3.
- Synthesis of a radiolabeled charged melatonin receptor ligand, Journal of Labelled Compounds and Radiopharmaceuticals. 1998 Jan | journal-article. doi: 10.1002/(SICI)1099-1344(199805)41:5<435::AID-JLCR97>3.0.CO;2-L.
- Chronic steroid sulfatase inhibition by (p-o-sulfamoyl)-N-tetradecanoyl tyramine increases dehydroepiandrosterone sulfate in whole brain, Life Sciences. 1997 Jan | journal-article. doi: 10.1016/S0024-3205(97)00961-2.
- Development of a high-affinity ligand that binds irreversibly to Mel1b melatonin receptors., Journal of medicinal chemistry. 1997 Jan | journal-article. doi: 10.1021/jm970437q.
- Enhanced plasma DHEAS, brain acetylcholine and memory mediated by steroid sulfatase inhibition, Brain Research. 1997 Jan | journal-article. doi: 10.1016/S0006-8993(97)00867-6.
- Inhibition of estrone sulfatase and proliferation of human breast cancer cells by nonsteroidal (p-O-sulfamoyl)-N-alkanoyl tyramines, Cancer Research. 1997 Jan | journal-article. .
- Structure-activity relationship studies of the amide functionality in (p-O-sulfamoyl)-N-alkanoyl tyramines as estrone sulfatase inhibitors, Steroids. 1997 Jan | journal-article. doi: 10.1016/S0039-128X(97)00038-X.
- Synthesis and receptor binding studies of quinolinic derivatives as melatonin receptor ligands, Bioorganic and Medicinal Chemistry Letters. 1997 Jan | journal-article. doi: 10.1016/S0960-894X(97)00392-2.
- Synthesis of sodium androst-5-ene-17-one 3β methylene sulfonate, Steroids. 1997 Jan | journal-article. doi: 10.1016/S0039-128X(97)00039-1.
- The development of a charged melatonin receptor ligand, Bioorganic and Medicinal Chemistry Letters. 1997 Jan | journal-article. doi: 10.1016/S0960-894X(97)00444-7.
- Enhancement of hippocampal acetylcholine release by the neurosteroid dehydroepiandrosterone sulfate: An in vivo microdialysis study, Brain Research. 1996 Jan | journal-article. doi: 10.1016/0006-8993(96)00751-2.
- In vivo effects of dehydroepiandrosterone sulfate (dheas) on acetylcholine release in the hippocampus of anesthetized rats, FASEB Journal. 1996 Jan | journal-article. .
- Inhibition of placental estrone sulfatase activity and MCF-7 breast cancer cell proliferation by estrone-3-amino derivatives, Journal of Steroid Biochemistry and Molecular Biology. 1996 Jan | journal-article. doi: 10.1016/S0960-0760(96)00089-1.
- Memory enhancement mediated by the steroid sulfatase inhibitor (p-O-sulfamoyl)-N-tetradecanoyl tyramine, Life Sciences. 1996 Jan | journal-article. doi: 10.1016/s0024-3205(96)00621-2.
- Synthesis and sulfatase inhibitory activities of non-steroidal estrone sulfatase inhibitors, Journal of Steroid Biochemistry and Molecular Biology. 1996 Jan | journal-article. doi: 10.1016/S0960-0760(96)00093-3.
- Estrogenicity, antiestrogenicity and estrone sulfatase inhibition of estrone-3-amine and estrone-3-thiol, Journal of Steroid Biochemistry and Molecular Biology. 1995 Jan | journal-article. doi: 10.1016/0960-0760(94)00176-M.
- Estrone sulfate analogs as estrone sulfatase inhibitors, Steroids. 1995 Jan | journal-article. doi: 10.1016/0039-128X(94)00048-H.
- Reversal of scopolamine induced amnesia in rats by the steroid sulfatase inhibitor estrone-3-O-sulfamate, Cognitive Brain Research. 1995 Jan | journal-article. doi: 10.1016/0926-6410(95)90016-0.
- Inhibition of human placental sterylsulfatase by synthetic analogs of estrone sulfate, Journal of Steroid Biochemistry and Molecular Biology. 1994 Jan | journal-article. doi: 10.1016/0960-0760(94)90130-9.
- In vitro uptake and autoradiographic localization of tritiated gossypol in Taenia taeniaeformis metacestodes, Parasitology Research. 1993 Jan | journal-article. doi: 10.1007/BF00932182.
- Synthesis and biochemical studies of estrone sulfatase inhibitors, Steroids. 1993 Jan | journal-article. doi: 10.1016/0039-128X(93)90045-O.
- Aromatase inhibition by 7-substituted steroids in human choriocarcinoma cell culture, Journal of Steroid Biochemistry and Molecular Biology. 1992 Jan | journal-article. doi: 10.1016/0960-0760(92)90228-B.
- Characteristics of covalent gossypol binding to microsomal proteins, Research Communications in Chemical Pathology and Pharmacology. 1992 Jan | journal-article. .
- Gossypolone suppresses progesterone synthesis in bovine luteal cells, Journal of Steroid Biochemistry and Molecular Biology. 1991 Jan | journal-article. doi: 10.1016/0960-0760(91)90082-G.
- 7-Substituted 1,4,6-androstatriene-3,17-diones as enzyme-activated irreversible inhibitors of aromatase, Journal of Steroid Biochemistry. 1990 Jan | journal-article. doi: 10.1016/0022-4731(90)90170-W.
- 7-substituted steroidal aromatase inhibitors: Structure-activity relationships and molecular modeling, Journal of Enzyme Inhibition and Medicinal Chemistry. 1990 Jan | journal-article. doi: 10.3109/14756369009040732.
- Biochemical and pharmacological development of steroidal inhibitors of aromatase, Journal of Steroid Biochemistry and Molecular Biology. 1990 Jan | journal-article. doi: 10.1016/0960-0760(90)90488-7.
- Diclofenac Sodium, Analytical Profiles of Drug Substances and Excipients. 1990 Jan | book. doi: 10.1016/S0099-5428(08)60366-4.
- Synthesis and Biochemical Studies of 7-Substituted 4,6-Androstadiene-3,17-diones as Aromatase Inhibitors, Journal of Medicinal Chemistry. 1990 Jan | journal-article. doi: 10.1021/jm00163a017.
- Effects of the aromatase inhibitor 7α-(4' -amino)phenylthio-4-androstene-3, 17-dione on 7, 12-dimethylbenz(a)anthracene-induced mammary carcinoma in rats, Cancer Research. 1988 Jan | journal-article. .
- 7 α -Substituted androstenediones as effective in vttro and in vivo inhibitors of aromatase, Steroids. 1987 Jan | journal-article. doi: 10.1016/0039-128X(83)90069-7.
- 7α-substituted steroidal aromatase inhibitors in hormone-dependent breast cancer in culture and in vivo [Poster 23], Steroids. 1987 Jan | journal-article. doi: 10.1016/0039-128x(87)90064-x.