Przemyslaw Radwanski, PharmD, PhD
Education
- Ph.D. Pharmacology and Toxicology, University of Utah
- Pharm.D., University of Illinois at Chicago
Journal Articles
Mezache L, Struckman HL, Greer-Short A, Baine S, Györke S, Radwański PB, Hund TJ, Veeraraghavan R. Vascular endothelial growth factor promotes atrial arrhythmias by inducing acute intercalated disk remodeling. Sci Rep. 2020 Nov 24;10(1):20463. doi: 10.1038/s41598-020-77562-5. PMID: 33235263; PMCID: PMC7687901.
Baine S, Thomas J, Bonilla I, Ivanova M, Belevych A, Li J, Veeraraghavan R, Radwanski PB, Carnes C, Gyorke S. Muscarinic-dependent phosphorylation of the cardiac ryanodine receptor by protein kinase G is mediated by PI3K-AKT-nNOS signaling. J Biol Chem. 2020 Aug 14;295(33):11720-11728. doi: 10.1074/jbc.RA120.014054. Epub 2020 Jun 24. PMID: 32580946; PMCID: PMC7450129.
Munger MA, Olğar Y, Koleske ML, Struckman HL, Mandrioli J, Lou Q, Bonila I, Kim K, Ramos Mondragon R, Priori SG, Volpe P, Valdivia HH, Biskupiak J, Carnes CA, Veeraraghavan R, Györke S, Radwański PB. Tetrodotoxin-Sensitive Neuronal- Type Na<sup>+</sup> Channels: A Novel and Druggable Target for Prevention of Atrial Fibrillation. J Am Heart Assoc. 2020 Jun 2;9(11):e015119. doi: 10.1161/JAHA.119.015119. Epub 2020 May 29. PMID: 32468902; PMCID: PMC7429002.
Hamilton S, Terentyeva R, Martin B, Perger F, Li J, Stepanov A, Bonilla IM, Knollmann BC, Radwański PB, Györke S, Belevych AE, Terentyev D. Increased RyR2 activity is exacerbated by calcium leak-induced mitochondrial ROS. Basic Res Cardiol. 2020 May 22;115(4):38. doi: 10.1007/s00395-020-0797-z. PMID: 32444920; PMCID: PMC7244455.
Struckman HL, Baine S, Thomas J, Mezache L, Mykytyn K, Györke S, Radwański PB, Veeraraghavan R. Super-Resolution Imaging Using a Novel High-Fidelity Antibody Reveals Close Association of the Neuronal Sodium Channel Na<sub>V</sub>1.6 with Ryanodine Receptors in Cardiac Muscle. Microsc Microanal. 2020 Feb;26(1):157-165. doi: 10.1017/S1431927619015289. PMID: 31931893; PMCID: PMC7061261.
Johnson CN, Pattanayek R, Potet F, Rebbeck RT, Blackwell DJ, Nikolaienko R, Sequeira V, Le Meur R, Radwański PB, Davis JP, Zima AV, Cornea RL, Damo SM, Györke S, George AL Jr, Knollmann BC. The CaMKII inhibitor KN93-calmodulin interaction and implications for calmodulin tuning of Na<sub>V</sub>1.5 and RyR2 function. Cell Calcium. 2019 Sep;82:102063. doi: 10.1016/j.ceca.2019.102063. Epub 2019 Jul 30. PMID: 31401388; PMCID: PMC6708471.
Bonilla IM, Belevych AE, Baine S, Stepanov A, Mezache L, Bodnar T, Liu B, Volpe P, Priori S, Weisleder N, Sakuta G, Carnes CA, Radwański PB, Veeraraghavan R, Gyorke S. Enhancement of Cardiac Store Operated Calcium Entry (SOCE) within Novel Intercalated Disk Microdomains in Arrhythmic Disease. Sci Rep. 2019 Jul 15;9(1):10179. doi: 10.1038/s41598-019-46427-x. PMID: 31308393; PMCID: PMC6629850.
Bress AP, Dodson JA, King JB, Sauer BC, Reese T, Crook J, Radwanski P, Knippenberg K, Greene T, Nelson RE, Munger MA, Weintraub WS, LaFleur J. Clinical and Economic Outcomes of Ranolazine Versus Conventional Antianginals Users Among Veterans With Chronic Stable Angina Pectoris. Am J Cardiol. 2018 Dec 1;122(11):1809-1816. doi: 10.1016/j.amjcard.2018.08.027. Epub 2018 Sep 8. PMID: 30292334.
Radwański PB, Johnson CN, Györke S, Veeraraghavan R. Cardiac Arrhythmias as Manifestations of Nanopathies: An Emerging View. Front Physiol. 2018 Sep 4;9:1228. doi: 10.3389/fphys.2018.01228. PMID: 30233404; PMCID: PMC6131669.
Koleske M, Bonilla I, Thomas J, Zaman N, Baine S, Knollmann BC, Veeraraghavan R, Györke S, Radwański PB. Tetrodotoxin-sensitive Na<sub>v</sub>s contribute to early and delayed afterdepolarizations in long QT arrhythmia models. J Gen Physiol. 2018 Jul 2;150(7):991-1002. doi: 10.1085/jgp.201711909. Epub 2018 May 23. PMID: 29793933; PMCID: PMC6028491.