Peixuan Guo

Peixuan Guo

Peixuan Guo, PhD

Sylvan G. Frank Endowed Chr
Unit / Department / Division
Pharmaceutics and Pharmacology
912 Biomedical Research Tower
Email Address
Phone Number

Professional Interests

Professional Interests

Support Staff
Cheyenne Wagner, Administrative Associate 

Journal Articles

Zhang L, Gardner ML, Jayasinghe L, Jordan M, Aldana J, Burns N, Freitas MA, Guo P. Detection of single peptide with only one amino acid modification via electronic fingerprinting using reengineered durable channel of Phi29 DNA packaging motor. Biomaterials. 2021 Jul 10;276:121022. doi: 10.1016/j.biomaterials.2021.121022. Epub ahead of print. PMID: 34298441.

Wang H, Guo P. Radiolabeled RNA Nanoparticles for Highly Specific Targeting and Efficient Tumor Accumulation with Favorable <i>In Vivo</i> Biodistribution. Mol Pharm. 2021 Jul 2. doi: 10.1021/acs.molpharmaceut.1c00035. Epub ahead of print. PMID: 34212728.

Blanco Carcache PJ, Guo S, Li H, Zhang K, Xu C, Chiu W, Guo P. Regulation of Reversible Conformational Change, Size Switching, and Immunomodulation of RNA Nanocubes. RNA. 2021 Jun 30:rna.078718.121. doi: 10.1261/rna.078718.121. Epub ahead of print. PMID: 34193550.

Binzel DW, Li X, Burns N, Khan E, Lee WJ, Chen LC, Ellipilli S, Miles W, Ho YS, Guo P. Thermostability, Tunability, and Tenacity of RNA as Rubbery Anionic Polymeric Materials in Nanotechnology and Nanomedicine-Specific Cancer Targeting with Undetectable Toxicity. Chem Rev. 2021 May 26. doi: 10.1021/acs.chemrev.1c00009. Epub ahead of print. PMID: 34038115.

Li Z, Yang L, Wang H, Binzel DW, Williams TM, Guo P. Non-Small-Cell Lung Cancer Regression by siRNA Delivered Through Exosomes That Display EGFR RNA Aptamer. Nucleic Acid Ther. 2021 May 17. doi: 10.1089/nat.2021.0002. Epub ahead of print. PMID: 33999716.

Li H, Zhang K, Binzel DW, Shlyakhtenko LS, Lyubchenko YL, Chiu W, Guo P. RNA nanotechnology to build a dodecahedral genome of single-stranded RNA virus. RNA Biol. 2021 Apr 29:1-11. doi: 10.1080/15476286.2021.1915620. Epub ahead of print. PMID: 33845711.

Saeed AFUH, Chan C, Guan H, Gong B, Guo P, Cheng X, Ouyang S. Structural Insights into gp16 ATPase in the Bacteriophage ϕ29 DNA Packaging Motor. Biochemistry. 2021 Mar 23;60(11):886-897. doi: 10.1021/acs.biochem.0c00935. Epub 2021 Mar 9. PMID: 33689296.

Shu D, Zhang L, Bai X, Yu J, Guo P. Stoichiometry of multi-specific immune checkpoint RNA Abs for T cell activation and tumor inhibition using ultra-stable RNA nanoparticles. Mol Ther Nucleic Acids. 2021 Mar 13;24:426-435. doi: 10.1016/j.omtn.2021.03.007. PMID: 33868786; PMCID: PMC8042240.

Wang H, Ellipilli S, Lee WJ, Li X, Vieweger M, Ho YS, Guo P. Multivalent rubber-like RNA nanoparticles for targeted co-delivery of paclitaxel and MiRNA to silence the drug efflux transporter and liver cancer drug resistance. J Control Release. 2021 Feb 10;330:173-184. doi: 10.1016/j.jconrel.2020.12.007. Epub 2020 Dec 13. PMID: 33316298; PMCID: PMC7923242.

Ghimire C, Wang H, Li H, Vieweger M, Xu C, Guo P. RNA Nanoparticles as Rubber for Compelling Vessel Extravasation to Enhance Tumor Targeting and for Fast Renal Excretion to Reduce Toxicity. ACS Nano. 2020 Oct 27;14(10):13180-13191. doi: 10.1021/acsnano.0c04863. Epub 2020 Sep 16. PMID: 32902260; PMCID: PMC7799665.

Li X , Vieweger M , Guo P . Self-assembly of four generations of RNA dendrimers for drug shielding with controllable layer-by-layer release. Nanoscale. 2020 Aug 21;12(31):16514-16525. doi: 10.1039/d0nr02614j. Epub 2020 Jul 30. PMID: 32729600; PMCID: PMC7448292.

Liang C, Weitao T, Zhou L, Guo P. Translation of the long-term fundamental studies on viral DNA packaging motors into nanotechnology and nanomedicine. Sci China Life Sci. 2020 Aug;63(8):1103-1129. doi: 10.1007/s11427-020-1752-1. Epub 2020 Jun 29. PMID: 32617827.

Guo P. High resolution structure of hexameric herpesvirus DNA-packaging motor elucidates revolving mechanism and ends 20-year fervent debate. Protein Cell. 2020 May;11(5):311-315. doi: 10.1007/s13238-020-00714-w. PMID: 32314326; PMCID: PMC7196596.

Ji Z, Jordan M, Jayasinghe L, Guo P. Insertion of channel of phi29 DNA packaging motor into polymer membrane for high-throughput sensing. Nanomedicine. 2020 Apr;25:102170. doi: 10.1016/j.nano.2020.102170. Epub 2020 Feb 6. PMID: 32035271.

Guo S, Vieweger M, Zhang K, Yin H, Wang H, Li X, Li S, Hu S, Sparreboom A, Evers BM, Dong Y, Chiu W, Guo P. Ultra-thermostable RNA nanoparticles for solubilizing and high-yield loading of paclitaxel for breast cancer therapy. Nat Commun. 2020 Feb 20;11(1):972. doi: 10.1038/s41467-020-14780-5. PMID: 32080195; PMCID: PMC7033104.

Abdelhameed A, Liao X, McElroy CA, Joice AC, Rakotondraibe L, Li J, Slebodnick C, Guo P, Wilson WD, Werbovetz KA. Synthesis and antileishmanial evaluation of thiazole orange analogs. Bioorg Med Chem Lett. 2020 Jan 1;30(1):126725. doi: 10.1016/j.bmcl.2019.126725. Epub 2019 Oct 4. PMID: 31732409.

Guo S, Xu C, Yin H, Hill J, Pi F, Guo P. Tuning the size, shape and structure of RNA nanoparticles for favorable cancer targeting and immunostimulation. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2020 Jan;12(1):e1582. doi: 10.1002/wnan.1582. Epub 2019 Aug 27. PMID: 31456362; PMCID: PMC6908753.