Headshot of Peixuan Guo

Peixuan Guo, PhD


Sylvan G. Frank Endowed Chair

Pharmaceutics and Pharmacology

406 Biomedical Research Tower
(614) 293-2114
Professional Website

Professional Interests

Dr. Guo works on both basic research and its subsequent practical applications, focusing on understanding the mechanisms and assembly of viral DNA packaging motor, and using components of the biomotor for various applications. By applying interdisciplinary approaches including chemistry, biophysics, biochemistry, nanotechnology, bioengineering, molecular biology, cell biology, computer modeling, and pharmaceutical sciences, Dr. Guo studies RNA, DNA and proteins and their interaction.

Dr. Guo’s current project areas are:

RNA nanotechnology and its application for the delivery of siRNA/miRNA/drug for the treatment of cancers, viral infection, and genetic diseases
Nanobiotechnology, including structure, function and mechanism of Phi29 DNA-packaging nanomotor
Single molecule imaging and optical instrumentation to study the interaction of RNA, DNA, and protein
Single pore technology for DNA sequencing, macromolecule detection, and disease diagnosis, using channels of variety of viral DNA packaging motors


Dr. Peixuan Guo, a pioneer of RNA nanotechnology, has held three endowed chair positions at three different prestigious universities, and currently is the Sylvan G. Frank Endowed Chair in Pharmaceutics and Drug Delivery and the director of the Center for RNA Nanobiotechnology and Nanomedicine at The Ohio State University. He is the president of the International Society of RNA Nanotechnology and Nanomedicine. He received his Ph.D. from U Minnesota in 1987 and conducted his postdoc at NIH under Bernard Moss. He joined Purdue University in 1990, tenured in 1993 and became a full professor in 1997, honored as a Purdue Distinguished Faculty Scholar in 1998. He served as the Director of the NIH Nanomedcine Develoment Center (NDC) from 2006-2011, was the Director of NCI Cancer Nanotech Platform Partnership Program from 2012-2017. To date, Dr. Guo invented 70 patents (13 granted and 57 in Provisional and PCT). He received the 2021 Innovator of the Year Award at The Ohio State University and was elected as a NAI Fellow in 2022.  

Support Staff: Cheyenne Wagner,


  • 1990, Postdoctoral Training Molecular Virology, National Institutes of Health, Bethesda, MD
  • 1989, Postdoctoral Training Molecular Virology, New York State Department of Health
  • 1987, PhD Microbiology & Genetics, University of Minnesota, Minneapolis, MN


  • Fellow of the National Academy of Inventors (NAI)
  • Director of Center for RNA Nanobiotechnology and Nanomedicine
  • President of International Society of RNA Nanotechnology and Nanomedicine
  • International Society of RNA Nanotechnology and Nanomedicine
  • Fellow of the National Academy of Inventors (NAI), 2022
  • Distinguished Chinese Alumni of the University of Minnesota, 2014
  • Distinguished Research Award, University of Cincinnati, 2010, 2011
  • Distinguished Alumni of The University of Minnesota, 2009
  • Lions Club Award for Cancer Research Excellence, 2006
  • One of five finalists for Feynman (Nobel Prize Laureate) Nanotechnology Award, 2005
  • Seed Award, 2005, 2006, 2007
  • Purdue Faculty Scholar, 1999-2004
  • Pfizer Distinguished Faculty Award for Research Excellence, 1995
  • First Award, NIH, USA, 1993