Liva Rakotondraibe, PhD

Associate Professor

Medicinal Chemistry and Pharmacognosy

Research Areas: Cancer, Division of Medicinal Chemistry & Pharmacognosy, Natural Products

Professional Interests

New natural product sources (new and unidentified fungal and bacterial microorganisms, microbial endophytes, new endemic and medicinal plant species, etc.) contain many undiscovered potential bioactive secondary metabolites that can be used to combat world’s deadly diseases including cancer, malaria, viral infections, and chemoresistance. Their investigation must be prioritized in order to discover new pharmacophores for potential drug candidates. My lab focuses on (1) bioassay-guided isolation, structural elucidation and development of bioactive compounds from natural sources, (2) Drug discovery from Madagascan natural products and (3) drug discovery from ethnomedicine. One of our recent ongoing projects is on the development of insecticides that can be used to control mosquito vector of Zika virus from Madagascan endemic plants.

Education

2003, PhD, Hiroshima University, Pharmaceutical Sciences (Medicinal Natural Product Chemistry
1998, DEA (Diplome d'Etude Approfondie), Equivalent to MS, Mention "Tres bien", University of Antananarivo, Organic Chemistry/ Natural Product Chemistry

Honors

Dean's Innovation Award, The Ohio State University College of Pharmacy, 2023
PRE President's Research Excellence Accelerator Award, 2022
JSPS-Bridge (Japanese Society for the Promotion of Science) Fellowship, 2017 - 2018
Postdoctoral Fellowship from the Japanese Society for the Promotion of Science (JSPS), 2005 - 2007
Japanese Government (Mombukagakusho): Ministry of Education, Culture, Sports, Science and Technology (MEXT), 1999 - 2003

Publications

Histoplasma capsulatum requires peroxisomes for multiple virulence functions including siderophore biosynthesis, mBio. 2023 Jul | journal-article. doi: 10.1128/mbio.03284-22.
Bioactive and unusual steroids from Penicillium fungi, Phytochemistry. 2023 May | journal-article. doi: 10.1016/j.phytochem.2023.113638.
Strategies for the discovery of potential anticancer agents from plants collected from Southeast Asian tropical rainforests as a case study, Natural Product Reports. 2023 Jan | journal-article. doi: 10.1039/D2NP00080F.
Understanding the Biosynthesis of Paxisterol in Lichen-Derived Penicillium aurantiacobrunneum for Production of Fluorinated Derivatives, Molecules. 2022 Mar | journal-article. doi: 10.3390/molecules27051641.
Modulation of the oral glucocorticoid system during black raspberry mediated oral cancer chemoprevention, Carcinogenesis. 2021 Dec | journal-article. doi: 10.1093/carcin/bgab118.
Activity in MCF-7 Estrogen-sensitive Breast Cancer Cells of Capsicodendrin from Cinnamosma fragrans, Anticancer Research. 2021 Dec | journal-article. doi: 10.21873/anticanres.15412.
Detecting and Differentiating Monosaccharide Enantiomers by 1H NMR Spectroscopy, Journal of Natural Products. 2021 Jul | journal-article. doi: 10.1021/acs.jnatprod.0c01120.
Structure-Activity Relationship of para-Carborane Selective Estrogen Receptor β Agonists., Journal of medicinal chemistry. 2021 Jun | journal-article. doi: 10.1021/acs.jmedchem.1c00555.
Chemotaxonomy and cytotoxicity of the liverwort Porella Viridissima, Natural Product Research. 2021 Jun | journal-article. doi: 10.1080/14786419.2019.1655022.
Spermidine alkaloid and glycosidic constituents of Vietnamese Homalium cochinchinensis, Phytochemistry Letters. 2021 Jun | journal-article. doi: 10.1016/j.phytol.2021.04.002.
Tumor suppressor p53 independent apoptosis in HT-29 cells by auransterol from Penicillium aurantiacobrunneum, Biomedicine & Pharmacotherapy. 2020 Jul | journal-article. doi: 10.1016/j.biopha.2020.110124.
Stop the crop: insights into the insecticidal mode of action of cinnamodial against mosquitoes, . 2020 May | preprint. doi: 10.1101/2020.05.30.125203.
Semi-synthetic cinnamodial analogues: Structural insights into the insecticidal and antifeedant activities of drimane sesquiterpenes against the mosquito Aedes aegypti, PLOS Neglected Tropical Diseases. 2020 Feb | journal-article. doi: 10.1371/journal.pntd.0008073.
Structurally Modified Cyclopenta[b]benzofuran Analogues Isolated from Aglaia perviridis, Journal of Natural Products. 2019 Oct | journal-article. doi: 10.1021/acs.jnatprod.9b00631.
α-Pyrone and Sterol Constituents of Penicillium aurantiacobrunneum, a Fungal Associate of the Lichen Niebla homalea, Journal of Natural Products. 2019 Sep | journal-article. doi: 10.1021/acs.jnatprod.9b00340.
Semi-synthetic Cinnamodial Analogues: Structural Insights into the Insecticidal and Antifeedant Activities of Drimane Sesquiterpenes Against the Mosquito Aedes aegypti, . 2019 Jan | other. doi: 10.1101/536961.
Ent-homocyclopiamine B, a Prenylated Indole Alkaloid of Biogenetic Interest from the Endophytic Fungus Penicillium concentricum, Molecules. 2019 Jan | journal-article. doi: 10.3390/molecules24020218.
Bioactivity-Guided Isolation of Totarane-Derived Diterpenes from Podocarpus neriifolius and Structure Revision of 3-Deoxy-2α-hydroxynagilactone E, Natural Products and Bioprospecting. 2019 Jan | journal-article. doi: 10.1007/s13659-019-0198-x.
Cytotoxic constituents from Penicillium concentricum, an endophytic fungus from Trichocolea tomentella, Anti-Cancer Drugs. 2019 Jan | journal-article. doi: 10.1097/CAD.0000000000000759.
Capsicodendrin from Cinnamosma fragrans Exhibits Antiproliferative and Cytotoxic Activity in Human Leukemia Cells: Modulation by Glutathione, Journal of Natural Products. 2018 Mar | journal-article. doi: 10.1021/acs.jnatprod.7b00887.
Total Synthesis of Scytonemide A Employing Weinreb AM Solid-Phase Resin, Journal of Natural Products. 2018 Mar | journal-article. doi: 10.1021/acs.jnatprod.7b00912.
A natural agonist of mosquito TRPA1 from the medicinal plant Cinnamosma fragrans that is toxic, antifeedant, and repellent to the yellow fever mosquito Aedes aegypti, PLoS Neglected Tropical Diseases. 2018 Jan | journal-article. doi: 10.1371/journal.pntd.0006265.
Novel bioactive natural products isolated from Madagascar plants and marine organisms (2009–2017), Chemical and Pharmaceutical Bulletin. 2018 Jan | journal-article. doi: 10.1248/cpb.c17-00395.
Halogenated Compounds from Directed Fermentation of Penicillium concentricum, an Endophytic Fungus of the Liverwort Trichocolea tomentella, Journal of Natural Products. 2017 May | journal-article. doi: 10.1021/acs.jnatprod.6b01069.
Bioactive drimane sesquiterpenoids and aromatic glycosides from Cinnamosma fragrans, Bioorganic and Medicinal Chemistry Letters. 2017 Jan | journal-article. doi: 10.1016/j.bmcl.2017.02.067.
Formation and exudation of non-volatile products of the arabidiol triterpenoid degradation pathway in Arabidopsis roots, Plant Signaling and Behavior. 2017 Jan | journal-article. doi: 10.1080/15592324.2016.1265722.
Phytochemical and cytotoxic investigations of pinguisanoids from liverwort Porella cordaeana, Phytochemistry Letters. 2017 Jan | journal-article. doi: 10.1016/j.phytol.2016.12.003.
Discovery of Anticancer Agents of Diverse Natural Origin, Anticancer Research. 2016 Nov | journal-article. doi: 10.21873/anticanres.11146.
Furoquinoline Alkaloids and Methoxyflavones from the Stem Bark of Melicope madagascariensis (Baker) T.G. Hartley, Natural Products and Bioprospecting. 2016 Sep | journal-article. doi: 10.1007/s13659-016-0106-6.
Review of Problems in Organic Structure Determination. A Practical Approach to NMR SpectroscopyProblems in Organic Structure Determination. A Practical Approach to NMR Spectroscopy. By Roger G. Linington (Simon Fraser University), Philip G. Williams (University of Hawaii), and John B. MacMillan (University of Texas Southwestern Medical Center). CRC Press/Taylor & Francis Group, Boca Raton, FL. 2016. 755 pp. 21 × 28 cm. $119.95. ISBN 978-1-4987-1962-9., Journal of Natural Products. 2016 Jul | journal-article. doi: 10.1021/acs.jnatprod.6b00518.
Correction to Antiproliferative Trihydroxyalkylcyclohexenones fromPleiogynium timoriense, Journal of Natural Products. 2016 Feb | journal-article. doi: 10.1021/acs.jnatprod.6b00073.
Aerobic decomposition of trialkylquercetins: Structure characterization and antiproliferative effect, Natural Product Communications. 2016 Jan | journal-article. .
Terpenoids, flavonoids and acetogenins from some Malagasy plants, Natural Product Communications. 2016 Jan | journal-article. .
Angiostatic actions of capsicodendrin through selective inhibition of VEGFR2-mediated AKT signaling and disregulated autophagy, Oncotarget. 2015 Nov | journal-article. doi: 10.18632/oncotarget.9307.
Rhamnosyl gallates and proanthocyanidins produced by Inga species and their antioxidant and antitumoral potential, Planta Medica. 2015 Nov | journal-article. doi: 10.1055/s-0035-1565470.
A new class of hybrid anticancer agents inspired by the synergistic effects of curcumin and genistein: Design, synthesis, and anti-proliferative evaluation, Bioorganic & Medicinal Chemistry Letters. 2015 Oct | journal-article. doi: 10.1016/j.bmcl.2015.08.064.
New Bioactive Lupane Triterpene Coumaroyl Esters Isolated from Buxus cochinchinensis, Planta Medica. 2015 Jul | journal-article. doi: 10.1055/s-0035-1546118.
Antiproliferative Compounds fromCleistanthus boivinianusfrom the Madagascar Dry Forest1, Journal of Natural Products. 2015 Jul | journal-article. doi: 10.1021/np501020m.
Antiproliferative Trihydroxyalkylcyclohexenones fromPleiogynium timoriense, Journal of Natural Products. 2015 Jul | journal-article. doi: 10.1021/acs.jnatprod.5b00119.
Antimalarial 5,6-Dihydro-α-pyrones fromCryptocarya rigidifolia: Related Bicyclic Tetrahydro-α-Pyrones Are Artifacts1, Journal of Natural Products. 2015 Jun | journal-article. doi: 10.1021/acs.jnatprod.5b00187.
Antiproliferative compounds from Ocotea macrocarpa from the Madagascar dry forest1, Tetrahedron Letters. 2015 Jun | journal-article. doi: 10.1016/j.tetlet.2015.01.172.
Antiproliferative compounds from Penicillium chrysogenum, a fungal associate of the liverwort Trichocolea tomentella, Planta Medica. 2015 Jun | journal-article. doi: 10.1055/s-0035-1556311.
Investigation of the antiproliferative activity of Linociera ramiflora and its isolates, Planta Medica. 2015 Jun | journal-article. doi: 10.1055/s-0035-1556492.
Neolignans and other metabolites from Ocotea cymosa from the Magadascar rain forest and their biological activities, Planta Medica. 2015 Jun | journal-article. doi: 10.1055/s-0035-1556463.
Antiproliferative Constituents of the Roots of EthiopianPodocarpus falcatusand Structure Revision of 2α-Hydroxynagilactone F and Nagilactone I, Journal of Natural Products. 2015 Apr | journal-article. doi: 10.1021/np501062f.
Neolignans and Other Metabolites fromOcotea cymosafrom the Madagascar Rain Forest and Their Biological Activities1, Journal of Natural Products. 2015 Mar | journal-article. doi: 10.1021/np5008153.
In Planta Variation of Volatile Biosynthesis: An Alternative Biosynthetic Route to the Formation of the Pathogen-Induced Volatile Homoterpene DMNT via Triterpene Degradation in Arabidopsis Roots, The Plant Cell. 2015 Feb | journal-article. doi: 10.1105/tpc.114.132209.
A Synthetic Butenolide Diterpene is now a Natural Product Isolated from Metaporana sericosepala, a Plant from the Madagascar Dry Forest, Natural product communications. 2015 Jan | journal-article. .
Antiproliferative and antiplasmodial compounds from selected Streptomyces species, Bioorganic and Medicinal Chemistry Letters. 2015 Jan | journal-article. doi: 10.1016/j.bmcl.2015.07.103.
Synthesis and anti-proliferative effects of quercetin derivatives, Natural Product Communications. 2015 Jan | journal-article. .
ChemInform Abstract: Nitrogen-Containing Dimeric nor-Multiflorane Triterpene from a Turraea sp., ChemInform. 2014 Oct | journal-article. doi: 10.1002/chin.201442218.
Antimalarial dipeptide from a Streptomyces sp. associate of the sponge Xestospongia muta, Planta Medica. 2014 Jul | journal-article. doi: 10.1055/s-0034-1382381.
Antiproliferative and antimalarial sesquiterpene lactones from Piptocoma antillana, Planta Medica. 2014 Jul | journal-article. doi: 10.1055/s-0034-1382507.
Effects of capsicodendrin in MCF-7 hormone-dependent breast cancer cells, Planta Medica. 2014 Jul | journal-article. doi: 10.1055/s-0034-1382506.
New bioactive lupane triterpene coumaroyl esters isolated from Buxus cochinchinensis, Planta Medica. 2014 Jul | journal-article. doi: 10.1055/s-0034-1382482.
SAR study of drimane sesquiterpenes from three Cinnamosma species of Madagascar, Planta Medica. 2014 Jul | journal-article. doi: 10.1055/s-0034-1382478.
Unusual cytotoxic sesquiterpene xylosides isolated from Nidorella sp., Planta Medica. 2014 Jul | journal-article. doi: 10.1055/s-0034-1382501.
Nitrogen-Containing Dimericnor-Multiflorane Triterpene from aTurraeasp., Organic Letters. 2014 May | journal-article. doi: 10.1021/ol500775r.
3,4-seco-24-homo-28-nor-Cycloartane and drimane-type sesquiterpenes and their lactams from the EtOAc-soluble fraction of a leaf extract of Cinnamosma fragrans and their biological activity, Journal of Natural Medicines. 2014 Mar | journal-article. doi: 10.1007/s11418-014-0828-x.
Isolation of antiplasmodial anthraquinones from Kniphofia ensifolia, and synthesis and structure–activity relationships of related compounds, Bioorganic & Medicinal Chemistry. 2014 Jan | journal-article. doi: 10.1016/j.bmc.2013.11.032.
Antiproliferative and antimalarial sesquiterpene lactones from piptocoma antillana from Puerto Rico [1], Natural Product Communications. 2014 Jan | journal-article. .
ChemInform Abstract: Eight New Diterpenoids and Two New Nor-Diterpenoids from the Stems of Croton cascarilloides, ChemInform. 2013 Aug | journal-article. doi: 10.1002/chin.201338199.
A New Bioactive Diterpene Glycoside from Molinaea retusa, Planta Medica. 2013 Jul | journal-article. doi: 10.1055/s-0033-1348686.
Determination of the Absolute Configuration of a Flavanone Isolated from a Madagascar Plant, Planta Medica. 2013 Jul | journal-article. doi: 10.1055/s-0033-1348723.
Isolation, Synthesis, and SAR Study of Antiplasmodial Anthraquinones from Kniphofia caulescens, Planta Medica. 2013 Jul | journal-article. doi: 10.1055/s-0033-1348745.
Structure elucidation of antiproliferative bisbenzylisoquinoline alkaloids from Anisocycla grandidieri from the Madagascar dry forest, Magnetic Resonance in Chemistry. 2013 Jun | journal-article. doi: 10.1002/mrc.3976.
Antiproliferative homoscalarane sesterterpenes from two Madagascan sponges, Bioorganic & Medicinal Chemistry. 2013 Jun | journal-article. doi: 10.1016/j.bmc.2013.03.078.
Antiproliferative and Antiplasmodial Dimeric Phloroglucinols fromMallotus oppositifoliusfrom the Madagascar Dry Forest(1), Journal of Natural Products. 2013 Mar | journal-article. doi: 10.1021/np300750q.
Two Antiproliferative Triterpene Saponins from Nematostylis anthophylla from the Highlands of Central Madagascar, Chemistry & Biodiversity. 2013 Feb | journal-article. doi: 10.1002/cbdv.201200156.
A new bioactive diterpene glycoside from Molinaea retusa from the Madagascar dry forest, Natural Product Communications. 2013 Jan | journal-article. .
Antiproliferative homoisoflavonoids and bufatrienolides from Urginea depressa, Journal of Natural Products. 2013 Jan | journal-article. doi: 10.1021/np300900a.
Bioactive compounds from Stuhlmannia moavi from the Madagascar dry forest, Bioorganic & Medicinal Chemistry. 2013 Jan | journal-article. doi: 10.1016/j.bmc.2013.10.038.
Eight New Diterpenoids and Two New Nor-Diterpenoids from the Stems of Croton cascarilloides, Chemical and Pharmaceutical Bulletin. 2013 Jan | journal-article. doi: 10.1248/cpb.c12-01002.
Antiproliferative compounds from the fabaceae family from the Madagascar dry forest, Planta Medica. 2012 Jul | journal-article. doi: 10.1055/s-0032-1320939.
Antiproliferative-assay directed isolation of scalarane sesterterpenes from an unidentified sponge from Madagascar, Planta Medica. 2012 Jul | journal-article. doi: 10.1055/s-0032-1320704.
Approaches to antiproliferatve agents from Metaporana sericosepala from the Madagascar dry forest, Planta Medica. 2012 Jul | journal-article. doi: 10.1055/s-0032-1321059.
Isolation, synthesis, and bioactivity of Calamenene sesquiterpenoids from Sterculia Capuronii from the Madagascar dry forest, Planta Medica. 2012 Jul | journal-article. doi: 10.1055/s-0032-1320251.
New antiproliferative trihydroxyalkylcyclohexenones from Pleiogynium timoriense, Planta Medica. 2012 Jul | journal-article. doi: 10.1055/s-0032-1320970.
An Endogenous Bile Acid and Dietary Sucrose from Skin Secretions of Alkaloid-Sequestering Poison Frogs, Journal of Natural Products. 2012 Mar | journal-article. doi: 10.1021/np200963r.
Antiproliferative Acetogenins from aUvariasp. from the Madagascar Dry Forest(1), Journal of Natural Products. 2012 Mar | journal-article. doi: 10.1021/np200697j.
C-Glycosyl flavonoids and coloratane-type sesquiterpene glucosides from the water-soluble fraction of a leaf extract of a Malagasy endemic plant, Cinnamosma fragrans (Canellaceae), Journal of Natural Medicines. 2012 Jan | journal-article. doi: 10.1007/s11418-012-0736-x.
Distribution of drimane sesquiterpenoids and tocopherols in liverworts, ferns and higher plants: Polygonaceae, canellaceae and winteraceae species, Natural Product Communications. 2012 Jan | journal-article. .
Glucosylated sesquiterpene alcohols from Fraxinus griffithii, Natural Product Communications. 2012 Jan | journal-article. .
Isolation and synthesis of two antiproliferative calamenene-type sesquiterpenoids from Sterculia tavia from the Madagascar Rain Forest, Bioorganic & Medicinal Chemistry. 2012 Jan | journal-article. doi: 10.1016/j.bmc.2012.10.012.
Two antiproliferative saponins of Tarenna grevei from the Madagascar dry forest [1], Natural Product Communications. 2012 Jan | journal-article. .
Entadosides A–D, triterpene saponins and a glucoside of the sulphur-containing amide from the kernel nuts of Entada phaseoloides (L.) Merrill, Journal of Natural Medicines. 2011 Oct | journal-article. doi: 10.1007/s11418-011-0591-1.
Antiplasmodial and Antiproliferative Pseudoguaianolides of Athroisma proteiforme from the Madagascar Dry Forest(1), Journal of Natural Products. 2011 Oct | journal-article. doi: 10.1021/np200499d.
Cardenolides of Leptadenia madagascariensis from the Madagascar dry forest, Bioorganic & Medicinal Chemistry. 2011 Jan | journal-article. doi: 10.1016/j.bmc.2010.11.021.
Astrotricoumarin, an antiproliferative 4′-hydroxy-2′,3′- dihydroprenylated methylcoumarin from an Astrotrichilia sp. from the Madagascar dry forest[1], Natural Product Communications. 2011 Jan | journal-article. .
Linderolides A–F, eudesmane-type sesquiterpene lactones and linderoline, a germacrane-type sesquiterpene from the roots of Lindera strychnifolia and their inhibitory activity on NO production in RAW 264.7 cells in vitro, Phytochemistry. 2011 Jan | journal-article. doi: 10.1016/j.phytochem.2011.08.004.
Four Diphenylpropanes and a Cycloheptadibenzofuran fromBussea sakalavafrom the Madagascar Dry Forest(1), Journal of Natural Products. 2010 Nov | journal-article. doi: 10.1021/np100411d.
Antiproliferative Compounds fromPongamiopsis pervilleanafrom the Madagascar Dry Forest(1), Journal of Natural Products. 2010 Sep | journal-article. doi: 10.1021/np100430r.
ChemInform Abstract: ent-Kaurane Diterpenoid Glycosides from the Leaves of Cussonia racemosa, a Malagasy Endemic Plant, ChemInform. 2010 May | journal-article. doi: 10.1002/chin.200232177.
New and Bioactive Natural Products Isolated from Madagascar Plants and Marine Organisms, Current Medicinal Chemistry. 2010 Apr | journal-article. doi: 10.2174/092986710790827834.
Secoiridoid and iridoid glucosides from the leaves of Fraxinus griffithii, Journal of Natural Medicines. 2009 Aug | journal-article. doi: 10.1007/s11418-009-0354-4.
ChemInform Abstract: Bryophytes: Bio- and Chemical Diversity, Bioactivity and Chemosystematics, ChemInform. 2009 Apr | journal-article. doi: 10.1002/chin.200917258.
Chemical constituents of Pteris cretica Linn. (Pteridaceae), Biochemical Systematics and Ecology. 2009 Apr | journal-article. doi: 10.1016/j.bse.2009.01.012.
ChemInform Abstract: Marchantiophyta (Liverworts): Rich Sources of Macrocyclic Bis(bibenzyls), ChemInform. 2009 Feb | journal-article. doi: 10.1002/chin.200906239.
Bryophytes: Bio- and Chemical Diversity, Bioactivity and Chemosystematics, HETEROCYCLES. 2009 Jan | journal-article. doi: 10.3987/rev-08-sr(f)3.
Chemical and biologically active constituents of Pteris multifida, Journal of Natural Medicines. 2008 Jun | journal-article. doi: 10.1007/s11418-008-0265-9.
Secondary Metabolites ofCinnamosma madagascariensisand Their α-Glucosidase Inhibitory Properties, Journal of Natural Products. 2008 Jan | journal-article. doi: 10.1021/np070474c.
Macaflavanones A-G, prenylated flavanones from the leaves of Macaranga tanarius, Journal of Natural Products. 2008 Jan | journal-article. doi: 10.1021/np800380d.
Marchantiophyta (Liverworts): Rich Sources of Macrocyclic Bis(bibenzyls), HETEROCYCLES. 2008 Jan | journal-article. doi: 10.3987/rev-08-sr(n)3.
Chemical Constituents of Malagasy Liverworts. 6. A Myltaylane Caffeate with Nitric Oxide Inhibitory Activity fromBazzania nitida, Journal of Natural Products. 2007 May | journal-article. doi: 10.1021/np060549x.
Chemical Constituents of Malagasy Liverworts: Cyclomyltaylanoids from Bazzania madagassa. Part 4., ChemInform. 2007 Apr | journal-article. doi: 10.1002/chin.200715171.
Cinnamacrins A−C, Cinnafragrin D, and Cytostatic Metabolites with α-Glucosidase Inhibitory Activity fromCinnamosma macrocarpa, Journal of Natural Products. 2007 Feb | journal-article. doi: 10.1021/np060435l.
Bioactive compounds from liverworts: Inhibition of lipopolysaccharide-induced inducible NOS mRNA in RAW 264.7 cells by Herbertenoids and Cuparenoids, Phytomedicine. 2007 Jan | journal-article. doi: 10.1016/j.phymed.2006.09.011.
Malagasy liverworts, sourcc of new and biologically active compounds, Natural Product Communications. 2007 Jan | journal-article. .
Phytochemistry of three selected liverworts: Conocephalum conicum, Plagiochila barteri and P. terebrans, Arkivoc. 2007 Jan | journal-article. .
Cinnafragrins A−C, Dimeric and Trimeric Drimane Sesquiterpenoids fromCinnamosmafragrans, and Structure Revision of Capsicodendrin⊥, Journal of Natural Products. 2006 Aug | journal-article. doi: 10.1021/np0601298.
Essential oil composition of four Croton species from Madagascar and their chemotaxonomy, Biochemical Systematics and Ecology. 2006 Aug | journal-article. doi: 10.1016/j.bse.2006.02.005.
Inhibitory activity of nitric oxide production in RAW 264.7 cells of daldinals A–C from the fungus Daldinia childiae and other metabolites isolated from inedible mushrooms, Journal of Natural Medicines. 2006 Aug | journal-article. doi: 10.1007/s11418-006-0010-1.
An Acetylated Eudesmane Glucoside from Apodytes dimidiata Growing in Madagascar, Zeitschrift für Naturforschung B. 2006 Jan | journal-article. doi: 10.1515/znb-2006-0123.
Chemical Constituents of Malagasy Liverworts, Part V: Prenyl Bibenzyls and Clerodane Diterpenoids with Nitric Oxide Inhibitory Activity from Radula appressa and Thysananthus spathulistipus, CHEMICAL & PHARMACEUTICAL BULLETIN. 2006 Jan | journal-article. doi: 10.1248/cpb.54.1046.
Chemical Constituents of Malagasy Liverworts. Part 5. Prenyl Bibenzyls and Clerodane Diterpenoids with Nitric Oxide Inhibitory Activity from Radula appressa and Thysananthus spathulistipus., ChemInform. 2006 Jan | journal-article. doi: 10.1002/chin.200652191.
Chemical constituents of Malagasy liverworts: Cyclomyltaylanoids from Bazzania madagassa, Phytochemistry. 2006 Jan | journal-article. doi: 10.1016/j.phytochem.2006.06.001.
Inhibition of Nitric Oxide Production in RAW 264.7 Cells by Azaphilones from Xylariaceous Fungi, Biological & Pharmaceutical Bulletin. 2006 Jan | journal-article. doi: 10.1248/bpb.29.34.
Momordica charantia Constituents and Antidiabetic Screening of the Isolated Major Compounds, CHEMICAL & PHARMACEUTICAL BULLETIN. 2006 Jan | journal-article. doi: 10.1248/cpb.54.1017.
Momordica charantia Constituents and Antidiabetic Screening of the Isolated Major Compounds., ChemInform. 2006 Jan | journal-article. doi: 10.1002/chin.200652188.
Penicillium sclerotiorum Catalyzes the Conversion of Herbertenediol into Its Dimers: Mastigophorenes A and B., ChemInform. 2005 Jul | journal-article. doi: 10.1002/chin.200529193.
Bis(bibenzyls) from Liverworts Inhibit Lipopolysaccharide-Induced Inducible NOS in RAW 264.7 Cells: A Study of Structure−Activity Relationships and Molecular Mechanism, Journal of Natural Products. 2005 Jan | journal-article. doi: 10.1021/np0502589.
Chemical Constituents of Malagasy Liverworts, Part III: Sesquiterpenoids from Bazzania decrescens and Bazzania madagassa, CHEMICAL & PHARMACEUTICAL BULLETIN. 2005 Jan | journal-article. doi: 10.1248/cpb.53.515.
Penicillium sclerotiorum Catalyzes the Conversion of Herbertenediol into Its Dimers: Mastigophorenes A and B, CHEMICAL & PHARMACEUTICAL BULLETIN. 2005 Jan | journal-article. doi: 10.1248/cpb.53.256.
Constituents of Isotachis aubertii (Isotachidaceae) collected in Madagascar, Biochemical Systematics and Ecology. 2004 Nov | journal-article. doi: 10.1016/j.bse.2004.04.009.
Chemical Constituents of Malagasy Liverworts, Part II: Mastigophoric Acid Methyl Ester of Biogenetic Interest from Mastigophora diclados (Lepicoleaceae Subf. Mastigophoroideae), CHEMICAL & PHARMACEUTICAL BULLETIN. 2004 Jan | journal-article. doi: 10.1248/cpb.52.1382.
Cussosaponins A—E, Triterpene Saponins from the Leaves of Cussonia racemosa, a Malagasy Endemic Plant., ChemInform. 2003 Mar | journal-article. doi: 10.1002/chin.200309174.
A New ent-Kaurane Diterpenoid Glycoside from the Leaves of Cussonia bojeri, a Malagasy Endemic Plant., ChemInform. 2003 Jan | journal-article. doi: 10.1002/chin.200303150.
ent-Kaurane diterpenoid glycosides from a Malagasy endemic plant, Cussonia vantsilana, Phytochemistry. 2002 Oct | journal-article. doi: 10.1016/s0031-9422(02)00263-7.
Clerodane and labdane diterpene glycosides from a Malagasy endemic plant, Cussonia racemosa, Phytochemistry. 2002 Jun | journal-article. doi: 10.1016/s0031-9422(02)00064-x.
A New ent-Kaurane Diterpenoid Glycoside from the Leaves of Cussonia bojeri, a Malagasy Endemic Plant, CHEMICAL & PHARMACEUTICAL BULLETIN. 2002 Jan | journal-article. doi: 10.1248/cpb.50.1122.
A new secoiridoid glucoside from a malagasy medicinal plant, Cassinopsis chapieleri, Natural Medicines. 2002 Jan | journal-article. .
Cussosaponins A—E, Triterpene Saponins from the Leaves of Cussonia racemosa, a Malagasy Endemic Plant, CHEMICAL & PHARMACEUTICAL BULLETIN. 2002 Jan | journal-article. doi: 10.1248/cpb.50.1290.
Ent-kaurane Diterpenoid Glycosides from the Leaves of Cussonia racemosa, a Malagasy Endemic Plant, CHEMICAL & PHARMACEUTICAL BULLETIN. 2002 Jan | journal-article. doi: 10.1248/cpb.50.268.
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