Liva Rakotondraibe, PhD
Professional Interests
New natural product sources (new and unidentified fungal and bacterial microorganisms, microbial endophytes, new endemic and medicinal plant species, etc.) contain many undiscovered potential bioactive secondary metabolites that can be used to combat world’s deadly diseases including cancer, malaria, viral infections, and chemoresistance. Their investigation must be prioritized in order to discover new pharmacophores for potential drug candidates. My lab focuses on (1) bioassay-guided isolation, structural elucidation and development of bioactive compounds from natural sources, (2) Drug discovery from Madagascan natural products and (3) drug discovery from ethnomedicine. One of our recent ongoing projects is on the development of insecticides that can be used to control mosquito vector of Zika virus from Madagascan endemic plants.
Education
- 2003, PhD, Hiroshima University, Pharmaceutical Sciences (Medicinal Natural Product Chemistry
- 1998, DEA (Diplome d'Etude Approfondie), Equivalent to MS, Mention "Tres bien", University of Antananarivo, Organic Chemistry/ Natural Product Chemistry
Honors
- JSPS-Bridge (Japanese Society for the Promotion of Science) Fellowship, 2017 - 2018
- Postdoctoral Fellowship from the Japanese Society for the Promotion of Science (JSPS), 2005 - 2007
- Japanese Government (Mombukagakusho): Ministry of Education, Culture, Sports, Science and Technology (MEXT), 1999 - 2003
Patents
- USE OF SESQUITERPENS AND THEIR ANALOGS AS GREEN INSECTICIDES FOR CONTROLLING DISEASE VECTORS AND PLANT PESTS (2016, April). OSURF T2015-271.
- Antimalarial phloroglucinol from Mallotus oppositifolius (2012, March). 61/717,824.
- Hypoglycemic agents containing bitter cucumber extracts, terpenoids isolated from them, and food and pharmaceutical compositions containing them (2005, November). JP 2007145782.
Journal Articles
Sedlák D, Wilson TA, Tjarks W, Radomska HS, Wang H, Kolla JN, LeśnikowskiZJ, Špičáková A, Ali T, Ishita K, Rakotondraibe LH, Vibhute S, Wang D,Anzenbacher P, Bennett C, Bartunek P, Coss CC. Structure-Activity Relationshipof Carborane Selective Estrogen Receptor β Agonists. J Med Chem.2021 Jul 8;64(13):9330-9353. doi: 10.1021/acs.jmedchem.1c00555. Epub 2021 Jun28. PMID: 34181409.
Inagaki M, Iwakuma R, Kawakami S, Otsuka H, Rakotondraibe HL. Detecting andDifferentiating Monosaccharide Enantiomers by NMR Spectroscopy. JNat Prod. 2021 Jun 30. doi: 10.1021/acs.jnatprod.0c01120. Epub ahead of print.PMID: 34191514.
Addo EM, Ren Y, Anaya-Eugenio GD, Ninh TN, Rakotondraibe HL, de Blanco EJC,Soejarto DD, Kinghorn AD. Spermidine alkaloid and glycosidic constituents of Vietnamese Homalium cochinchinensis. Phytochem Lett. 2021 Jun;43:154-162.doi: 10.1016/j.phytol.2021.04.002. Epub 2021 Apr 15. PMID: 33927787; PMCID:PMC8078847.
Kalsi M, Walter A, Lee B, DeLaat A, Trigueros RR, Happel K, Sepesy R, NguyenB, Manwill PK, Rakotondraibe LH, Piermarini PM. Stop the crop: Insights into theinsecticidal mode of action of cinnamodial against mosquitoes. Pestic BiochemPhysiol. 2021 Jan;171:104743. doi: 10.1016/j.pestbp.2020.104743. Epub 2020 Nov8. PMID: 33357565; PMCID: PMC7770332.
Zhang Y, Tan CY, Spjut RW, Fuchs JR, Kinghorn AD, Rakotondraibe LH.Specialized metabolites of the United States lichen Niebla homalea and theirantiproliferative activities. Phytochemistry. 2020 Dec;180:112521. doi:10.1016/j.phytochem.2020.112521. Epub 2020 Oct 21. PMID: 33099129; PMCID:PMC7970382.
Métoyer B, Benatrehina A, Rakotondraibe LH, Thouvenot L, Asakawa Y, Nour M,Raharivelomanana P. Dimeric and esterified sesquiterpenes from the liverwortChiastocaulon caledonicum. Phytochemistry. 2020 Nov;179:112495. doi:10.1016/j.phytochem.2020.112495. Epub 2020 Aug 22. PMID: 32847771.
Anaya-Eugenio GD, Tan CY, Rakotondraibe LH, Carcache de Blanco EC. Tumorsuppressor p53 independent apoptosis in HT-29 cells by auransterol fromPenicillium aurantiacobrunneum. Biomed Pharmacother. 2020 Jul;127:110124. doi:10.1016/j.biopha.2020.110124. Epub 2020 May 11. PMID: 32407985; PMCID:PMC7584345.
Manwill PK, Kalsi M, Wu S, Martinez Rodriguez EJ, Cheng X, Piermarini PM,Rakotondraibe HL. Semi-synthetic cinnamodial analogues: Structural insights intothe insecticidal and antifeedant activities of drimane sesquiterpenes againstthe mosquito Aedes aegypti. PLoS Negl Trop Dis. 2020 Feb 26;14(2):e0008073. doi:10.1371/journal.pntd.0008073. PMID: 32101555; PMCID: PMC7062286.
Abdelhameed A, Liao X, McElroy CA, Joice AC, Rakotondraibe L, Li J,Slebodnick C, Guo P, Wilson WD, Werbovetz KA. Synthesis and antileishmanialevaluation of thiazole orange analogs. Bioorg Med Chem Lett. 2020 Jan1;30(1):126725. doi: 10.1016/j.bmcl.2019.126725. Epub 2019 Oct 4. PMID:31732409.
Inocente EA, Nguyen B, Manwill PK, Benatrehina A, Kweka E, Wu S, Cheng X,Rakotondraibe LH, Piermarini PM. Insecticidal and Antifeedant Activities ofMalagasy Medicinal Plant (Cinnamosma sp.) Extracts and Drimane-TypeSesquiterpenes against Mosquitoes. Insects. 2019 Oct25;10(11):373. doi: 10.3390/insects10110373. PMID: 31731570; PMCID: PMC6920793.