Kwangwoon “Jon” Lee, PhD

Education

• 2019-2025, Postdoc Chemical Biology, Brigham and Women’s Hospital / Harvard Medical School
• 2012-2019, Ph.D. Biochemistry, The Graduate Center, City University of New York
• 2006-2010, B.S. Biochemistry, University of California, Santa Barbara

Honors

• 2025, Dana-Farber / Harvard Cancer Center (Neuro-Oncology Program) Career Enhancement Program Award through the National Cancer Institute-sponsored Specialized Program of Research Excellence (SPORE)
• 2024, Best Abstract Award, 8th Annual Cardiovascular Bioengineering (CVBE) Symposium
• 2021-2023, American Heart Association Postdoctoral Fellowship
• 2015-2017, American Heart Association Predoctoral Fellowship

Publications

• Structural and enzymatic plasticity of SIRT6 deacylase activity., The Journal of biological chemistry. 2025 Mar | journal-article. doi: 10.1016/j.jbc.2025.108446.
• UM171 glues asymmetric CRL3-HDAC1/2 assembly to degrade CoREST corepressors., Nature. 2025 Feb | journal-article. doi: 10.1038/s41586-024-08532-4.
• Uncoupling histone modification crosstalk by engineering lysine demethylase LSD1, Nature Chemical Biology. 2025 Feb | journal-article. doi: 10.1038/s41589-024-01671-9.
• Deubiquitinase processing of a non-natural linkage of ubiquitinated-PTEN., Bioorganic chemistry. 2025 Jan | journal-article. doi: 10.1016/j.bioorg.2025.108223.
• Circular Engineered Sortase for Interrogating Histone H3 in Chromatin., Journal of the American Chemical Society. 2024 Nov | journal-article. doi: 10.1021/jacs.4c12585.
• Protein semisynthesis reveals plasticity in HECT E3 ubiquitin ligase mechanisms, Nature Chemistry. 2024 Nov | journal-article. doi: 10.1038/s41557-024-01576-z.
• A circular engineered sortase for interrogating histone H3 in chromatin, . 2024 Sep | preprint. doi: 10.1101/2024.09.10.612318.
• Multifaceted regulation of Sirtuin 2 (Sirt2) Deacetylase Activity., The Journal of biological chemistry. 2024 Aug | journal-article. doi: 10.1016/j.jbc.2024.107722.
• An autoinhibitory switch of the LSD1 disordered region controls enhancer silencing., Molecular cell. 2024 Jun | journal-article. doi: 10.1016/j.molcel.2024.05.017.
• Deficiency of lncRNA MERRICAL abrogates macrophage chemotaxis and diabetes-associated atherosclerosis., Cell reports. 2024 Feb | journal-article. doi: 10.1016/j.celrep.2024.113815.
• Structural Basis of Sirtuin 6-Catalyzed Nucleosome Deacetylation., Journal of the American Chemical Society. 2023 Mar | journal-article. doi: 10.1021/jacs.2c13512.
• Distinct biochemical properties of the class I histone deacetylase complexes. , Current opinion in chemical biology. 2022 Jul | journal-article. doi: 10.1016/j.cbpa.2022.102179.
• Histone H2B Deacylation Selectivity: Exploring Chromatin's Dark Matter with an Engineered Sortase., Journal of the American Chemical Society. 2022 Feb | journal-article. doi: 10.1021/jacs.1c13555.
• Diverse nucleosome Site-Selectivity among histone deacetylase complexes, eLife. 2020 Jun | journal-article. doi: 10.7554/eLife.57663.
• The role of calcium in the interaction between calmodulin and a minimal functional construct of eukaryotic elongation factor 2 kinase., Protein science : a publication of the Protein Society. 2019 Dec | journal-article. doi: 10.1002/pro.3753.
• Structural Dynamics of the Activation of Elongation Factor 2 Kinase by Ca2+-Calmodulin., Journal of molecular biology. 2018 May | journal-article. doi: 10.1016/j.jmb.2018.05.033.
• Structural Basis for the Recognition of Eukaryotic Elongation Factor 2 Kinase by Calmodulin., Structure (London, England : 1993). 2016 Aug | journal-article. doi: 10.1016/j.str.2016.06.015.
• The linker between the dimerization and catalytic domains of the CheA histidine kinase propagates changes in structure and dynamics that are important for enzymatic activity., Biochemistry. 2014 Jan | journal-article. doi: 10.1021/bi4012379.
• Conformational coupling between receptor and kinase binding sites through a conserved salt bridge in a signaling complex scaffold protein., PLoS computational biology. 2013 Nov | journal-article. doi: 10.1371/journal.pcbi.1003337.
• CheA-receptor interaction sites in bacterial chemotaxis., Journal of molecular biology. 2012 May | journal-article. doi: 10.1016/j.jmb.2012.05.023.