Karl Werbovetz

Karl Werbovetz

Karl Werbovetz, PhD

Unit / Department / Division
Medicinal Chemistry and Pharmacognosy
342 Parks Hall
Email Address
Phone Number

Professional Interests

Professional Interests

Parasitic diseases have a devastating effect on public health in developing areas of the world. Research in Karl Werbovetz’s group focuses on the discovery and development of new drug candidates against the protozoan parasitic diseases leishmaniasis, trypanosomiasis, and malaria, with most of our recent efforts concentrating on visceral leishmaniasis (VL) and human African trypanosomiasis (HAT).


  • 1993, PhD, University of Virginia, Chemistry
  • 1988, BS, State University of New York at Binghamton, Chemistry


  • Distinguished Teaching Award, 2005

Journal Articles

  • Pandharkar T, Zhu X, Mathur R, Jiang J, Schmittgen TD, Shaha C, Werbovetz KA. Correction for Pandharkar et al., "Studies on the Antileishmanial Mechanism of Action of the Arylimidamide DB766: Azole Interactions and Role of CYP5122A1". Antimicrob Agents Chemother. 2018 Jan;62(1).
  • Joice AC, Yang S, Farahat AA, Meeds H, Feng M, Li J, Boykin DW, Wang MZ, Werbovetz KA. Antileishmanial Efficacy and Pharmacokinetics of DB766-Azole Combinations. Antimicrob Agents Chemother. 2018 Jan;62(1).
  • Zhu X, Farahat AA, Mattamana M, Joice A, Pandharkar T, Holt E, Banerjee M, Gragg JL, Hu L, Kumar A, Yang S, Wang MZ, Boykin DW, Werbovetz KA. Synthesis and pharmacological evaluation of mono-arylimidamides as antileishmanial agents. Bioorg Med Chem Lett. 2016 05 15;26(10):2551-2556.
  • Naman CB, Gromovsky AD, Vela CM, Fletcher JN, Gupta G, Varikuti S, Zhu X, Zywot EM, Chai H, Werbovetz KA, Satoskar AR, Kinghorn AD. Antileishmanial and Cytotoxic Activity of Some Highly Oxidized Abietane Diterpenoids from the Bald Cypress, Taxodium distichum. J Nat Prod. 2016 Mar 25;79(3):598-606.
  • Zhu X, Van Horn KS, Barber MM, Yang S, Wang MZ, Manetsch R, Werbovetz KA. SAR refinement of antileishmanial N(2),N(4)-disubstituted quinazoline-2,4-diamines. Bioorg Med Chem. 2015 Aug 15;23(16):5182-9.
  • Pandharkar T, Zhu X, Mathur R, Jiang J, Schmittgen TD, Shaha C, Werbovetz KA. Studies on the antileishmanial mechanism of action of the arylimidamide DB766: azole interactions and role of CYP5122A1. Antimicrob Agents Chemother. 2014 Aug;58(8):4682-9.
  • Werbovetz KA, Riccio ES, Furimsky A, Richard JV, He S, Iyer L, Mirsalis J. Evaluation of Antitrypanosomal Dihydroquinolines for Hepatotoxicity, Mutagenicity, and Methemoglobin Formation In Vitro. Int J Toxicol. 2014 07;33(4):282-287.
  • Yi B, Long S, González-Cestari TF, Henderson BJ, Pavlovicz RE, Werbovetz K, Li C, McKay DB. Discovery of benzamide analogs as negative allosteric modulators of human neuronal nicotinic receptors: pharmacophore modeling and structure-activity relationship studies. Bioorg Med Chem. 2013 Aug 01;21(15):4730-43.
  • Endeshaw M, Zhu X, He S, Pandharkar T, Cason E, Mahasenan KV, Agarwal H, Li C, Munde M, Wilson WD, Bahar M, Doskotch RW, Kinghorn AD, Kaiser M, Brun R, Drew ME, Werbovetz KA. 8,8-dialkyldihydroberberines with potent antiprotozoal activity. J Nat Prod. 2013 Mar 22;76(3):311-5.
  • Reid CS, Farahat AA, Zhu X, Pandharkar T, Boykin DW, Werbovetz KA. Antileishmanial bis-arylimidamides: DB766 analogs modified in the linker region and bis-arylimidamide structure-activity relationships. Bioorg Med Chem Lett. 2012 Nov 15;22(22):6806-10.