Headshot of Joshua Englert

Joshua Englert

Pulmonary Disease Critical Care Medicine


  • 2005, MD, cum laude, University of Pittsburgh Medical School, Medicine
  • 2000, BS, High Distinction, The Pennsylvania State University, Premedicine
  • State of Ohio Medical License, Ohio Medical Board
  • Board Certified in Critical Care Medicine, American Board of Internal Medicine
  • Board Certified in Pulmonary Disease, American Board of Internal Medicine
  • Board Certified in Internal Medicine, American Board of Internal Medicine
  • State of Massachusetts Medical License, Massachusetts Medical Board


  • BAL Award, 2018
  • Outstanding Young Investigator Award, 2017 - 2017
  • K Travel Award, 2016 - 2016
  • Grant Review and Support Program, 2014 - 2014
  • Young Physician Scientist Award, 2014
  • Chair's Research Award, 2014
  • Loan Repayment Award, 2012 - 2014
  • Loan Repayment Award, 2009 - 2011
  • Nominee, Best Resident Teacher Award, 2007
  • Brinton Prize, 2005
  • Alpha Omega Alpha, 2004 - 2004
  • Academy of Achievement Summit, 2004
  • Robert and Gertrude Harris Foundation Scholarship, 2001 - 2003
  • Ruth E. Duffy Scholarship, 1999 - 1999
  • Research Experience for Undergraduates (REU) Fellow, 1999
  • Alpha Epsilon Delta, 1998


  • Chung, S.; Kim, J.Y.; Song, M-A.; Park, G.Y. et al. FoxO1 is a critical regulator of M2-like macrophage activation in allergic asthma. Allergy. 2019 Mar; 74(3):535-548.
  • Hume, P.S.; Varon, J.; Englert, J.A.; Hurwitz, S. et al. Trends in “usual care” for septic shock Infection Control and Hospital Epidemiology. 2018 Jul; 1-2.
  • Hay, B.R.; Shilo, K.; Englert, J.A. Bilateral lung masses and dyspnea in a young woman Annals of the American Thoracic Society. 2018 Jul; 15(7):875-879.
  • Casey, J.D.; Englert, J.A.; Katz, J.T.; Miller, A.L. et al. An unexpected expectoration New England Journal of Medicine. 2018 Mar; 378(9):853-858.
  • Englert, J.A.; Christman, J.W.; Ballinger, M.N. Unhinging the machinery of sepsis: An unexpected role for vascular smooth muscle Journal of Leukocyte Biology. 2018 Jan; .
  • Higuita-Castro, N.; Nelson, M.T.; Shukla, V.; Agudelo-Garcia, P.A. et al. Using a Novel Microfabricated Model of the Alveolar-Capillary Barrier to Investigate the Effect of Matrix Structure on Atelectrauma Scientific Reports. 2017 Dec; 7(1):.
  • Englert, J.A.; Crouser, E.D. Steroids and β-Agonists in acute respiratory distress syndrome: Timing is everything Critical Care Medicine. 2017 May; 45(5):914-915.
  • Hepokoski, M.; Englert, J.A.; Baron, R.M.; Crotty-Alexander, L.E. et al. Ventilator-induced lung injury increases expression of endothelial inflammatory mediators in the kidney American Journal of Physiology - Renal Physiology. 2017 Apr; 312(4):F654-F660.
  • Ghanta, S.; Tsoyi, K.; Liu, X.; Nakahira, K. et al. Mesenchymal stromal cells deficient in autophagy proteins are susceptible to oxidative injury and mitochondrial dysfunction American Journal of Respiratory Cell and Molecular Biology. 2017 Mar; 56(3):300-309.
  • Putman, R.K.; Hunninghake, G.M.; Dieffenbach, P.B.; Barragan-Bradford, D. et al. Interstitial Lung Abnormalities Are Associated with Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2017 Jan; 195(1):138-141.
  • Englert, J.A.; Rogers, A.J. Metabolism, Metabolomics, and Nutritional Support of Patients with Sepsis Clinics in Chest Medicine. 2016 Jun; 37(2):321-331.
  • Hou, H.W.; Wu, L.; Amador-Munoz, D.P.; Vera, M.P. et al. Broad spectrum immunomodulation using biomimetic blood cell margination for sepsis therapy Lab on a Chip - Miniaturisation for Chemistry and Biology. 2016 Jan; 16(4):688-699.
  • Englert,Joshua,A; Macias,Alvaro,A; Amador-Munoz,Diana; Vera,Miguel,Pinilla; Isabelle,Colleen; Guan,Jiazhen; Magaoay,Brady; Velandia,Margarita,Suarez; Coronata,Anna; Lee,Awapuhi; Fredenburgh,Laura,E; Culley,Deborah,J; Crosby,Gregory; Baron,Rebecca,M Isoflurane Ameliorates Acute Lung Injury by Preserving Epithelial Tight Junction Integrity ANESTHESIOLOGY. 2015 Aug; 123(2):377-388.
  • Haspel,Jeffrey,A; Chettimada,Sukrutha; Shaik,Rahamthulla,S; Chu,Jen-Hwa; Raby,Benjamin,A; Cernadas,Manuela; Carey,Vincent; Process,Vanessa; Hunninghake,G,Matthew; Ifedigbo,Emeka; Lederer,James,A; Englert,Joshua; Pelton,Ashley; Coronata,Anna; Fredenburgh,Laura,E; Choi,Augustine,MK Circadian rhythm reprogramming during lung inflammation NATURE COMMUNICATIONS. 2014 Sep; 5 4753.
  • Lai,Peggy,S; Fresco,Jennifer,M; Pinilla,Miguel,A; Macias,Alvaro,A; Brown,Ronald,D; Englert,Joshua,A; Hofmann,Oliver; Lederer,James,A; Hide,Winston; Christiani,David,C; Cernadas,Manuela; Baron,Rebecca,M Chronic Endotoxin Exposure Produces Airflow Obstruction and Lung Dendritic Cell Expansion AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. 2012 Aug; 47(2):209-217.
  • Fredenburgh,Laura,E; Velandia,Margarita,MSuarez; Ma,Jun; Olszak,Torsten; Cernadas,Manuela; Englert,Joshua,A; Chung,Su,Wol; Liu,Xiaoli; Begay,Cynthia; Padera,Robert,F; Blumberg,Richard,S; Walsh,Stephen,R; Baron,Rebecca,M; Perrella,Mark,A Cyclooxygenase-2 Deficiency Leads to Intestinal Barrier Dysfunction and Increased Mortality during Polymicrobial Sepsis JOURNAL OF IMMUNOLOGY. 2011 Nov; 187(10):5255-5267.
  • Haspel,Jeffrey; Shaik,Rahamthulla,S; Ifedigbo,Emeka; Nakahira,Kiichi; Dolinay,Tamas; Englert,Joshua,A; Choi,Augustine,MK Characterization of macroautophagic flux in vivo using a leupeptin-based assay AUTOPHAGY. 2011 Jun; 7(6):629-642.
  • Nakahira,Kiichi; Haspel,Jeffrey,Adam; Rathinam,Vijay,AK; Lee,Seon-Jin; Dolinay,Tamas; Lam,Hilaire,C; Englert,Joshua,A; Rabinovitch,Marlene; Cernadas,Manuela; Kim,Hong,Pyo; Fitzgerald,Katherine,A; Ryter,Stefan,W; Choi,Augustine,MK Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome NATURE IMMUNOLOGY. 2011 Mar; 12(3):222-U57.
  • Yang,Runkuan; Harada,Tomoyuki; Mollen,Kevin,P; Prince,Jose,M; Levy,Ryan,M; Englert,Joshua,A; Gallowitsch-Puerta,Margot; Yang,LiHong; Yang,Huan; Tracey,Kevin,J; Harbrecht,Brian,G; Billiar,Timothy,R; Fink,Mitchell,P Anti-HMGB1 neutralizing antibody ameliorates gut barrier dysfunction and improves survival after hemorrhagic shock MOLECULAR MEDICINE. 2006 Apr; 12(4-6):105-114.
  • Killeen,M,E; Englert,J,A; Stolz,D,B; Song,M,C; Han,Y,S; Delude,R,L; Kellum,J,A; Fink,M,P The phase 2 enzyme inducers ethacrynic acid, DL-sulforaphane, and oltipraz inhibit lipopolysaccharide-induced high-mobility group box 1 secretion by RAW 264.7 cells JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2006 Mar; 316(3):1070-1079.
  • Sappington,P,L; Cruz,R,J; Harada,T; Yang,R,K; Han,Y,S; Englert,J,A; Ajami,A,A; Killeen,M,E; Delude,R,L; Fink,M,P The ethyl pyruvate analogues, diethyl oxaloproprionate, 2-acetamidoacrylate, and methyl-2-acetamidoacrylate, exhibit anti-inflammatory properties in vivo and/or in vitro BIOCHEMICAL PHARMACOLOGY. 2005 Nov; 70(11):1579-1592.
  • Englert, J. The multiple organ dysfunction syndrome and late-phase mortality in sepsis. Current infectious disease reports. 2005 Sep; 7(5):.
  • Yang,R,K; Harada,T; Li,J,Y; Uchiyama,T; Han,Y,S; Englert,J,A; Fink,M,P Bile modulates intestinal epithelial barrier function via an extracellular signal related kinase 1/2 dependent mechanism INTENSIVE CARE MEDICINE. 2005 May; 31(5):709-717.
  • Han,Y,S; Englert,J,A; Yang,R,K; Delude,R,L; Fink,M,P Ethyl pyruvate inhibits nuclear factor-kappa B-dependent signaling by directly targeting p65 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2005 Mar; 312(3):1097-1105.
  • Han,Y,S; Englert,J,A; Delude,R,L; Fink,M,P Ethacrynic acid inhibits multiple steps in the NF-kappa B signaling pathway SHOCK. 2005 Jan; 23(1):45-53.