James Fuchs

James Fuchs

James Fuchs, PhD

Professor
Medicinal Chemistry and Pharmacognosy
634 Riffe Building
fuchs.42@osu.edu
(614) 247-7377

Professional Interests

Natural products have always played a key role for medicinal chemists in the process of drug discovery. Employing the structural scaffolds and biological activity of these compounds as a starting point, our group intends to use synthetic chemistry as a tool to probe biological problems. Specifically, Dr. Fuch’s lab utilizes synthetic methods to prepare these bioactive natural products and their analogues, gains insight into the structure–activity relationships of ligand/receptor systems, and investigates biosynthetic pathways. Ultimately, the goal is not simply to prepare these natural products, but to improve upon their activity and pharmacological profiles.

Education

  • 2007, Postdoctoral Fellow, The Scripps Research Institute, Medicinal/Organic Chemistry
  • 2005, PhD, Pennsylvania State University, Organic Chemistry
  • 1998, BS, cum laude, University Honors, Honors in Chemistry, University of Toledo, Chemistry

Journal Articles

  • Young AN, Herrera D, Huntsman AC, Korkmaz MA, Lantvit DD, Mazumder S, Kolli S, Coss CC, King S, Wang H, Swanson SM, Kinghorn AD, Zhang X, Phelps MA, Aldrich LN, Fuchs JR, Burdette JE. Phyllanthusmin Derivatives Induce Apoptosis and Reduce Tumor Burden in High-Grade Serous Ovarian Cancer by Late-Stage Autophagy Inhibition. Mol Cancer Ther. 2018 Oct;17(10):2123-2135.
  • Crnkovic CM, Krunic A, May DS, Wilson TA, Kao D, Burdette JE, Fuchs JR, Oberlies NH, Orjala J. Calothrixamides A and B from the Cultured Cyanobacterium Calothrix sp. UIC 10520.J Nat Prod. 2018 Sep 28;81(9):2083-2090.
  • Woodard JL, Huntsman AC, Patel PA, Chai HB, Kanagasabai R, Karmahapatra S, Young AN, Ren Y, Cole MS, Herrera D, Yalowich JC, Kinghorn AD, Burdette JE, Fuchs JR. Synthesis and antiproliferative activity of derivatives of the phyllanthusmin class of arylnaphthalene lignan lactones. Bioorg Med Chem. 2018 05 15;26(9):2354-2364.
  • Wilson TA, Tokarski RJ, Sullivan P, Demoret RM, Orjala J, Rakotondraibe LH, Fuchs JR. Total Synthesis of Scytonemide A Employing Weinreb AM Solid-Phase Resin. J Nat Prod. 2018 Mar 23;81(3):534-542.
  • Hoyte AC, Jamin AV, Koneru PC, Kobe MJ, Larue RC, Fuchs JR, Engelman AN, Kvaratskhelia M. Resistance to pyridine-based inhibitor KF116 reveals an unexpected role of integrase in HIV-1 Gag-Pol polyprotein proteolytic processing. J Biol Chem. 2017 12 01;292(48):19814-19825.
  • Oghumu S, Varikuti S, Saljoughian N, Terrazas C, Huntsman AC, Parinandi NL, Fuchs JR, Kinghorn AD, Satoskar AR. Pentalinonsterol, a Constituent of Pentalinon andrieuxii, Possesses Potent Immunomodulatory Activity and Primes T Cell Immune Responses. J Nat Prod. 2017 Sep 22;80(9):2515-2523.
  • Lin L, Jou D, Wang Y, Ma H, Liu T, Fuchs J, Li PK, Lü J, Li C, Lin J. STAT3 as a potential therapeutic target in ALDH+ and CD44+/CD24+ stem cell-like pancreatic cancer cells. Int J Oncol. 2016 Dec;49(6):2265-2274.
  • Patel D, Antwi J, Koneru PC, Serrao E, Forli S, Kessl JJ, Feng L, Deng N, Levy RM, Fuchs JR, Olson AJ, Engelman AN, Bauman JD, Kvaratskhelia M, Arnold E. A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain. J Biol Chem. 2016 Nov 04;291(45):23569-23577.
  • Deng N, Hoyte A, Mansour YE, Mohamed MS, Fuchs JR, Engelman AN, Kvaratskhelia M, Levy R. Allosteric HIV-1 integrase inhibitors promote aberrant protein multimerization by directly mediating inter-subunit interactions: Structural and thermodynamic modeling studies. Protein Sci. 2016 11;25(11):1911-1917.
  • Kinghorn AD, DE Blanco EJ, Lucas DM, Rakotondraibe HL, Orjala J, Soejarto DD, Oberlies NH, Pearce CJ, Wani MC, Stockwell BR, Burdette JE, Swanson SM, Fuchs JR, Phelps MA, Xu L, Zhang X, Shen YY. Discovery of Anticancer Agents of Diverse Natural Origin. Anticancer Res. 2016 11;36(11):5623-5637.