Esperanza Carcache de Blanco

Esperanza headshot

Esperanza Carcache de Blanco, PhD

Associate Professor
Unit / Department / Division
Medicinal Chemistry and Pharmacognosy
442 Parks Hall
Phone Number

Professional Interests

Professional Interests

Dr. Carcache de Blanco's research interests focus on the discovery of bioactive constituents from natural product sources with potential application in cancer chemoprevention and chemotherapy. She is also interested in the study of botanical dietary supplements and other herbal products used in traditional medicine.


  • 2005, National Cancer Institute Postdoctoral Fellowship, University of Illinois at Chicago, Pharmacognosy
  • 2003, PhD, University of Illinois at Chicago, Pharmacognosy
  • 1997, MS, University of Illinois at Chicago, Pharmacognosy
  • 1986, BS, Outstanding Student (1st Place), National Autonomous University of Nicaragua, Pharmacy


  • Travel Research Award, 2008 - 2008
  • UIC Health Science Auxiliary Award Fellowship, 2003 - 2003
  • Van Doren Scholar, 2003 - 2003
  • Student Research Award/The American Society of Pharmacognosy, 2003
  • UIC Health Science Auxiliary Award Fellowship, University of Illinois at Chicago, 2002
  • J. William Fulbright Foreign Scholarship Board and United States Information Agency Award, Washington, DC, 1994 - 1997
  • Outstanding Instructor, Asociación Nicaragüense de Educadores de Nicaragua, 1988
  • Outstanding Undergraduate Student, 1986 - 1986
  • Outstanding Teaching Assistant, UNAN-León, León, Nicaragua, 1986

Journal Articles

  • Forestrania, R. C., Anaya-Eugenio, G. D., Acuña, U. M., Ren, Y., Elya, B., & de Blanco, E. C. (2020). Secondary metabolites from Garcinia daedalanthera Pierre leaves (Clusiaceae). Natural Product Research, 1-7.
  • Naz S, Tabassum S, Freitas Fernandes N, Mujahid M, Zia M, Carcache de Blanco EJ. Anticancer and antibacterial potential of Rhus punjabensis and CuO nanoparticles. Nat Prod Res. 2018 Oct 15;:1-6.
  • Tang Z, Acuña UM, Fernandes NF, Chettiar S, Li PK, DE Blanco EC. Structure-Activity Relationship of Niclosamide Derivatives. Anticancer Res. 2017 06;37(6):2839-2843.
  • Ren Y, Benatrehina PA, Muñoz Acuña U, Yuan C, Chai HB, Ninh TN, Carcache de Blanco EJ, Soejarto DD, Kinghorn AD. Isolation of Bioactive Rotenoids and Isoflavonoids from the Fruits of Millettia caerulea. Planta Med. 2016 Jul;82(11-12):1096-104.
  • Muñoz Acuña U, Carcache PJ, Matthew S, Carcache de Blanco EJ. New acyclic bis phenylpropanoid and neolignans, from Myristica fragrans Houtt., exhibiting PARP-1 and NF-κB inhibitory effects. Food Chem. 2016 Jul 01;202:269-75.
  • Pan L, Muñoz Acuña U, Chai H, Park HY, Ninh TN, Thanh BV, Merino EF, Cassera MB, Rakotondraibe LH, Carcache de Blanco EJ, Soejarto DD, Kinghorn AD. New Bioactive Lupane Triterpene Coumaroyl Esters Isolated from Buxus cochinchinensis. Planta Med. 2015 Aug;81(12-13):1133-40.
  • Acuña UM, Zi J, Orjala J, Carcache de Blanco EJ. Ambiguine I Isonitrile from Fischerella ambigua Induces Caspase-Independent Cell Death in MCF-7 Hormone Dependent Breast Cancer Cells. Int J Cancer Res (Tortola). 2015 Mar;49(1):1655-1662.
  • Pérez LB, Still PC, Naman CB, Ren Y, Pan L, Chai HB, Carcache de Blanco EJ, Ninh TN, Van Thanh B, Swanson SM, Soejarto DD, Kinghorn AD. Investigation of Vietnamese plants for potential anticancer agents. Phytochem Rev. 2014 Dec;13(4):727-739.
  • Pan L, Terrazas C, Muñoz Acuña U, Ninh TN, Chai H, Carcache de Blanco EJ, Soejarto DD, Satoskar AR, Kinghorn AD. Bioactive indole alkaloids isolated from Alstonia angustifolia. Phytochem Lett. 2014 Dec;10:54-59.
  • Yong Y, Pan L, Ren Y, Fatima N, Ahmed S, Chang LC, Zhang X, Kinghorn AD, Swanson SM, Carcache de Blanco EJ. Assay development for the discovery of semaphorin 3B inducing agents from natural product sources. Fitoterapia. 2014 Oct;98:184-91.
  • Bueno Pérez L, Pan L, Muñoz Acuña U, Li J, Chai HB, Gallucci JC, Ninh TN, Carcache de Blanco EJ, Soejarto DD, Kinghorn AD. Caeruleanone A, a rotenoid with a new arrangement of the D-ring from the fruits of Millettia caerulea. Org Lett. 2014 Mar 07;16(5):1462-5.