Esperanza Carcache de Blanco

Esperanza headshot

Esperanza Carcache de Blanco, PhD

Associate Professor
Medicinal Chemistry and Pharmacognosy
442 Parks Hall
carcache-de-blan.1@osu.edu
(614) 247-7815

Professional Interests

Dr. Carcache de Blanco's research interests focus on the discovery of bioactive constituents from natural product sources with potential application in cancer chemoprevention and chemotherapy. She is also interested in the study of botanical dietary supplements and other herbal products used in traditional medicine.

Education

  • 2005, National Cancer Institute Postdoctoral Fellowship, University of Illinois at Chicago, Pharmacognosy
  • 2003, PhD, University of Illinois at Chicago, Pharmacognosy
  • 1997, MS, University of Illinois at Chicago, Pharmacognosy
  • 1986, BS, Outstanding Student (1st Place), National Autonomous University of Nicaragua, Pharmacy

Honors

  • Travel Research Award, 2008 - 2008
  • UIC Health Science Auxiliary Award Fellowship, 2003 - 2003
  • Van Doren Scholar, 2003 - 2003
  • Student Research Award/The American Society of Pharmacognosy, 2003
  • UIC Health Science Auxiliary Award Fellowship, University of Illinois at Chicago, 2002
  • J. William Fulbright Foreign Scholarship Board and United States Information Agency Award, Washington, DC, 1994 - 1997
  • Outstanding Instructor, Asociación Nicaragüense de Educadores de Nicaragua, 1988
  • Outstanding Undergraduate Student, 1986 - 1986
  • Outstanding Teaching Assistant, UNAN-León, León, Nicaragua, 1986

Journal Articles

Anaya-Eugenio GD, Eggers NA, Ren Y, Rivera-ChÁvez J, Kinghorn AD, Carcache DE Blanco EJ. Apoptosis Induced by (+)-Betulin Through NF-κB Inhibition in MDA- MB-231 Breast Cancer Cells. Anticancer Res. 2020 Dec;40(12):6637-6647. doi: 10.21873/anticanres.14688. Epub 2020 Dec 7. PMID: 33288558; PMCID: PMC7849021.

Anaya-Eugenio GD, Tan CY, Rakotondraibe LH, Carcache de Blanco EC. Tumor suppressor p53 independent apoptosis in HT-29 cells by auransterol from Penicillium aurantiacobrunneum. Biomed Pharmacother. 2020 Jul;127:110124. doi: 10.1016/j.biopha.2020.110124. Epub 2020 May 11. PMID: 32407985; PMCID: PMC7584345.

Forestrania RC, Anaya-Eugenio GD, Acuña UM, Ren Y, Elya B, de Blanco EC. Secondary metabolites from Garcinia daedalanthera Pierre leaves (Clusiaceae). Nat Prod Res. 2020 Jun 12:1-7. doi: 10.1080/14786419.2020.1777117. Epub ahead of print. PMID: 32530310.

Naz S, Tabassum S, Freitas Fernandes N, Mujahid M, Zia M, Carcache de Blanco EJ. Anticancer and antibacterial potential of Rhus punjabensis and CuO nanoparticles. Nat Prod Res. 2020 Mar;34(5):720-725. doi: 10.1080/14786419.2018.1495633. Epub 2018 Oct 15. PMID: 30320505.

Agarwal G, Wilson JR, Kurina SJ, Anaya-Eugenio GD, Ninh TN, Burdette JE, Soejarto DD, Cheng X, Carcache de Blanco EJ, Rakotondraibe LH, Kinghorn AD. Structurally Modified Cyclopenta[<i>b</i>]benzofuran Analogues Isolated from Aglaia perviridis. J Nat Prod. 2019 Oct 25;82(10):2870-2877. doi: 10.1021/acs.jnatprod.9b00631. Epub 2019 Oct 17. PMID: 31621322; PMCID: PMC6819999.

Tan CY, Wang F, Anaya-Eugenio GD, Gallucci JC, Goughenour KD, Rappleye CA, Spjut RW, Carcache de Blanco EJ, Kinghorn AD, Rakotondraibe LH. α-Pyrone and Sterol Constituents of <i>Penicillium aurantiacobrunneum, a Fungal Associate of the Lichen Niebla homalea. J Nat Prod. 2019 Sep 27;82(9):2529-2536. doi: 10.1021/acs.jnatprod.9b00340. Epub 2019 Aug 29. PMID: 31465222; PMCID: PMC6858793.

Anaya-Eugenio GD, Rebollar-Ramos D, González MDC, Raja H, Mata R, Carcache de Blanco EJ. Apoptotic activity of xanthoquinodin JBIR-99, from Parengyodontium album MEXU 30054, in PC-3 human prostate cancer cells. Chem Biol Interact. 2019 Sep 25;311:108798. doi: 10.1016/j.cbi.2019.108798. Epub 2019 Aug 18. PMID: 31433962.

Deblais L, Helmy YA, Kumar A, Antwi J, Kathayat D, Acuna UM, Huang HC, de Blanco EC, Fuchs JR, Rajashekara G. Novel narrow spectrum benzyl thiophene sulfonamide derivatives to control Campylobacter. J Antibiot (Tokyo). 2019 Jul;72(7):555-565. doi: 10.1038/s41429-019-0168-x. Epub 2019 Mar 27. PMID: 30918323.

Anaya-Eugenio GD, Addo EM, Ezzone N, Henkin JM, Ninh TN, Ren Y, Soejarto DD, Kinghorn AD, Carcache de Blanco EJ. Caspase-Dependent Apoptosis in Prostate Cancer Cells and Zebrafish by Corchorusoside C from Streptocaulon juventas. J Nat Prod. 2019 Jun 28;82(6):1645-1655. doi: 10.1021/acs.jnatprod.9b00140. Epub 2019 May 23. PMID: 31120251; PMCID: PMC6615048.

Anaya-Eugenio GD, Ali T, Rakotondraibe LH, Carcache de Blanco E. Cytotoxic constituents from Penicillium concentricum, an endophytic fungus from Trichocolea tomentella. Anticancer Drugs. 2019 Apr;30(4):323-329. doi: 10.1097/CAD.0000000000000759. PMID: 30688672.