A. Douglas Kinghorn

Image
A. Douglas Kinghorn

A. Douglas Kinghorn, PhD, DSc

Title
Professor and Jack L. Beal Chair
Unit / Department / Division
Medicinal Chemistry and Pharmacognosy
Address
446 Parks Hall
Email Address
Phone Number

Professional Interests

Professional Interests

The research interests of Dr. Kinghorn are on the isolation, characterization, and biological evaluation of natural products of higher plant origin, and he has worked in particular on compounds with potential antimicrobial, cancer chemotherapeutic, cancer chemopreventive, sweet-tasting, and bitterness-blocking effects. Dr. Kinghorn is the former Editor in Chief (1994-2019) and current Emeritus Editor (2020-present) of the "Journal of Natural Products" (co-published by the American Chemical Society and the American Society of Pharmacognosy) and is Series Editor in Chief of the book series "Progress in the Chemistry of Organic Natural Products" (published by Springer Nature, Cham, Switzerland) (2008-present).

Education

  • 1990, D.Sc., University of London
  • 1975, Ph.D., University of London
  • 1970, M.S., University of Strathclyde
  • 1969, B.Pharm. (Special), University of Bradford

Honors

  • Egon Stahl Award in Gold, GA (Society of Medicinal Plant and Natural Product Research), 2020
  • Dr. Norman R. Farnsworth Keynote Lecturer, University of Illinois at Chicago, 2016
  • Distinguished Scholar Awardee (DSA), The Ohio State University, 2016
  • Coy W. Waller Distinguished Lecture Award, University of Mississippi, 2014
  • David Chu Lecture Award, University of Buffalo, 2014
  • Honorary Member, Phytochemical Society of Asia, 2012
  • Honorary Doctor of Science (D.Sc.) degree, University of Bradford, 2011
  • Norman R. Farnsworth Excellence in Botanical Research Award, American Botanical Council, Austin, TX, 2011
  • Norman R. Farnsworth ASP Research Achievement Award, American Society of Pharmacognosy 2010
  • Award of Merit, National Institutes of Health/National Cancer Institute, 2010
  • Percy Julian Memorial Lecture Award, Howard University, 2010

Journal Articles

Ren Y, Wu S, Burdette JE, Cheng X, Kinghorn AD. Structural Insights into the Interactions of Digoxin and Other Targets for the Inhibition of Cancer Cell Proliferation. Molecules. 2021 Jun 16;26(12):3672. doi: 10.3390/molecules26123672. PMID: 34208576; PMCID: PMC8234910.

Addo EM, Ren Y, Anaya-Eugenio GD, Ninh TN, Rakotondraibe HL, de Blanco EJC, Soejarto DD, Kinghorn AD. Spermidine alkaloid and glycosidic constituents of Vietnamese Phytochem Lett. 2021 Jun;43:154-162. doi: 10.1016/j.phytol.2021.04.002. Epub 2021 Apr 15. PMID: 33927787; PMCID: PMC8078847.

Agarwal G, Chang LS, Soejarto DD, Kinghorn AD. Update on Phytochemical and Biological Studies on Rocaglate Derivatives from Aglaia Species. Planta Med. 2021 Mar 30. doi: 10.1055/a-1401-9562. Epub ahead of print. PMID: 33784769.

Anaya-Eugenio GD, Blanco Carcache PJ, Ninh TN, Ren Y, Soejarto DD, Kinghorn AD. A pentamethoxylated flavone from Glycosmis ovoidea promotes apoptosis through the intrinsic pathway and inhibits migration of MCF-7 breast cancer cells. Phytother Res. 2021 Mar;35(3):1634-1645. doi: 10.1002/ptr.6930. Epub 2020 Oct 30. PMID: 33124130; PMCID: PMC8005457.

Ren Y, Kinghorn AD. Antitumor potential of the protein phosphatase inhibitor, cantharidin, and selected derivatives. Bioorg Med Chem. 2021 Feb 15;32:116012. doi: 10.1016/j.bmc.2021.116012. Epub 2021 Jan 9. PMID: 33454654; PMCID: PMC7854516.

Ren Y, Kinghorn AD. Development of Potential Antitumor Agents from the Scaffolds of Plant-Derived Terpenoid Lactones. J Med Chem. 2020 Dec 24;63(24):15410-15448. doi: 10.1021/acs.jmedchem.0c01449. Epub 2020 Dec 8. PMID: 33289552; PMCID: PMC7812702.

Zhang Y, Tan CY, Spjut RW, Fuchs JR, Kinghorn AD, Rakotondraibe LH. Specialized metabolites of the United States lichen Niebla homalea and their antiproliferative activities. Phytochemistry. 2020 Dec;180:112521. doi: 10.1016/j.phytochem.2020.112521. Epub 2020 Oct 21. PMID: 33099129; PMCID: PMC7970382.

Anaya-Eugenio GD, Eggers NA, Ren Y, Rivera-ChÁvez J, Kinghorn AD, Carcache DE Blanco EJ. Apoptosis Induced by (+)-Betulin Through NF-κB Inhibition in MDA- MB-231 Breast Cancer Cells. Anticancer Res. 2020 Dec;40(12):6637-6647. doi: 10.21873/anticanres.14688. Epub 2020 Dec 7. PMID: 33288558; PMCID: PMC7849021.

Shriwas P, Chen X, Kinghorn AD, Ren Y. Plant-derived glucose transport inhibitors with potential antitumor activity. Phytother Res. 2020 May;34(5):1027-1040. doi: 10.1002/ptr.6587. Epub 2019 Dec 10. PMID: 31823431; PMCID: PMC7263379.

Ren Y, Ribas HT, Heath K, Wu S, Ren J, Shriwas P, Chen X, Johnson ME, Cheng X, Burdette JE, Kinghorn AD. Targeted Cytotoxicity of (+)-Digoxin and Several Semisynthetic Derivatives. J Nat Prod. 2020 Mar 27;83(3):638-648. doi: 10.1021/acs.jnatprod.9b01060. Epub 2020 Feb 25. PMID: 32096998; PMCID: PMC7243443.