Dan Shu

Image
Dan Shu

Dan Shu, PhD

Title
Research Associate Professor
Unit / Department / Division
Pharmaceutics and Pharmacology
Address
914 Biomedical Research Tower
Email Address
Phone Number

Professional Interests

Professional Interests

Dr. Shu’s research is focused on (1) RNA nanotechnology: use RNA as a nanotechnology platform to construct RNA nanoparticles with functional modalities for therapeutics, targeting, and diagnostics (ACS Nano, 2015; Nature Nanotechnology, 2011; Nano Letters, 2004); and (2) Single molecule biophysical studies: use single-molecule detection (such as FRET) to understand the structure-function relationship for individual biomolecules (ACS Nano, 2010; EMBO Journal, 2007; RNA, 2007). Her long-term objective is to focus on the development and translation of RNA nanotechnology-based therapeutics and imaging agents into clinical trials.

Journal Articles

  • Shu Y, Yin H, Rajabi M, Li H, Vieweger M, Guo S, Shu D, Guo P. RNA-based micelles: A novel platform for paclitaxel loading and delivery. J Control Release. 2018 Apr 28;276:17-29.
  • Smith JA, Braga A, Verheyen J, Basilico S, Bandiera S, Alfaro-Cervello C, Peruzzotti-Jametti L, Shu D, Haque F, Guo P, Pluchino S. RNA Nanotherapeutics for the Amelioration of Astroglial Reactivity. Mol Ther Nucleic Acids. 2018 Mar 02;10:103-121.
  • Xu C, Haque F, Jasinski DL, Binzel DW, Shu D, Guo P. Favorable biodistribution, specific targeting and conditional endosomal escape of RNA nanoparticles in cancer therapy. Cancer Lett. 2018 02 01;414:57-70.
  • Yang X, Xu Y, Wang T, Shu D, Guo P, Miskimins K, Qian SY. Erratum to "Inhibition of cancer migration and invasion by knocking down delta-5-desaturase in COX-2 overexpressed cancer cells" [Redox Biol. 11 (2017) 653-662]. Redox Biol. 2017 08;12:1062.
  • Lee TJ, Yoo JY, Shu D, Li H, Zhang J, Yu JG, Jaime-Ramirez AC, Acunzo M, Romano G, Cui R, Sun HL, Luo Z, Old M, Kaur B, Guo P, Croce CM. RNA Nanoparticle-Based Targeted Therapy for Glioblastoma through Inhibition of Oncogenic miR-21. Mol Ther. 2017 07 05;25(7):1544-1555.
  • Yang X, Xu Y, Wang T, Shu D, Guo P, Miskimins K, Qian SY. Inhibition of cancer migration and invasion by knocking down delta-5-desaturase in COX-2 overexpressed cancer cells. Redox Biol. 2017 04;11:653-662.
  • Zhang Y, Leonard M, Shu Y, Yang Y, Shu D, Guo P, Zhang X. Overcoming Tamoxifen Resistance of Human Breast Cancer by Targeted Gene Silencing Using Multifunctional pRNA Nanoparticles. ACS Nano. 2017 01 24;11(1):335-346.
  • Zhao Z, Zhang H, Shu D, Montemagno C, Ding B, Li J, Guo P. Construction of Asymmetrical Hexameric Biomimetic Motors with Continuous Single-Directional Motion by Sequential Coordination. Small. 2017 Jan;13(1).
  • Li H, Zhang K, Pi F, Guo S, Shlyakhtenko L, Chiu W, Shu D, Guo P. Controllable Self-Assembly of RNA Tetrahedrons with Precise Shape and Size for Cancer Targeting. Adv Mater. 2016 Sep;28(34):7501-7.
  • Binzel DW, Shu Y, Li H, Sun M, Zhang Q, Shu D, Guo B, Guo P. Specific Delivery of MiRNA for High Efficient Inhibition of Prostate Cancer by RNA Nanotechnology. Mol Ther. 2016 08;24(7):1267-77.