Cynthia Carnes

Image
Cynthia Carnes

Cynthia Carnes, PharmD, PhD

Title
Senior Associate Dean
Unit / Department / Division
Pharmacology
Pharmacy Practice and Science
Address
217A Parks Hall
Email Address
Phone Number

Professional Interests

Professional Interests

My research is focused on cardiac arrhythmias (abnormal heart rhythms), particularly in heart failure. We use an integrated approach from proteins to cells to tissues to the intact organism to study the causes, and potential treatments of cardiac arrhythmias. My clinical practice is at the Ambulatory Care Center at the Ross Heart Hospital, where I provide patient care in antiarrhythmic medication monitoring.

Education

  • 1996, PhD, The Ohio State University, Pharmacy and Veterinary Clinical Sciences
  • 1988, PharmD, University of Utah, Pharmacy
  • 1983, BS, University of Texas, Pharmacy

Journal Articles

  • Györke S, Belevych AE, Liu B, Kubasov IV, Carnes CA, Radwański PB. The role of luminal Ca regulation in Ca signaling refractoriness and cardiac arrhythmogenesis. J Gen Physiol. 2017 Sep 04;149(9):877-888.
  • Tanwar V, Gorr MW, Velten M, Eichenseer CM, Long VP, Bonilla IM, Shettigar V, Ziolo MT, Davis JP, Baine SH, Carnes CA, Wold LE. In Utero Particulate Matter Exposure Produces Heart Failure, Electrical Remodeling, and Epigenetic Changes at Adulthood. J Am Heart Assoc. 2017 Apr 11;6(4).
  • Belevych AE, Ho HT, Bonilla IM, Terentyeva R, Schober KE, Terentyev D, Carnes CA, Györke S. The role of spatial organization of Ca2+ release sites in the generation of arrhythmogenic diastolic Ca2+ release in myocytes from failing hearts. Basic Res Cardiol. 2017 07;112(4):44.
  • Long VP, Carnes CA, Vecchiet J, Houmsse M, Hirsch A, Snider MJ. Evaluation of a pharmacist-managed electrolyte protocol in outpatients on antiarrhythmic medications. J Am Pharm Assoc (2003). 2017 Jul - Aug;57(4):526-531.
  • Ho HT, Belevych AE, Liu B, Bonilla IM, Radwański PB, Kubasov IV, Valdivia HH, Schober K, Carnes CA, Györke S. Muscarinic Stimulation Facilitates Sarcoplasmic Reticulum Ca Release by Modulating Ryanodine Receptor 2 Phosphorylation Through Protein Kinase G and Ca/Calmodulin-Dependent Protein Kinase II. Hypertension. 2016 11;68(5):1171-1178.
  • Smith SA, Hughes LD, Kline CF, Kempton AN, Dorn LE, Curran J, Makara M, Webb TR, Wright P, Voigt N, Binkley PF, Janssen PM, Kilic A, Carnes CA, Dobrev D, Rasband MN, Hund TJ, Mohler PJ. Dysfunction of the β2-spectrin-based pathway in human heart failure. Am J Physiol Heart Circ Physiol. 2016 06 01;310(11):H1583-91.
  • Bonilla IM, Nishijima Y, Vargas-Pinto P, Baine SH, Sridhar A, Li C, Billman GE, Carnes CA. Chronic Omega-3 Polyunsaturated Fatty Acid Treatment Variably Affects Cellular Repolarization in a Healed Post-MI Arrhythmia Model. Front Physiol. 2016;7:225.
  • Long VP, Carnes CA. Treating cocaine cardiotoxicity: Does receptor subtype matter? Trends Cardiovasc Med. 2015 Aug;25(6):527-8.
  • Little SC, Curran J, Makara MA, Kline CF, Ho HT, Xu Z, Wu X, Polina I, Musa H, Meadows AM, Carnes CA, Biesiadecki BJ, Davis JP, Weisleder N, Györke S, Wehrens XH, Hund TJ, Mohler PJ. Protein phosphatase 2A regulatory subunit B56α limits phosphatase activity in the heart. Sci Signal. 2015 Jul 21;8(386):ra72.
  • Sturm AC, Kline CF, Glynn P, Johnson BL, Curran J, Kilic A, Higgins RS, Binkley PF, Janssen PM, Weiss R, Raman SV, Fowler SJ, Priori SG, Hund TJ, Carnes CA, Mohler PJ. Use of whole exome sequencing for the identification of Ito-based arrhythmia mechanism and therapy. J Am Heart Assoc. 2015 May 26;4(5).