Cynthia Carnes

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Cynthia Carnes

Cynthia Carnes, PharmD, PhD

Title
Senior Associate Dean, Research and Graduate Education and Professor
Unit / Department / Division
Outcomes and Translational Sciences
Address
217A Parks Hall
Email Address
Phone Number

Professional Interests

Professional Interests

My research is focused on cardiac arrhythmias (abnormal heart rhythms), particularly in heart failure. We use an integrated approach from proteins to cells to tissues to the intact organism to study the causes, and potential treatments of cardiac arrhythmias. My clinical practice is at the Ambulatory Care Center at the Ross Heart Hospital, where I provide patient care in antiarrhythmic medication monitoring.

Support Staff
Liz Gibson, Administrative Associate

Education

  • 1996, PhD, The Ohio State University, Pharmacy and Veterinary Clinical Sciences
  • 1988, PharmD, University of Utah, Pharmacy
  • 1983, BS, University of Texas, Pharmacy

Journal Articles

Baine S, Bonilla I, Belevych A, Stepanov A, Dorn LE, Terentyeva R, Terentyev D, Accornero F, Carnes CA, Gyorke S. Pyridostigmine improves cardiac function and rhythmicity through RyR2 stabilization and inhibition of STIM1-mediated calcium entry in heart failure. J Cell Mol Med. 2021 May;25(10):4637-4648. doi: 10.1111/jcmm.16356. Epub 2021 Mar 23. PMID: 33755308; PMCID: PMC8107086.

Huang KM, Zavorka Thomas M, Magdy T, Eisenmann ED, Uddin ME, DiGiacomo DF, Pan A, Keiser M, Otter M, Xia SH, Li Y, Jin Y, Fu Q, Gibson AA, Bonilla IM, Carnes CA, Corps KN, Coppola V, Smith SA, Addison D, Nies AT, Bundschuh R, Chen T, Lustberg MB, Wang J, Oswald S, Campbell MJ, Yan PS, Baker SD, Hu S, Burridge PW, Sparreboom A. Targeting OCT3 attenuates doxorubicin-induced cardiac injury. Proc Natl Acad Sci U S A. 2021 Feb 2;118(5):e2020168118. doi: 10.1073/pnas.2020168118. PMID: 33495337; PMCID: PMC7865186.

Baine S, Thomas J, Bonilla I, Ivanova M, Belevych A, Li J, Veeraraghavan R, Radwanski PB, Carnes C, Gyorke S. Muscarinic-dependent phosphorylation of the cardiac ryanodine receptor by protein kinase G is mediated by PI3K-AKT-nNOS signaling. J Biol Chem. 2020 Aug 14;295(33):11720-11728. doi: 10.1074/jbc.RA120.014054. Epub 2020 Jun 24. PMID: 32580946; PMCID: PMC7450129.

Munger MA, Olğar Y, Koleske ML, Struckman HL, Mandrioli J, Lou Q, Bonila I, Kim K, Ramos Mondragon R, Priori SG, Volpe P, Valdivia HH, Biskupiak J, Carnes CA, Veeraraghavan R, Györke S, Radwański PB. Tetrodotoxin-Sensitive Neuronal- Type Na<sup>+</sup> Channels: A Novel and Druggable Target for Prevention of Atrial Fibrillation. J Am Heart Assoc. 2020 Jun 2;9(11):e015119. doi: 10.1161/JAHA.119.015119. Epub 2020 May 29. PMID: 32468902; PMCID: PMC7429002.

Long VP 3rd, Bonilla IM, Baine S, Glynn P, Kumar S, Schober K, Mowrey K, Weiss R, Lee NY, Mohler PJ, Györke S, Hund TJ, Fedorov VV, Carnes CA. Chronic heart failure increases negative chronotropic effects of adenosine in canine sinoatrial cells via A1R stimulation and GIRK-mediated. Life Sci. 2020 Jan 1;240:117068. doi: 10.1016/j.lfs.2019.117068. Epub 2019 Nov 18. PMID: 31751583; PMCID: PMC7294905.

Grimmer JA, Tanwar V, Youtz DJ, Adelstein JM, Baine SH, Carnes CA, Baer LA, Stanford KI, Wold LE. Exercise does not ameliorate cardiac dysfunction in obese mice exposed to fine particulate matter. Life Sci. 2019 Dec 15;239:116885. doi: 10.1016/j.lfs.2019.116885. Epub 2019 Oct 23. PMID: 31655193; PMCID: PMC6898783.

Uddin ME, Sun X, Huang KM, Hu S, Carnes CA, Sparreboom A, Fu Q. Development and validation of a UPLC-MS/MS analytical method for dofetilide in mouse plasma and urine, and its application to pharmacokinetic study. J Pharm Biomed Anal. 2019 Aug 5;172:183-188. doi: 10.1016/j.jpba.2019.04.041. Epub 2019 Apr 19. PMID: 31055183; PMCID: PMC6548664.

Bonilla IM, Belevych AE, Baine S, Stepanov A, Mezache L, Bodnar T, Liu B, Volpe P, Priori S, Weisleder N, Sakuta G, Carnes CA, Radwański PB, Veeraraghavan R, Gyorke S. Enhancement of Cardiac Store Operated Calcium Entry (SOCE) within Novel Intercalated Disk Microdomains in Arrhythmic Disease. Sci Rep. 2019 Jul 15;9(1):10179. doi: 10.1038/s41598-019-46427-x. PMID: 31308393; PMCID: PMC6629850.

Györke S, Belevych AE, Liu B, Kubasov IV, Carnes CA, Radwański PB. The role of luminal Ca regulation in Ca signaling refractoriness and cardiac arrhythmogenesis. J Gen Physiol. 2017 Sep 4;149(9):877-888. doi: 10.1085/jgp.201711808. Epub 2017 Aug 10. PMID: 28798279; PMCID: PMC5583712.

Long VP III, Carnes CA, Vecchiet J, Houmsse M, Hirsch A, Snider MJ. Evaluation of a pharmacist-managed electrolyte protocol in outpatients on antiarrhythmic medications. J Am Pharm Assoc (2003). 2017 Jul-Aug;57(4):526-531. doi: 10.1016/j.japh.2017.05.001. Epub 2017 Jun 10. PMID: 28610942.