Cynthia Carnes

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Cynthia Carnes

Cynthia Carnes, PharmD, PhD

Title
Senior Associate Dean
Unit / Department / Division
Pharmacology
Pharmacy Practice and Science
Address
217A Parks Hall
Email Address
Phone Number

Professional Interests

Professional Interests

My research is focused on cardiac arrhythmias (abnormal heart rhythms), particularly in heart failure. We use an integrated approach from proteins to cells to tissues to the intact organism to study the causes, and potential treatments of cardiac arrhythmias. My clinical practice is at the Ambulatory Care Center at the Ross Heart Hospital, where I provide patient care in antiarrhythmic medication monitoring.

Support Staff
Corinne Rubright, Administrative Associate

Education

  • 1996, PhD, The Ohio State University, Pharmacy and Veterinary Clinical Sciences
  • 1988, PharmD, University of Utah, Pharmacy
  • 1983, BS, University of Texas, Pharmacy

Journal Articles

  • Györke S, Belevych AE, Liu B, Kubasov IV, Carnes CA, Radwański PB. The role of luminal Ca regulation in Ca signaling refractoriness and cardiac arrhythmogenesis. J Gen Physiol. 2017 Sep 04;149(9):877-888.
  • Tanwar V, Gorr MW, Velten M, Eichenseer CM, Long VP, Bonilla IM, Shettigar V, Ziolo MT, Davis JP, Baine SH, Carnes CA, Wold LE. In Utero Particulate Matter Exposure Produces Heart Failure, Electrical Remodeling, and Epigenetic Changes at Adulthood. J Am Heart Assoc. 2017 Apr 11;6(4).
  • Belevych AE, Ho HT, Bonilla IM, Terentyeva R, Schober KE, Terentyev D, Carnes CA, Györke S. The role of spatial organization of Ca2+ release sites in the generation of arrhythmogenic diastolic Ca2+ release in myocytes from failing hearts. Basic Res Cardiol. 2017 07;112(4):44.
  • Long VP, Carnes CA, Vecchiet J, Houmsse M, Hirsch A, Snider MJ. Evaluation of a pharmacist-managed electrolyte protocol in outpatients on antiarrhythmic medications. J Am Pharm Assoc (2003). 2017 Jul - Aug;57(4):526-531.
  • Ho HT, Belevych AE, Liu B, Bonilla IM, Radwański PB, Kubasov IV, Valdivia HH, Schober K, Carnes CA, Györke S. Muscarinic Stimulation Facilitates Sarcoplasmic Reticulum Ca Release by Modulating Ryanodine Receptor 2 Phosphorylation Through Protein Kinase G and Ca/Calmodulin-Dependent Protein Kinase II. Hypertension. 2016 11;68(5):1171-1178.
  • Smith SA, Hughes LD, Kline CF, Kempton AN, Dorn LE, Curran J, Makara M, Webb TR, Wright P, Voigt N, Binkley PF, Janssen PM, Kilic A, Carnes CA, Dobrev D, Rasband MN, Hund TJ, Mohler PJ. Dysfunction of the β2-spectrin-based pathway in human heart failure. Am J Physiol Heart Circ Physiol. 2016 06 01;310(11):H1583-91.
  • Bonilla IM, Nishijima Y, Vargas-Pinto P, Baine SH, Sridhar A, Li C, Billman GE, Carnes CA. Chronic Omega-3 Polyunsaturated Fatty Acid Treatment Variably Affects Cellular Repolarization in a Healed Post-MI Arrhythmia Model. Front Physiol. 2016;7:225.
  • Long VP, Carnes CA. Treating cocaine cardiotoxicity: Does receptor subtype matter? Trends Cardiovasc Med. 2015 Aug;25(6):527-8.
  • Little SC, Curran J, Makara MA, Kline CF, Ho HT, Xu Z, Wu X, Polina I, Musa H, Meadows AM, Carnes CA, Biesiadecki BJ, Davis JP, Weisleder N, Györke S, Wehrens XH, Hund TJ, Mohler PJ. Protein phosphatase 2A regulatory subunit B56α limits phosphatase activity in the heart. Sci Signal. 2015 Jul 21;8(386):ra72.
  • Sturm AC, Kline CF, Glynn P, Johnson BL, Curran J, Kilic A, Higgins RS, Binkley PF, Janssen PM, Weiss R, Raman SV, Fowler SJ, Priori SG, Hund TJ, Carnes CA, Mohler PJ. Use of whole exome sequencing for the identification of Ito-based arrhythmia mechanism and therapy. J Am Heart Assoc. 2015 May 26;4(5).
  • Smith SA, Sturm AC, Curran J, Kline CF, Little SC, Bonilla IM, Long VP, Makara M, Polina I, Hughes LD, Webb TR, Wei Z, Wright P, Voigt N, Bhakta D, Spoonamore KG, Zhang C, Weiss R, Binkley PF, Janssen PM, Kilic A, Higgins RS, Sun M, Ma J, Dobrev D, Zhang M, Carnes CA, Vatta M, Rasband MN, Hund TJ, Mohler PJ. Dysfunction in the βII spectrin-dependent cytoskeleton underlies human arrhythmia. Circulation. 2015 Feb 24;131(8):695-708.
  • Long VP, Bonilla IM, Vargas-Pinto P, Nishijima Y, Sridhar A, Li C, Mowrey K, Wright P, Velayutham M, Kumar S, Lee NY, Zweier JL, Mohler PJ, Györke S, Carnes CA. Heart failure duration progressively modulates the arrhythmia substrate through structural and electrical remodeling. Life Sci. 2015 Feb 15;123:61-71.
  • Carnes CA. What is the role of pharmacogenetics in optimization of warfarin dosing? Trends Cardiovasc Med. 2015 Jan;25(1):42-3.
  • Lou Q, Hansen BJ, Fedorenko O, Csepe TA, Kalyanasundaram A, Li N, Hage LT, Glukhov AV, Billman GE, Weiss R, Mohler PJ, Györke S, Biesiadecki BJ, Carnes CA, Fedorov VV. Upregulation of adenosine A1 receptors facilitates sinoatrial node dysfunction in chronic canine heart failure by exacerbating nodal conduction abnormalities revealed by novel dual-sided intramural optical mapping. Circulation. 2014 Jul 22;130(4):315-24.
  • Bonilla IM, Long VP, Vargas-Pinto P, Wright P, Belevych A, Lou Q, Mowrey K, Yoo J, Binkley PF, Fedorov VV, Györke S, Janssen PM, Kilic A, Mohler PJ, Carnes CA. Calcium-activated potassium current modulates ventricular repolarization in chronic heart failure. PLoS One. 2014;9(10):e108824.
  • Glukhov AV, Hage LT, Hansen BJ, Pedraza-Toscano A, Vargas-Pinto P, Hamlin RL, Weiss R, Carnes CA, Billman GE, Fedorov VV. Sinoatrial node reentry in a canine chronic left ventricular infarct model: role of intranodal fibrosis and heterogeneity of refractoriness. Circ Arrhythm Electrophysiol. 2013 Oct;6(5):984-94.
  • Bonkowski J, Carnes C, Melucci J, Mirtallo J, Prier B, Reichert E, Moffatt-Bruce S, Weber R. Effect of barcode-assisted medication administration on emergency department medication errors. Acad Emerg Med. 2013 Aug;20(8):801-6.
  • Belevych AE, Radwański PB, Carnes CA, Györke S. 'Ryanopathy': causes and manifestations of RyR2 dysfunction in heart failure. Cardiovasc Res. 2013 May 01;98(2):240-7.
  • Bonilla IM, Sridhar A, Nishijima Y, Györke S, Cardounel AJ, Carnes CA. Differential effects of the peroxynitrite donor, SIN-1, on atrial and ventricular myocyte electrophysiology. J Cardiovasc Pharmacol. 2013 May;61(5):401-7.
  • Belevych AE, Ho HT, Terentyeva R, Bonilla IM, Terentyev D, Carnes CA, Gyorke S, Billman GE. Dietary omega-3 fatty acids promote arrhythmogenic remodeling of cellular Ca2+ handling in a postinfarction model of sudden cardiac death. PLoS One. 2013;8(10):e78414.