Organic / Medicinal Chemistry and Chemical Biology
The Peterson laboratory synthesizes chemical tools for studies of biological systems. We investigate diverse biological targets, and we extensively employ fluorescence-based and imaging-based methods to evaluate the effects of small molecules on isolated proteins, living cells, and model organisms. Working in the fields of organic / medicinal chemistry and chemical biology, our recent research efforts have been focused on the discovery of new types of anticancer agents, identification of their biomolecular targets, and the synthesis of probes of molecular mechanisms of action.
- B.S. Chemistry, University of Nevada, Reno, 1990
- Ph.D. Chemistry, University of California, Los Angeles, 1994
- Damon Runyon-Walter Winchell Cancer Research Foundation Postdoctoral Fellow, Harvard University 1995-1998
- Named the John W. Wolfe Chair in Cancer Research, 2020
- Elected Fellow of the American Association for the Advancement of Science (AAAS), 2013
- Regents Distinguished Professor of Medicinal Chemistry, The University of Kansas, 2008-2019
- Named an Eminent Scholar by the Kansas Bioscience Authority, 2008
- Camille Dreyfus Teacher Scholar, 2004
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- Quantification of Engagement of Microtubules by Small Molecules in Living Cells by Flow Cytometry, ACS Bio & Med Chem Au. 2022 Oct | journal-article. doi: 10.1021/acsbiomedchemau.2c00031.
- Pacific Blue-Taxoids as Fluorescent Molecular Probes of Microtubules, Methods in Molecular Biology. 2022 Jan | book-chapter. doi: 10.1007/978-1-0716-1983-4_28.
- Synthesis of a fluorinated pyronin that enables blue light to rapidly depolarize mitochondria, RSC Medicinal Chemistry. 2022 Jan | journal-article. doi: 10.1039/D1MD00395J.
- Carnosine Protects Macrophages against the Toxicity of Aβ1-42 Oligomers by Decreasing Oxidative Stress, Biomedicines. 2021 Apr | journal-article. doi: 10.3390/biomedicines9050477.
- The C. elegans CHP1 homolog, pbo-1, functions in innate immunity by regulating the pH of the intestinal lumen, PLOS Pathogens. 2020 Jan | journal-article. doi: 10.1371/journal.ppat.1008134.
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