Our research is devoted to drug discovery and development for the treatment of cancer as well as inherited genetic disorders. We integrate our specialty in pharmaceutics, pharmaceutical chemistry, biomedical engineering, materials formulation, and animal studies to design novel therapeutic medicines and uncover their mechanisms of actions. The ultimate goal is to translate our scientific results and technological inventions into more effective treatment and more fulfilling lives for all individuals.
- 2014, Postdoctoral Fellow, Massachusetts Institute of Technology & Harvard Medical School
- 2009, PhD, University of North Carolina at Chapel Hill, Medicinal and Pharmaceutical Chemistry (MS, PhD),
- 2005, MS, Shanghai Institute of Organic Chemistry, Organic Chemistry
- 2002, BS, Peking University, Pharmaceutical Science
- Certificate in Applied Biostatistics, Harvard Medical School
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- NIGMS-Maximizing Investigators' Research Award (MIRA), 2016 - 2021
- New Investigator Grant, 2016 - 2017
- Research Project Award, 2016 - 2017
- Early Career Investigator Award, 2015 - 2017
- ResearchReward, 2015 - 2016
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- Li B, Niu Y, Ji W, Dong Y. Strategies for the CRISPR-Based Therapeutics. Trends Pharmacol Sci. 2020 Jan;41(1):55-65.
- Zhao P, Zhang Y, Li W, Jeanty C, Xiang G, Dong Y. Recent advances of antibody drug conjugates for clinical applications. Acta Pharm Sin B. 2020 Sep;10(9):1589-1600.
- Hou X, Zhang X, Zhao W, Zeng C, Deng B, McComb DW, Du S, Zhang C, Li W, Dong Y. Vitamin lipid nanoparticles enable adoptive macrophage transfer for the treatment of multidrug-resistant bacterial sepsis. Nat Nanotechnol. 2020 Jan;15(1):41-46.
- Zeng C, Zhang C, Walker PG, Dong Y. Formulation and Delivery Technologies for mRNA Vaccines. Curr Top Microbiol Immunol. 2020 Jun 2.
- Li B, Yan J, Zhang Y, Li W, Zeng C, Zhao W, Hou X, Zhang C, Dong Y. CRISPR- Cas12a Possesses Unconventional DNase Activity that Can Be Inactivated by Synthetic Oligonucleotides. Mol Ther Nucleic Acids. 2020 Mar 6;19:1043-1052.
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