Moray Campbell

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Moray Campbell

Moray Campbell, PhD

Title
Associate Professor
Unit / Department / Division
Pharmaceutics and Pharmacology
Address
442 Riffe Building
Email Address
Phone Number

Professional Interests

Professional Interests

My research goal is to define epigenomic mechanisms that are cancer drivers, and exploit this understanding in diagnostic settings and targeted therapies. Specifically, we focus on understanding how epigenomic events disrupt transcription in solid tumors, notably prostate and breast cancer. To achieve this research goal my group undertakes interdisciplinary approaches. Thus we aim to conceive, design, and interpret experiments that are undertaken both in the wet lab, in Eppendorf tubes, and in the dry lab, at the computer command line.

Education

  • 2016, MS in Bioinformatics, Johns Hopkins University
  • 1994, PhD, Microbiology, University of Kent
  • 1990, BSc, Applied and Industrial Biology, London South Bank University

Honors

  • Dean’s Innovative Research Award, 2019
  • Clinical Sciences Translational Research Fellow, 2011
  • Royal Society Travel Award, 2001
  • Gillard Exchange Fellowship, 2000
  • Pfizer Travel Award, 2000
  • Leukemia Research Fund Wilsede Scholarship, 1998
  • Young Investigator Award, 1997
  • Faculty Degree Prize, 1990

Journal Articles

  • Fleet, J.C.; Campbell, M.J.; Carlberg, C.; Demay, M.B. et al. Highlights from the 21st Workshop on Vitamin D in Barcelona, May 2018 J Steroid Biochem Mol Biol. 2019 May; 189 210-217.
  • Johnson, T.S.; Li, S.; Franz, E.; Huang, Z. et al. PseudoFuN: Deriving functional potentials of pseudogenes from integrative relationships with genes and microRNAs across 32 cancers GigaScience. 2019 May; 8(5):.
  • Ebron, J.S.; Shankar, E.; Singh, J.; Sikand, K. et al. MiR-644a Disrupts Oncogenic Transformation and Warburg Effect by Direct Modulation of Multiple Genes of Tumor-Promoting Pathways Cancer Res. 2019 Apr; 79(8):1844-1856.
  • Rajasekaran, S.; Selvan, L.D.N.; Dotts, K.; Kumar, R. et al. Non-coding and coding transcriptional profiles are significantly altered in pediatric retinoblastoma tumors Frontiers in Oncology. 2019 Jan; 9(MAR):.
  • Campbell, M.J. High-Dimensional Data Approaches to Understanding Nuclear Hormone Receptor Signaling Methods Mol Biol. 2019 Jan; 1966 291-311.
  • Campbell, M.J. Tales from topographic oceans: Topologically associated domains and cancer Endocrine-Related Cancer. 2019 Jan; 26(11):R611-R626.
  • Long, M.D.; Singh, P.K.; Russell, J.R.; Llimos, G. et al. The miR-96 and RARγ signaling axis governs androgen signaling and prostate cancer progression Oncogene. 2019 Jan; 38(3):421-444.
  • Fletcher, A.; Read, M.L.; Thornton, C.E.M.; Larner, D.P. et al. Pharmacologically targeting a novel pathway of sodium iodide symporter trafficking to enhance radioiodine uptake bioRxiv. 2019 Jan; .
  • Read, M.L.; Modasia, B.; Fletcher, A.; Thompson, R.J. et al. PTTG and PBF Functionally Interact with p53 and Predict Overall Survival in Head and Neck Cancer Cancer Res. 2018 Oct; 78(20):5863-5876.
  • Long, M.D.; Rosario, S.; Sucheston-Campbell, L.; Smiraglia, D. et al. MiR-96 targets retinoic acid receptor gamma crosstalk with the androgen receptor to drive aggressive prostate cancer Cancer Research. 2018 Aug; 78(16):29-30.
  • Long, M.D.; Singh, P.K.; Llimos, G.; Rosario, S. et al. Stage-specific and global functions of NCOR2 in prostate cancer progression Endocrine Abstracts. 2018 Mar; .
  • Campbell, M.J.; Trump, D.L. Vitamin D Receptor Signaling and Cancer Endocrinol Metab Clin North Am. 2017 Dec; 46(4):1009-1038.
  • Affronti, H.C.; Long, M.D.; Rosario, S.R.; Gillard, B.M. et al. Dietary folate levels alter the kinetics and molecular mechanism of prostate cancer recurrence in the CWR22 model Oncotarget. 2017 Nov; 8(61):103758-103774.
  • Long, M.D.; Campbell, M.J. Integrative genomic approaches to dissect clinically-significant relationships between the VDR cistrome and gene expression in primary colon cancer J Steroid Biochem Mol Biol. 2017 Oct; 173 130-138.
  • Campbell, M.J. Bioinformatic approaches to interrogating vitamin D receptor signaling Mol Cell Endocrinol. 2017 Sep; 453 3-13.
  • Long, M.D.; Smiraglia, D.J.; Campbell, M.J. The Genomic Impact of DNA CpG Methylation on Gene Expression; Relationships in Prostate Cancer Biomolecules. 2017 Feb; 7(1):.
  • Singh, P.K.; van den Berg, P.R.; Long, M.D.; Vreugdenhil, A. et al. Integration of VDR genome wide binding and GWAS genetic variation data reveals co-occurrence of VDR and NF-κB binding that is linked to immune phenotypes BMC Genomics. 2017 Feb; 18(1):132-132.
  • Yates, C.; Long, M.D.; Campbell, M.J.; Sucheston-Campbell, L. miRNAs as drivers of TMPRSS2-ERG negative prostate tumors in African American men Front Biosci (Landmark Ed). 2017 Jan; 22 212-229.
  • Trevino, V.; Cassese, A.; Herbert, J.; Antzack, P. et al. A Network Biology Approach Infers Signals Linking Adjacent Normal And Tumour Prostate Epithelial Cells PLoS Comput Biol. 2016 Apr; 12(4):.
  • Trevino, V.; Cassese, A.; Nagy, Z.; Zhuang, X. et al. A Network Biology Approach Identifies Molecular Cross-Talk between Normal Prostate Epithelial and Prostate Carcinoma Cells PLoS Comput Biol. 2016 Apr; 12(4):e1004884-e1004884.
  • Doig, C.L.; Battaglia, S.; Khanim, F.L.; Bunce, C.M. et al. Knockdown of AKR1C3 exposes a potential epigenetic susceptibility in prostate cancer cells J Steroid Biochem Mol Biol. 2016 Jan; 155(Pt A):47-55.
  • Dhiman, V.K.; Attwood, K.; Campbell, M.J.; Smiraglia, D.J. Hormone stimulation of androgen receptor mediates dynamic changes in DNA methylation patterns at regulatory elements Oncotarget. 2015 Dec; 6(40):42575-42589.
  • Long, M.D.; Campbell, M.J. Pan-cancer analyses of the nuclear receptor superfamily Nucl Receptor Res. 2015 Dec; 2 .
  • Campbell, M. Epigenetic regulation of androgen receptor function in prostate cancer Endocrine Abstracts. 2015 Nov; .
  • Thorne, J.L.; Campbell, M.J. Nuclear receptors and the Warburg effect in cancer Int J Cancer. 2015 Oct; 137(7):1519-1527.
  • Long, M.D.; van den Berg, P.R.; Russell, J.L.; Singh, P.K. et al. Integrative genomic analysis in K562 chronic myelogenous leukemia cells reveals that proximal NCOR1 binding positively regulates genes that govern erythroid differentiation and Imatinib sensitivity Nucleic Acids Res. 2015 Sep; 43(15):7330-7348.
  • Long, M.D.; Sucheston-Campbell, L.E.; Campbell, M.J. Vitamin D receptor and RXR in the post-genomic era J Cell Physiol. 2015 Apr; 230(4):758-766.
  • Singh, P.K.; Long, M.D.; Battaglia, S.; Hu, Q. et al. VDR regulation of microRNA differs across prostate cell models suggesting extremely flexible control of transcription Epigenetics. 2015 Jan; 10(1):40-49.
  • Long, M.D.; van den Berg, P.; Campbell, M.J.; Singh, P.K. et al. An integrative genomic pipeline to target the NCOR1 cistrome with precision Cancer Research. 2014 Oct; 74(19):.
  • Singh, P.K.; Long, M.D.; Dhiman, V.K.; Zhu, Q. et al. Evolution of the NCOR1 and NCOR2/SMRT cistromes in prostate cancer progression Cancer Research. 2014 Oct; 74(19):.
  • Cancers Editorial Office, Acknowledgement to Reviewers of Cancers in 2013 Cancers. 2014 Mar; 6(1):491-493.
  • Singh, P.K.; Preus, P.; Hu, Q.; Yan, L. et al. Identification of microRNA expression levels in the serum of prostate cancer patients that predicts the risk of biochemical failure Oncotarget. 2014 Feb; 5(3):824-840.
  • Singh, P.K.; Preus, L.; Hu, Q.; Yan, L. et al. Serum microRNA expression patterns that predict early treatment failure in prostate cancer patients Oncotarget. 2014 Feb; 5(3):824-840.
  • Long, M.D.; Thorne, J.L.; Russell, J.; Battaglia, S. et al. Cooperative behavior of the nuclear receptor superfamily and its deregulation in prostate cancer Carcinogenesis. 2014 Feb; 35(2):262-271.
  • Campbell, M.J. Vitamin D and the RNA transcriptome: more than mRNA regulation Front Physiol. 2014 Jan; 5 181-181.
  • Ryynänen, J.; Seuter, S.; Campbell, M.J.; Carlberg, C. Gene regulatory scenarios of primary 1,25-dihydroxyvitamin d3 target genes in a human myeloid leukemia cell line Cancers (Basel). 2013 Oct; 5(4):1221-1241.
  • Singh, P.K.; Campbell, M.J. The Interactions of microRNA and Epigenetic Modifications in Prostate Cancer Cancers (Basel). 2013 Aug; 5(3):998-1019.
  • Doig, C.L.; Singh, P.K.; Thorne, J.L.; Battaglia, S. et al. NCOR1 promoter recruitment is distorted in prostate cancer and leads to aberrant DNA methylation Carcinogenesis. 2013 Feb; 34(2):248-256.
  • Carlberg, C.; Campbell, M.J. Vitamin D receptor signaling mechanisms: integrated actions of a well-defined transcription factor Steroids. 2013 Feb; 78(2):127-136.
  • Doig, C.L.; Singh, P.K.; Dhiman, V.K.; Thorne, J.L. et al. Recruitment of NCOR1 to VDR target genes is enhanced in prostate cancer cells and associates with altered DNA methylation patterns Carcinogenesis. 2013 Feb; 34(2):248-256.
  • Singh, P.K.; Doig, C.L.; Dhiman, V.K.; Turner, B.M. et al. Epigenetic distortion to VDR transcriptional regulation in prostate cancer cells Journal of Steroid Biochemistry and Molecular Biology. 2013 Jan; 136(1):258-263.
  • Campbell, M.J.; Wolf, D.; Mukhtar, R.A.; Tandon, V. et al. The prognostic implications of macrophages expressing proliferating cell nuclear antigen in breast cancer depend on immune context PLoS One. 2013 Jan; 8(10):e79114-e79114.
  • Upadhyay, S.K.; Verone, A.; Shoemaker, S.; Qin, M. et al. 1, 25-Dihydroxyvitamin D3 (1,25(OH)2D3) Signaling Capacity and the Epithelial-Mesenchymal Transition in Non-Small Cell Lung Cancer (NSCLC): Implications for Use of 1,25 (OH) 2D3 in NSCLC Treatment Cancers. 2013 Jan; 5(4):1504-1521.
  • Maguire, O.; Pollock, C.; Martin, P.; Owen, A. et al. Regulation of CYP3A4 and CYP3A5 expression and modulation of "intracrine" metabolism of androgens in prostate cells by liganded vitamin D receptor Mol Cell Endocrinol. 2012 Nov; 364(1-2):54-64.
  • Singh, P.K.; Dhiman, V.; Turner, B.M.; Smiraglia, D.J. et al. Selective epigenetic distortion to VDR transcriptional regulation in prostate cancer cells Journal of Steroid Biochemistry and Molecular Biology. 2012 Oct; .
  • Pereira, F.; Barbáchano, A.; Singh, P.K.; Campbell, M.J. et al. Vitamin D has wide regulatory effects on histone demethylase genes Cell Cycle. 2012 Mar; 11(6):1081-1089.
  • Kolodkin, A.N.; Bruggeman, F.J.; Plant, N.; Mone, M.J. et al. Design principles of nuclear receptor signalling: How complex networking improves signal transduction Toxicology. 2011 Dec; 290(2-3):131-132.
  • Pereira, F.; Barbáchano, A.; Silva, J.; Bonilla, F. et al. KDM6B/JMJD3 histone demethylase is induced by vitamin D and modulates its effects in colon cancer cells Hum Mol Genet. 2011 Dec; 20(23):4655-4665.
  • Trevino, V.; Tadesse, M.G.; Vannucci, M.; Al-Shahrour, F. et al. Analysis of normal-tumour tissue interaction in tumours: prediction of prostate cancer features from the molecular profile of adjacent normal cells PLoS One. 2011 Mar; 6(3):e16492-e16492.
  • Thorne, J.L.; Maguire, O.; Doig, C.L.; Battaglia, S. et al. Epigenetic control of a VDR-governed feed-forward loop that regulates p21 (waf1/cip1) expression and function in non-malignant prostate cells Nucleic Acids Research. 2011 Mar; 39(6):2045-2056.
  • Kolodkin, A.N.; Bruggeman, F.J.; Plant, N.; Moné, M.J. et al. Design principles of nuclear receptor signaling: how complex networking improves signal transduction Mol Syst Biol. 2010 Dec; 6 446-446.
  • Battaglia, S.; Maguire, O.; Thorne, J.L.; Hornung, L.B. et al. Elevated NCOR1 disrupts PPARalpha/gamma signaling in prostate cancer and forms a targetable epigenetic lesion Carcinogenesis. 2010 Sep; 31(9):1650-1660.
  • Battaglia, S.; Maguire, O.; Campbell, M.J. Transcription factor co-repressors in cancer biology: roles and targeting Int J Cancer. 2010 Jun; 126(11):2511-2519.
  • Watkins, R.J.; Read, M.L.; Smith, V.E.; Sharma, N. et al. PTTG Binding Factor – a New Gene in Breast Cancer Cancer Research. 2010 May; 70(9):3739-3749.
  • Watkins, R.J.; Read, M.L.; Smith, V.E.; Sharma, N. et al. Pituitary tumor transforming gene binding factor: a new gene in breast cancer Cancer Res. 2010 May; 70(9):3739-3749.
  • Campbell, M.J. Myeloid differentiation continues to reveal the complexity of nuclear receptor signaling Cell Cycle. 2009 Mar; 8(5):675-675.
  • Abedin, S.A.; Thorne, J.L.; Battaglia, S.; Maguire, O. et al. Elevated NCOR1 disrupts a network of dietary-sensing nuclear receptors in bladder cancer cells Carcinogenesis. 2009 Mar; 30(3):449-456.
  • Thorne, J.L.; Campbell, M.J.; Turner, B.M. Transcription factors, chromatin and cancer International Journal of Biochemistry and Cell Biology. 2009 Jan; 41(1):164-175.
  • Boult, J.K.R.; Tanière, P.; Hallissey, M.T.; Campbell, M.J. et al. Oesophageal adenocarcinoma is associated with a deregulation in the MYC/MAX/MAD network Br J Cancer. 2008 Jun; 98(12):1985-1992.
  • Abedin, S.A.; Thorne, J.; Battaglia, S.; Doherty, A.P. et al. Targeting Farnesoid X receptor in bladder cancer cells BJU International. 2008 Jun; 101 43-43.
  • Thorne, J.; Campbell, M.J. The vitamin D receptor in cancer Proc Nutr Soc. 2008 May; 67(2):115-127.
  • Campbell, M.J.; Carlberg, C.; Koeffler, H.P. A Role for the PPARgamma in Cancer Therapy PPAR Res. 2008 Jan; 2008 314974-314974.
  • Campbell, M. Staying power. Nature. 2007 Mar; 446(7134):468.
  • Anderson, M.R.; Harrison, R.; Atherfold, P.A.; Campbell, M.J. et al. Met receptor signaling: A key effector in esophageal adenocarcinoma Clinical Cancer Research. 2006 Oct; 12(20 PART 1):5936-5943.
  • Campbell, M.J.; Adorini, L. The vitamin D receptor as a therapeutic target Expert Opin Ther Targets. 2006 Oct; 10(5):735-748.
  • Campbell, M.J. Nuclear receptor capacity to perceive dietary signals is disrupted in solid tumours by epigenetic mechanisms Chemico-Biological Interactions. 2006 Jul; 161(3):188-188.
  • Colston, K.W.; Lowe, L.C.; Mansi, J.L.; Campbell, M.J. Vitamin D status and breast cancer risk Anticancer Research. 2006 Jul; 26(4 A):2573-2580.
  • Abedin, S.A.; Banwell, C.M.; Colston, K.W.; Carlberg, C. et al. Epigenetic corruption of VDR signalling in malignancy Anticancer Research. 2006 Jul; 26(4 A):2557-2566.
  • Abedin, S.A.; Banwell, C.M.; Colston, K.W.; Carlberg, C. et al. Epigenetic corruption of VDR signalling in malignancy Anticancer Res. 2006 Jul; 26(4A):2557-2566.
  • Colston, K.W.; Lowe, L.C.; Mansi, J.L.; Campbell, M.J. Vitamin D status and breast cancer risk Anticancer Res. 2006 Jul; 26(4A):2573-2580.
  • Abedin, S.A.; Veerakumarasivam, A.; Kelly, J.; Neal, D.E. et al. Targeting novel nuclear receptors with histone deacetylase inhibitor combination therapy in bladder cancer European Urology Supplements. 2006 Apr; 5(2):36-36.
  • Banwell, C.M.; McCartney, D.P.; Guy, M.; Miles, A.E. et al. Elevated expression of the nuclear receptor co-repressor (NCoR1) attenuates vitamin D receptor signaling in breast cancer cells Clinical Cancer Research. 2006 Apr; 12(7):2004-2013.
  • Banwell, C.M.; MacCartney, D.P.; Guy, M.; Miles, A.E. et al. Altered nuclear receptor corepressor expression attenuates vitamin D receptor signaling in breast cancer cells Clinical Cancer Research. 2006 Apr; 12(7 I):2004-2013.
  • Yee, S.W.; Campbell, M.J.; Simons, C. Inhibition of Vitamin D<inf>3</inf> metabolism enhances VDR signalling in androgen-independent prostate cancer cells Journal of Steroid Biochemistry and Molecular Biology. 2006 Mar; 98(4-5):228-235.
  • Campbell, M.J.; Abedin, S.A. Vitamin D and cancer Expert Rev Endocrinol Metab. 2006 Mar; 1(2):219-231.
  • Abedin, S.A.; Gommersall, L.M.; Banwell, C.M.; Colston, K.W. et al. Epigenetic disruption of VDR signaling in solid tumors Anticancer Research. 2006 Jan; Jul-Aug;26(4A):2573-2580.
  • Saramäki, A.; Banwell, C.M.; Campbell, M.J.; Carlberg, C. Regulation of the human p21(waf1/cip1) gene promoter via multiple binding sites for p53 and the vitamin D3 receptor Nucleic Acids Res. 2006 Jan; 34(2):543-554.
  • Towsend, K.; Trevino, V.; Falciani, F.; Stewart, P.M. et al. Identification of VDR-responsive gene signatures in breast cancer cells Oncology. 2006 Jan; 71(1-2):111-123.
  • Townsend, K.; Evans, K.N.; Campbell, M.J.; Colston, K.W. et al. Biological actions of extra-renal 25-hydroxyvitamin D-1alpha-hydroxylase and implications for chemoprevention and treatment J Steroid Biochem Mol Biol. 2005 Oct; 97(1-2):103-109.
  • Townsend, K.; Banwell, C.M.; Guy, M.; Colston, K.W. et al. Autocrine metabolism of vitamin D in normal and malignant breast tissue Clin Cancer Res. 2005 May; 11(9):3579-3586.
  • Boult, J.K.R.; Bury, J.P.; Bullock, A.J.; Campbell, M.J. et al. Regulation of the MYC network in the progression to oesophageal adenocarcinoma GUT. 2005 Apr; 54 A87-A87.
  • Lansky, E.P.; Jiang, W.; Mo, H.; Bravo, L. et al. Possible synergistic prostate cancer suppression by anatomically discrete pomegranate fractions Invest New Drugs. 2005 Jan; 23(1):11-20.
  • Townsend, K.; Guy, M.; Campbell, M.J.; Mansi, J.L. et al. Expression of 25-hydroxyvitamin D-3-1 alpha-hydroxylase (CYP27B1) is increased in breast tumors compared to paired normals Journal of Bone and Mineral Research. 2004 Oct; 19 S123-S123.
  • Khanim, F.L.; Gommersall, L.M.; Wood, V.H.J.; Smith, K.L. et al. Altered SMRT levels disrupt vitamin D3 receptor signalling in prostate cancer cells Oncogene. 2004 Sep; 23(40):6712-6725.
  • Lowe, L.C.; Guy, M.; Townsend, K.; Campbell, M.J. et al. Low 25 hydroxyvitamin D-3 levels and breast cancer risk in a UK Caucasian population British Journal of Cancer. 2004 Jul; 91 S25-S25.
  • Gommersall, L.M.; Albrecht, M.; Jiang, W.G.; Kumi-Diaka, J. et al. Novel anticancer properties of pomegranate extracts; Suppression of proliferation, invasion and xenograft growth of human prostate cancer cells British Journal of Cancer. 2004 Jul; 91 S58-S58.
  • Banwell, C.M.; Vaisanen, S.; Guy, M.; Colston, K.W. et al. NCOR1 is frequently elevated in breast cancer cells; Molecular and clinical significance British Journal of Cancer. 2004 Jul; 91 S22-S22.
  • Ma, J.F.; Nonn, L.; Campbell, M.J.; Hewison, M. et al. Mechanisms of decreased Vitamin D 1alpha-hydroxylase activity in prostate cancer cells Mol Cell Endocrinol. 2004 Jun; 221(1-2):67-74.
  • Gommersall, L.M.; Khanim, F.L.; Peehl, D.M.; Doherty, A.H. et al. Epigenetic repression of transcription by the Vitamin D3 receptor in prostate cancer cells J Steroid Biochem Mol Biol. 2004 May; 89-90(1-5):251-256.
  • Banwell, C.M.; O'Neill, L.P.; Uskokovic, M.R.; Campbell, M.J. Targeting 1alpha,25-dihydroxyvitamin D3 antiproliferative insensitivity in breast cancer cells by co-treatment with histone deacetylation inhibitors J Steroid Biochem Mol Biol. 2004 May; 89-90(1-5):245-249.
  • Gommersall, L.; Marsden, E.; Doherty, A.; Pheel, D. et al. 83 Targeted disruption of receptor signalling in prostate cancer European Urology Supplements. 2004 Feb; 3(2):23-23.
  • Albrecht, M.; Jiang, W.; Kumi-Diaka, J.; Lansky, E.P. et al. Pomegranate extracts potently suppress proliferation, xenograft growth, and invasion of human prostate cancer cells J Med Food. 2004 Jan; 7(3):274-283.
  • Albrecht, M.; Jiang, W.G.; Kumi-Diaka, J.; Lansky, E.P. et al. Pomegranate extracts potently suppress proliferation, xenograft growth, and invasion of human prostate cancer cells Journal of Medicinal Food. 2004 Jan; 7(3):274-283.
  • Gommersall, L.M.; Albrecht, M.; Jiang, W.; Lansky, E.P. et al. Pomegranate extracts potently suppress proliferation, xenograft growth and invasion of human prostate cancer cells European Urology Supplements. 2003 Sep; 2(6):138-138.
  • Banwell, C.M.; O'Neill, L.P.; Campbell, M.J. Vitamin D receptor signalling is corrupted in breast cancer cells via a histone deacetylation mechansim British Journal of Cancer. 2003 Jul; 88 S59-S59.
  • Banwell, C.M.; Moore, J.S.; O'Neill, L.P.; Turner, B.M. et al. Suppression of vitamin D signaling in breast cancer cells involves silencing of p21(WAF1/CIP1) through aberrant histone deactylase activity Recent Results in Cancer Research. 2003 Jan; 164 83-98.
  • Banwell, C.M.; Singh, R.; Stewart, P.M.; Uskokovic, M.R. et al. Antiproliferative signalling by 1,25(OH)2D3 in prostate and breast cancer is suppressed by a mechanism involving histone deacetylation Recent Results Cancer Res. 2003 Jan; 164 83-98.
  • Banwel, C.M.; Singh, R.; Stewart, P.M.; Uskokovic, M.R. et al. 1 Molecular Biology of Vitamin D-Antiproliferative Signalling by 1, 25 (OH) 2D3 in Prostate and Breast Cancer Is Suppressed by a Mechanism Involving Histone Deacetylation Recent Results in Cancer Research. 2003 Jan; 164 83-98.
  • Campbell, M.J.; Scott, J.; Seo, T.; Maecker, H.T. et al. Intracellular cytokine profile of T cells from women with breast cancer: immune dysfunction and micrometastases Breast Cancer Research and Treatment. 2002 Dec; 76 S80-S80.
  • Kállay, E.; Adlercreutz, H.; Farhan, H.; Lechner, D. et al. Phytoestrogens Regulate Vitamin D Metabolism in the Mouse Colon: Relevance for Colon Tumor Prevention and Therapy The Journal of Nutrition. 2002 Nov; 132(11):3490S-3493S.
  • Miles, A.; Singh, R.; Colston, K.; Reddy, S.G. et al. The role of 25(OH)D-3-24-hydroxylase mediated metabolism of 1 alpha,25(OH)(2)D-3 in the growth of cancer cells Anti-Cancer Drugs. 2002 Jun; 13(5):A5-A5.
  • Khanim, F.; Banwell, C.M.; Montalvo, L.; Smith, D.L. et al. Suppression of vitamin D-3 signalling by aberrant histone deacetylation Anti-Cancer Drugs. 2002 Jun; 13(5):A4-A5.
  • Campbell, M.J.; Haleagrahara, N.; Jackie, T.; Chakravarthi, S. et al. Automated assays for superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase activity International Journal of Pharmacology. 2002 Jan; 7(2):803-811.
  • Smith, K.L.; O'Neill, L.P.; Turner, B.M.; Campbell, M.J. Suppression of vitamin D signalling in prostate cancer by a mechanism involving histone deacetylation British Journal of Cancer. 2001 Jul; 85 19-19.
  • Miles, A.E.; Moore, J.S.; Ng, F.L.; Colston, K.W. et al. CYP24 action in breast cancer cells British Journal of Cancer. 2001 Jul; 85 46-46.
  • Rashid, S.F.; Moore, J.S.; Walker, E.; Driver, P.M. et al. Synergistic growth inhibition of prostate cancer cells by 1α,25 Dihydroxyvitamin D3 and its 19-nor-hexafluoride analogs in combination with either sodium butyrate or trichostatin A Oncogene. 2001 Apr; 20(15):1860-1872.
  • Rashid, S.F.; Mountford, J.C.; Gombart, A.F.; Campbell, M.J. 1alpha,25-dihydroxyvitamin D(3) displays divergent growth effects in both normal and malignant cells Steroids. 2001 Mar; 66(3-5):433-440.
  • Rao, D.S.; Campbell, M.J.; Koeffler, H.P.; Ishizuka, S. et al. Metabolism of 1alpha,25-dihydroxyvitamin D(3) in human promyelocytic leukemia (HL-60) cells: in vitro biological activities of the natural metabolites of 1alpha,25-dihydroxyvitamin D(3) produced in HL-60 cells Steroids. 2001 Mar; 66(3-5):423-431.
  • Uskokovic, M.R.; Norman, A.W.; Manchand, P.S.; Studzinski, G.P. et al. Highly active analogs of 1alpha,25-dihydroxyvitamin D(3) that resist metabolism through C-24 oxidation and C-3 epimerization pathways Steroids. 2001 Mar; 66(3-5):463-471.
  • Rashid, S.F.; Mountford, J.; Gombart, A.F.; Campbell, M.J. The C-24 metabolites of 1,25 dihydroxyvitamin D3 display divergent growth effects in both normal and malignant cells. Chemistry and Biology of Vitamin D Analogs Steroids. 2001 Jan; 66(3-5):433-440.
  • Campbell, M.J.; Gombart, A.F.; Kwok, S.H.; Park, S. et al. The anti-proliferative effects of 1alpha,25(OH)2D3 on breast and prostate cancer cells are associated with induction of BRCA1 gene expression Oncogene. 2000 Oct; 19(44):5091-5097.
  • Lee, N.E.; Williard, P.G.; Brown, A.J.; Campbell, M.J. et al. Synthesis and biological activities of the two C(23) epimers of 1α,23,25-trihydroxy-24-oxo-19-nor-vitamin D3: Novel analogs of 1α,23(S),25-trihydroxy-24-oxo-vitamin D3, a natural metabolite of 1α,25- dihydroxyvitamin D3 Steroids. 2000 May; 65(5):252-265.
  • Rao, D.S.; Campbell, M.J.; Koeffler, H.P.; Ishizuka, S. et al. Pathways of 1 alpha,25dihydroxyvitamin D-3 metabolism in human promyelocytic leukemia [HL-60] cells: In vitro biological activities of the various natural metabolites of 1 alpha,25-dihdroxyvitamin D-3 Produced in HL-60 cells Pediatric Research. 2000 Apr; 47(4):138A-138A.
  • Elstner, E.; Campbell, M.J.; Munker, R.; Shintaku, P. et al. Novel 20-epi-vitamin D3 analog combined with 9-cis-retinoic acid markedly inhibits colony growth of prostate cancer cells Prostate. 1999 Aug; 40(3):141-149.
  • Rashid, S.; Myers, V.; Engel, J.; Brown, G. et al. The anti-proliferative action of 1 alpha,25 dihydroxyvitamin D-3 in prostate cancer cells is suppressed by a mechanism involving deacetylation British Journal of Cancer. 1999 Jul; 80 26-26.
  • Campbell, M.J.; Drayson, M.T.; Durham, J.; Wallington, L. et al. Metabolism of 1α,25(OH)<inf>2</inf>D<inf>3</inf> and its 20-epi analog integrates clonal expansion, maturation and apoptosis during HL-60 cell differentiation Molecular and Cellular Endocrinology. 1999 Mar; 149(1-2):169-183.
  • Campbell, M.J.; Park, S.; Uskokovic, M.R.; Dawson, M.I. et al. Synergistic inhibition of prostate cancer cell lines by a 19-nor hexafluoride vitamin D3 analogue and anti-activator protein 1 retinoid Br J Cancer. 1999 Jan; 79(1):101-107.
  • Campbell, M.J.; Park, S.; Uskokovic, M.R.; Dawson, M.I. et al. Expression of retinoic acid receptor-beta sensitizes prostate cancer cells to growth inhibition mediated by combinations of retinoids and a 19-nor hexafluoride vitamin D3 analog Endocrinology. 1998 Apr; 139(4):1972-1980.
  • Campbell, M.J.; Dawson, M.; Koeffler, H.P. Growth inhibition of DU-145 prostate cancer cells by a Bcl-2 antisense oligonucleotide is enhanced by N-(2-hydroxyphenyl)all-trans retinamide Br J Cancer. 1998 Mar; 77(5):739-744.
  • Asou, H.; Koike, M.; Elstner, E.; Campbell, M.J. et al. 19-nor vitamin D analogs: A new class of potent inhibitors of proliferation and inducers of differentiation of human myeloid leukemia cell lines Blood. 1998 Jan; 92(7):2441-2449.
  • Koike, M.; Elstner, E.; Campbell, M.J.; Asou, H. et al. 19-nor-hexafluoride analogue of vitamin D3: a novel class of potent inhibitors of proliferation of human breast cell lines Cancer Res. 1997 Oct; 57(20):4545-4550.
  • Gombart, A.F.; Yang, R.; Campbell, M.J.; Berman, J.D. et al. Inhibition of growth of human leukemia cell lines by retrovirally expressed wild-type p16INK4A Leukemia. 1997 Oct; 11(10):1673-1680.
  • Verbeek, W.; Gombart, A.F.; Shiohara, M.; Campbell, M. et al. Vitamin D receptor: No evidence for allele-specific mRNA stability in cells which are heterozygous for the Taq I restriction enzyme polymorphism Biochemical and Biophysical Research Communications. 1997 Sep; 238(1):77-80.
  • Campbell, M.J.; Reddy, G.S.; Koeffler, H.P. Vitamin D3 analogs and their 24-oxo metabolites equally inhibit clonal proliferation of a variety of cancer cells but have differing molecular effects J Cell Biochem. 1997 Sep; 66(3):413-425.
  • Campbell, M.J.; Elstner, E.; Holden, S.; Uskokovic, M. et al. Inhibition of proliferation of prostate cancer cells by a 19-nor-hexafluoride vitamin D3 analogue involves the induction of p21waf1, p27kip1 and E-cadherin J Mol Endocrinol. 1997 Aug; 19(1):15-27.
  • Miller, C.W.; Morosetti, R.; Campbell, M.J.; Mendoza, S. et al. Integrity of the 1,25-dihydroxyvitamin D3 receptor in bone, lung, and other cancers Mol Carcinog. 1997 Aug; 19(4):254-257.
  • Umiel, T.; Campbell, M.; Cho, S.; Deem, R. et al. Potent tumoricidal effects of a human cytotoxic T-cell line (TALL-104) against prostate cancer Int J Oncol. 1997 Jun; 10(6):1125-1131.
  • Campbell, M.J.; Koeffler, H.P. Toward therapeutic intervention of cancer by vitamin D compounds J Natl Cancer Inst. 1997 Feb; 89(3):182-185.
  • Uskokovic, M.R.; Studzinski, G.P.; Gardner, J.P.; Reddy, S.G. et al. The 16-ene vitamin D analogs Current Pharmaceutical Design. 1997 Feb; 3(1):99-123.
  • Verbeek, W.; Gombart, A.F.; Shiohara, M.; Campbell, M.J. et al. Vitamin D receptor; No evidence for allele-specific mRNA stability in tumor cell lines and normal lymphocytes which are heterozygous for the Taq I restriction enzyme polymorphism Biochemical and Biophysical Research Communications. 1997 Jan; 238 77-80.
  • Miller, C.W.; Aslo, A.; Campbell, M.J.; Kawamata, N. et al. Alterations of the p15, p16,and p18 genes in osteosarcoma Cancer Genet Cytogenet. 1996 Feb; 86(2):136-142.
  • Gombart, A.F.; Campbell, M.J.; Yang, R.; Cho, S.K. et al. Retroviral transfer and expression of the human p16INK4A gene inhibits the proliferation of human leukemias Blood. 1995 Nov; 86(10):1715-1715.
  • CAMPBELL, M.J.; Walter, R.P.; Singleton, R.; Knowles, C.J. Investigation of the Stability and Selectivity of Phenylalanine Transport Across a Supported Liquid Membrane Journal of Chemical Technology and Biotechnology. 1994 Jul; 60(3):263-273.
  • Campbell, M.J.; Walter, R.P.; McLoughlin, R.; Knowles, C.J. Effect of temperature on protein conformation and activity during ultrafiltration Journal of Membrane Science. 1993 Mar; 78(1-2):35-43.
  • Read ML, Modasia B, Fletcher A, Thompson RJ, Brookes K, Rae PC, Nieto HR, Poole VL, Roberts S, Campbell MJ, Boelaert K, Turnell AS, Smith VE, Mehanna H, McCabe CJ. PTTG and PBF Functionally Interact with p53 and Predict Overall Survival in Head and Neck Cancer. Cancer Res. 2018 Oct 15;78(20):5863-5876.
  • Long MD, Singh PK, Russell JR, Llimos G, Rosario S, Rizvi A, van den Berg PR, Kirk J, Sucheston-Campbell LE, Smiraglia DJ, Campbell MJ. The miR-96 and RARγ signaling axis governs androgen signaling and prostate cancer progression. Oncogene. 2018 Aug 17.
  • Tessari A, Parbhoo K, Pawlikowski M, Fassan M, Rulli E, Foray C, Fabbri A, Embrione V, Ganzinelli M, Capece M, Campbell MJ, Broggini M, La Perle K, Farina G, Cole S, Marabese M, Hernandez M, Amann JM, Pruneri G, Carbone DP, Garassino MC, Croce CM, Palmieri D, Coppola V. RANBP9 affects cancer cells response to genotoxic stress and its overexpression is associated with worse response to platinum in NSCLC patients. Oncogene. 2018 Aug 03.
  • Campbell MJ, Trump DL. Vitamin D Receptor Signaling and Cancer. Endocrinol Metab Clin North Am. 2017 12;46(4):1009-1038.
  • Affronti HC, Long MD, Rosario SR, Gillard BM, Karasik E, Boerlin CS, Pellerite AJ, Foster BA, Attwood K, Pili R, Wilton JH, Campbell MJ, Smiraglia DJ. Dietary folate levels alter the kinetics and molecular mechanism of prostate cancer recurrence in the CWR22 model. Oncotarget. 2017 Nov 28;8(61):103758-103774.
  • Long MD, Campbell MJ. Integrative genomic approaches to dissect clinically-significant relationships between the VDR cistrome and gene expression in primary colon cancer. J Steroid Biochem Mol Biol. 2017 10;173:130-138.
  • Campbell MJ. Bioinformatic approaches to interrogating vitamin D receptor signaling. Mol Cell Endocrinol. 2017 09 15;453:3-13.
  • Long MD, Smiraglia DJ, Campbell MJ. The Genomic Impact of DNA CpG Methylation on Gene Expression; Relationships in Prostate Cancer. Biomolecules. 2017 02 14;7(1).
  • Singh PK, van den Berg PR, Long MD, Vreugdenhil A, Grieshober L, Ochs-Balcom HM, Wang J, Delcambre S, Heikkinen S, Carlberg C, Campbell MJ, Sucheston-Campbell LE. Integration of VDR genome wide binding and GWAS genetic variation data reveals co-occurrence of VDR and NF-κB binding that is linked to immune phenotypes. BMC Genomics. 2017 02 06;18(1):132.