Mark Drew

Mark Drew, PhD

Title
Research Assistant Professor
Unit / Department / Division
Medicinal Chemistry and Pharmacognosy
Address
792 Biomedical Research Tower
Email Address
Phone Number

Education

  • 2002, Ph.D., Johns Hopkins University, School of Medicine
  • 1991, B.A., Seattle Pacific University

Honors

  • Nominated as 2010 Distinguished Undergraduate Mentor,

Journal Articles

  • Walker, DM, Mahfooz, N, Kemme, KA, Patel, VC, Spangler, M, Drew, ME.. "Plasmodium falciparum Erythrocytic Stage Parasites Require the Putative Autophagy Protein PfAtg7 for Normal Growth." PLoS ONE. Vol. 8, (June 2013.): e67047-.
  • Harris, MT, Walker, DM, Drew, ME, Mitchell, WG, Dao, K, Schroeder, CE, Flaherty, DP, Weiner, WS, Golden, JE, Morris, JC.. "Interrogating a Hexokinase-Selected Small-Molecule Library for Inhibitors of Plasmodium falciparum Hexokinase." Antimicrobial Agents and Chemotherapy. Vol. 57, (May 2013.): 3731-7.
  • Endeshaw,Molla; Zhu,Xiaohua; He,Shanshan; Pandharkar,Trupti; Cason,Emily; Mahasenan,Kiran,V; Agarwal,Hitesh; Li,Chenglong; Munde,Manoj; Wilson,W,David; Bahar,Mark; Doskotch,Raymond,W; Kinghorn,A,Douglas; Kaiser,Marcel; Brun,Reto; Drew,Mark,E; Werbovetz,Karl,A. "8,8-Dialkyldihydroberberines with Potent Antiprotozoal Activity." JOURNAL OF NATURAL PRODUCTS. Vol. 76, no. 3. (March 2013.): 311-315.
  • Endeshaw, M, Zhu, X, He, S, Pandharkar, T, Cason, E, Mahasenan, KV, Agarwal, H, Li, C, Munde, M, Wilson, WD, Bahar, M, Doskotch, RW, Kinghorn, AD, Kaiser, M, Brun, R, Drew, ME, Werbovetz, KA.. "8,8-dialkyldihydroberberines with potent antiprotozoal activity." Journal of Natural Products. Vol. 76, (March 2013.): 311-5.
  • He S, Werbovetz KA, Drew ME. "The induction of oxidative stress in T. brucei by the antitrypanosomal dihydroquinolone OSU-40." Antimicrobial Agents and Chemotherapy. (February 2012.): -.
  • Abandeh FI, Drew ME, Sopirala MM. "Carbapenem-Hydrolyzing Gram-Negative Bacteria: Current Options for Treatment and Review of Drugs in Development." Recent Patents on Anti-Infective Drug Discovery. (January 2012.): -.
  • Bahar M, Deng Y, Zhu X, He S, Pandharkar T, Drew ME, Navarro-Vázquez A, Anklin C, Gil RR, Doskotch RW, Werbovetz KA, Kinghorn AD. "Potent antiprotozoal activity of a novel semi-synthetic berberine derivative." Bioorganic and Medicinal Chemistry Letters. Vol. 9, no. 21. (May 2011.): 2606-2610.
  • Drew,Mark,E; Banerjee,Ritu; Uffman,Eric,W; Gilbertson,Scott; Rosenthal,Philip,J; Goldberg,Daniel,E. "Plasmodium food vacuole plasmepsins are activated by falcipains." JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 283, no. 19. (May 2008.): 12870-12876.
  • Drew, Mark, E; Banerjee, Ritu; Uffman, Eric, W; Gilbertson, Scott; Rosenthal, Philip, J; Goldberg, Daniel E. "Plasmodium food vacuole plasmepsins are activated by falcipains.." The Journal of biological chemistry. Vol. 283, no. 19. (January 2008.): 12870-6.
  • Motyka, Shawn, A; Drew, Mark, E; Yildirir, Gokben; Englund, Paul T. "Overexpression of a cytochrome b5 reductase-like protein causes kinetoplast DNA loss in Trypanosoma brucei.." The Journal of biological chemistry. Vol. 281, no. 27. (January 2006.): 18499-506.
  • Liu, Jun; Gluzman, Ilya, Y; Drew, Mark, E; Goldberg, Daniel E. "The role of Plasmodium falciparum food vacuole plasmepsins.." The Journal of biological chemistry. Vol. 280, no. 2. (January 2005.): 1432-7.
  • Drew, Mark, E; Morris, James, C; Wang, Zefeng; Wells, Lance; Sanchez, Marco; Landfear, Scott, M; Englund, Paul T. "The adenosine analog tubercidin inhibits glycolysis in Trypanosoma brucei as revealed by an RNA interference library.." The Journal of biological chemistry. Vol. 278, no. 47. (January 2003.): 46596-600.
  • Wang, Zefeng; Drew, Mark, E; Morris, James, C; Englund, Paul T. "Asymmetrical division of the kinetoplast DNA network of the trypanosome.." The EMBO journal. Vol. 21, no. 18. (January 2002.): 4998-5005.
  • Morris, James, C; Wang, Zefeng; Drew, Mark, E; Englund, Paul T. "Glycolysis modulates trypanosome glycoprotein expression as revealed by an RNAi library.." The EMBO journal. Vol. 21, no. 17. (January 2002.): 4429-38.
  • Grams, Jayleen; Morris, James, C; Drew, Mark, E; Wang, Zefeng; Englund, Paul, T; Hajduk, Stephen L. "A trypanosome mitochondrial RNA polymerase is required for transcription and replication.." The Journal of biological chemistry. Vol. 277, no. 19. (January 2002.): 16952-9.
  • Drew, M, E; Englund, P T. "Intramitochondrial location and dynamics of Crithidia fasciculata kinetoplast minicircle replication intermediates.." The Journal of cell biology. Vol. 153, no. 4. (January 2001.): 735-44.
  • Morris, J, C; Drew, M, E; Klingbeil, M, M; Motyka, S, A; Saxowsky, T, T; Wang, Z; Englund, P T. "Replication of kinetoplast DNA: an update for the new millennium.." International journal for parasitology. Vol. 31, no. 5-6. (January 2001.): 453-8.
  • Abu-Elneel, K; Robinson, D, R; Drew, M, E; Englund, P, T; Shlomai, J. "Intramitochondrial localization of universal minicircle sequence-binding protein, a trypanosomatid protein that binds kinetoplast minicircle replication origins.." The Journal of cell biology. Vol. 153, no. 4. (January 2001.): 725-34.
  • Morris, J, C; Wang, Z; Drew, M, E; Paul, K, S; Englund, P T. "Inhibition of bloodstream form Trypanosoma brucei gene expression by RNA interference using the pZJM dual T7 vector.." Molecular and biochemical parasitology. Vol. 117, no. 1. (January 2001.): 111-3.
  • Klingbeil, M, M; Drew, M, E; Liu, Y; Morris, J, C; Motyka, S, A; Saxowsky, T, T; Wang, Z; Englund, P T. "Unlocking the secrets of trypanosome kinetoplast DNA network replication.." Protist. Vol. 152, no. 4. (January 2001.): 255-62.
  • Wang, Z; Morris, J, C; Drew, M, E; Englund, P T. "Inhibition of Trypanosoma brucei gene expression by RNA interference using an integratable vector with opposing T7 promoters.." The Journal of biological chemistry. Vol. 275, no. 51. (January 2000.): 40174-9.
  • Carter, N, S; Drew, M, E; Sanchez, M; Vasudevan, G; Landfear, S, M; Ullman, B. "Cloning of a novel inosine-guanosine transporter gene from Leishmania donovani by functional rescue of a transport-deficient mutant.." The Journal of biological chemistry. Vol. 275, no. 27. (January 2000.): 20935-41.
  • Vasudevan, G; Carter, N, S; Drew, M, E; Beverley, S, M; Sanchez, M, A; Seyfang, A; Ullman, B; Landfear, S M. "Cloning of Leishmania nucleoside transporter genes by rescue of a transport-deficient mutant.." Proceedings of the National Academy of Sciences of the United States of America. Vol. 95, no. 17. (January 1998.): 9873-8.
  • Klamo, E, M; Drew, M, E; Landfear, S, M; Kavanaugh, M P. "Kinetics and stoichiometry of a proton/myo-inositol cotransporter.." The Journal of biological chemistry. Vol. 271, no. 25. (January 1996.): 14937-43.
  • Feagin, J, E; Drew, M E. "Plasmodium falciparum: alterations in organelle transcript abundance during the erythrocytic cycle.." Experimental parasitology. Vol. 80, no. 3. (January 1995.): 430-40.
  • Langford, C, K; Kavanaugh, M, P; Stenberg, P, E; Drew, M, E; Zhang, W; Landfear, S M. "Functional expression and subcellular localization of a high-Km hexose transporter from Leishmania donovani.." Biochemistry. Vol. 34, no. 37. (January 1995.): 11814-21.
  • Drew, M, E; Langford, C, K; Klamo, E, M; Russell, D, G; Kavanaugh, M, P; Landfear, S M. "Functional expression of a myo-inositol/H+ symporter from Leishmania donovani.." Molecular and cellular biology. Vol. 15, no. 10. (January 1995.): 5508-15.