Pharmaceutics and Pharmacology

Jeffrey Johnston

Jeffrey Johnston
Senior Lecturer
Pharmaceutics and Pharmacology
johnston.14@osu.edu
(614) 292-2607
2002, PhD, The Ohio State University, Pharmaceutics
1993, BS, The Ohio State University, Microbiology
Walker AR, Klisovic R, Johnston JS, Jiang Y, Geyer S, Kefauver C, Binkley P, Byrd JC, Grever MR, Garzon R, Phelps MA, Marcucci G, Blum KA, Blum W. Pharmacokinetics and dose escalation of the heat shock protein inhibitor 17-allyamino-17-demethoxygeldanamycin in combination with bortezomib in relapsed or refractory acute myeloid leukemia. Leuk Lymphoma. 2013 Sep;54(9):1996-2002. doi: 10.3109/10428194.2012.760733. Epub 2013 Jan 24. PMID: 23256542; PMCID: PMC3860322.
Poi MJ, Hofmeister CC, Johnston JS, Edwards RB, Jansak BS, Lucas DM, Farag SS, Dalton JT, Devine SM, Grever MR, Phelps MA. Standard pentostatin dose reductions in renal insufficiency are not adequate: selected patients with steroid-refractory acute graft-versus-host disease. Clin Pharmacokinet. 2013 Aug;52(8):705-12. doi: 10.1007/s40262-013-0064-7. PMID: 23588536; PMCID: PMC3720841.
Baiocchi RA, Alinari L, Lustberg ME, Lin TS, Porcu P, Li X, Johnston JS, Byrd JC, Blum KA. Phase 2 trial of rituximab and bortezomib in patients with relapsed or refractory mantle cell and follicular lymphoma. Cancer. 2011 Jun 1;117(11):2442-51. doi: 10.1002/cncr.25792. Epub 2010 Dec 14. PMID: 24048792; PMCID: PMC3116936.
Knoell DL, Johnston JS, Bao S, Kelley KA. A genotyping exercise for pharmacogenetics in pharmacy practice. Am J Pharm Educ. 2009 May 27;73(3):43. doi: 10.5688/aj730343. PMID: 19564986; PMCID: PMC2703267.
Alinari L, White VL, Earl CT, Ryan TP, Johnston JS, Dalton JT, Ferketich AK, Lai R, Lucas DM, Porcu P, Blum KA, Byrd JC, Baiocchi RA. Combination bortezomib and rituximab treatment affects multiple survival and death pathways to promote apoptosis in mantle cell lymphoma. MAbs. 2009 Jan-Feb;1(1):31-40. doi: 10.4161/mabs.1.1.7472. PMID: 20046572; PMCID: PMC2715189.
Johnston JS, Phelps MA, Blum KA, Blum W, Grever MR, Farley KL, Dalton JT. Development and validation of a rapid and sensitive high-performance liquid chromatography-mass spectroscopy assay for determination of 17-(allylamino)-17-demethoxygeldanamycin and 17-(amino)-17-demethoxygeldanamycin in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Aug 1;871(1):15-21. doi: 10.1016/j.jchromb.2008.06.029. Epub 2008 Jun 26. PMID: 18635408; PMCID: PMC3782378.
Phelps MA, Rozewski DM, Johnston JS, Farley KL, Albanese KA, Byrd JC, Lin TS, Grever MR, Dalton JT. Development and validation of a sensitive liquid chromatography/mass spectrometry method for quantitation of flavopiridol in plasma enables accurate estimation of pharmacokinetic parameters with a clinically active dosing schedule. J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Jun 1;868(1-2):110-5. doi: 10.1016/j.jchromb.2008.04.023. Epub 2008 Apr 22. PMID: 18490204; PMCID: PMC2504738.
Gao W, Johnston JS, Miller DD, Dalton JT. Interspecies differences in pharmacokinetics and metabolism of S-3-(4-acetylamino- phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethylphenyl)-propionamide: the role of N-acetyltransferase. Drug Metab Dispos. 2006 Feb;34(2):254-60. doi: 10.1124/dmd.105.007120. Epub 2005 Nov 4. PMID: 16272403; PMCID: PMC2039883.
Johnston JS, Johnson A, Gan Y, Wientjes MG, Au JL. Synergy between 3'-azido-3'-deoxythymidine and paclitaxel in human pharynx FaDu cells. Pharm Res. 2003 Jul;20(7):957-61. doi: 10.1023/a:1024431218327. PMID: 12880279.

Keli Hu

Headshot of Keli Hu
Keli Hu
Associate Professor
Pharmaceutics and Pharmacology
Research Areas
Cardiovascular Disorders,
Pharmaceutics & Pharmacology
530 Parks Hall
hu.175@osu.edu
(614) 292-5433
The long-term research goal in Dr. Hu's laboratory is to understand the mechanisms in myocardial ischemia and cardioprotection. The lab is particularly interested in studying the regulation of ion channels and their signaling molecules in the cardiovascular system, with a special emphasis on subcellular localization, traffic regulation, molecular mechanisms and their physiological relevance, particularly as these processes relate to human cardiovascular diseases. The ultimate goal is to explore the challenges in identifying therapeutic targets and to help developing preventive and therapeutic strategies for cardiovascular diseases.
Postdoctoral Fellow, VA New York Harbor Healthcare System/University of California San Francisco, USA
PhD, Pharmacology, McGill University, Canada
MD, Xiangya College of Medicine, Central South University, China
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85115623480&partnerID=MN8TOARS' target='_blank' class='bux-link'>TASK-1 regulates mitochondrial function under hypoxia</a>, Biochemical and Biophysical Research Communications. 2021 Jan | journal-article. doi: 10.1016/j.bbrc.2021.09.032.
<a href='https://doi.org/10.1016/j.bbamcr.2017.06.016' target='_blank' class='bux-link'>Functional interaction of the two-pore domain potassium channel TASK-1 and caveolin-3.</a>, Biochimica et biophysica acta. Molecular cell research. 2017 Jun | journal-article. doi: 10.1016/j.bbamcr.2017.06.016.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85007572131&partnerID=MN8TOARS' target='_blank' class='bux-link'>Regulation of protein kinase C-epsilon and its age-dependence</a>, Biochemical and Biophysical Research Communications. 2017 Jan | journal-article. doi: 10.1016/j.bbrc.2016.12.012.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84956648784&partnerID=MN8TOARS' target='_blank' class='bux-link'>Endurance exercise accelerates myocardial tissue oxygenation recovery and reduces ischemia reperfusion injury in mice</a>, PLoS ONE. 2014 Jan | journal-article. doi: 10.1371/journal.pone.0114205.
<a href='https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23420830/?tool=EBI' target='_blank' class='bux-link'>MOG1 rescues defective trafficking of Na(v)1.5 mutations in Brugada syndrome and sick sinus syndrome.</a>, Circulation. Arrhythmia and electrophysiology. 2013 Feb | journal-article. doi: 10.1161/circep.111.000206.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84868517764&partnerID=MN8TOARS' target='_blank' class='bux-link'>GLUT12 functions as a basal and insulin-independent glucose transporter in the heart</a>, Biochimica et Biophysica Acta - Molecular Basis of Disease. 2013 Jan | journal-article. doi: 10.1016/j.bbadis.2012.09.013.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84862820687&partnerID=MN8TOARS' target='_blank' class='bux-link'>Molecular mechanism underlying adenosine receptor-mediated mitochondrial targeting of protein kinase C</a>, Biochimica et Biophysica Acta - Molecular Cell Research. 2012 Jan | journal-article. doi: 10.1016/j.bbamcr.2011.12.012.
<a href='https://doi.org/10.1159/000303045' target='_blank' class='bux-link'>Role for SUR2A in coupling cardiac K(ATP) channels to caveolin-3.</a>, Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2010 Mar | journal-article. doi: 10.1159/000303045.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-77949502858&partnerID=MN8TOARS' target='_blank' class='bux-link'>Peroxynitrite-mediated oxidative modifications of complex II: Relevance in myocardial infarction</a>, Biochemistry. 2010 Jan | journal-article. doi: 10.1021/bi9018237.
<a href='https://doi.org/10.1016/j.bbamcr.2009.10.007' target='_blank' class='bux-link'>Adenosine A(1) receptors selectively target protein kinase C isoforms to the caveolin-rich plasma membrane in cardiac myocytes.</a>, Biochimica et biophysica acta. 2009 Oct | journal-article. doi: 10.1016/j.bbamcr.2009.10.007.
<a href='https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19851835/?tool=EBI' target='_blank' class='bux-link'>Opening of the mitoKATP channel and decoupling of mitochondrial complex II and III contribute to the suppression of myocardial reperfusion hyperoxygenation.</a>, Molecular and cellular biochemistry. 2009 Oct | journal-article. doi: 10.1007/s11010-009-0283-2.
<a href='https://doi.org/10.1016/j.bbrc.2009.05.100' target='_blank' class='bux-link'>Caveolin-3 negatively regulates recombinant cardiac K(ATP) channels.</a>, Biochemical and biophysical research communications. 2009 May | journal-article. doi: 10.1016/j.bbrc.2009.05.100.
<a href='https://doi.org/10.1093/cvr/cvp039' target='_blank' class='bux-link'>Regulation of ATP-sensitive K+ channels by caveolin-enriched microdomains in cardiac myocytes.</a>, Cardiovascular research. 2009 Jan | journal-article. doi: 10.1093/cvr/cvp039.
<a href='https://doi.org/10.1161/HYPERTENSIONAHA.108.110817' target='_blank' class='bux-link'>Protein kinase C-epsilon induces caveolin-dependent internalization of vascular adenosine 5'-triphosphate-sensitive K+ channels.</a>, Hypertension (Dallas, Tex. : 1979). 2008 Jul | journal-article. doi: 10.1161/hypertensionaha.108.110817.
<a href='https://doi.org/10.1093/cvr/cvm028' target='_blank' class='bux-link'>Novel functional role of heat shock protein 90 in ATP-sensitive K+ channel-mediated hypoxic preconditioning.</a>, Cardiovascular research. 2007 Oct | journal-article. doi: 10.1093/cvr/cvm028.
<a href='https://doi.org/10.1152/ajpheart.01035.2006' target='_blank' class='bux-link'>Protein kinase C isoform-dependent modulation of ATP-sensitive K+ channels in mitochondrial inner membrane.</a>, American journal of physiology. Heart and circulatory physiology. 2007 Mar | journal-article. doi: 10.1152/ajpheart.01035.2006.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-3843085271&partnerID=MN8TOARS' target='_blank' class='bux-link'>Functional basis of sinus bradycardia in congenital heart block.</a>, Circulation research. 2004 Jan | journal-article. doi: 10.1161/01.res.0000121566.01778.06.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-0037566573&partnerID=MN8TOARS' target='_blank' class='bux-link'>ATP-sensitive potassium channel traffic regulation by adenosine and protein kinase C</a>, Neuron. 2003 Jan | journal-article. doi: 10.1016/S0896-6273(03)00256-3.
<a href='https://doi.org/10.1006/jaut.2002.0594' target='_blank' class='bux-link'>Cardiac 5-HT(4) serotoninergic receptors, 52kD SSA/Ro and autoimmune-associated congenital heart block.</a>, Journal of autoimmunity. 2002 Aug | journal-article. doi: 10.1006/jaut.2002.0594.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-0035916899&partnerID=MN8TOARS' target='_blank' class='bux-link'>Direct inhibition of expressed cardiac L- and T-type calcium channels by IgG from mothers whose children have congenital heart block</a>, Circulation. 2001 Jan | journal-article. doi: 10.1161/01.CIR.103.11.1599.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-0034917605&partnerID=MN8TOARS' target='_blank' class='bux-link'>Down-regulation of L-type calcium channel in pups born to 52 kDa SSA/Ro immunized rabbits</a>, FASEB Journal. 2001 Jan | journal-article. doi: 10.1096/fj.01-0052com.
<a href='https://doi.org/10.1152/ajpheart.2000.279.6.H2658' target='_blank' class='bux-link'>Evidence for functional role of epsilonPKC isozyme in the regulation of cardiac Ca(2+) channels.</a>, American journal of physiology. Heart and circulatory physiology. 2000 Dec | journal-article. doi: 10.1152/ajpheart.2000.279.6.h2658.
<a href='https://doi.org/10.1152/ajpheart.1999.276.2.H488' target='_blank' class='bux-link'>Adenosine-induced activation of ATP-sensitive K+ channels in excised membrane patches is mediated by PKC.</a>, The American journal of physiology. 1999 Feb | journal-article. doi: 10.1152/ajpheart.1999.276.2.h488.
<a href='https://doi.org/10.1161/01.res.78.3.492' target='_blank' class='bux-link'>Protein kinase C activates ATP-sensitive K+ current in human and rabbit ventricular myocytes.</a>, Circulation research. 1996 Mar | journal-article. doi: 10.1161/01.res.78.3.492.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-0028868582&partnerID=MN8TOARS' target='_blank' class='bux-link'>Mechanisms of ischemic preconditioning in rat hearts: Involvement of α(1B)-adrenoceptors, pertussis toxin-sensitive G proteins, and protein kinase C</a>, Circulation. 1995 Jan | journal-article. doi: 10.1161/01.CIR.92.8.2259.
<a href='' target='_blank' class='bux-link'>Thinking skill of beta-receptor blocking agent discovered by 1988 Nobel Prize Winner Dr. Black</a>, Medicine & Philosophy. 1990 Jan | journal-article. .
<a href='' target='_blank' class='bux-link'>Comparative effects of captopril, nitroprusside, dopamine and lanatoside C on a new model of rabbit congestive heart failure.</a>, Zhongguo yao li xue bao = Acta pharmacologica Sinica. 1988 Sep | journal-article. .

Kari Hoyt

Headshot of Kari Hoyt
Kari Hoyt
Professor
Kimberly Professor of Pharmacy
Pharmaceutics and Pharmacology
Research Areas
Central Nervous System Disorders,
Clinical & Pre-Clinical Pharmacology,
Pharmaceutics & Pharmacology,
Endowed Faculty
412 Riffe
hoyt.31@osu.edu
(614) 292-6636
Professional Website
Our research team members are engaged in pre-clinical target identification for pharmacologic treatment of neurodegenerative and psychiatric disorders. We use in vivo and in vitro high-resolution fluorescence microscopy and high-content analysis of live neurons to reveal complex interactions between signaling pathways that regulate cell survival/function and circadian clock signaling. This work is designed to identify new avenues of chronotherapeutic target development for CNS disorders. Current work focuses on two related themes: (1) Alzheimer’s Disease and desynchronization of cortico-limbic circadian rhythms and (2) MAPK signaling: gates, oscillators and circadian timing.
PhD, Pharmacology, University of Pittsburgh School of Medicine
Dean's Innovative Research Award, 2019
<a href='https://doi.org/10.1016/j.neuroscience.2023.02.003' target='_blank' class='bux-link'>Ribosomal S6 Kinase Regulates the Timing and Entrainment of the Mammalian Circadian Clock Located in the Suprachiasmatic Nucleus</a>, Neuroscience. 2023 Apr | journal-article. doi: 10.1016/j.neuroscience.2023.02.003.
<a href='https://doi.org/10.1371/journal.pone.0249430' target='_blank' class='bux-link'>Light-induced changes in the suprachiasmatic nucleus transcriptome regulated by the ERK/MAPK pathway</a>, PLOS ONE. 2021 Jun | journal-article. doi: 10.1371/journal.pone.0249430.
<a href='https://doi.org/10.1111/ejn.15043' target='_blank' class='bux-link'>SynGAP is expressed in the murine suprachiasmatic nucleus and regulates circadian‐gated locomotor activity and light‐entrainment capacity</a>, European Journal of Neuroscience. 2021 Feb | journal-article. doi: 10.1111/ejn.15043.
<a href='http://europepmc.org/articles/PMC6279806' target='_blank' class='bux-link'>Data highlighting the expression of two miR-132/212 target genes-Sirt1 and Pten-after chronic stress.</a>, Data in brief. 2018 Nov | journal-article. doi: 10.1016/j.dib.2018.11.042.
<a href='http://europepmc.org/abstract/med/30342060' target='_blank' class='bux-link'>miR-132/212 is induced by stress and its dysregulation triggers anxiety-related behavior.</a>, Neuropharmacology. 2018 Oct | journal-article. doi: 10.1016/j.neuropharm.2018.10.020.
<a href='http://europepmc.org/abstract/med/29661834' target='_blank' class='bux-link'>miR-132 couples the circadian clock to daily rhythms of neuronal plasticity and cognition.</a>, Learning & memory (Cold Spring Harbor, N.Y.). 2018 Apr | journal-article. doi: 10.1101/lm.047191.117.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85042161216&partnerID=MN8TOARS' target='_blank' class='bux-link'>Circadian expression and functional characterization of PEA-15 within the mouse suprachiasmatic nucleus</a>, European Journal of Neuroscience. 2018 Jan | journal-article. doi: 10.1111/ejn.13850.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85032348124&partnerID=MN8TOARS' target='_blank' class='bux-link'>Mitogen- and stress-activated protein kinase 1 regulates status epilepticus- evoked cell death in the hippocampus</a>, ASN Neuro. 2017 Jan | journal-article. doi: 10.1177/1759091417726607.
<a href='http://europepmc.org/articles/PMC5049877' target='_blank' class='bux-link'>The miR-132/212 locus: a complex regulator of neuronal plasticity, gene expression and cognition.</a>, RNA & disease (Houston, Tex.). 2016 Aug | journal-article. .
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84966659011&partnerID=MN8TOARS' target='_blank' class='bux-link'>Activation of Mitofusin2 by Smad2-RIN1 Complex during Mitochondrial Fusion</a>, Molecular Cell. 2016 Jan | journal-article. doi: 10.1016/j.molcel.2016.04.010.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84964806228&partnerID=MN8TOARS' target='_blank' class='bux-link'>Modulation of learning and memory by the targeted deletion of the circadian clock gene Bmal1 in forebrain circuits</a>, Behavioural Brain Research. 2016 Jan | journal-article. doi: 10.1016/j.bbr.2016.04.027.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84975810774&partnerID=MN8TOARS' target='_blank' class='bux-link'>Status epilepticus stimulates NDEL1 expression via the CREB/CRE pathway in the adult mouse brain</a>, Neuroscience. 2016 Jan | journal-article. doi: 10.1016/j.neuroscience.2016.06.010.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84916623167&partnerID=MN8TOARS' target='_blank' class='bux-link'>Mitogen and stress-activated kinases 1/2 regulate ischemia-induced hippocampal progenitor cell proliferation and neurogenesis</a>, Neuroscience. 2015 Jan | journal-article. doi: 10.1016/j.neuroscience.2014.10.053.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84877962497&partnerID=MN8TOARS' target='_blank' class='bux-link'>Clock and light regulation of the CREB coactivator CRTC1 in the suprachiasmatic circadian clock</a>, Journal of Neuroscience. 2013 Jan | journal-article. doi: 10.1523/JNEUROSCI.4202-12.2013.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84868661274&partnerID=MN8TOARS' target='_blank' class='bux-link'>Mitogen- and stress-activated kinases regulate progenitor cell proliferation and neuron development in the adult dentate gyrus</a>, Journal of Neurochemistry. 2012 Jan | journal-article. doi: 10.1111/jnc.12035.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-70349767918&partnerID=MN8TOARS' target='_blank' class='bux-link'>CREB is a key regulator of striatal vulnerability in chemical and genetic models of Huntington's disease</a>, Neurobiology of Disease. 2009 Jan | journal-article. doi: 10.1016/j.nbd.2009.07.014.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-59449090590&partnerID=MN8TOARS' target='_blank' class='bux-link'>The CREB/CRE transcriptional pathway: Protection against oxidative stress-mediated neuronal cell death</a>, Journal of Neurochemistry. 2009 Jan | journal-article. doi: 10.1111/j.1471-4159.2008.05864.x.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-48249155328&partnerID=MN8TOARS' target='_blank' class='bux-link'>IGF-1 receptor-mediated ERK/MAPK signaling couples status epilepticus to progenitor cell proliferation in the subgranular layer of the dentate gyrus</a>, GLIA. 2008 Jan | journal-article. doi: 10.1002/glia.20653.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-34548608676&partnerID=MN8TOARS' target='_blank' class='bux-link'>Bioenergetic and oxidative effects of free 3-nitrotyrosine in culture: Selective vulnerability of dopaminergic neurons and increased sensitivity of non-dopaminergic neurons to dopamine oxidation</a>, Journal of Neurochemistry. 2007 Jan | journal-article. doi: 10.1111/j.1471-4159.2007.04735.x.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-33846369453&partnerID=MN8TOARS' target='_blank' class='bux-link'>Cardiac dysfunction in the R6/2 mouse model of Huntington's disease</a>, Neurobiology of Disease. 2007 Jan | journal-article. doi: 10.1016/j.nbd.2006.09.016.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-34548095002&partnerID=MN8TOARS' target='_blank' class='bux-link'>Metformin therapy in a transgenic mouse model of Huntington's disease</a>, Neuroscience Letters. 2007 Jan | journal-article. doi: 10.1016/j.neulet.2006.10.039.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-33744514434&partnerID=MN8TOARS' target='_blank' class='bux-link'>A sensitive and selective assay of neuronal degeneration in cell culture</a>, Journal of Neuroscience Methods. 2006 Jan | journal-article. doi: 10.1016/j.jneumeth.2005.12.030.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-13944252487&partnerID=MN8TOARS' target='_blank' class='bux-link'>Activity-dependent neuroprotection and cAMP response element-binding protein (CREB): Kinase coupling, stimulus intensity, and temporal regulation of CREB phosphorylation at serine 133</a>, Journal of Neuroscience. 2005 Jan | journal-article. doi: 10.1523/JNEUROSCI.4288-04.2005.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-0742287915&partnerID=MN8TOARS' target='_blank' class='bux-link'>CRE-Mediated Transcription Is Increased in Huntington's Disease Transgenic Mice</a>, Journal of Neuroscience. 2004 Jan | journal-article. doi: 10.1523/JNEUROSCI.3493-03.2004.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-0038751749&partnerID=MN8TOARS' target='_blank' class='bux-link'>The ERK/MAP kinase pathway couples light to immediate-early gene expression in the suprachiasmatic nucleus</a>, European Journal of Neuroscience. 2003 Jan | journal-article. doi: 10.1046/j.1460-9568.2003.02592.x.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-0034057293&partnerID=MN8TOARS' target='_blank' class='bux-link'>Inhibition of glutamate-induced mitochondrial depolarization by tamoxifen in cultured neurons</a>, Journal of Pharmacology and Experimental Therapeutics. 2000 Jan | journal-article. .
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-0033378683&partnerID=MN8TOARS' target='_blank' class='bux-link'>Metabolic and glutamatergic disturbances in the Huntington's disease transgenic mouse</a>, Annals of the New York Academy of Sciences. 1999 Jan | book. doi: 10.1111/j.1749-6632.1999.tb07841.x.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-0031819440&partnerID=MN8TOARS' target='_blank' class='bux-link'>Alkalinization prolongs recovery from glutamate-induced increases in intracellular Ca<sup>2+</sup> concentration by enhancing Ca<sup>2+</sup> efflux through the mitochondrial Na<sup>+</sup>/Ca<sup>2+</sup> exchanger in cultured rat forebrain neurons</a>, Journal of Neurochemistry. 1998 Jan | journal-article. .
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-0031596610&partnerID=MN8TOARS' target='_blank' class='bux-link'>Reverse Na<sup>+</sup>/Ca<sup>2+</sup>exchange contributes to glutamate-induced intracellular Ca<sup>2+</sup>concentration increases in cultured rat forebrain neurons</a>, Molecular Pharmacology. 1998 Jan | journal-article. doi: 10.1124/mol.53.4.742.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-0032523737&partnerID=MN8TOARS' target='_blank' class='bux-link'>The role of intracellular Na<sup>+</sup> and mitochondria in buffering of kainate-induced intracellular free Ca<sup>2+</sup> changes in rat forebrain neurones</a>, Journal of Physiology. 1998 Jan | journal-article. doi: 10.1111/j.1469-7793.1998.103bo.x.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-0031056507&partnerID=MN8TOARS' target='_blank' class='bux-link'>Characterization of hydrogen peroxide toxicity in cultured rat forebrain neurons</a>, Neurochemical Research. 1997 Jan | journal-article. doi: 10.1023/A:1022403224901.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-0031080112&partnerID=MN8TOARS' target='_blank' class='bux-link'>Mechanisms of dopamine-induced cell death in cultured rat forebrain neurons: Interactions with and differences from glutamate-induced cell death</a>, Experimental Neurology. 1997 Jan | journal-article. doi: 10.1006/exnr.1996.6374.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-0030729437&partnerID=MN8TOARS' target='_blank' class='bux-link'>Trifluoperazine and dibucaine-induced inhibition of glutamate-induced mitochondrial depolarization in rat cultured forebrain neurones</a>, British Journal of Pharmacology. 1997 Jan | journal-article. doi: 10.1038/sj.bjp.0701442.
<a href='' target='_blank' class='bux-link'>Intracellular Signalling in Glutamate Excitotoxicity</a>, Neurodegenerative Diseases. 1996 Jan | other. doi: 10.1007/978-1-4899-0209-2_1.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-0030602914&partnerID=MN8TOARS' target='_blank' class='bux-link'>Localization of D<inf>1</inf>dopamine receptors on live cultured striatal neurons by quantitative fluorescence microscopy</a>, Brain Research. 1996 Jan | journal-article. doi: 10.1016/S0006-8993(96)00436-2.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-0028959590&partnerID=MN8TOARS' target='_blank' class='bux-link'>Cyclothiazide Modulates AMPA Receptor‐Mediated Increases in Intracellular Free Ca<sup>2+</sup> and Mg<sup>2+</sup> in Cultured Neurons from Rat Brain</a>, Journal of Neurochemistry. 1995 Jan | journal-article. doi: 10.1046/j.1471-4159.1995.64052049.x.
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Peixuan Guo

Headshot of Peixuan Guo
Peixuan Guo
Professor
Sylvan G. Frank Endowed Chair
Pharmaceutics and Pharmacology
Research Areas
Cancer,
Nanotechnology & Drug Delivery Systems,
Pharmaceutics & Pharmacology
406 Biomedical Research Tower
guo.1091@osu.edu
(614) 293-2114
Professional Website
Dr. Guo works on both basic research and its subsequent practical applications, focusing on understanding the mechanisms and assembly of viral DNA packaging motor, and using components of the biomotor for various applications. By applying interdisciplinary approaches including chemistry, biophysics, biochemistry, nanotechnology, bioengineering, molecular biology, cell biology, computer modeling, and pharmaceutical sciences, Dr. Guo studies RNA, DNA and proteins and their interaction.

Dr. Guo’s current project areas are:

RNA nanotechnology and its application for the delivery of siRNA/miRNA/drug for the treatment of cancers, viral infection, and genetic diseases
Nanobiotechnology, including structure, function and mechanism of Phi29 DNA-packaging nanomotor
Single molecule imaging and optical instrumentation to study the interaction of RNA, DNA, and protein
Single pore technology for DNA sequencing, macromolecule detection, and disease diagnosis, using channels of variety of viral DNA packaging motors

Dr. Peixuan Guo, a pioneer of RNA nanotechnology, has held three endowed chair positions at three different prestigious universities, and currently is the Sylvan G. Frank Endowed Chair in Pharmaceutics and Drug Delivery and the director of the Center for RNA Nanobiotechnology and Nanomedicine at The Ohio State University. He is the president of the International Society of RNA Nanotechnology and Nanomedicine. He received his Ph.D. from U Minnesota in 1987 and conducted his postdoc at NIH under Bernard Moss. He joined Purdue University in 1990, tenured in 1993 and became a full professor in 1997, honored as a Purdue Distinguished Faculty Scholar in 1998. He served as the Director of the NIH Nanomedcine Develoment Center (NDC) from 2006-2011, was the Director of NCI Cancer Nanotech Platform Partnership Program from 2012-2017. To date, Dr. Guo invented 70 patents (13 granted and 57 in Provisional and PCT). He received the 2021 Innovator of the Year Award at The Ohio State University and was elected as a NAI Fellow in 2022.  

Support Staff: Cheyenne Wagner, Wagner.1330@osu.edu

1990, Postdoctoral Training Molecular Virology, National Institutes of Health, Bethesda, MD
1989, Postdoctoral Training Molecular Virology, New York State Department of Health
1987, PhD Microbiology & Genetics, University of Minnesota, Minneapolis, MN
Fellow of the National Academy of Inventors (NAI)
Director of Center for RNA Nanobiotechnology and Nanomedicine
President of International Society of RNA Nanotechnology and Nanomedicine
International Society of RNA Nanotechnology and Nanomedicine
Fellow of the National Academy of Inventors (NAI), 2022
Distinguished Chinese Alumni of the University of Minnesota, 2014
Distinguished Research Award, University of Cincinnati, 2010, 2011
Distinguished Alumni of The University of Minnesota, 2009
Lions Club Award for Cancer Research Excellence, 2006
One of five finalists for Feynman (Nobel Prize Laureate) Nanotechnology Award, 2005
Seed Award, 2005, 2006, 2007
Purdue Faculty Scholar, 1999-2004
Pfizer Distinguished Faculty Award for Research Excellence, 1995
First Award, NIH, USA, 1993
<a href='http://dx.doi.org/10.1016/j.biomaterials.2023.122432' target='_blank' class='bux-link'>RNA four-way junction (4WJ) for spontaneous cancer-targeting, effective tumor-regression, metastasis suppression, fast renal excretion and undetectable toxicity</a>, Biomaterials. 2024 Mar | journal-article. doi: 10.1016/j.biomaterials.2023.122432.
<a href='http://dx.doi.org/10.1021/acs.molpharmaceut.3c00845' target='_blank' class='bux-link'>In Vitro and In Vivo Evaluation of the Pathology and Safety Aspects of Three- and Four-Way Junction RNA Nanoparticles</a>, Molecular Pharmaceutics. 2024 Jan | journal-article. doi: 10.1021/acs.molpharmaceut.3c00845.
<a href='http://dx.doi.org/10.1016/j.omtn.2023.07.027' target='_blank' class='bux-link'>Targeting oncogenic KRAS in non-small cell lung cancer with EGFR aptamer-conjugated multifunctional RNA nanoparticles</a>, Molecular Therapy - Nucleic Acids. 2023 Sep | journal-article. doi: 10.1016/j.omtn.2023.07.027.
<a href='http://dx.doi.org/10.1016/j.omtn.2023.07.013' target='_blank' class='bux-link'>Tumor targeting and therapeutic assessments of RNA nanoparticles carrying α9-nAChR aptamer and anti-miR-21 in triple-negative breast cancers</a>, Molecular Therapy - Nucleic Acids. 2023 Sep | journal-article. doi: 10.1016/j.omtn.2023.07.013.
<a href='http://dx.doi.org/10.1016/j.nano.2023.102667' target='_blank' class='bux-link'>Ligand-displaying-exosomes using RNA nanotechnology for targeted delivery of multi-specific drugs for liver cancer regression</a>, Nanomedicine: Nanotechnology, Biology and Medicine. 2023 Jun | journal-article. doi: 10.1016/j.nano.2023.102667.
<a href='http://dx.doi.org/10.1016/j.isci.2023.106922' target='_blank' class='bux-link'>Revolving hexameric ATPases as asymmetric motors to translocate double-stranded DNA genome along one strand</a>, iScience. 2023 Jun | journal-article. doi: 10.1016/j.isci.2023.106922.
<a href='http://dx.doi.org/10.1002/exp.20210056' target='_blank' class='bux-link'>Revolving ATPase motors as asymmetrical hexamers in translocating lengthy dsDNA via conformational changes and electrostatic interactions in phi29, T7, herpesvirus, mimivirus, E. coli, and Streptomyces</a>, Exploration. 2023 Feb | journal-article. doi: 10.1002/exp.20210056.
<a href='http://dx.doi.org/10.1016/j.nano.2022.102642' target='_blank' class='bux-link'>Nipple fluid for breast cancer diagnosis using the nanopore of Phi29 DNA-packaging motor</a>, Nanomedicine: Nanotechnology, Biology and Medicine. 2023 Feb | journal-article. doi: 10.1016/j.nano.2022.102642.
<a href='http://dx.doi.org/10.1016/j.biomaterials.2022.121863' target='_blank' class='bux-link'>Voltage controlled shutter regulates channel size and motion direction of protein aperture as durable nano-electric rectifier-----An opinion in biomimetic nanoaperture</a>, Biomaterials. 2022 Dec | journal-article. doi: 10.1016/j.biomaterials.2022.121863.
<a href='http://dx.doi.org/10.1016/j.apsb.2022.11.019' target='_blank' class='bux-link'>Targeted delivery of RNAi to cancer cells using RNA-ligand displaying exosome</a>, Acta Pharmaceutica Sinica B. 2022 Nov | journal-article. doi: 10.1016/j.apsb.2022.11.019.
<a href='http://dx.doi.org/10.1016/j.nano.2022.102590' target='_blank' class='bux-link'>Proof-of-concept for speedy development of rapid and simple at-home method for potential diagnosis of early COVID-19 mutant infections using nanogold and aptamer</a>, Nanomedicine: Nanotechnology, Biology and Medicine. 2022 Sep | journal-article. doi: 10.1016/j.nano.2022.102590.
<a href='http://europepmc.org/abstract/med/35526663' target='_blank' class='bux-link'>The dynamic, motile and deformative properties of RNA nanoparticles facilitate the third milestone of drug development.</a>, Advanced drug delivery reviews. 2022 May | journal-article. doi: 10.1016/j.addr.2022.114316.
<a href='http://dx.doi.org/10.1158/0008-5472.can-21-2229' target='_blank' class='bux-link'>Targeting Squalene Epoxidase Interrupts Homologous Recombination via the ER Stress Response and Promotes Radiotherapy Efficacy</a>, Cancer Research. 2022 Apr | journal-article. doi: 10.1158/0008-5472.can-21-2229.
<a href='http://dx.doi.org/10.1261/rna.079020.121' target='_blank' class='bux-link'>VfoldMCPX: predicting multistrand RNA complexes</a>, RNA. 2022 Apr | journal-article. doi: 10.1261/rna.079020.121.
<a href='http://dx.doi.org/10.1016/j.csbj.2022.11.007' target='_blank' class='bux-link'>Biomotors, viral assembly, and RNA nanobiotechnology: Current achievements and future directions</a>, Computational and Structural Biotechnology Journal. 2022 Jan | journal-article. doi: 10.1016/j.csbj.2022.11.007.
<a href='http://dx.doi.org/10.1039/d1bm01264a' target='_blank' class='bux-link'>Macromolecule sensing and tumor biomarker detection by harnessing terminal size and hydrophobicity of viral DNA packaging motor channels into membranes and flow cells</a>, Biomaterials Science. 2022 Jan | journal-article. doi: 10.1039/d1bm01264a.
<a href='https://doi.org/10.1021/acsnano.0c10240' target='_blank' class='bux-link'>The International Society of RNA Nanotechnology and Nanomedicine (ISRNN): The Present and Future of the Burgeoning Field.</a>, ACS nano. 2021 Oct | journal-article. doi: 10.1021/acsnano.0c10240.
<a href='https://europepmc.org/articles/PMC8463318' target='_blank' class='bux-link'>Rational design for controlled release of Dicer-substrate siRNA harbored in phi29 pRNA-based nanoparticles.</a>, Molecular therapy. Nucleic acids. 2021 Aug | journal-article. doi: 10.1016/j.omtn.2021.07.021.
<a href='https://europepmc.org/articles/PMC8388119' target='_blank' class='bux-link'>Identification of Arginine Finger as the Starter of the Biomimetic Motor in Driving Double-Stranded DNA.</a>, ACS nano. 2021 Jul | journal-article. doi: 10.1021/acsnano.1c02973.
<a href='https://doi.org/10.1016/j.biomaterials.2021.121022' target='_blank' class='bux-link'>Detection of single peptide with only one amino acid modification via electronic fingerprinting using reengineered durable channel of Phi29 DNA packaging motor.</a>, Biomaterials. 2021 Jul | journal-article. doi: 10.1016/j.biomaterials.2021.121022.
<a href='https://doi.org/10.1021/acs.molpharmaceut.1c00035' target='_blank' class='bux-link'>Radiolabeled RNA Nanoparticles for Highly Specific Targeting and Efficient Tumor Accumulation with Favorable <i>In Vivo</i> Biodistribution.</a>, Molecular pharmaceutics. 2021 Jul | journal-article. doi: 10.1021/acs.molpharmaceut.1c00035.
<a href='https://doi.org/10.1261/rna.078718.121' target='_blank' class='bux-link'>Regulation of reversible conformational change, size switching, and immunomodulation of RNA nanocubes.</a>, RNA (New York, N.Y.). 2021 Jun | journal-article. doi: 10.1261/rna.078718.121.
<a href='https://doi.org/10.1021/acs.chemrev.1c00009' target='_blank' class='bux-link'>Thermostability, Tunability, and Tenacity of RNA as Rubbery Anionic Polymeric Materials in Nanotechnology and Nanomedicine-Specific Cancer Targeting with Undetectable Toxicity.</a>, Chemical reviews. 2021 May | journal-article. doi: 10.1021/acs.chemrev.1c00009.
<a href='https://doi.org/10.1089/nat.2021.0002' target='_blank' class='bux-link'>Non-Small-Cell Lung Cancer Regression by siRNA Delivered Through Exosomes That Display EGFR RNA Aptamer.</a>, Nucleic acid therapeutics. 2021 May | journal-article. doi: 10.1089/nat.2021.0002.
<a href='https://doi.org/10.1080/15476286.2021.1915620' target='_blank' class='bux-link'>RNA nanotechnology to build a dodecahedral genome of single-stranded RNA virus.</a>, RNA biology. 2021 Apr | journal-article. doi: 10.1080/15476286.2021.1915620.
<a href='https://europepmc.org/articles/PMC8042240' target='_blank' class='bux-link'>Stoichiometry of multi-specific immune checkpoint RNA Abs for T cell activation and tumor inhibition using ultra-stable RNA nanoparticles.</a>, Molecular therapy. Nucleic acids. 2021 Mar | journal-article. doi: 10.1016/j.omtn.2021.03.007.
<a href='https://doi.org/10.1021/acs.biochem.0c00935' target='_blank' class='bux-link'>Structural Insights into gp16 ATPase in the Bacteriophage ϕ29 DNA Packaging Motor.</a>, Biochemistry. 2021 Mar | journal-article. doi: 10.1021/acs.biochem.0c00935.
<a href='http://dx.doi.org/10.1016/b978-0-12-809633-8.21520-3' target='_blank' class='bux-link'>Nanotechnology Application of Bacteriophage DNA Packaging Nanomotors</a>, Encyclopedia of Virology. 2021 Jan | book-chapter. doi: 10.1016/b978-0-12-809633-8.21520-3.
<a href='https://doi.org/10.1016/j.jconrel.2020.12.007' target='_blank' class='bux-link'>Multivalent rubber-like RNA nanoparticles for targeted co-delivery of paclitaxel and MiRNA to silence the drug efflux transporter and liver cancer drug resistance.</a>, Journal of controlled release : official journal of the Controlled Release Society. 2020 Dec | journal-article. doi: 10.1016/j.jconrel.2020.12.007.
<a href='https://europepmc.org/articles/PMC7799665' target='_blank' class='bux-link'>RNA Nanoparticles as Rubber for Compelling Vessel Extravasation to Enhance Tumor Targeting and for Fast Renal Excretion to Reduce Toxicity.</a>, ACS nano. 2020 Sep | journal-article. doi: 10.1021/acsnano.0c04863.
<a href='https://europepmc.org/articles/PMC8412138' target='_blank' class='bux-link'>3D RNA nanocage for encapsulation and shielding of hydrophobic biomolecules to improve the <i>in vivo</i> biodistribution.</a>, Nano research. 2020 Sep | journal-article. doi: 10.1007/s12274-020-2996-1.
<a href='https://europepmc.org/articles/PMC7448292' target='_blank' class='bux-link'>Self-assembly of four generations of RNA dendrimers for drug shielding with controllable layer-by-layer release.</a>, Nanoscale. 2020 Jul | journal-article. doi: 10.1039/d0nr02614j.
<a href='https://doi.org/10.1007/s11427-020-1752-1' target='_blank' class='bux-link'>Translation of the long-term fundamental studies on viral DNA packaging motors into nanotechnology and nanomedicine.</a>, Science China. Life sciences. 2020 Jun | journal-article. doi: 10.1007/s11427-020-1752-1.
<a href='https://europepmc.org/articles/PMC7196596' target='_blank' class='bux-link'>High resolution structure of hexameric herpesvirus DNA-packaging motor elucidates revolving mechanism and ends 20-year fervent debate.</a>, Protein & cell. 2020 May | journal-article. doi: 10.1007/s13238-020-00714-w.
<a href='https://europepmc.org/articles/PMC7033104' target='_blank' class='bux-link'>Ultra-thermostable RNA nanoparticles for solubilizing and high-yield loading of paclitaxel for breast cancer therapy.</a>, Nature communications. 2020 Feb | journal-article. doi: 10.1038/s41467-020-14780-5.
<a href='https://doi.org/10.1016/j.nano.2020.102170' target='_blank' class='bux-link'>Insertion of channel of phi29 DNA packaging motor into polymer membrane for high-throughput sensing.</a>, Nanomedicine : nanotechnology, biology, and medicine. 2020 Feb | journal-article. doi: 10.1016/j.nano.2020.102170.
<a href='https://europepmc.org/articles/PMC7001639' target='_blank' class='bux-link'>Single Functionalized pRNA/Gold Nanoparticle for Ultrasensitive MicroRNA Detection Using Electrochemical Surface-Enhanced Raman Spectroscopy.</a>, Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2019 Dec | journal-article. doi: 10.1002/advs.201902477.
<a href='https://doi.org/10.1016/j.bmcl.2019.126725' target='_blank' class='bux-link'>Synthesis and antileishmanial evaluation of thiazole orange analogs.</a>, Bioorganic & medicinal chemistry letters. 2019 Oct | journal-article. doi: 10.1016/j.bmcl.2019.126725.
<a href='https://europepmc.org/articles/PMC6864502' target='_blank' class='bux-link'>RNA Nanotechnology to Solubilize Hydrophobic Antitumor Drug for Targeted Delivery.</a>, Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2019 Sep | journal-article. doi: 10.1002/advs.201900951.
<a href='https://europepmc.org/articles/PMC6908753' target='_blank' class='bux-link'>Tuning the size, shape and structure of RNA nanoparticles for favorable cancer targeting and immunostimulation.</a>, Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology. 2019 Aug | journal-article. doi: 10.1002/wnan.1582.
<a href='https://europepmc.org/articles/PMC6874920' target='_blank' class='bux-link'>Folate-displaying exosome mediated cytosolic delivery of siRNA avoiding endosome trapping.</a>, Journal of controlled release : official journal of the Controlled Release Society. 2019 Aug | journal-article. doi: 10.1016/j.jconrel.2019.08.021.
<a href='https://europepmc.org/articles/PMC7062307' target='_blank' class='bux-link'>Construction of RNA nanotubes.</a>, Nano research. 2019 Jul | journal-article. doi: 10.1007/s12274-019-2463-z.
<a href='https://europepmc.org/articles/PMC6595433' target='_blank' class='bux-link'>Controlling the Revolving and Rotating Motion Direction of Asymmetric Hexameric Nanomotor by Arginine Finger and Channel Chirality.</a>, ACS nano. 2019 May | journal-article. doi: 10.1021/acsnano.8b08849.
<a href='https://europepmc.org/articles/PMC6724551' target='_blank' class='bux-link'>Channel from bacterial virus T7 DNA packaging motor for the differentiation of peptides composed of a mixture of acidic and basic amino acids.</a>, Biomaterials. 2019 May | journal-article. doi: 10.1016/j.biomaterials.2019.119222.
<a href='https://europepmc.org/articles/PMC6612664' target='_blank' class='bux-link'>Delivery of Anti-miRNA for Triple-Negative Breast Cancer Therapy Using RNA Nanoparticles Targeting Stem Cell Marker CD133.</a>, Molecular therapy : the journal of the American Society of Gene Therapy. 2019 Apr | journal-article. doi: 10.1016/j.ymthe.2019.04.018.
<a href='https://europepmc.org/articles/PMC6601620' target='_blank' class='bux-link'>The Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research.</a>, Cell. 2019 Apr | journal-article. doi: 10.1016/j.cell.2019.03.023.
<a href='https://europepmc.org/articles/PMC6542271' target='_blank' class='bux-link'>One-Pot Production of RNA Nanoparticles via Automated Processing and Self-Assembly.</a>, ACS nano. 2019 Mar | journal-article. doi: 10.1021/acsnano.9b00649.
<a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542267' target='_blank' class='bux-link'>RNA Micelles for the Systemic Delivery of Anti-miRNA for Cancer Targeting and Inhibition without Ligand.</a>, ACS nano. 2018 Dec | journal-article. doi: 10.1021/acsnano.8b07948.
<a href='https://europepmc.org/articles/PMC6305700' target='_blank' class='bux-link'>Specific delivery of delta-5-desaturase siRNA via RNA nanoparticles supplemented with dihomo-γ-linolenic acid for colon cancer suppression.</a>, Redox biology. 2018 Dec | journal-article. doi: 10.1016/j.redox.2018.101085.
<a href='https://europepmc.org/articles/PMC6746408' target='_blank' class='bux-link'>Plant-Derived Exosomal MicroRNAs Shape the Gut Microbiota.</a>, Cell host & microbe. 2018 Oct | journal-article. doi: 10.1016/j.chom.2018.10.001.
<a href='https://europepmc.org/articles/PMC6168523' target='_blank' class='bux-link'>Arrowtail RNA for Ligand Display on Ginger Exosome-like Nanovesicles to Systemic Deliver siRNA for Cancer Suppression.</a>, Scientific reports. 2018 Oct | journal-article. doi: 10.1038/s41598-018-32953-7.
<a href='https://europepmc.org/articles/PMC6599617' target='_blank' class='bux-link'>Photo-controlled release of paclitaxel and model drugs from RNA pyramids.</a>, Nano research. 2018 Sep | journal-article. doi: 10.1007/s12274-018-2174-x.
<a href='https://europepmc.org/articles/PMC6309972' target='_blank' class='bux-link'>Nano-channel of viral DNA packaging motor as single pore to differentiate peptides with single amino acid difference.</a>, Biomaterials. 2018 Aug | journal-article. doi: 10.1016/j.biomaterials.2018.08.005.
<a href='https://europepmc.org/articles/PMC6051894' target='_blank' class='bux-link'>Methods for construction and characterization of simple or special multifunctional RNA nanoparticles based on the 3WJ of phi29 DNA packaging motor.</a>, Methods (San Diego, Calif.). 2018 Mar | journal-article. doi: 10.1016/j.ymeth.2018.02.025.
<a href='https://europepmc.org/articles/PMC5964609' target='_blank' class='bux-link'>RNA-based micelles: A novel platform for paclitaxel loading and delivery.</a>, Journal of controlled release : official journal of the Controlled Release Society. 2018 Feb | journal-article. doi: 10.1016/j.jconrel.2018.02.014.
<a href='https://doi.org/10.1007/978-1-4939-8556-2_21' target='_blank' class='bux-link'>Methods for Single-Molecule Sensing and Detection Using Bacteriophage Phi29 DNA Packaging Motor.</a>, Methods in molecular biology (Clifton, N.J.). 2018 Jan | journal-article. doi: 10.1007/978-1-4939-8556-2_21.
<a href='https://europepmc.org/articles/PMC5910665' target='_blank' class='bux-link'>The Effect of Size and Shape of RNA Nanoparticles on Biodistribution.</a>, Molecular therapy : the journal of the American Society of Gene Therapy. 2017 Dec | journal-article. doi: 10.1016/j.ymthe.2017.12.018.
<a href='https://europepmc.org/articles/PMC5762263' target='_blank' class='bux-link'>Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression.</a>, Nature nanotechnology. 2017 Dec | journal-article. doi: 10.1038/s41565-017-0012-z.
<a href='https://europepmc.org/articles/PMC5994363' target='_blank' class='bux-link'>Engineering of protein nanopores for sequencing, chemical or protein sensing and disease diagnosis.</a>, Current opinion in biotechnology. 2017 Dec | journal-article. doi: 10.1016/j.copbio.2017.11.006.
<a href='https://europepmc.org/articles/PMC5738063' target='_blank' class='bux-link'>RNA Nanotherapeutics for the Amelioration of Astroglial Reactivity.</a>, Molecular therapy. Nucleic acids. 2017 Nov | journal-article. doi: 10.1016/j.omtn.2017.11.008.
<a href='https://europepmc.org/articles/PMC6029979' target='_blank' class='bux-link'>RNA nanoparticle distribution and clearance in the eye after subconjunctival injection with and without thermosensitive hydrogels.</a>, Journal of controlled release : official journal of the Controlled Release Society. 2017 Nov | journal-article. doi: 10.1016/j.jconrel.2017.11.028.
<a href='https://europepmc.org/articles/PMC5739991' target='_blank' class='bux-link'>RNA versatility, flexibility, and thermostability for practice in RNA nanotechnology and biomedical applications.</a>, Wiley interdisciplinary reviews. RNA. 2017 Nov | journal-article. doi: 10.1002/wrna.1452.
<a href='https://europepmc.org/articles/PMC5733572' target='_blank' class='bux-link'>Assessment and comparison of thermal stability of phosphorothioate-DNA, DNA, RNA, 2'-F RNA, and LNA in the context of Phi29 pRNA 3WJ.</a>, RNA (New York, N.Y.). 2017 Oct | journal-article. doi: 10.1261/rna.063057.117.
<a href='https://europepmc.org/articles/PMC5701797' target='_blank' class='bux-link'>Size, Shape, and Sequence-Dependent Immunogenicity of RNA Nanoparticles.</a>, Molecular therapy. Nucleic acids. 2017 Oct | journal-article. doi: 10.1016/j.omtn.2017.10.010.
<a href='https://europepmc.org/articles/PMC5770098' target='_blank' class='bux-link'>Hydrophobic Effect from Conjugated Chemicals or Drugs on In Vivo Biodistribution of RNA Nanoparticles.</a>, Human gene therapy. 2017 Oct | journal-article. doi: 10.1089/hum.2017.054.
<a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844565' target='_blank' class='bux-link'>Favorable biodistribution, specific targeting and conditional endosomal escape of RNA nanoparticles in cancer therapy.</a>, Cancer letters. 2017 Oct | journal-article. doi: 10.1016/j.canlet.2017.09.043.
<a href='https://doi.org/10.2217/nnm-2017-0209' target='_blank' class='bux-link'>Advances in nanopore sensing promises to transform healthcare.</a>, Nanomedicine (London, England). 2017 Jul | journal-article. doi: 10.2217/nnm-2017-0209.
<a href='https://europepmc.org/articles/PMC5446216' target='_blank' class='bux-link'>Directional mechanical stability of Bacteriophage φ29 motor's 3WJ-pRNA: Extraordinary robustness along portal axis.</a>, Science advances. 2017 May | journal-article. doi: 10.1126/sciadv.1601684.
<a href='https://europepmc.org/articles/PMC5498816' target='_blank' class='bux-link'>Broccoli-Derived Nanoparticle Inhibits Mouse Colitis by Activating Dendritic Cell AMP-Activated Protein Kinase.</a>, Molecular therapy : the journal of the American Society of Gene Therapy. 2017 Mar | journal-article. doi: 10.1016/j.ymthe.2017.01.025.
<a href='https://europepmc.org/articles/PMC5333189' target='_blank' class='bux-link'>Advancement of the Emerging Field of RNA Nanotechnology.</a>, ACS nano. 2017 Feb | journal-article. doi: 10.1021/acsnano.6b05737.
<a href='https://europepmc.org/articles/PMC5421631' target='_blank' class='bux-link'>Channel of viral DNA packaging motor for real time kinetic analysis of peptide oxidation states.</a>, Biomaterials. 2017 Jan | journal-article. doi: 10.1016/j.biomaterials.2017.01.031.
<a href='https://europepmc.org/articles/PMC5288391' target='_blank' class='bux-link'>Inhibition of cancer migration and invasion by knocking down delta-5-desaturase in COX-2 overexpressed cancer cells.</a>, Redox biology. 2017 Jan | journal-article. doi: 10.1016/j.redox.2017.01.016.
<a href='https://europepmc.org/articles/PMC5498802' target='_blank' class='bux-link'>RNA Nanoparticle-Based Targeted Therapy for Glioblastoma through Inhibition of Oncogenic miR-21.</a>, Molecular therapy : the journal of the American Society of Gene Therapy. 2017 Jan | journal-article. doi: 10.1016/j.ymthe.2016.11.016.
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<a href='https://doi.org/10.1016/0166-0934(93)90114-7' target='_blank' class='bux-link'>Transactivation of the early SV40 promoter by avian infectious laryngotracheitis virus in avian hepatoma cells.</a>, Journal of virological methods. 1993 Dec | journal-article. doi: 10.1016/0166-0934(93)90114-7.
<a href='https://doi.org/10.1016/0166-0934(93)90146-i' target='_blank' class='bux-link'>An avian hepatoma cell line for the cultivation of infectious laryngotracheitis virus and for the expression of foreign genes with a mammalian promoter.</a>, Journal of virological methods. 1993 Aug | journal-article. doi: 10.1016/0166-0934(93)90146-i.
<a href='https://doi.org/10.1006/prep.1993.1017' target='_blank' class='bux-link'>Tracking and elimination of an interfering polypeptide coexpressed with the vaccinia virus mRNA capping enzyme overproduced in Escherichia coli.</a>, Protein expression and purification. 1993 Apr | journal-article. doi: 10.1006/prep.1993.1017.
<a href='https://doi.org/10.1016/0042-6822(91)90787-c' target='_blank' class='bux-link'>sRNA of phage phi 29 of Bacillus subtilis mediates DNA packaging of phi 29 proheads assembled in Escherichia coli.</a>, Virology. 1991 Nov | journal-article. doi: 10.1016/0042-6822(91)90787-c.
<a href='https://europepmc.org/articles/PMC4167689' target='_blank' class='bux-link'>Regulation of the phage phi 29 prohead shape and size by the portal vertex.</a>, Virology. 1991 Jul | journal-article. doi: 10.1016/0042-6822(91)90149-6.
<a href='https://europepmc.org/articles/PMC54039' target='_blank' class='bux-link'>Interaction and mutual stabilization of the two subunits of vaccinia virus mRNA capping enzyme coexpressed in Escherichia coli.</a>, Proceedings of the National Academy of Sciences of the United States of America. 1990 Jun | journal-article. doi: 10.1073/pnas.87.11.4023.
<a href='https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/2157895/?tool=EBI' target='_blank' class='bux-link'>Coexpression by vaccinia virus recombinants of equine herpesvirus 1 glycoproteins gp13 and gp14 results in potentiated immunity.</a>, Journal of virology. 1990 May | journal-article. doi: 10.1128/jvi.64.5.2399-2406.1990.
<a href='https://doi.org/10.1016/0378-1119(90)90309-f' target='_blank' class='bux-link'>Characterization of the gene and an antigenic determinant of equine herpesvirus type-1 glycoprotein 14 with homology to gB-equivalent glycoproteins of other herpesviruses.</a>, Gene. 1990 Mar | journal-article. doi: 10.1016/0378-1119(90)90309-f.
<a href='https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/2550665/?tool=EBI' target='_blank' class='bux-link'>Expression in recombinant vaccinia virus of the equine herpesvirus 1 gene encoding glycoprotein gp13 and protection of immunized animals.</a>, Journal of virology. 1989 Oct | journal-article. doi: 10.1128/jvi.63.10.4189-4198.1989.
<a href='https://europepmc.org/articles/PMC306194' target='_blank' class='bux-link'>Characterization of the small RNA of the bacteriophage phi 29 DNA packaging machine.</a>, Nucleic acids research. 1987 Sep | journal-article. doi: 10.1093/nar/15.17.7081.
<a href='https://doi.org/10.1016/0022-2836(87)90120-3' target='_blank' class='bux-link'>Initiation events in in-vitro packaging of bacteriophage phi 29 DNA-gp3.</a>, Journal of molecular biology. 1987 Sep | journal-article. doi: 10.1016/0022-2836(87)90120-3.
<a href='https://doi.org/10.1016/0022-2836(87)90121-5' target='_blank' class='bux-link'>Prohead and DNA-gp3-dependent ATPase activity of the DNA packaging protein gp16 of bacteriophage phi 29.</a>, Journal of molecular biology. 1987 Sep | journal-article. doi: 10.1016/0022-2836(87)90121-5.
<a href='https://doi.org/10.1126/science.3107124' target='_blank' class='bux-link'>A small viral RNA is required for in vitro packaging of bacteriophage phi 29 DNA.</a>, Science (New York, N.Y.). 1987 May | journal-article. doi: 10.1126/science.3107124.
<a href='https://europepmc.org/articles/PMC323545' target='_blank' class='bux-link'>A defined system for in vitro packaging of DNA-gp3 of the Bacillus subtilis bacteriophage phi 29.</a>, Proceedings of the National Academy of Sciences of the United States of America. 1986 May | journal-article. doi: 10.1073/pnas.83.10.3505.

Rajgopal Govindarajan

Headshot of Rajgopal Govindarajan
Rajgopal Govindarajan
Professor
Pharmaceutics and Pharmacology
Research Areas
Pharmaceutics & Pharmacology,
Cancer,
Chemical Biology
544 Riffe
govindarajan.21@osu.edu
(614) 247-8269
Professional Website
Dr. Govindarajan’s laboratory is interested in understanding and overcoming drug resistance in pancreatic cancer. His training is in the areas of animal sciences, cancer biology and drug transport-based pharmacokinetics, and has extensively used cell and animal models to evaluate nucleoside and oligonucleotide therapies. He also developed several new insights into the pharmacology and cytotoxicity of nucleoside analog drugs. Current focuses in his laboratory are to understand the epigenetic alterations in pancreatic cancer and to evaluate novel epigenetic reversal agents for effective pancreatic cancer treatment. Understanding epigenetic regulation of pluripotent stem cell factors in microRNA biogenesis is also of interest.
Postdoc - University of Washington, Seattle, WA
PhD - University of Nebraska Medical Center, Omaha, NE
MVSc - Indian Veterinary Research Institute, India
BVSc - Madras Veterinary College, TANUVAS, India
Research Scholar, 2015 - 2019
Guest Editor, 2015 - 2015
2015 Reviewer, 2015 - 2015
Elected member, 2014 - 2017
2013 Reviewer, 2013 - 2013
Deans Pharmacy Special Endowment Fund Award, 2013 - 2013
Cancer Research Award, 2012 - 2012
College of Pharmacy Meritorious Research Productivity Award, 2012 - 2012
Poster of Distinction, 2011 - 2011
Randy Ellison Cancer Research Award, 2011 - 2011
AAPS Exceptional Abstract & Podium Presentation Award, 2011 - 2011
Developmental Research Project Award, 2009 - 2010
Developmental Research Project Award, 2008 - 2009
Training Support Grant, 2007 - 2007
Exceptional Abstract & Podium Presentation Award, 2007 - 2007
Reichenbach Presidential Fellowship, 2004 - 2005
Norm and Bernice Harris Award for Outstanding Work in Cancer Research during Graduate Studies, 2003 - 2003
Graduate Fellowship, , 2002-2005, 2002 - 2005
Best Poster Award (II prize), 2002 - 2002
Senior Research Fellowship, 1999 - 2000
Junior Research Fellowship-Animal Biotechnology, 1997 - 1999
Sharma P, LaRosa C, Antwi J, Govindarajan R, Werbovetz KA. Imidazoles as Potential Anticancer Agents: An Update on Recent Studies. Molecules. 2021 Jul 11;26(14):4213. doi: 10.3390/molecules26144213. PMID: 34299488.
Persaud AK, Nair S, Rahman MF, Raj R, Weadick B, Nayak D, McElroy C, Shanmugam M, Knoblaugh S, Cheng X, Govindarajan R. Facilitative lysosomal transport of bile acids alleviates ER stress in mouse hematopoietic precursors. Nat Commun. 2021 Feb 23;12(1):1248. doi: 10.1038/s41467-021-21451-6. PMID: 33623001; PMCID: PMC7902824.
Weadick B, Nayak D, Persaud AK, Hung SW, Raj R, Campbell MJ, Chen W, Li J, Williams TM, Govindarajan R. EMT-Induced Gemcitabine Resistance in Pancreatic Cancer Involves the Functional Loss of Equilibrative Nucleoside Transporter 1. Mol Cancer Ther. 2021 Feb;20(2):410-422. doi: 10.1158/1535-7163.MCT-20-0316. Epub 2020 Dec 9. PMID: 33298588.
Wani A, Al Rihani SB, Sharma A, Weadick B, Govindarajan R, Khan SU, Sharma PR, Dogra A, Nandi U, Reddy CN, Bharate SS, Singh G, Bharate SB, Vishwakarma RA, Kaddoumi A, Kumar A. Crocetin promotes clearance of amyloid-β by inducing autophagy via the STK11/LKB1-mediated AMPK pathway. Autophagy. 2021 Jan 19:1-20. doi: 10.1080/15548627.2021.1872187. Epub ahead of print. PMID: 33404280.
Kim JY, Bai Y, Jayne LA, Hector RD, Persaud AK, Ong SS, Rojesh S, Raj R, Feng MJHH, Chung S, Cianciolo RE, Christman JW, Campbell MJ, Gardner DS, Baker SD, Sparreboom A, Govindarajan R, Singh H, Chen T, Poi M, Susztak K, Cobb SR, Pabla NS. A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury. Nat Commun. 2020 Apr 21;11(1):1924. doi: 10.1038/s41467-020-15638-6. PMID: 32317630; PMCID: PMC7174303.
Nair S, Strohecker AM, Persaud AK, Bissa B, Muruganandan S, McElroy C, Pathak R, Williams M, Raj R, Kaddoumi A, Sparreboom A, Beedle AM, Govindarajan R. Adult stem cell deficits drive Slc29a3 disorders in mice. Nat Commun. 2019 Jul 3;10(1):2943. doi: 10.1038/s41467-019-10925-3. PMID: 31270333; PMCID: PMC6610100.
Muruganandan S, Govindarajan R, Sinal CJ. Bone Marrow Adipose Tissue and Skeletal Health. Curr Osteoporos Rep. 2018 Aug;16(4):434-442. doi: 10.1007/s11914-018-0451-y. PMID: 29855795; PMCID: PMC6239196.
Rahman MF, Raj R, Govindarajan R. Identification of Structural and Molecular Features Involved in the Transport of 3'-Deoxy-Nucleoside Analogs by Human Equilibrative Nucleoside Transporter 3. Drug Metab Dispos. 2018 May;46(5):600-609. doi: 10.1124/dmd.117.079400. Epub 2018 Mar 12. PMID: 29530865; PMCID: PMC5896370.
Singh A, Govindarajan R. ENT3 utilizes a pH Sensing Mechanism for Transport. Channels (Austin). 2018 Jan 1;12(1):78-80. doi: 10.1080/19336950.2017.1389581. Epub 2017 Nov 15. PMID: 28985132; PMCID: PMC5972795.
Rahman MF, Askwith C, Govindarajan R. Molecular determinants of acidic pH- dependent transport of human equilibrative nucleoside transporter 3. J Biol Chem. 2017 Sep 8;292(36):14775-14785. doi: 10.1074/jbc.M117.787952. Epub 2017 Jul 20. PMID: 28729424; PMCID: PMC5592659.

Eric Eisenmann

Eric Eisenmann headshot
Eric Eisenmann
Assistant Professor
Pharmaceutics and Pharmacology
Research Areas
Pharmaceutics & Pharmacology,
Cancer,
Central Nervous System Disorders
eisenmann.11@osu.edu
Professional Website
My current research focuses on determining how targeted and cytotoxic chemotherapy impact the brain and how drug transporters contribute to these effects. Consistent with this research, I am interested in the translational pharmacology of anticancer therapeutics, especially the characterization of preclinical and clinical pharmacokinetics and pharmacodynamics.
2021, PhD in Pharmaceutical Sciences, The Ohio State University
2017, PharmD, Ohio Northern University
2015, BS Psychology, Ohio Northern University
<a href='https://doi.org/10.1158/1078-0432.CCR-23-2351' target='_blank' class='bux-link'>Unique Cabozantinib Dosing Considerations in People Living with HIV and Cancer</a>, Clinical Cancer Research. 2023 Dec | journal-article. doi: 10.1158/1078-0432.CCR-23-2351.
<a href='https://doi.org/10.1016/j.heliyon.2023.e20972' target='_blank' class='bux-link'>Exploring pharmacokinetics of talazoparib in ABCB1/ABCG2-deficient mice using a novel UHPLC-MS/MS method</a>, Heliyon. 2023 Nov | journal-article. doi: 10.1016/j.heliyon.2023.e20972.
<a href='https://doi.org/10.1158/1078-0432.c.6527766.v1' target='_blank' class='bux-link'>Data from Sorafenib Population Pharmacokinetics and Skin Toxicities in Children and Adolescents with Refractory/Relapsed Leukemia or Solid Tumor Malignancies</a>, . 2023 Mar | preprint. doi: 10.1158/1078-0432.c.6527766.v1.
<a href='https://doi.org/10.1158/1078-0432.c.6527766' target='_blank' class='bux-link'>Data from Sorafenib Population Pharmacokinetics and Skin Toxicities in Children and Adolescents with Refractory/Relapsed Leukemia or Solid Tumor Malignancies</a>, . 2023 Mar | preprint. doi: 10.1158/1078-0432.c.6527766.
<a href='https://doi.org/10.1158/1078-0432.22471074.v1' target='_blank' class='bux-link'>Supplementary Data from Sorafenib Population Pharmacokinetics and Skin Toxicities in Children and Adolescents with Refractory/Relapsed Leukemia or Solid Tumor Malignancies</a>, . 2023 Mar | preprint. doi: 10.1158/1078-0432.22471074.v1.
<a href='https://doi.org/10.1158/1078-0432.22471074' target='_blank' class='bux-link'>Supplementary Data from Sorafenib Population Pharmacokinetics and Skin Toxicities in Children and Adolescents with Refractory/Relapsed Leukemia or Solid Tumor Malignancies</a>, . 2023 Mar | preprint. doi: 10.1158/1078-0432.22471074.
<a href='https://doi.org/10.3390/cancers15010029' target='_blank' class='bux-link'>TP-0903 Is Active in Preclinical Models of Acute Myeloid Leukemia with TP53 Mutation/Deletion</a>, Cancers. 2022 Dec | journal-article. doi: 10.3390/cancers15010029.
<a href='https://doi.org/10.3390/molecules27206815' target='_blank' class='bux-link'>Itraconazole-Induced Increases in Gilteritinib Exposure Are Mediated by CYP3A and OATP1B</a>, Molecules. 2022 Oct | journal-article. doi: 10.3390/molecules27206815.
<a href='https://doi.org/10.3390/pharmaceutics14091933' target='_blank' class='bux-link'>A Metabolomics Approach for Predicting OATP1B-Type Transporter-Mediated Drug–Drug Interaction Liabilities</a>, Pharmaceutics. 2022 Sep | journal-article. doi: 10.3390/pharmaceutics14091933.
<a href='https://doi.org/10.1182/bloodadvances.2022007952' target='_blank' class='bux-link'>BMX kinase mediates gilteritinib resistance in FLT3-mutated AML through microenvironmental factors</a>, Blood Advances. 2022 Sep | journal-article. doi: 10.1182/bloodadvances.2022007952.
<a href='https://doi.org/10.3390/ijms23158607' target='_blank' class='bux-link'>MATE1 Deficiency Exacerbates Dofetilide-Induced Proarrhythmia</a>, International Journal of Molecular Sciences. 2022 Aug | journal-article. doi: 10.3390/ijms23158607.
<a href='https://doi.org/10.3390/pharmaceutics14040694' target='_blank' class='bux-link'>Interaction of Antifungal Drugs with CYP3A- and OATP1B-Mediated Venetoclax Elimination</a>, Pharmaceutics. 2022 Mar | journal-article. doi: 10.3390/pharmaceutics14040694.
<a href='https://doi.org/10.1111/bcpt.13623' target='_blank' class='bux-link'>Boosting the oral bioavailability of anticancer drugs through intentional drug–drug interactions</a>, Basic & Clinical Pharmacology & Toxicology. 2022 Jan | journal-article. doi: 10.1111/bcpt.13623.
<a href='https://doi.org/10.1158/2767-9764.CRC-21-0076' target='_blank' class='bux-link'>Intentional Modulation of Ibrutinib Pharmacokinetics through CYP3A Inhibition</a>, Cancer Research Communications. 2021 Nov | journal-article. doi: 10.1158/2767-9764.CRC-21-0076.
<a href='https://doi.org/10.1073/pnas.2020168118' target='_blank' class='bux-link'>Targeting OCT3 attenuates doxorubicin-induced cardiac injury</a>, Proceedings of the National Academy of Sciences. 2021 Feb | journal-article. doi: 10.1073/pnas.2020168118.
<a href='https://doi.org/10.1172/jci.insight.140169' target='_blank' class='bux-link'>TP-0903 is active in models of drug-resistant acute myeloid leukemia</a>, JCI Insight. 2020 Dec | journal-article. doi: 10.1172/jci.insight.140169.
<a href='https://doi.org/10.3390/pharmaceutics12090856' target='_blank' class='bux-link'>Role of OATP1B1 and OATP1B3 in Drug-Drug Interactions Mediated by Tyrosine Kinase Inhibitors</a>, Pharmaceutics. 2020 Sep | journal-article. doi: 10.3390/pharmaceutics12090856.
<a href='http://dx.doi.org/10.1016/j.jchromb.2020.122176' target='_blank' class='bux-link'>Development and validation of a sensitive UHPLC-MS/MS analytical method for venetoclax in mouse plasma, and its application to pharmacokinetic studies</a>, Journal of Chromatography B. 2020 Sep | journal-article. doi: 10.1016/j.jchromb.2020.122176.
<a href='https://doi.org/10.3390/pharmaceutics12090788' target='_blank' class='bux-link'>Influence of Probenecid on the Pharmacokinetics and Pharmacodynamics of Sorafenib</a>, Pharmaceutics. 2020 Aug | journal-article. doi: 10.3390/pharmaceutics12090788.
<a href='http://dx.doi.org/10.1172/jci136796' target='_blank' class='bux-link'>Neuronal uptake transporters contribute to oxaliplatin neurotoxicity in mice</a>, Journal of Clinical Investigation. 2020 Jun | journal-article. doi: 10.1172/jci136796.
<a href='https://doi.org/10.1158/1078-0432.CCR-19-0470' target='_blank' class='bux-link'>Sorafenib Population Pharmacokinetics and Skin Toxicities in Children and Adolescents with Refractory/Relapsed Leukemia or Solid Tumor Malignancies</a>, Clinical Cancer Research. 2019 Dec | journal-article. doi: 10.1158/1078-0432.CCR-19-0470.
<a href='http://dx.doi.org/10.1016/j.pnpbp.2018.09.003' target='_blank' class='bux-link'>Myocardial hypersensitivity to ischemic injury is not reversed by clonidine or propranolol in a predator-based rat model of posttraumatic stress disorder</a>, Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2019 Mar | journal-article. doi: 10.1016/j.pnpbp.2018.09.003.
<a href='http://dx.doi.org/10.1016/j.alcohol.2018.01.004' target='_blank' class='bux-link'>Predator-based psychosocial stress model of PTSD differentially influences voluntary ethanol consumption depending on methodology</a>, Alcohol. 2018 Aug | journal-article. doi: 10.1016/j.alcohol.2018.01.004.
<a href='' target='_blank' class='bux-link'>Acute Stress Decreases but Chronic Stress Increases Myocardial Sensitivity to Ischemic Injury in Rodents</a>, Frontiers in Psychiatry. 2016 Apr | journal-article. doi: 10.3389/fpsyt.2016.00071.
<a href='' target='_blank' class='bux-link'>Sex-dependent effects of sleep deprivation on myocardial sensitivity to ischemic injury</a>, Stress. 2016 Mar | journal-article. doi: 10.3109/10253890.2016.1152469.
<a href='' target='_blank' class='bux-link'>Sex-dependent effects of chronic psychosocial stress on myocardial sensitivity to ischemic injury</a>, Stress. 2015 Oct | journal-article. doi: 10.3109/10253890.2015.1087505.

Christopher Coss

Headshot of Christopher Coss
Christopher Coss
Assistant Professor
Pharmaceutics and Pharmacology
Research Areas
Pharmaceutics & Pharmacology,
Cancer
504 Riffe
coss.16@osu.edu
(614) 688-1309
Professional Website
Dr. Coss' research focuses on endocrine disease mechanisms and developing novel therapies for advanced prostate cancer. He also has an interest in chemoprevention of prostate and hepatocellular carcinomas using novel hormonal approaches.
2008, PhD, The Ohio State University, Pharmacy, Pharmaceutical Sciences, and Administration, Other
2003, BS, Cum Laude with Honors, The Ohio State University, Molecular Genetics
2003, BS, Cum Laude with Honors, The Ohio State University, Computer Science
Endocrine Society Early Investigator Award, 2015 - 2016
Sedlák D, Wilson TA, Tjarks W, Radomska HS, Wang H, Kolla JN, Leśnikowski ZJ, Špičáková A, Ali T, Ishita K, Rakotondraibe LH, Vibhute S, Wang D, Anzenbacher P, Bennett C, Bartunek P, Coss CC. Structure-Activity Relationship of Carborane Selective Estrogen Receptor β Agonists. J Med Chem. 2021 Jul 8;64(13):9330-9353. doi: 10.1021/acs.jmedchem.1c00555. Epub 2021 Jun 28. PMID: 34181409.
Collier KA, Valencia H, Newton H, Hade EM, Sborov DW, Cavaliere R, Poi M, Phelps MA, Liva SG, Coss CC, Wang J, Khountham S, Monk P, Shapiro CL, Piekarz R, Hofmeister CC, Welling DB, Mortazavi A. A phase 1 trial of the histone deacetylase inhibitor AR-42 in patients with neurofibromatosis type 2-associated tumors and advanced solid malignancies. Cancer Chemother Pharmacol. 2021 May;87(5):599-611. doi: 10.1007/s00280-020-04229-3. Epub 2021 Jan 25. PMID: 33492438; PMCID: PMC8162746.
Zhang P, Brinton LT, Williams K, Sher S, Orwick S, Tzung-Huei L, Mims AS, Coss CC, Kulp SK, Youssef Y, Chan WK, Mitchell S, Mustonen A, Cannon M, Phillips H, Lehman AM, Kauffman T, Beaver L, Canfield D, Grieselhuber NR, Alinari L, Sampath D, Yan P, Byrd JC, Blachly JS, Lapalombella R. Targeting DNA Damage Repair Functions of Two Histone Deacetylases, HDAC8 and SIRT6, Sensitizes Acute Myeloid Leukemia to NAMPT Inhibition. Clin Cancer Res. 2021 Apr 15;27(8):2352-2366. doi: 10.1158/1078-0432.CCR-20-3724. Epub 2021 Feb 4. PMID: 33542077; PMCID: PMC8054771.
Helms TH, Mullins RD, Thomas-Ahner JM, Kulp SK, Campbell MJ, Lucas F, Schmidt N, LeMoine DM, Getaneh S, Xie Z, Phelps MA, Clinton SK, Coss CC. Inhibition of androgen/AR signaling inhibits diethylnitrosamine (DEN) induced tumour initiation and remodels liver immune cell networks. Sci Rep. 2021 Feb 11;11(1):3646. doi: 10.1038/s41598-021-82252-x. PMID: 33574348; PMCID: PMC7878907.
Mukherjee D, DiVincenzo MJ, Torok M, Choueiry F, Kumar RJ, Deems A, Miller JL, Hinton A, Geraghty C, Maranon JA, Kulp SK, Coss C, Carson WE 3rd, Conwell DL, Hart PA, Cooperstone JL, Mace TA. Soy-tomato enriched diet reduces inflammation and disease severity in a pre-clinical model of chronic pancreatitis. Sci Rep. 2020 Dec 11;10(1):21824. doi: 10.1038/s41598-020-78762-9. PMID: 33311549; PMCID: PMC7733503.
Xie Z, Chen M, Goswami S, Mani R, Wang D, Kulp SK, Coss CC, Schaaf LJ, Cui F, Byrd JC, Jennings RN, Schober KK, Freed C, Lewis S, Malbrue R, Muthusamy N, Bennett C, Kisseberth WC, Phelps MA. Pharmacokinetics and Tolerability of the Novel Non-immunosuppressive Fingolimod Derivative, OSU-2S, in Dogs and Comparisons with Data in Mice and Rats. AAPS J. 2020 Jul 16;22(4):92. doi: 10.1208/s12248-020-00474-9. PMID: 32676788; PMCID: PMC7814188.
Liva SG, Coss CC, Wang J, Blum W, Klisovic R, Bhatnagar B, Walsh K, Geyer S, Zhao Q, Garzon R, Marcucci G, Phelps MA, Walker AR. Phase I study of AR-42 and decitabine in acute myeloid leukemia. Leuk Lymphoma. 2020 Jun;61(6):1484-1492. doi: 10.1080/10428194.2020.1719095. Epub 2020 Feb 8. PMID: 32037935; PMCID: PMC7375689.
Jain R, Coss C, Whooley P, Phelps M, Owen DH. The Role of Malnutrition and Muscle Wasting in Advanced Lung Cancer. Curr Oncol Rep. 2020 May 15;22(6):54. doi: 10.1007/s11912-020-00916-9. PMID: 32409907.
Liva SG, Tseng YC, Dauki AM, Sovic MG, Vu T, Henderson SE, Kuo YC, Benedict JA, Zhang X, Remaily BC, Kulp SK, Campbell M, Bekaii-Saab T, Phelps MA, Chen CS, Coss CC. Overcoming resistance to anabolic SARM therapy in experimental cancer cachexia with an HDAC inhibitor. EMBO Mol Med. 2020 Feb 7;12(2):e9910. doi: 10.15252/emmm.201809910. Epub 2020 Jan 13. PMID: 31930715; PMCID: PMC7005646.
Dauki AM, Blachly JS, Kautto EA, Ezzat S, Abdel-Rahman MH, Coss CC. Transcriptionally Active Androgen Receptor Splice Variants Promote Hepatocellular Carcinoma Progression. Cancer Res. 2020 Feb 1;80(3):561-575. doi: 10.1158/0008-5472.CAN-19-1117. Epub 2019 Nov 4. PMID: 31685543; PMCID: PMC7002251.

Emanuele Cocucci

Headshot of Emanuele Cocucci
Emanuele Cocucci
Assistant Professor
Pharmaceutics and Pharmacology
Research Areas
Chemical Biology,
Cancer,
Nanotechnology & Drug Delivery Systems,
Pharmaceutics & Pharmacology
cocucci.1@osu.edu
(614) 366-4412
Dr. Cocucci studies basic mechanisms of membrane trafficking and is interested in how these processes deviate during cancer development when compared to normal cells. His research adopts multiple techniques, including traditional biochemistry, cell biology, and high resolution fluorescent live cell microscopy. Dr. Cocucci’s goal is to define novel targets for cancer therapy and to improve drug delivery, studying the internalization pathways and the mechanisms of endosomal escape adopted by artificial and biological nanovectors.
2008, PhD - Molecular Medicine, Vita-Salute San Raffaele University
2004, Board in Pharmacology - Clinical Pharmacology, Universita degli Studi di Milano
2000, MD - Medicine and Surgery, Universita degli Studi di Milano
Advanced Imaging Center (AIC), 2017
GlaxoSmithKline and Immune Disease Institute Fellowship, 2008 - 2010
FEBS Short Term Fellowship, 2006
Marie Curie Fellowship, 2002 - 2003
<a href='https://doi.org/10.1158/1541-7786.c.6545634.v1' target='_blank' class='bux-link'>Data from Redefining CD56 as a Biomarker and Therapeutic Target in Multiple Myeloma</a>, . 2023 Apr | preprint. doi: 10.1158/1541-7786.c.6545634.v1.
<a href='https://doi.org/10.1158/1541-7786.c.6545634' target='_blank' class='bux-link'>Data from Redefining CD56 as a Biomarker and Therapeutic Target in Multiple Myeloma</a>, . 2023 Apr | preprint. doi: 10.1158/1541-7786.c.6545634.
<a href='https://doi.org/10.1158/1541-7786.22528158.v1' target='_blank' class='bux-link'>Supplementary Figure from Redefining CD56 as a Biomarker and Therapeutic Target in Multiple Myeloma</a>, . 2023 Apr | preprint. doi: 10.1158/1541-7786.22528158.v1.
<a href='https://doi.org/10.1158/1541-7786.22528158' target='_blank' class='bux-link'>Supplementary Figure from Redefining CD56 as a Biomarker and Therapeutic Target in Multiple Myeloma</a>, . 2023 Apr | preprint. doi: 10.1158/1541-7786.22528158.
<a href='https://doi.org/10.1158/1541-7786.22528161.v1' target='_blank' class='bux-link'>Supplementary Figure from Redefining CD56 as a Biomarker and Therapeutic Target in Multiple Myeloma</a>, . 2023 Apr | preprint. doi: 10.1158/1541-7786.22528161.v1.
<a href='https://doi.org/10.1158/1541-7786.22528161' target='_blank' class='bux-link'>Supplementary Figure from Redefining CD56 as a Biomarker and Therapeutic Target in Multiple Myeloma</a>, . 2023 Apr | preprint. doi: 10.1158/1541-7786.22528161.
<a href='https://doi.org/10.1158/1541-7786.MCR-21-0828' target='_blank' class='bux-link'>Redefining CD56 as a Biomarker and Therapeutic Target in Multiple Myeloma</a>, Molecular Cancer Research. 2022 Jul | journal-article. doi: 10.1158/1541-7786.MCR-21-0828.
<a href='https://doi.org/10.1101/2022.05.10.491399' target='_blank' class='bux-link'>Extracellular Vesicle exchange is favored by cell proximity</a>, . 2022 May | preprint. doi: 10.1101/2022.05.10.491399.
<a href='https://doi.org/10.1016/j.devcel.2021.10.019' target='_blank' class='bux-link'>De novo endocytic clathrin coats develop curvature at early stages of their formation.</a>, Developmental cell. 2021 Nov | journal-article. doi: 10.1016/j.devcel.2021.10.019.
<a href='https://europepmc.org/articles/PMC8410027' target='_blank' class='bux-link'>Optimizing extracellular vesicles' isolation from chronic lymphocytic leukemia patient plasma and cell line supernatant.</a>, JCI insight. 2021 Aug | journal-article. doi: 10.1172/jci.insight.137937.
<a href='https://doi.org/10.1073/pnas.2010438118' target='_blank' class='bux-link'>CALM supports clathrin-coated vesicle completion upon membrane tension increase</a>, Proceedings of the National Academy of Sciences. 2021 Jun | journal-article. doi: 10.1073/pnas.2010438118.
<a href='https://doi.org/10.1016/j.bbagen.2020.129752' target='_blank' class='bux-link'>Microscopy approaches to study extracellular vesicles.</a>, Biochimica et biophysica acta. General subjects. 2020 Sep | journal-article. doi: 10.1016/j.bbagen.2020.129752.
<a href='https://doi.org/10.1016/bs.mie.2020.06.015' target='_blank' class='bux-link'>Imaging intercellular interaction and extracellular vesicle exchange in a co-culture model of chronic lymphocytic leukemia and stromal cells by lattice light-sheet fluorescence microscopy.</a>, Methods in enzymology. 2020 Aug | journal-article. doi: 10.1016/bs.mie.2020.06.015.
<a href='https://doi.org/10.1080/15548627.2020.1771858' target='_blank' class='bux-link'>Live imaging of intra-lysosome pH in cell lines and primary neuronal culture using a novel genetically encoded biosensor.</a>, Autophagy. 2020 Jun | journal-article. doi: 10.1080/15548627.2020.1771858.
<a href='https://doi.org/10.1080/20013078.2019.1684862' target='_blank' class='bux-link'>Biological membranes in EV biogenesis, stability, uptake, and cargo transfer: an ISEV position paper arising from the ISEV membranes and EVs workshop</a>, Journal of Extracellular Vesicles. 2019 Dec | journal-article. doi: 10.1080/20013078.2019.1684862.
<a href='http://europepmc.org/abstract/PPR/PPR87114' target='_blank' class='bux-link'>Endocytic Clathrin Coats Develop Curvature at Early Stages of Their Formation</a>, . 2019 Jul | other. doi: 10.1101/715219.
<a href='http://europepmc.org/abstract/med/30637094' target='_blank' class='bux-link'>Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.</a>, Journal of extracellular vesicles. 2018 Nov | journal-article. doi: 10.1080/20013078.2018.1535750.
<a href='http://europepmc.org/abstract/med/30129019' target='_blank' class='bux-link'>Measuring Clathrin-Coated Vesicle Formation with Single-Molecule Resolution.</a>, Methods in molecular biology (Clifton, N.J.). 2018 Jan | journal-article. doi: 10.1007/978-1-4939-8719-1_15.
<a href='http://europepmc.org/abstract/med/28828661' target='_blank' class='bux-link'>Imaging of Isolated Extracellular Vesicles Using Fluorescence Microscopy.</a>, Methods in molecular biology (Clifton, N.J.). 2017 Jan | journal-article. doi: 10.1007/978-1-4939-7253-1_19.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85018513198&partnerID=MN8TOARS' target='_blank' class='bux-link'>MYC mediates large oncosome-induced fibroblast reprogramming in prostate cancer</a>, Cancer Research. 2017 Jan | journal-article. doi: 10.1158/0008-5472.CAN-16-2942.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85002744526&partnerID=MN8TOARS' target='_blank' class='bux-link'>Role of Passive Diffusion, Transporters, and Membrane Trafficking-Mediated Processes in Cellular Drug Transport</a>, Clinical Pharmacology and Therapeutics. 2017 Jan | journal-article. doi: 10.1002/cpt.545.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84994627608&partnerID=MN8TOARS' target='_blank' class='bux-link'>Membrane dynamics of dividing cells imaged by lattice light-sheet microscopy</a>, Molecular Biology of the Cell. 2016 Jan | journal-article. doi: 10.1091/mbc.E16-03-0164.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84925267233&partnerID=MN8TOARS' target='_blank' class='bux-link'>EVpedia: A community web portal for extracellular vesicles research</a>, Bioinformatics. 2015 Jan | journal-article. doi: 10.1093/bioinformatics/btu741.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84929506373&partnerID=MN8TOARS' target='_blank' class='bux-link'>Ectosomes and exosomes: Shedding the confusion between extracellular vesicles</a>, Trends in Cell Biology. 2015 Jan | journal-article. doi: 10.1016/j.tcb.2015.01.004.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84957808674&partnerID=MN8TOARS' target='_blank' class='bux-link'>Meeting report: Discussions and preliminary findings on extracellular RNA measurement methods from laboratories in the NIH Extracellular RNA Communication Consortium</a>, Journal of Extracellular Vesicles. 2015 Jan | journal-article. doi: 10.3402/jev.v4.26533.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84908565116&partnerID=MN8TOARS' target='_blank' class='bux-link'>Dynamin recruitment and membrane scission at the neck of a clathrin-coated pit</a>, Molecular Biology of the Cell. 2014 Jan | journal-article. doi: 10.1091/mbc.E14-07-1240.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84872195772&partnerID=MN8TOARS' target='_blank' class='bux-link'>Single-molecule analysis of fluorescently labeled G-protein-coupled receptors reveals complexes with distinct dynamics and organization</a>, Proceedings of the National Academy of Sciences of the United States of America. 2013 Jan | journal-article. doi: 10.1073/pnas.1205798110.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84870401535&partnerID=MN8TOARS' target='_blank' class='bux-link'>Dynamics of Intracellular Clathrin/AP1- and Clathrin/AP3-Containing Carriers</a>, Cell Reports. 2012 Jan | journal-article. doi: 10.1016/j.celrep.2012.09.025.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84864197258&partnerID=MN8TOARS' target='_blank' class='bux-link'>Errarum: Ectosomes (Current Biology (2011) 21 (R940-R941))</a>, Current Biology. 2012 Jan | journal-article. doi: 10.1016/j.cub.2012.07.014.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84861307148&partnerID=MN8TOARS' target='_blank' class='bux-link'>Limited transferrin receptor clustering allows rapid diffusion of canine parvovirus into clathrin endocytic structures</a>, Journal of Virology. 2012 Jan | journal-article. doi: 10.1128/JVI.07194-11.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84864634144&partnerID=MN8TOARS' target='_blank' class='bux-link'>The first five seconds in the life of a clathrin-coated pit</a>, Cell. 2012 Jan | journal-article. doi: 10.1016/j.cell.2012.05.047.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84871702725&partnerID=MN8TOARS' target='_blank' class='bux-link'>Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation</a>, PLoS Biology. 2012 Jan | journal-article. doi: 10.1371/journal.pbio.1001450.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85027917194&partnerID=MN8TOARS' target='_blank' class='bux-link'>ARFGAP1 promotes AP-2-dependent endocytosis</a>, Nature Cell Biology. 2011 Jan | journal-article. doi: 10.1038/ncb2221.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-82955189251&partnerID=MN8TOARS' target='_blank' class='bux-link'>Ectosomes</a>, Current Biology. 2011 Jan | journal-article. doi: 10.1016/j.cub.2011.10.011.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-70349764506&partnerID=MN8TOARS' target='_blank' class='bux-link'>Distinct dynamics of endocytic clathrin-coated pits and coated plaques</a>, PLoS Biology. 2009 Jan | journal-article. doi: 10.1371/journal.pbio.1000191.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-59249089695&partnerID=MN8TOARS' target='_blank' class='bux-link'>Shedding microvesicles: artefacts no more</a>, Trends in Cell Biology. 2009 Jan | journal-article. doi: 10.1016/j.tcb.2008.11.003.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-55049087015&partnerID=MN8TOARS' target='_blank' class='bux-link'>The regulated exocytosis of enlargeosomes is mediated by a SNARE machinery that includes VAMP4</a>, Journal of Cell Science. 2008 Jan | journal-article. doi: 10.1242/jcs.032029.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-34249035506&partnerID=MN8TOARS' target='_blank' class='bux-link'>Enlargeosome traffic: Exocytosis triggered by various signals is followed by endocytosis, membrane shedding or both</a>, Traffic. 2007 Jan | journal-article. doi: 10.1111/j.1600-0854.2007.00566.x.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-34948817753&partnerID=MN8TOARS' target='_blank' class='bux-link'>The Ca2+-dependent exocytosis of enlargeosomes is greatly reinforced by genistein via a non-tyrosine kinase-dependent mechanism</a>, FEBS Letters. 2007 Jan | journal-article. doi: 10.1016/j.febslet.2007.09.026.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-33845694498&partnerID=MN8TOARS' target='_blank' class='bux-link'>Macropinocytosis: Regulated coordination of endocytic and exocytic membrane traffic events</a>, Journal of Cell Science. 2006 Jan | journal-article. doi: 10.1242/jcs.03238.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-33645021543&partnerID=MN8TOARS' target='_blank' class='bux-link'>Non-secretory exocytoses in the brain</a>, Journal of Physiology Paris. 2006 Jan | journal-article. doi: 10.1016/j.jphysparis.2005.12.081.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-9444225970&partnerID=MN8TOARS' target='_blank' class='bux-link'>Enlargeosome, an exocytic vesicle resistant to nonionic detergents, undergoes endocytosis via a nonacidic route</a>, Molecular Biology of the Cell. 2004 Jan | journal-article. doi: 10.1091/mbc.E04-07-0577.
<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-0036903036&partnerID=MN8TOARS' target='_blank' class='bux-link'>Regulated exocytosis: A novel, widely expressed system</a>, Nature Cell Biology. 2002 Jan | journal-article. doi: 10.1038/ncb888.

Daelynn Buelow

Headshot of Daelynn Buelow
Daelynn Buelow
Research Scientist
Pharmaceutics and Pharmacology
Research Areas
Clinical & Pre-Clinical Pharmacology
buelow.18@osu.edu
(614) 685-7542
Professional Website
2002-2007, PhD - University of Alberta: Edmonton, AB, CA
2008-2010, Post Doctoral Studies - Washington State University
<a href='https://doi.org/10.1182/bloodadvances.2022007952' target='_blank' class='bux-link'>BMX kinase mediates gilteritinib resistance in FLT3-mutated AML through microenvironmental factors.</a>, Blood advances. 2022 Sep | journal-article. doi: 10.1182/bloodadvances.2022007952.
<a href='https://doi.org/10.1158/1078-0432.CCR-21-4450' target='_blank' class='bux-link'>Preclinical and Pilot Study of Type I FLT3 Tyrosine Kinase Inhibitor, Crenolanib, with Sorafenib in Acute Myeloid Leukemia and FLT3-Internal Tandem Duplication.</a>, Clinical cancer research : an official journal of the American Association for Cancer Research. 2022 Jun | journal-article. doi: 10.1158/1078-0432.ccr-21-4450.
<a href='https://europepmc.org/articles/PMC9153019' target='_blank' class='bux-link'>Gilteritinib-induced upregulation of S100A9 is mediated through BCL6 in acute myeloid leukemia.</a>, Blood advances. 2021 Dec | journal-article. doi: 10.1182/bloodadvances.2021005614.
<a href='https://europepmc.org/articles/PMC8687141' target='_blank' class='bux-link'>Gilteritinib Inhibits Glutamine Uptake and Utilization in <i>FLT3</i>-ITD-Positive AML.</a>, Molecular cancer therapeutics. 2021 Sep | journal-article. doi: 10.1158/1535-7163.mct-21-0071.
<a href='https://europepmc.org/articles/PMC7877866' target='_blank' class='bux-link'>DNA Methylation-Based Epigenetic Repression of SLC22A4 Promotes Resistance to Cytarabine in Acute Myeloid Leukemia.</a>, Clinical and translational science. 2020 Sep | journal-article. doi: 10.1111/cts.12861.
<a href='https://europepmc.org/articles/PMC6732269' target='_blank' class='bux-link'>Skin fibroblasts of patients with geleophysic dysplasia due to FBN1 mutations have lysosomal inclusions and losartan improves their microfibril deposition defect.</a>, Molecular genetics & genomic medicine. 2019 Jul | journal-article. doi: 10.1002/mgg3.844.
<a href='https://europepmc.org/articles/PMC6858927' target='_blank' class='bux-link'>Preclinical activity and a pilot phase I study of pacritinib, an oral JAK2/FLT3 inhibitor, and chemotherapy in FLT3-ITD-positive AML.</a>, Investigational new drugs. 2019 May | journal-article. doi: 10.1007/s10637-019-00786-4.
<a href='https://europepmc.org/articles/PMC6522510' target='_blank' class='bux-link'>A high-throughput screen indicates gemcitabine and JAK inhibitors may be useful for treating pediatric AML.</a>, Nature communications. 2019 May | journal-article. doi: 10.1038/s41467-019-09917-0.
<a href='https://europepmc.org/articles/PMC6335421' target='_blank' class='bux-link'>Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms.</a>, Nature communications. 2019 Jan | journal-article. doi: 10.1038/s41467-018-08263-x.
<a href='https://europepmc.org/articles/PMC5749502' target='_blank' class='bux-link'>Hypoxia-induced upregulation of BMX kinase mediates therapeutic resistance in acute myeloid leukemia.</a>, The Journal of clinical investigation. 2017 Dec | journal-article. doi: 10.1172/jci91893.
<a href='https://europepmc.org/articles/PMC5102776' target='_blank' class='bux-link'>Transcriptome profiling of patient derived xenograft models established from pediatric acute myeloid leukemia patients confirm maintenance of FLT3-ITD mutation.</a>, Leukemia & lymphoma. 2016 Jun | journal-article. doi: 10.1080/10428194.2016.1187272.
<a href='https://europepmc.org/articles/PMC5818632' target='_blank' class='bux-link'>Comparative Evaluation of Four Real-Time PCR Methods for the Quantitative Detection of Epstein-Barr Virus from Whole Blood Specimens.</a>, The Journal of molecular diagnostics : JMD. 2016 May | journal-article. doi: 10.1016/j.jmoldx.2016.02.002.
<a href='https://europepmc.org/articles/PMC4879274' target='_blank' class='bux-link'>Quantitative Assessment of Commutability for Clinical Viral Load Testing Using a Digital PCR-Based Reference Standard.</a>, Journal of clinical microbiology. 2016 Apr | journal-article. doi: 10.1128/jcm.03346-15.
<a href='https://europepmc.org/articles/PMC4905720' target='_blank' class='bux-link'>ABCC4 Is a Determinant of Cytarabine-Induced Cytotoxicity and Myelosuppression.</a>, Clinical and translational science. 2016 Feb | journal-article. doi: 10.1111/cts.12366.
<a href='https://doi.org/10.5858/arpa.2013-0592-OA' target='_blank' class='bux-link'>Quantitative multiplexed detection of common pulmonary fungal pathogens by labeled primer polymerase chain reaction.</a>, Archives of pathology & laboratory medicine. 2014 Nov | journal-article. doi: 10.5858/arpa.2013-0592-oa.
<a href='https://doi.org/10.1016/j.jcv.2013.05.008' target='_blank' class='bux-link'>Comparison of two multiplexed PCR assays for the detection of HSV-1, HSV-2, and VZV with extracted and unextracted cutaneous and mucosal specimens.</a>, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology. 2013 Jun | journal-article. doi: 10.1016/j.jcv.2013.05.008.
<a href='https://europepmc.org/articles/PMC4188534' target='_blank' class='bux-link'>Capsaicin-sensitive vagal afferent neurons contribute to the detection of pathogenic bacterial colonization in the gut.</a>, Journal of neuroimmunology. 2013 Mar | journal-article. doi: 10.1016/j.jneuroim.2013.01.009.
<a href='https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23303501/?tool=EBI' target='_blank' class='bux-link'>PCR followed by electrospray ionization mass spectrometry for broad-range identification of fungal pathogens.</a>, Journal of clinical microbiology. 2013 Jan | journal-article. doi: 10.1128/jcm.02621-12.
<a href='https://doi.org/10.3109/13693786.2012.666681' target='_blank' class='bux-link'>Evaluation of multiplexed PCR and liquid-phase array for identification of respiratory fungal pathogens.</a>, Medical mycology. 2012 Mar | journal-article. doi: 10.3109/13693786.2012.666681.
<a href='https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21435039/?tool=EBI' target='_blank' class='bux-link'>Campylobacter jejuni survival within human epithelial cells is enhanced by the secreted protein CiaI.</a>, Molecular microbiology. 2011 Apr | journal-article. doi: 10.1111/j.1365-2958.2011.07645.x.
<a href='https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21317318/?tool=EBI' target='_blank' class='bux-link'>Structure of the periplasmic stress response protein CpxP.</a>, Journal of bacteriology. 2011 Feb | journal-article. doi: 10.1128/jb.01296-10.
<a href='https://doi.org/10.1111/j.1365-2958.2009.06982.x' target='_blank' class='bux-link'>Three (and more) component regulatory systems - auxiliary regulators of bacterial histidine kinases.</a>, Molecular microbiology. 2009 Nov | journal-article. doi: 10.1111/j.1365-2958.2009.06982.x.
<a href='https://doi.org/10.1007/978-0-387-78885-2_6' target='_blank' class='bux-link'>Two-component signaling and gram negative envelope stress response systems.</a>, Advances in experimental medicine and biology. 2008 Jan | journal-article. doi: 10.1007/978-0-387-78885-2_6.
<a href='https://europepmc.org/articles/PMC1251582' target='_blank' class='bux-link'>Cpx signal transduction is influenced by a conserved N-terminal domain in the novel inhibitor CpxP and the periplasmic protease DegP.</a>, Journal of bacteriology. 2005 Oct | journal-article. doi: 10.1128/jb.187.19.6622-6630.2005.