Pharmaceutics and Pharmacology

Abhijit Shinde

Research Scientist

Parks 551

shinde.63@osu.edu

Jack Yalowich

Professor

Pharmaceutics and Pharmacology

Research Areas

Cancer,

Infectious Diseases,

Pharmaceutics & Pharmacology

532 Parks Hall

yalowich.1@osu.edu

(614) 688-5980

Dr. Yalowich’s lab focuses on mechanisms of action and resistance to a class of anticancer agents known as DNA topoisomerase IIα (TOP2α; 170 kDa ) inhibitors, such as the anticancer agent etoposide. Ongoing projects characterize alternative RNA processing/intronic polyadenylation of TOP2α pre-mRNA that results in formation of a 90 kDa truncated form of TOP2α in acquired resistance to etoposide. Strategies to circumvent drug resistance involve CRISPR/Cas9 gene editing to restore proper RNA splicing function in resistant cells. In addition, the role of micro-RNAs as determinants of anticancer drug resistance is under investigation. Finally, the Yalowich lab actively collaborates with Dr. Mark-Mitton-Fry from the Division of Medicinal Chemistry and Pharmacognosy to evaluate the mechanisms of action and efficacy of newly synthesized Novel Bacterial Topoisomerase Inhibitors (NBTIs).

Dr. Yalowich’s educational background includes a B.A. in Biology and Chemistry from Lehigh University, a Ph.D. in Biochemical Pharmacology from S.U.N.Y Buffalo studying anticancer drugs that target the essential enzyme Thymidylate synthase, and postdoctoral training at the Medical College of Virginia (antifolate studies) and University of Florida, evaluating DNA topoisomerase II inhibitors where his research focus has remained. His first academic position was at St. Jude Children’s Hospital in Memphis, TN as an Assistant Member, followed by a position as Assistant Professor and tenured Associate Professor in the Department of Pharmacology and Chemical Biology at the University of Pittsburgh School of Medicine. In 2010, he joined the faculty of The Ohio State University College of Pharmacy as Professor (and Chair 2015-2017) in the Division of Pharmacology (since 2020 the Division of Pharmaceutics and Pharmacology). Aside from maintaining a productive and funded research enterprise, Dr. Yalowich has chaired two separate NIH peer-review panels and serves on the executive committee for the Division of Cancer Pharmacology at the American Society for Pharmacology and Experimental Therapeutics.

View My Bibliography from NCBI

1974 - BA, Chemistry & Biology, Lehigh University

1980 - PhD, Biochemical Pharmacology, State University of New York at Buffalo

1980-1983, Postdoctoral Fellow, Department of Medicine, Medical College of Virginia

2017 - Present: Secretary-Treasurer; Division for Cancer Pharmacology; American Society for Pharmacology and Experimental Therapeutics

2016 - Present: Editorial Board; Journal of Pharmacology and Experimental Therapeutics

2015-2017: Chair; Division of Pharmacology, College of Pharmacy, The Ohio State University

2012-2016: Chair; Molecular Targets for Cancer Intervention [ZRG BMCT-C (01)] study section, National Cancer Institute (NCI/NIH)

2004-2009: Chair (2007-2009) and Chartered Member; Basic Mechanism of Cancer Therapeutics (BMCT) study Section, National Cancer Institute (NCI/NIH)

1999-2005: Chair (2004 & 2005) and Member; Panel G: Experimental Therapeutics, Carcinogenesis, & Medicinal Chemistry study section, National Cancer Institute of Canada (NCIC)

1984-1986: Special Fellow; Leukemia Society of America

<a href='https://doi.org/10.1124/jpet.123.002038' target='_blank' class='bux-link'>Use of CRISPR/Cas9 with Homology-Directed Repair to Gene-Edit Topoisomerase IIβin Human Leukemia K562 Cells: Generation of a Resistance Phenotype</a>, Journal of Pharmacology and Experimental Therapeutics. 2024 May | journal-article. doi: 10.1124/jpet.123.002038.

<a href='https://doi.org/10.1128/aac.00482-23' target='_blank' class='bux-link'>Novel bacterial topoisomerase inhibitors: unique targeting activities of amide enzyme-binding motifs for tricyclic analogs</a>, Antimicrobial Agents and Chemotherapy. 2023 Oct | journal-article. doi: 10.1128/aac.00482-23.

<a href='https://doi.org/10.3390/ijms241512107' target='_blank' class='bux-link'>Actions of a Novel Bacterial Topoisomerase Inhibitor against Neisseria gonorrhoeae Gyrase and Topoisomerase IV: Enhancement of Double-Stranded DNA Breaks</a>, International Journal of Molecular Sciences. 2023 Jul | journal-article. doi: 10.3390/ijms241512107.

<a href='https://doi.org/10.1124/jpet.122.001429' target='_blank' class='bux-link'>Effects of hsa-miR-9-3p and hsa-miR-9-5p on Topoisomerase IIβExpression in Human Leukemia K562 Cells with Acquired Resistance to Etoposide</a>, Journal of Pharmacology and Experimental Therapeutics. 2023 Feb | journal-article. doi: 10.1124/jpet.122.001429.

<a href='https://doi.org/10.3390/cancers14133148' target='_blank' class='bux-link'>Intronic Polyadenylation in Acquired Cancer Drug Resistance Circumvented by Utilizing CRISPR/Cas9 with Homology-Directed Repair: The Tale of Human DNA Topoisomerase IIα</a>, Cancers. 2022 Jun | journal-article. doi: 10.3390/cancers14133148.

<a href='http://europepmc.org/abstract/med/34614347' target='_blank' class='bux-link'>Optimization of TopoIV Potency, ADMET Properties, and hERG Inhibition of 5-Amino-1,3-dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Identification of a Lead with In Vivo Efficacy against MRSA.</a>, Journal of medicinal chemistry. 2021 Oct | journal-article. doi: 10.1021/acs.jmedchem.1c01250.

<a href='http://europepmc.org/abstract/med/33446509' target='_blank' class='bux-link'>CRISPR/Cas9 Genome Editing of the Human Topoisomerase IIα Intron 19 5' Splice Site Circumvents Etoposide Resistance in Human Leukemia K562 Cells.</a>, Molecular pharmacology. 2021 Jan | journal-article. doi: 10.1124/molpharm.120.000173.

<a href='http://europepmc.org/abstract/med/33335666' target='_blank' class='bux-link'>Dioxane-Linked Amide Derivatives as Novel Bacterial Topoisomerase Inhibitors against Gram-Positive Staphylococcus aureus.</a>, ACS medicinal chemistry letters. 2020 Oct | journal-article. doi: 10.1021/acsmedchemlett.0c00428.

<a href='http://europepmc.org/abstract/med/32402932' target='_blank' class='bux-link'>Novel bacterial topoisomerase inhibitors derived from isomannide.</a>, European journal of medicinal chemistry. 2020 Apr | journal-article. doi: 10.1016/j.ejmech.2020.112324.

<a href='http://europepmc.org/abstract/med/32566920' target='_blank' class='bux-link'>Effects of DNA topoisomerase IIα splice variants on acquired drug resistance.</a>, Cancer drug resistance (Alhambra, Calif.). 2020 Feb | journal-article. doi: 10.20517/cdr.2019.117.

<a href='http://europepmc.org/abstract/med/31836624' target='_blank' class='bux-link'>hsa-miR-9-3p and hsa-miR-9-5p as Post-Transcriptional Modulators of DNA Topoisomerase IIα in Human Leukemia K562 Cells with Acquired Resistance to Etoposide.</a>, Molecular pharmacology. 2019 Dec | journal-article. doi: 10.1124/mol.119.118315.

<a href='http://europepmc.org/abstract/med/31041863' target='_blank' class='bux-link'>1,3-Dioxane-Linked Bacterial Topoisomerase Inhibitors with Enhanced Antibacterial Activity and Reduced hERG Inhibition.</a>, ACS infectious diseases. 2019 May | journal-article. doi: 10.1021/acsinfecdis.8b00375.

<a href='http://europepmc.org/abstract/med/29871847' target='_blank' class='bux-link'>Synthesis and anti-staphylococcal activity of novel bacterial topoisomerase inhibitors with a 5-amino-1,3-dioxane linker moiety.</a>, Bioorganic & medicinal chemistry letters. 2018 Jun | journal-article. doi: 10.1016/j.bmcl.2018.06.003.

<a href='http://europepmc.org/abstract/med/29656990' target='_blank' class='bux-link'>Synthesis and antiproliferative activity of derivatives of the phyllanthusmin class of arylnaphthalene lignan lactones.</a>, Bioorganic & medicinal chemistry. 2018 Mar | journal-article. doi: 10.1016/j.bmc.2018.03.033.

<a href='http://europepmc.org/abstract/med/29514855' target='_blank' class='bux-link'>The Novel C-terminal Truncated 90-kDa Isoform of Topoisomerase IIα (TOP2α/90) Is a Determinant of Etoposide Resistance in K562 Leukemia Cells via Heterodimerization with the TOP2α/170 Isoform.</a>, Molecular pharmacology. 2018 Mar | journal-article. doi: 10.1124/mol.117.111567.

<a href='http://europepmc.org/abstract/med/29406734' target='_blank' class='bux-link'>Capsicodendrin from Cinnamosma fragrans Exhibits Antiproliferative and Cytotoxic Activity in Human Leukemia Cells: Modulation by Glutathione.</a>, Journal of natural products. 2018 Feb | journal-article. doi: 10.1021/acs.jnatprod.7b00887.

<a href='http://europepmc.org/abstract/med/27974648' target='_blank' class='bux-link'>Alternative RNA Processing of Topoisomerase IIα in Etoposide-Resistant Human Leukemia K562 Cells: Intron Retention Results in a Novel C-Terminal Truncated 90-kDa Isoform.</a>, The Journal of pharmacology and experimental therapeutics. 2016 Nov | journal-article. doi: 10.1124/jpet.116.237107.

<a href='http://europepmc.org/abstract/med/26660439' target='_blank' class='bux-link'>Mechanisms of Action and Reduced Cardiotoxicity of Pixantrone; a Topoisomerase II Targeting Agent with Cellular Selectivity for the Topoisomerase IIα Isoform.</a>, The Journal of pharmacology and experimental therapeutics. 2015 Dec | journal-article. doi: 10.1124/jpet.115.228650.

<a href='http://europepmc.org/abstract/med/26637632' target='_blank' class='bux-link'>TRIM72 modulates caveolar endocytosis in repair of lung cells.</a>, American journal of physiology. Lung cellular and molecular physiology. 2015 Dec | journal-article. doi: 10.1152/ajplung.00089.2015.

<a href='http://europepmc.org/abstract/med/27047316' target='_blank' class='bux-link'>Experimental procedures to identify and validate specific mRNA targets of miRNAs.</a>, EXCLI journal. 2015 Jul | journal-article. doi: 10.17179/excli2015-319.

<a href='http://europepmc.org/abstract/med/25922181' target='_blank' class='bux-link'>Structure-based design, synthesis and biological testing of piperazine-linked bis-epipodophyllotoxin etoposide analogs.</a>, Bioorganic & medicinal chemistry. 2015 Apr | journal-article. doi: 10.1016/j.bmc.2015.04.022.

<a href='http://europepmc.org/abstract/med/25596805' target='_blank' class='bux-link'>Cytotoxic and natural killer cell stimulatory constituents of Phyllanthus songboiensis.</a>, Phytochemistry. 2015 Jan | journal-article. doi: 10.1016/j.phytochem.2014.12.014.

<a href='http://europepmc.org/abstract/med/25550273' target='_blank' class='bux-link'>Cellular mechanisms of the cytotoxicity of the anticancer drug elesclomol and its complex with Cu(II).</a>, Biochemical pharmacology. 2014 Dec | journal-article. doi: 10.1016/j.bcp.2014.12.008.

<a href='http://europepmc.org/abstract/med/25282653' target='_blank' class='bux-link'>Structure-based design, synthesis and biological testing of etoposide analog epipodophyllotoxin-N-mustard hybrid compounds designed to covalently bind to topoisomerase II and DNA.</a>, Bioorganic & medicinal chemistry. 2014 Sep | journal-article. doi: 10.1016/j.bmc.2014.09.014.

<a href='http://europepmc.org/abstract/med/24937209' target='_blank' class='bux-link'>Potent cytotoxic arylnaphthalene lignan lactones from Phyllanthus poilanei.</a>, Journal of natural products. 2014 Jun | journal-article. doi: 10.1021/np5002785.

<a href='http://europepmc.org/abstract/med/23041231' target='_blank' class='bux-link'>The anticancer multi-kinase inhibitor dovitinib also targets topoisomerase I and topoisomerase II.</a>, Biochemical pharmacology. 2012 Oct | journal-article. doi: 10.1016/j.bcp.2012.09.023.

<a href='http://europepmc.org/abstract/med/22503743' target='_blank' class='bux-link'>The anticancer thiosemicarbazones Dp44mT and triapine lack inhibitory effects as catalytic inhibitors or poisons of DNA topoisomerase IIα.</a>, Biochemical pharmacology. 2012 Apr | journal-article. doi: 10.1016/j.bcp.2012.03.021.

<a href='http://europepmc.org/abstract/med/22041173' target='_blank' class='bux-link'>Design, synthesis, and biological evaluation of a novel series of bisintercalating DNA-binding piperazine-linked bisanthrapyrazole compounds as anticancer agents.</a>, Bioorganic & medicinal chemistry. 2011 Oct | journal-article. doi: 10.1016/j.bmc.2011.10.012.

<a href='http://europepmc.org/abstract/med/21497582' target='_blank' class='bux-link'>Cadmium is a catalytic inhibitor of DNA topoisomerase II.</a>, Journal of inorganic biochemistry. 2011 Feb | journal-article. doi: 10.1016/j.jinorgbio.2011.02.007.

<a href='http://europepmc.org/abstract/med/21097707' target='_blank' class='bux-link'>Myeloperoxidase-dependent oxidation of etoposide in human myeloid progenitor CD34+ cells.</a>, Molecular pharmacology. 2010 Nov | journal-article. doi: 10.1124/mol.110.068718.

<a href='http://europepmc.org/abstract/med/20496255' target='_blank' class='bux-link'>Toxicity issues in cancer drug development.</a>, Current opinion in investigational drugs (London, England : 2000). 2010 Jun | journal-article. .

<a href='http://europepmc.org/abstract/med/20471276' target='_blank' class='bux-link'>Design, synthesis and biological evaluation of a novel series of anthrapyrazoles linked with netropsin-like oligopyrrole carboxamides as anticancer agents.</a>, Bioorganic & medicinal chemistry. 2010 Apr | journal-article. doi: 10.1016/j.bmc.2010.04.028.

<a href='http://europepmc.org/abstract/med/20145018' target='_blank' class='bux-link'>The mismatch repair system modulates curcumin sensitivity through induction of DNA strand breaks and activation of G2-M checkpoint.</a>, Molecular cancer therapeutics. 2010 Feb | journal-article. doi: 10.1158/1535-7163.mct-09-0627.

<a href='http://europepmc.org/abstract/med/20006518' target='_blank' class='bux-link'>A diazirine-based photoaffinity etoposide probe for labeling topoisomerase II.</a>, Bioorganic & medicinal chemistry. 2009 Nov | journal-article. doi: 10.1016/j.bmc.2009.11.048.

<a href='http://europepmc.org/abstract/med/19457675' target='_blank' class='bux-link'>The structure-based design, synthesis, and biological evaluation of DNA-binding amide linked bisintercalating bisanthrapyrazole anticancer compounds.</a>, Bioorganic & medicinal chemistry. 2009 May | journal-article. doi: 10.1016/j.bmc.2009.04.072.

<a href='http://europepmc.org/abstract/med/18258442' target='_blank' class='bux-link'>The structure-based design, synthesis and biological evaluation of DNA-binding bisintercalating bisanthrapyrazole anticancer compounds.</a>, Bioorganic & medicinal chemistry. 2008 Jan | journal-article. doi: 10.1016/j.bmc.2008.01.033.

<a href='http://europepmc.org/abstract/med/18197631' target='_blank' class='bux-link'>Thiol-modulated mechanisms of the cytotoxicity of thimerosal and inhibition of DNA topoisomerase II alpha.</a>, Chemical research in toxicology. 2008 Jan | journal-article. doi: 10.1021/tx700341n.

<a href='http://europepmc.org/abstract/med/18045852' target='_blank' class='bux-link'>A three-dimensional quantitative structure-activity analysis of a new class of bisphenol topoisomerase IIalpha inhibitors.</a>, Molecular pharmacology. 2007 Nov | journal-article. doi: 10.1124/mol.107.041624.

<a href='http://europepmc.org/abstract/med/17854709' target='_blank' class='bux-link'>Mechanism of the cytotoxicity of the diazoparaquinone antitumor antibiotic kinamycin F.</a>, Free radical biology & medicine. 2007 Jul | journal-article. doi: 10.1016/j.freeradbiomed.2007.07.005.

<a href='http://europepmc.org/abstract/med/17021249' target='_blank' class='bux-link'>c-Abl kinase regulates curcumin-induced cell death through activation of c-Jun N-terminal kinase.</a>, Molecular pharmacology. 2006 Oct | journal-article. doi: 10.1124/mol.106.026575.

<a href='http://europepmc.org/abstract/med/16926632' target='_blank' class='bux-link'>Kinamycins A and C, bacterial metabolites that contain an unusual diazo group, as potential new anticancer agents: antiproliferative and cell cycle effects.</a>, Anti-cancer drugs. 2006 Aug | journal-article. doi: 10.1097/01.cad.0000224442.78211.27.

<a href='http://europepmc.org/abstract/med/16859314' target='_blank' class='bux-link'>A structure-based 3D-QSAR study of anthrapyrazole analogues of the anticancer agents losoxantrone and piroxantrone.</a>, Journal of chemical information and modeling. 2006 Jul | journal-article. doi: 10.1021/ci060056y.

<a href='http://europepmc.org/abstract/med/16838078' target='_blank' class='bux-link'>Increased mutant frequencies in the HPRT gene locus of leukemia HL-60 cells treated with succinylacetone.</a>, Cell biology and toxicology. 2006 Jul | journal-article. doi: 10.1007/s10565-006-0171-4.

<a href='http://europepmc.org/abstract/med/16841962' target='_blank' class='bux-link'>Myeloperoxidase-catalyzed metabolism of etoposide to its quinone and glutathione adduct forms in HL60 cells.</a>, Chemical research in toxicology. 2006 Jul | journal-article. doi: 10.1021/tx0600595.

<a href='http://europepmc.org/abstract/med/16690782' target='_blank' class='bux-link'>Mechanisms of cardiolipin oxidation by cytochrome c: relevance to pro- and antiapoptotic functions of etoposide.</a>, Molecular pharmacology. 2006 May | journal-article. doi: 10.1124/mol.106.022731.

<a href='http://europepmc.org/abstract/med/16010589' target='_blank' class='bux-link'>Structure-activity study of the interaction of bioreductive benzoquinone alkylating agents with DNA topoisomerase II.</a>, Cancer chemotherapy and pharmacology. 2005 Jul | journal-article. doi: 10.1007/s00280-005-0040-5.

<a href='http://europepmc.org/abstract/med/15602006' target='_blank' class='bux-link'>Biochemical and proteomics approaches to characterize topoisomerase IIalpha cysteines and DNA as targets responsible for cisplatin-induced inhibition of topoisomerase IIalpha.</a>, Molecular pharmacology. 2004 Dec | journal-article. doi: 10.1124/mol.104.004416.

<a href='http://europepmc.org/abstract/med/15231869' target='_blank' class='bux-link'>Discovery and characterization of novel small molecule inhibitors of human Cdc25B dual specificity phosphatase.</a>, Molecular pharmacology. 2004 Jul | journal-article. doi: 10.1124/mol.104.001784.

<a href='http://europepmc.org/abstract/med/14630936' target='_blank' class='bux-link'>Lipid antioxidant, etoposide, inhibits phosphatidylserine externalization and macrophage clearance of apoptotic cells by preventing phosphatidylserine oxidation.</a>, The Journal of biological chemistry. 2003 Nov | journal-article. doi: 10.1074/jbc.m309929200.

<a href='http://europepmc.org/abstract/med/12595076' target='_blank' class='bux-link'>Direct evidence for recycling of myeloperoxidase-catalyzed phenoxyl radicals of a vitamin E homologue, 2,2,5,7,8-pentamethyl-6-hydroxy chromane, by ascorbate/dihydrolipoate in living HL-60 cells.</a>, Biochimica et biophysica acta. 2003 Mar | journal-article. doi: 10.1016/s0304-4165(02)00509-3.

<a href='http://europepmc.org/abstract/med/12126799' target='_blank' class='bux-link'>Anti-/pro-oxidant effects of phenolic compounds in cells: are colchicine metabolites chain-breaking antioxidants?</a>, Toxicology. 2002 Aug | journal-article. doi: 10.1016/s0300-483x(02)00199-3.

<a href='http://europepmc.org/abstract/med/12467229' target='_blank' class='bux-link'>The histone deacetylase inhibitor sodium butyrate induces DNA topoisomerase II alpha expression and confers hypersensitivity to etoposide in human leukemic cell lines.</a>, Molecular cancer therapeutics. 2001 Dec | journal-article. .

<a href='http://europepmc.org/abstract/med/11691792' target='_blank' class='bux-link'>Pro-oxidant and antioxidant mechanisms of etoposide in HL-60 cells: role of myeloperoxidase.</a>, Cancer research. 2001 Nov | journal-article. .

<a href='http://europepmc.org/abstract/med/11425578' target='_blank' class='bux-link'>Synthesis and biological activity of a photoaffinity etoposide probe.</a>, Bioorganic & medicinal chemistry. 2001 Jul | journal-article. doi: 10.1016/s0968-0896(01)00102-x.

<a href='http://europepmc.org/abstract/med/11396475' target='_blank' class='bux-link'>Antioxidant mechanisms of nitric oxide against iron-catalyzed oxidative stress in cells.</a>, Antioxidants & redox signaling. 2001 Apr | journal-article. doi: 10.1089/152308601300185160.

<a href='http://europepmc.org/abstract/med/11179439' target='_blank' class='bux-link'>The catalytic DNA topoisomerase II inhibitor dexrazoxane (ICRF-187) induces differentiation and apoptosis in human leukemia K562 cells.</a>, Molecular pharmacology. 2001 Mar | journal-article. doi: 10.1124/mol.59.3.453.

<a href='http://europepmc.org/abstract/med/11046078' target='_blank' class='bux-link'>The catalytic DNA topoisomerase II inhibitor dexrazoxane (ICRF-187) induces endopolyploidy in Chinese hamster ovary cells.</a>, The Journal of pharmacology and experimental therapeutics. 2000 Nov | journal-article. .

<a href='http://europepmc.org/abstract/med/10906134' target='_blank' class='bux-link'>Regulation of DNA-dependent protein kinase activity by ionizing radiation-activated abl kinase is an ATM-dependent process.</a>, The Journal of biological chemistry. 2000 Sep | journal-article. doi: 10.1074/jbc.m004302200.

<a href='http://europepmc.org/abstract/med/10772954' target='_blank' class='bux-link'>Myeloperoxidase-catalyzed phenoxyl radicals of vitamin E homologue, 2,2,5,7,8-pentamethyl- 6-hydroxychromane, do not induce oxidative stress in live HL-60 cells.</a>, Biochemical and biophysical research communications. 2000 Apr | journal-article. doi: 10.1006/bbrc.2000.2564.

<a href='http://europepmc.org/abstract/med/10462537' target='_blank' class='bux-link'>Mechanism-based chemopreventive strategies against etoposide-induced acute myeloid leukemia: free radical/antioxidant approach.</a>, Molecular pharmacology. 1999 Sep | journal-article. doi: 10.1124/mol.56.3.494.

<a href='http://europepmc.org/abstract/med/10451363' target='_blank' class='bux-link'>Mechanisms of nitric oxide protection against tert-butyl hydroperoxide-induced cytotoxicity in iNOS-transduced human erythroleukemia cells.</a>, Biochemistry. 1999 Aug | journal-article. doi: 10.1021/bi9829229.

<a href='http://europepmc.org/abstract/med/9920290' target='_blank' class='bux-link'>Induction of human breast cancer cell apoptosis from G2/M preceded by stimulation into the cell cycle by Z-1,1-dichloro-2,3-diphenylcyclopropane.</a>, Biochemical pharmacology. 1999 Jan | journal-article. doi: 10.1016/s0006-2952(98)00289-5.

<a href='http://europepmc.org/abstract/med/10194547' target='_blank' class='bux-link'>The cardioprotective and DNA topoisomerase II inhibitory agent dexrazoxane (ICRF-187) antagonizes camptothecin-mediated growth inhibition of Chinese hamster ovary cells by inhibition of DNA synthesis.</a>, Anti-cancer drugs. 1999 Jan | journal-article. doi: 10.1097/00001813-199901000-00007.

<a href='http://europepmc.org/abstract/med/9660545' target='_blank' class='bux-link'>The one-ring open hydrolysis intermediates of the cardioprotective agent dexrazoxane (ICRF-187) do not inhibit the growth of Chinese hamster ovary cells or the catalytic activity of DNA topoisomerase II.</a>, Anti-cancer drugs. 1998 Jun | journal-article. doi: 10.1097/00001813-199806000-00014.

<a href='http://europepmc.org/abstract/med/9351975' target='_blank' class='bux-link'>Mitindomide is a catalytic inhibitor of DNA topoisomerase II that acts at the bisdioxopiperazine binding site.</a>, Molecular pharmacology. 1997 Nov | journal-article. doi: 10.1124/mol.52.5.839.

<a href='http://europepmc.org/abstract/med/9256159' target='_blank' class='bux-link'>Characterization of a Chinese hamster ovary cell line with acquired resistance to the bisdioxopiperazine dexrazoxane (ICRF-187) catalytic inhibitor of topoisomerase II.</a>, Biochemical pharmacology. 1997 Jun | journal-article. doi: 10.1016/s0006-2952(97)00013-0.

<a href='http://europepmc.org/abstract/med/9139677' target='_blank' class='bux-link'>Nitric oxide prevents oxidative damage produced by tert-butyl hydroperoxide in erythroleukemia cells via nitrosylation of heme and non-heme iron. Electron paramagnetic resonance evidence.</a>, The Journal of biological chemistry. 1997 May | journal-article. doi: 10.1074/jbc.272.19.12328.

<a href='http://europepmc.org/abstract/med/9113091' target='_blank' class='bux-link'>Chemical synthesis and biological activity of a novel fluorescent etoposide derivative.</a>, Biochemical pharmacology. 1997 Mar | journal-article. doi: 10.1016/s0006-2952(96)00906-9.

<a href='http://europepmc.org/abstract/med/8809092' target='_blank' class='bux-link'>Non-random peroxidation of different classes of membrane phospholipids in live cells detected by metabolically integrated cis-parinaric acid.</a>, Biochimica et biophysica acta. 1996 Sep | journal-article. doi: 10.1016/0005-2736(96)00083-1.

<a href='http://europepmc.org/abstract/med/8759037' target='_blank' class='bux-link'>Collateral sensitivity to the bisdioxopiperazine dexrazoxane (ICRF-187) in etoposide (VP-16)-resistant human leukemia K562 cells.</a>, Biochemical pharmacology. 1996 Aug | journal-article. doi: 10.1016/0006-2952(96)00338-3.

<a href='http://europepmc.org/abstract/med/8862724' target='_blank' class='bux-link'>The effect of dexrazoxane (ICRF-187) on doxorubicin- and daunorubicin-mediated growth inhibition of Chinese hamster ovary cells.</a>, Anti-cancer drugs. 1996 Jul | journal-article. doi: 10.1097/00001813-199607000-00011.

<a href='http://europepmc.org/abstract/med/8632756' target='_blank' class='bux-link'>Genesis of discrete higher order DNA fragments in apoptotic human prostatic carcinoma cells.</a>, Molecular pharmacology. 1996 Feb | journal-article. .

<a href='http://europepmc.org/abstract/med/20650183' target='_blank' class='bux-link'>Reduction of phenoxyl radicals of the antitumour agent etoposide (VP-16) by glutathione and protein sulfhydryls in human leukaemia cells: Implications for cytotoxicity.</a>, Toxicology in vitro : an international journal published in association with BIBRA. 1996 Feb | journal-article. doi: 10.1016/0887-2333(95)00106-9.

<a href='http://europepmc.org/abstract/med/7476909' target='_blank' class='bux-link'>Hypophosphorylation of topoisomerase II in etoposide (VP-16)-resistant human leukemia K562 cells associated with reduced levels of beta II protein kinase C.</a>, Molecular pharmacology. 1995 Nov | journal-article. .

<a href='http://europepmc.org/abstract/med/7562588' target='_blank' class='bux-link'>Induction of apoptosis in murine and human neuroblastoma cell lines by the enediyne natural product neocarzinostatin.</a>, The Journal of pharmacology and experimental therapeutics. 1995 Oct | journal-article. .

<a href='http://europepmc.org/abstract/med/7575679' target='_blank' class='bux-link'>A QSAR study comparing the cytotoxicity and DNA topoisomerase II inhibitory effects of bisdioxopiperazine analogs of ICRF-187 (dexrazoxane).</a>, Biochemical pharmacology. 1995 Sep | journal-article. doi: 10.1016/0006-2952(95)00218-o.

<a href='http://europepmc.org/abstract/med/7538671' target='_blank' class='bux-link'>Metallothionein protects against the cytotoxic and DNA-damaging effects of nitric oxide.</a>, Proceedings of the National Academy of Sciences of the United States of America. 1995 May | journal-article. doi: 10.1073/pnas.92.10.4452.

<a href='http://europepmc.org/abstract/med/7716769' target='_blank' class='bux-link'>Phenoxyl radicals of etoposide (VP-16) can directly oxidize intracellular thiols: protective versus damaging effects of phenolic antioxidants.</a>, Toxicology and applied pharmacology. 1995 Apr | journal-article. doi: 10.1006/taap.1995.1070.

<a href='http://europepmc.org/abstract/med/7969039' target='_blank' class='bux-link'>Differential induction of etoposide-mediated apoptosis in human leukemia HL-60 and K562 cells.</a>, Molecular pharmacology. 1994 Oct | journal-article. .

<a href='http://europepmc.org/abstract/med/8068642' target='_blank' class='bux-link'>Ascorbate is the primary reductant of the phenoxyl radical of etoposide in the presence of thiols both in cell homogenates and in model systems.</a>, Biochemistry. 1994 Aug | journal-article. doi: 10.1021/bi00198a034.

<a href='http://europepmc.org/abstract/med/8068039' target='_blank' class='bux-link'>Increased c-jun/AP-1 levels in etoposide-resistant human leukemia K562 cells.</a>, Biochemical pharmacology. 1994 Aug | journal-article. doi: 10.1016/0006-2952(94)90282-8.

<a href='http://europepmc.org/abstract/med/8058057' target='_blank' class='bux-link'>Reduced phosphorylation of topoisomerase II in etoposide-resistant human leukemia K562 cells.</a>, Molecular pharmacology. 1994 Jul | journal-article. .

<a href='http://europepmc.org/abstract/med/8195159' target='_blank' class='bux-link'>Cytoplasmic metallothionein overexpression protects NIH 3T3 cells from tert-butyl hydroperoxide toxicity.</a>, The Journal of biological chemistry. 1994 May | journal-article. .

<a href='http://europepmc.org/abstract/med/8142256' target='_blank' class='bux-link'>Altered stability of etoposide-induced topoisomerase II-DNA complexes in resistant human leukaemia K562 cells.</a>, British journal of cancer. 1994 Apr | journal-article. doi: 10.1038/bjc.1994.131.

<a href='http://europepmc.org/abstract/med/8183243' target='_blank' class='bux-link'>Interference by doxorubicin with DNA unwinding in MCF-7 breast tumor cells.</a>, Molecular pharmacology. 1994 Apr | journal-article. .

<a href='http://europepmc.org/abstract/med/7808339' target='_blank' class='bux-link'>Interactions of phenoxyl radical of antitumor drug, etoposide, with reductants in solution and in cell and nuclear homogenates: electron spin resonance and high-performance liquid chromatography.</a>, Methods in enzymology. 1994 Jan | journal-article. doi: 10.1016/0076-6879(94)34134-6.

<a href='http://europepmc.org/abstract/med/7865904' target='_blank' class='bux-link'>P-glycoprotein mediates profound resistance to bisantrene.</a>, Oncology research. 1994 Jan | journal-article. .

<a href='http://europepmc.org/abstract/med/8267650' target='_blank' class='bux-link'>Altered gene expression in human leukemia K562 cells selected for resistance to etoposide.</a>, Biochemical pharmacology. 1993 Dec | journal-article. doi: 10.1016/0006-2952(93)90643-b.

<a href='http://europepmc.org/abstract/med/8246608' target='_blank' class='bux-link'>Mutational inactivation of the p53 gene in the human erythroid leukemic K562 cell line.</a>, Leukemia research. 1993 Dec | journal-article. doi: 10.1016/0145-2126(93)90161-d.

<a href='http://europepmc.org/abstract/med/8339261' target='_blank' class='bux-link'>Dissociation between bulk damage to DNA and the antiproliferative activity of teniposide (VM-26) in the MCF-7 breast tumor cell line: evidence for induction of gene-specific damage and alterations in gene expression.</a>, Cancer research. 1993 Aug | journal-article. .

<a href='http://europepmc.org/abstract/med/8168727' target='_blank' class='bux-link'>Tyrosinase-induced phenoxyl radicals of etoposide (VP-16): interaction with reductants in model systems, K562 leukemic cell and nuclear homogenates.</a>, Free radical research communications. 1993 Jan | journal-article. doi: 10.3109/10715769309056527.

<a href='http://europepmc.org/abstract/med/1985163' target='_blank' class='bux-link'>A phase II study of combined methotrexate and teniposide infusions prior to reinduction therapy in relapsed childhood acute lymphoblastic leukemia: a Pediatric Oncology Group study.</a>, Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 1991 Jan | journal-article. doi: 10.1200/jco.1991.9.1.139.

<a href='http://europepmc.org/abstract/med/2194652' target='_blank' class='bux-link'>Pharmacokinetics of continuous infusion of methotrexate and teniposide in pediatric cancer patients.</a>, Cancer research. 1990 Jul | journal-article. .

<a href='http://europepmc.org/abstract/med/2561738' target='_blank' class='bux-link'>Expression of protein-associated DNA damage in the alkaline elution assay in the absence of enzymatic deproteinization.</a>, Cancer communications. 1989 Jan | journal-article. .

<a href='http://europepmc.org/abstract/med/3469013' target='_blank' class='bux-link'>Atypical multiple drug resistance in a human leukemic cell line selected for resistance to teniposide (VM-26).</a>, Cancer research. 1987 Mar | journal-article. .

<a href='http://europepmc.org/abstract/med/2879622' target='_blank' class='bux-link'>Effects of microtubule inhibitors on etoposide accumulation and DNA damage in human K562 cells in vitro.</a>, Cancer research. 1987 Feb | journal-article. .

<a href='http://europepmc.org/abstract/med/3568269' target='_blank' class='bux-link'>Expressions of resistance and cross-resistance in teniposide-resistant L1210 cells.</a>, Cancer chemotherapy and pharmacology. 1987 Jan | journal-article. doi: 10.1007/bf00254563.

<a href='http://europepmc.org/abstract/med/3861238' target='_blank' class='bux-link'>Effects of verapamil on etoposide, vincristine, and adriamycin activity in normal human bone marrow granulocyte-macrophage progenitors and in human K562 leukemia cells in vitro.</a>, Cancer research. 1985 Oct | journal-article. .

<a href='http://europepmc.org/abstract/med/3160352' target='_blank' class='bux-link'>Rapid determination of thymidylate synthase activity and its inhibition in intact L1210 leukemia cells in vitro.</a>, Biochemical pharmacology. 1985 Jul | journal-article. doi: 10.1016/0006-2952(85)90788-9.

<a href='http://europepmc.org/abstract/med/3978633' target='_blank' class='bux-link'>Verapamil-induced augmentation of etoposide accumulation in L1210 cells in vitro.</a>, Cancer research. 1985 Apr | journal-article. .

<a href='http://europepmc.org/abstract/med/6094001' target='_blank' class='bux-link'>Role of topoisomerase II in mediating epipodophyllotoxin-induced DNA cleavage.</a>, Cancer research. 1984 Dec | journal-article. .

<a href='http://europepmc.org/abstract/med/6744270' target='_blank' class='bux-link'>Potentiation of etoposide-induced DNA damage by calcium antagonists in L1210 cells in vitro.</a>, Cancer research. 1984 Aug | journal-article. .

<a href='http://europepmc.org/abstract/med/6692420' target='_blank' class='bux-link'>Analysis of the inhibitory effects of VP-16-213 (etoposide) and podophyllotoxin on thymidine transport and metabolism in Ehrlich ascites tumor cells in vitro.</a>, Cancer research. 1984 Mar | journal-article. .

<a href='http://europepmc.org/abstract/med/6193686' target='_blank' class='bux-link'>Characteristics of the accumulation of methotrexate polyglutamate derivatives in Ehrlich ascites tumor cells and isolated rat hepatocytes.</a>, Advances in experimental medicine and biology. 1983 Jan | journal-article. doi: 10.1007/978-1-4757-5241-0_17.

<a href='http://europepmc.org/abstract/med/6179605' target='_blank' class='bux-link'>Teniposide (VM-26)- and etoposide (VP-16-213)-induced augmentation of methotrexate transport and polyglutamylation in Ehrlich ascites tumor cells in vitro.</a>, Cancer research. 1982 Sep | journal-article. .

<a href='http://europepmc.org/abstract/med/6177396' target='_blank' class='bux-link'>Augmentation of the intracellular levels of polyglutamyl derivatives of methotrexate by vincristine and probenecid in Ehrlich ascites tumor cells.</a>, Cancer research. 1982 Jul | journal-article. .

<a href='http://europepmc.org/abstract/med/6120169' target='_blank' class='bux-link'>Rapid formation of poly-gamma-glutamyl derivatives of methotrexate and their association with dihydrofolate reductase as assessed by high pressure liquid chromatography in the Ehrlich ascites tumor cell in vitro.</a>, The Journal of biological chemistry. 1982 Feb | journal-article. .

Alex Sparreboom

Professor

Pharmaceutics and Pharmacology

Outcomes and Translational Sciences

Research Areas

Cancer,

Pharmaceutics & Pharmacology,

Clinical & Pre-Clinical Pharmacology

408 Biomedical Research Tower

sparreboom.1@osu.edu

614-292-4293

Professional Website

Dr. Sparreboom's research studies the contribution of solute carriers to chemotherapy-induced toxicity profiles, identifies chemical inhibitors of critical transporters, translates the findings to clinical trials in collaboration with scientists and oncologists, and ultimately improves the long-term outcome of patients with cancer by modulating the therapeutic window of widely-used chemotherapeutics. His research is currently focused on the development of transport modulators that could be used in conjunction with platinum-based drugs and tyrosine-kinase inhibitors, with emphasis on the development of innovative preclinical model systems.

PhD, 1996, The Netherlands Cancer Institute/Utrecht University, Pharmacy

MSc, 1993, Utrecht University, Pharmacy

BSc, 1989, Utrecht University, Pharmacy

<a href='https://www.mdpi.com/1420-3049/27/20/6815' target='_blank' class='bux-link'>Itraconazole-Induced Increases in Gilteritinib Exposure Are Mediated by CYP3A and OATP1B</a>, Molecules. 2022 Oct | journal-article. doi: 10.3390/molecules27206815.

<a href='https://www.mdpi.com/1999-4923/14/9/1933' target='_blank' class='bux-link'>A Metabolomics Approach for Predicting OATP1B-Type Transporter-Mediated Drug–Drug Interaction Liabilities</a>, Pharmaceutics. 2022 Sep | journal-article. doi: 10.3390/pharmaceutics14091933.

<a href='https://www.mdpi.com/1422-0067/23/15/8607' target='_blank' class='bux-link'>MATE1 Deficiency Exacerbates Dofetilide-Induced Proarrhythmia</a>, International Journal of Molecular Sciences. 2022 Aug | journal-article. doi: 10.3390/ijms23158607.

Dan Shu

Research Associate Professor

Pharmaceutics and Pharmacology

Research Areas

Pharmaceutics & Pharmacology,

Nanotechnology & Drug Delivery Systems,

Cancer

shu.135@osu.edu

(614) 293-2148

Dr. Shu’s research is focused on (1) RNA nanotechnology: use RNA as a nanotechnology platform to construct RNA nanoparticles with functional modalities for therapeutics, targeting, and diagnostics (ACS Nano, 2015; Nature Nanotechnology, 2011; Nano Letters, 2004); and (2) Single molecule biophysical studies: use single-molecule detection (such as FRET) to understand the structure-function relationship for individual biomolecules (ACS Nano, 2010; EMBO Journal, 2007; RNA, 2007). Her long-term objective is to focus on the development and translation of RNA nanotechnology-based therapeutics and imaging agents into clinical trials.

1990 - M.D., Tongji Medical University

<a href='http://dx.doi.org/10.1016/j.nano.2022.102590' target='_blank' class='bux-link'>Proof-of-concept for speedy development of rapid and simple at-home method for potential diagnosis of early COVID-19 mutant infections using nanogold and aptamer</a>, Nanomedicine: Nanotechnology, Biology and Medicine. 2022 Sep | journal-article. doi: 10.1016/j.nano.2022.102590.

<a href='http://dx.doi.org/10.1016/j.omtn.2021.07.021' target='_blank' class='bux-link'>Rational design for controlled release of Dicer-substrate siRNA harbored in phi29 pRNA-based nanoparticles</a>, Molecular Therapy - Nucleic Acids. 2021 Sep | journal-article. doi: 10.1016/j.omtn.2021.07.021.

<a href='http://dx.doi.org/10.1016/j.omtn.2021.03.007' target='_blank' class='bux-link'>Stoichiometry of multi-specific immune checkpoint RNA Abs for T cell activation and tumor inhibition using ultra-stable RNA nanoparticles</a>, Molecular Therapy - Nucleic Acids. 2021 Jun | journal-article. doi: 10.1016/j.omtn.2021.03.007.

<a href='http://dx.doi.org/10.1016/j.omtn.2020.08.024' target='_blank' class='bux-link'>EpCAM-Targeted 3WJ RNA Nanoparticle Harboring Delta-5-Desaturase siRNA Inhibited Lung Tumor Formation via DGLA Peroxidation</a>, Molecular Therapy - Nucleic Acids. 2020 Dec | journal-article. doi: 10.1016/j.omtn.2020.08.024.

<a href='http://dx.doi.org/10.1016/j.nano.2020.102298' target='_blank' class='bux-link'>Growth inhibitory and anti-metastatic activity of epithelial cell adhesion molecule targeted three-way junctional delta-5-desaturase siRNA nanoparticle for breast cancer therapy</a>, Nanomedicine: Nanotechnology, Biology and Medicine. 2020 Nov | journal-article. doi: 10.1016/j.nano.2020.102298.

<a href='http://dx.doi.org/10.1142/9789811218026_0008' target='_blank' class='bux-link'>Specific Delivery of SiRNA to Tumor Cells via Innovative pRNA Nanoparticles: A Novel Promising Cancer Treatment Strategy</a>, Soft Matter and Biomaterials on the Nanoscale. 2020 Aug | book-chapter. doi: 10.1142/9789811218026_0008.

<a href='http://dx.doi.org/10.1016/j.ymthe.2019.04.018' target='_blank' class='bux-link'>Delivery of Anti-miRNA for Triple-Negative Breast Cancer Therapy Using RNA Nanoparticles Targeting Stem Cell Marker CD133</a>, Molecular Therapy. 2019 Jul | journal-article. doi: 10.1016/j.ymthe.2019.04.018.

<a href='http://dx.doi.org/10.1016/j.redox.2018.101085' target='_blank' class='bux-link'>Specific delivery of delta-5-desaturase siRNA via RNA nanoparticles supplemented with dihomo-γ-linolenic acid for colon cancer suppression</a>, Redox Biology. 2019 Feb | journal-article. doi: 10.1016/j.redox.2018.101085.

<a href='http://dx.doi.org/10.1021/acsnano.8b07948' target='_blank' class='bux-link'>RNA Micelles for the Systemic Delivery of Anti-miRNA for Cancer Targeting and Inhibition without Ligand</a>, ACS Nano. 2019 Jan | journal-article. doi: 10.1021/acsnano.8b07948.

<a href='http://dx.doi.org/10.1016/j.jconrel.2018.02.014' target='_blank' class='bux-link'>RNA-based micelles: A novel platform for paclitaxel loading and delivery</a>, Journal of Controlled Release. 2018 Apr | journal-article. doi: 10.1016/j.jconrel.2018.02.014.

<a href='http://dx.doi.org/10.1016/j.omtn.2017.11.008' target='_blank' class='bux-link'>RNA Nanotherapeutics for the Amelioration of Astroglial Reactivity</a>, Molecular Therapy - Nucleic Acids. 2018 Mar | journal-article. doi: 10.1016/j.omtn.2017.11.008.

<a href='http://dx.doi.org/10.1016/j.canlet.2017.09.043' target='_blank' class='bux-link'>Favorable biodistribution, specific targeting and conditional endosomal escape of RNA nanoparticles in cancer therapy</a>, Cancer Letters. 2018 Feb | journal-article. doi: 10.1016/j.canlet.2017.09.043.

<a href='http://dx.doi.org/10.1016/j.ymthe.2016.11.016' target='_blank' class='bux-link'>RNA Nanoparticle-Based Targeted Therapy for Glioblastoma through Inhibition of Oncogenic miR-21</a>, Molecular Therapy. 2017 Jul | journal-article. doi: 10.1016/j.ymthe.2016.11.016.

<a href='http://dx.doi.org/10.1016/j.redox.2017.01.016' target='_blank' class='bux-link'>Inhibition of cancer migration and invasion by knocking down delta-5-desaturase in COX-2 overexpressed cancer cells</a>, Redox Biology. 2017 Apr | journal-article. doi: 10.1016/j.redox.2017.01.016.

<a href='http://dx.doi.org/10.1021/acsnano.6b05910' target='_blank' class='bux-link'>Overcoming Tamoxifen Resistance of Human Breast Cancer by Targeted Gene Silencing Using Multifunctional pRNA Nanoparticles</a>, ACS Nano. 2017 Jan | journal-article. doi: 10.1021/acsnano.6b05910.

<a href='http://dx.doi.org/10.1002/smll.201601600' target='_blank' class='bux-link'>Construction of Asymmetrical Hexameric Biomimetic Motors with Continuous Single-Directional Motion by Sequential Coordination</a>, Small. 2017 Jan | journal-article. doi: 10.1002/smll.201601600.

<a href='http://dx.doi.org/10.1002/adma.201601976' target='_blank' class='bux-link'>Controllable Self‐Assembly of RNA Tetrahedrons with Precise Shape and Size for Cancer Targeting</a>, Advanced Materials. 2016 Sep | journal-article. doi: 10.1002/adma.201601976.

<a href='http://dx.doi.org/10.1038/mt.2016.85' target='_blank' class='bux-link'>Specific Delivery of MiRNA for High Efficient Inhibition of Prostate Cancer by RNA Nanotechnology</a>, Molecular Therapy. 2016 Jul | journal-article. doi: 10.1038/mt.2016.85.

<a href='http://dx.doi.org/10.1021/acsnano.5b02471' target='_blank' class='bux-link'>Systemic Delivery of Anti-miRNA for Suppression of Triple Negative Breast Cancer Utilizing RNA Nanotechnology</a>, ACS Nano. 2015 Oct | journal-article. doi: 10.1021/acsnano.5b02471.

<a href='http://dx.doi.org/10.1038/srep10726' target='_blank' class='bux-link'>Regression of Gastric Cancer by Systemic Injection of RNA Nanoparticles Carrying both Ligand and siRNA</a>, Scientific Reports. 2015 Sep | journal-article. doi: 10.1038/srep10726.

<a href='http://dx.doi.org/10.1089/nat.2014.0525' target='_blank' class='bux-link'>RNA Nanoparticles Derived from Three-Way Junction of Phi29 Motor pRNA Are Resistant to I-125 and Cs-131 Radiation</a>, Nucleic Acid Therapeutics. 2015 Aug | journal-article. doi: 10.1089/nat.2014.0525.

<a href='http://dx.doi.org/10.2217/nnm.15.37' target='_blank' class='bux-link'>New approach to develop ultra-high inhibitory drug using the power function of the stoichiometry of the targeted nanomachine or biocomplex</a>, Nanomedicine. 2015 Jul | journal-article. doi: 10.2217/nnm.15.37.

<a href='http://dx.doi.org/10.18632/oncotarget.3632' target='_blank' class='bux-link'>RNA nanoparticle as a vector for targeted siRNA delivery into glioblastoma mouse model</a>, Oncotarget. 2015 Jun | journal-article. doi: 10.18632/oncotarget.3632.

<a href='http://dx.doi.org/10.1007/s11095-013-1226-x' target='_blank' class='bux-link'>Ocular Delivery of pRNA Nanoparticles: Distribution and Clearance After Subconjunctival Injection</a>, Pharmaceutical Research. 2014 Apr | journal-article. doi: 10.1007/s11095-013-1226-x.

<a href='http://dx.doi.org/10.1016/j.addr.2013.11.006' target='_blank' class='bux-link'>Stable RNA nanoparticles as potential new generation drugs for cancer therapy</a>, Advanced Drug Delivery Reviews. 2014 Feb | journal-article. doi: 10.1016/j.addr.2013.11.006.

<a href='http://dx.doi.org/10.1093/nar/gkt885' target='_blank' class='bux-link'>Programmable folding of fusion RNA in vivo and in vitro driven by pRNA 3WJ motif of phi29 DNA packaging motor</a>, Nucleic Acids Research. 2014 Jan | journal-article. doi: 10.1093/nar/gkt885.

<a href='http://dx.doi.org/10.1038/nprot.2013.097' target='_blank' class='bux-link'>Fabrication of pRNA nanoparticles to deliver therapeutic RNAs and bioactive compounds into tumor cells</a>, Nature Protocols. 2013 Sep | journal-article. doi: 10.1038/nprot.2013.097.

<a href='http://dx.doi.org/10.1261/rna.037002.112' target='_blank' class='bux-link'>Fabrication of 14 different RNA nanoparticles for specific tumor targeting without accumulation in normal organs</a>, RNA. 2013 Jun | journal-article. doi: 10.1261/rna.037002.112.

<a href='http://dx.doi.org/10.1016/j.nantod.2012.06.010' target='_blank' class='bux-link'>Ultrastable synergistic tetravalent RNA nanoparticles for targeting to cancers</a>, Nano Today. 2012 Aug | journal-article. doi: 10.1016/j.nantod.2012.06.010.

<a href='http://dx.doi.org/10.1038/nnano.2011.105' target='_blank' class='bux-link'>Thermodynamically stable RNA three-way junction for constructing multifunctional nanoparticles for delivery of therapeutics</a>, Nature Nanotechnology. 2011 Oct | journal-article. doi: 10.1038/nnano.2011.105.

<a href='http://dx.doi.org/10.1016/j.ymeth.2011.01.008' target='_blank' class='bux-link'>Assembly of multifunctional phi29 pRNA nanoparticles for specific delivery of siRNA and other therapeutics to targeted cells</a>, Methods. 2011 Jun | journal-article. doi: 10.1016/j.ymeth.2011.01.008.

<a href='http://dx.doi.org/10.1021/nn1014853' target='_blank' class='bux-link'>Dual-Channel Single-Molecule Fluorescence Resonance Energy Transfer to Establish Distance Parameters for RNA Nanoparticles</a>, ACS Nano. 2010 Nov | journal-article. doi: 10.1021/nn1014853.

<a href='http://dx.doi.org/10.1021/nl101939e' target='_blank' class='bux-link'>One-Way Traffic of a Viral Motor Channel for Double-Stranded DNA Translocation</a>, Nano Letters. 2010 Sep | journal-article. doi: 10.1021/nl101939e.

<a href='http://dx.doi.org/10.1117/12.847457' target='_blank' class='bux-link'>Design and application of single fluorophore dual-view imaging system containing both the objective- and prism-type TIRF</a>, Single Molecule Spectroscopy and Imaging III. 2010 Feb | journal-article. doi: 10.1117/12.847457.

<a href='http://dx.doi.org/10.1007/s10544-009-9364-y' target='_blank' class='bux-link'>Construction of a laser combiner for dual fluorescent single molecule imaging of pRNA of phi29 DNA packaging motor</a>, Biomedical Microdevices. 2010 Feb | journal-article. doi: 10.1007/s10544-009-9364-y.

<a href='http://dx.doi.org/10.1007/s10439-009-9723-0' target='_blank' class='bux-link'>Construction of Bacteriophage Phi29 DNA Packaging Motor and its Applications in Nanotechnology and Therapy</a>, Annals of Biomedical Engineering. 2009 Oct | journal-article. doi: 10.1007/s10439-009-9723-0.

<a href='http://dx.doi.org/10.1109/lissa.2009.4906725' target='_blank' class='bux-link'>Approaches for stoichiometry and distance determination of nanometer bio-complex by dual-channel single molecule imaging</a>, 2009 IEEE/NIH Life Science Systems and Applications Workshop. 2009 Apr | journal-article. doi: 10.1109/lissa.2009.4906725.

<a href='http://dx.doi.org/10.1109/lissa.2009.4906696' target='_blank' class='bux-link'>Fabrication of polyvalent therapeutic RNA nanoparticles for specific delivery of siRNA, ribozyme and drugs to targeted cells for cancer therapy</a>, 2009 IEEE/NIH Life Science Systems and Applications Workshop. 2009 Apr | journal-article. doi: 10.1109/lissa.2009.4906696.

<a href='http://dx.doi.org/10.1039/b903428e' target='_blank' class='bux-link'>Evaluation of specific delivery of chimeric phi29 pRNA/siRNA nanoparticles to multiple tumor cells</a>, Molecular BioSystems. 2009 Jan | journal-article. doi: 10.1039/b903428e.

<a href='http://dx.doi.org/10.1021/ja806075d' target='_blank' class='bux-link'>Reversible Switching of pRNA Activity on the DNA Packaging Motor of Bacteriophage phi29</a>, Journal of the American Chemical Society. 2008 Dec | journal-article. doi: 10.1021/ja806075d.

<a href='http://dx.doi.org/10.1063/1.3000606' target='_blank' class='bux-link'>Bright-field analysis of phi29 DNA packaging motor using a magnetomechanical system</a>, Applied Physics Letters. 2008 Oct | journal-article. doi: 10.1063/1.3000606.

<a href='http://dx.doi.org/10.1016/j.bbrc.2008.05.094' target='_blank' class='bux-link'>Modular assembly of chimeric phi29 packaging RNAs that support DNA packaging</a>, Biochemical and Biophysical Research Communications. 2008 Aug | journal-article. doi: 10.1016/j.bbrc.2008.05.094.

<a href='http://dx.doi.org/10.1261/rna.587607' target='_blank' class='bux-link'>Instrumentation and metrology for single RNA counting in biological complexes or nanoparticles by a single-molecule dual-view system</a>, RNA. 2007 Oct | journal-article. doi: 10.1261/rna.587607.

<a href='http://dx.doi.org/10.1038/sj.emboj.7601506' target='_blank' class='bux-link'>Counting of six pRNAs of phi29 DNA-packaging motor with customized single-molecule dual-view system</a>, The EMBO Journal. 2007 Jan | journal-article. doi: 10.1038/sj.emboj.7601506.

<a href='http://dx.doi.org/10.1021/nl0494497' target='_blank' class='bux-link'>Bottom-up Assembly of RNA Arrays and Superstructures as Potential Parts in Nanotechnology</a>, Nano Letters. 2004 Sep | journal-article. doi: 10.1021/nl0494497.

<a href='http://dx.doi.org/10.1016/j.jviromet.2003.08.015' target='_blank' class='bux-link'>A simple mathematical formula for stoichiometry quantification of viral and nanobiological assemblage using slopes of log/log plot curves</a>, Journal of Virological Methods. 2004 Jan | journal-article. doi: 10.1016/j.jviromet.2003.08.015.

<a href='http://dx.doi.org/10.1016/s0378-1119(03)00729-7' target='_blank' class='bux-link'>Gene cloning, purification, and stoichiometry quantification of phi29 anti-receptor gp12 with potential use as special ligand for gene delivery</a>, Gene. 2003 Oct | journal-article. doi: 10.1016/s0378-1119(03)00729-7.

<a href='http://dx.doi.org/10.1038/sj.gt.3302002' target='_blank' class='bux-link'>Bacterial virus phi29 pRNA as a hammerhead ribozyme escort to destroy hepatitis B virus</a>, Gene Therapy. 2003 Aug | journal-article. doi: 10.1038/sj.gt.3302002.

<a href='http://dx.doi.org/10.1166/jnn.2003.160' target='_blank' class='bux-link'>Construction of phi29 DNA-Packaging RNA Monomers, Dimers, and Trimers with Variable Sizes and Shapes as Potential Parts for Nanodevices</a>, Journal of Nanoscience and Nanotechnology. 2003 Aug | journal-article. doi: 10.1166/jnn.2003.160.

<a href='http://dx.doi.org/10.1016/s0042-6822(03)00011-4' target='_blank' class='bux-link'>Only one pRNA hexamer but multiple copies of the DNA-packaging protein gp16 are needed for the motor to package bacterial virus phi29 genomic DNA</a>, Virology. 2003 Apr | journal-article. doi: 10.1016/s0042-6822(03)00011-4.

<a href='http://dx.doi.org/10.1074/jbc.m209895200' target='_blank' class='bux-link'>A Viral RNA That Binds ATP and Contains a Motif Similar to an ATP-binding Aptamer from SELEX</a>, Journal of Biological Chemistry. 2003 Feb | journal-article. doi: 10.1074/jbc.m209895200.

<a href='http://dx.doi.org/10.1007/bf02895600' target='_blank' class='bux-link'>Growth-promoting effect of recombinant human growth hormone and stanozolol in girls with Turner syndrome</a>, Journal of Tongji Medical University. 1999 Mar | journal-article. doi: 10.1007/bf02895600.

<a href='http://dx.doi.org/10.1007/bf02888117' target='_blank' class='bux-link'>Study on the relationship between cytogenetics and phenotypic effect in Turner’s syndrome</a>, Journal of Tongji Medical University. 1996 Dec | journal-article. doi: 10.1007/bf02888117.

<a href='http://dx.doi.org/10.1007/bf02897672' target='_blank' class='bux-link'>Clinical significance of multiple hypothalamic-pituitary functions assessment in patients with Turner’s syndrome</a>, Journal of Tongji Medical University. 1994 Dec | journal-article. doi: 10.1007/bf02897672.

<a href='http://dx.doi.org/10.1007/bf02887852' target='_blank' class='bux-link'>The screening diagnosis of tetrahydrobiopterin deficient phenylketonuria</a>, Journal of Tongji Medical University. 1992 Dec | journal-article. doi: 10.1007/bf02887852.

Popat Patil

Faculty Emeritus

Emeritus

Pharmaceutics and Pharmacology

538 Parks Hall

patil.1@osu.edu

(614) 292-7238

Professor Emeritus Popat N. Patil received his B. Pharm degree in 1956 from the L. M. College of Pharmacy of Gujarat University in India. He was awarded his M.S. (1960) and Ph.D. (1963) degrees in pharmacology from the Ohio State University. He taught and conducted research in molecular pharmacology at the University for over 50 years. His research interests are in stereochemical aspects of sympathomimetic amines and their blockers, quantitative parameters of drug receptor interactions at the cell membrane, initial components of drug efficacy, and drug antagonism. The study of ocular pharmacology and toxicology interest him greatly. He investigated drug melanin interactions to explain the long duration of pupillary dilation of atropine-like topical medications in the light or heavily pigmented eye. His interest also extends to elucidating the unique pharmacologic actions of new substances discovered from plants. He has over 150 peer-reviewed publications on these topics. In 1979 he was awarded the Miriam R. Balshone Award for teaching nervous system pharmacology and therapeutics. He has been a member of the American Society of Pharmacology and Experimental Therapeutics and is a Fellow of the American Association for the Advancement of Science. In 1979-81 he was selected as Kimberly Professor. In 1980 Professor Patil received the Senior Scientist Award (Humbolt Award) for research in Germany. He is a life member of the Ohio Academy of Sciences and Alexander Von Humbolt Association of America. He retired in 2005 and published Discoveries in Pharmacological Sciences (World Scientific, 2012). Recently he and Professor Emeritus Robert Buerki with Linus Learning (2019) published the book A History of Drug Sciences at The Ohio State University, College of Pharmacy. He has been elected to the Emeritus Academy at the Ohio State University.

Mitch A. Phelps

Professor

Pharmaceutics and Pharmacology

Outcomes and Translational Sciences

Research Areas

Cancer,

Pharmaceutics & Pharmacology,

Clinical & Pre-Clinical Pharmacology

506 Riffe Building

phelps.32@osu.edu

(614) 688-4370

Professional Website

Dr. Phelps’ lab is involved in both pre-clinical and clinical development of numerous small molecule anti-cancer and immuno-modulatory agents under development. Their work aims to understand the mechanisms involved in the absorption, distribution, metabolism, and excretion (i.e. pharmacokinetics, PK) of these agents, and how both the PK and pharmacodynamic (PD) effects of these agents are altered by genetic differences (polymorphisms) among individuals (i.e. pharmacogenetics, PG).

2005, PhD, The Ohio State University, Biophysics

1999, MLHR, The Ohio State University, Labor and Human Resources

1992, BA, Ohio Wesleyan University, Physics

Outstanding Graduate Student Award, 2005

Predoctoral Fellowship, 2004

Predoctoral Fellowship, 2003 - 2004

Ray Travel Award, 2003

Hazel Brown Teaching Award, 2001

<a href='https://doi.org/10.1158/1078-0432.CCR-23-1683' target='_blank' class='bux-link'>Antibody Drug Clearance: An Underexplored Marker of Outcomes with Checkpoint Inhibitors</a>, Clinical Cancer Research. 2024 Mar | journal-article. doi: 10.1158/1078-0432.CCR-23-1683.

<a href='https://doi.org/10.1093/oncolo/oyad221' target='_blank' class='bux-link'>Phase I Study of Entinostat, Atezolizumab, Carboplatin, and Etoposide in Previously Untreated Extensive-Stage Small Cell Lung Cancer, ETCTN 10399</a>, The Oncologist. 2023 Nov | journal-article. doi: 10.1093/oncolo/oyad221.

<a href='https://doi.org/10.1007/s40262-023-01240-8' target='_blank' class='bux-link'>Clinical Pharmacokinetics and Pharmacodynamics of Daratumumab</a>, Clinical Pharmacokinetics. 2023 Jun | journal-article. doi: 10.1007/s40262-023-01240-8.

<a href='https://doi.org/10.1158/1078-0432.c.6529547.v1' target='_blank' class='bux-link'>Data from Early Intervention with Lenalidomide in Patients with High-risk Chronic Lymphocytic Leukemia</a>, . 2023 Mar | preprint. doi: 10.1158/1078-0432.c.6529547.v1.

<a href='https://doi.org/10.1158/1078-0432.c.6529547' target='_blank' class='bux-link'>Data from Early Intervention with Lenalidomide in Patients with High-risk Chronic Lymphocytic Leukemia</a>, . 2023 Mar | preprint. doi: 10.1158/1078-0432.c.6529547.

<a href='https://doi.org/10.1158/1078-0432.22476989.v1' target='_blank' class='bux-link'>Supplementary Data from Early Intervention with Lenalidomide in Patients with High-risk Chronic Lymphocytic Leukemia</a>, . 2023 Mar | preprint. doi: 10.1158/1078-0432.22476989.v1.

<a href='https://doi.org/10.1158/1078-0432.22476989' target='_blank' class='bux-link'>Supplementary Data from Early Intervention with Lenalidomide in Patients with High-risk Chronic Lymphocytic Leukemia</a>, . 2023 Mar | preprint. doi: 10.1158/1078-0432.22476989.

<a href='https://doi.org/10.3390/cancers15061755' target='_blank' class='bux-link'>Dichotomous Nitric Oxide–Dependent Post-Translational Modifications of STAT1 Are Associated with Ipilimumab Benefits in Melanoma</a>, Cancers. 2023 Mar | journal-article. doi: 10.3390/cancers15061755.

<a href='https://www.mdpi.com/1422-0067/23/13/7066' target='_blank' class='bux-link'>The Neonatal Fc Receptor Is Elevated in Monocyte-Derived Immune Cells in Pancreatic Cancer</a>, International Journal of Molecular Sciences. 2022 Jun | journal-article. doi: 10.3390/ijms23137066.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85121974898&partnerID=MN8TOARS' target='_blank' class='bux-link'>A Single Nucleotide Polymorphism (SNP) in the SLC22A3 Transporter Gene Is Associated with the Severity of Oral Mucositis in Multiple Myeloma Patients Receiving Autologous Stem Cell Transplant Followed by Melphalan Therapy</a>, Anticancer Research. 2022 Jan | journal-article. doi: 10.21873/anticanres.15497.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85125857380&partnerID=MN8TOARS' target='_blank' class='bux-link'>Discovery of Anticancer Agents of Diverse Natural Origin</a>, Journal of Natural Products. 2022 Jan | journal-article. doi: 10.1021/acs.jnatprod.2c00036.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85125467362&partnerID=MN8TOARS' target='_blank' class='bux-link'>PP2A is a therapeutically targetable driver of cell fate decisions via a c-Myc/p21 axis in human and murine acute myeloid leukemia</a>, Blood. 2022 Jan | journal-article. doi: 10.1182/blood.2020010344.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85124160577&partnerID=MN8TOARS' target='_blank' class='bux-link'>Serum Albumin: Early Prognostic Marker of Benefit for Immune Checkpoint Inhibitor Monotherapy But Not Chemoimmunotherapy</a>, Clinical Lung Cancer. 2022 Jan | journal-article. doi: 10.1016/j.cllc.2021.12.010.

<a href='https://doi.org/10.1007/s00280-020-04229-3' target='_blank' class='bux-link'>A phase 1 trial of the histone deacetylase inhibitor AR-42 in patients with neurofibromatosis type 2-associated tumors and advanced solid malignancies</a>, Cancer Chemotherapy and Pharmacology. 2021 May | journal-article. doi: 10.1007/s00280-020-04229-3.

<a href='https://europepmc.org/articles/PMC7878907' target='_blank' class='bux-link'>Inhibition of androgen/AR signaling inhibits diethylnitrosamine (DEN) induced tumour initiation and remodels liver immune cell networks.</a>, Scientific reports. 2021 Feb | journal-article. doi: 10.1038/s41598-021-82252-x.

<a href='https://europepmc.org/articles/PMC8420755' target='_blank' class='bux-link'>Murine cancer cachexia models replicate elevated catabolic pembrolizumab clearance in humans.</a>, JCSM rapid communications. 2021 Feb | journal-article. doi: 10.1002/rco2.32.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85104581751&partnerID=MN8TOARS' target='_blank' class='bux-link'>Approaches to handling missing or “problematic” pharmacology data: Pharmacokinetics</a>, CPT: Pharmacometrics and Systems Pharmacology. 2021 Jan | journal-article. doi: 10.1002/psp4.12611.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85102696234&partnerID=MN8TOARS' target='_blank' class='bux-link'>Pharmacological Prevention of Neonatal Opioid Withdrawal in a Pregnant Guinea Pig Model</a>, Frontiers in Pharmacology. 2021 Jan | journal-article. doi: 10.3389/fphar.2020.613328.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85108412516&partnerID=MN8TOARS' target='_blank' class='bux-link'>Phase 2 study of ibrutinib in classic and variant hairy cell leukemia</a>, Blood. 2021 Jan | journal-article. doi: 10.1182/blood.2020009688.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85110286055&partnerID=MN8TOARS' target='_blank' class='bux-link'>Phase I evaluation of lenvatinib and weekly paclitaxel in patients with recurrent endometrial, ovarian, fallopian tube, or primary peritoneal Cancer</a>, Gynecologic Oncology. 2021 Jan | journal-article. doi: 10.1016/j.ygyno.2021.06.032.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85116561982&partnerID=MN8TOARS' target='_blank' class='bux-link'>Population Pharmacokinetic Analysis from First-in-Human Data for HDAC Inhibitor, REC-2282 (AR-42), in Patients with Solid Tumors and Hematologic Malignancies: A Case Study for Evaluating Flat vs. Body Size Normalized Dosing</a>, European Journal of Drug Metabolism and Pharmacokinetics. 2021 Jan | journal-article. doi: 10.1007/s13318-021-00722-z.

<a href='https://doi.org/10.1158/1078-0432.CCR-20-1280' target='_blank' class='bux-link'>Early Intervention with Lenalidomide in Patients with High-risk Chronic Lymphocytic Leukemia</a>, Clinical Cancer Research. 2020 Dec | journal-article. doi: 10.1158/1078-0432.CCR-20-1280.

<a href='https://doi.org/10.1002/ajh.25958' target='_blank' class='bux-link'>A phase I study of lenalidomide plus chemotherapy with idarubicin and cytarabine in patients with relapsed or refractory acute myeloid leukemia and high‐risk myelodysplastic syndrome</a>, American Journal of Hematology. 2020 Dec | journal-article. doi: 10.1002/ajh.25958.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85078279389&partnerID=MN8TOARS' target='_blank' class='bux-link'>A phase I study of an oral selective gamma secretase (GS) inhibitor RO4929097 in combination with neoadjuvant paclitaxel and carboplatin in triple negative breast cancer</a>, Investigational New Drugs. 2020 Jan | journal-article. doi: 10.1007/s10637-020-00895-5.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85092122035&partnerID=MN8TOARS' target='_blank' class='bux-link'>Association of anril polymorphism with overall survival in adult patients with hematologic malignancies after allogeneic hematopoietic stem cell transplantation</a>, Anticancer Research. 2020 Jan | journal-article. doi: 10.21873/anticanres.14585.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85078638878&partnerID=MN8TOARS' target='_blank' class='bux-link'>Overcoming resistance to anabolic SARM therapy in experimental cancer cachexia with an HDAC inhibitor</a>, EMBO Molecular Medicine. 2020 Jan | journal-article. doi: 10.15252/emmm.201809910.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85088158306&partnerID=MN8TOARS' target='_blank' class='bux-link'>Pharmacokinetics and Tolerability of the Novel Non-immunosuppressive Fingolimod Derivative, OSU-2S, in Dogs and Comparisons with Data in Mice and Rats</a>, AAPS Journal. 2020 Jan | journal-article. doi: 10.1208/s12248-020-00474-9.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85102910806&partnerID=MN8TOARS' target='_blank' class='bux-link'>Pharmacological prevention of neonatal opioid withdrawal in a pregnant guinea pig model.</a>, bioRxiv. 2020 Jan | other. doi: 10.1101/2020.07.25.221192.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85079218552&partnerID=MN8TOARS' target='_blank' class='bux-link'>Phase I study of AR-42 and decitabine in acute myeloid leukemia</a>, Leukemia and Lymphoma. 2020 Jan | journal-article. doi: 10.1080/10428194.2020.1719095.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85066016898&partnerID=MN8TOARS' target='_blank' class='bux-link'>Preclinical activity and a pilot phase I study of pacritinib, an oral JAK2/FLT3 inhibitor, and chemotherapy in FLT3-ITD-positive AML</a>, Investigational New Drugs. 2020 Jan | journal-article. doi: 10.1007/s10637-019-00786-4.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85093643251&partnerID=MN8TOARS' target='_blank' class='bux-link'>Replication study: Coding-independent regulation of the tumor suppressor pten by competing endogenous mRNAs</a>, eLife. 2020 Jan | journal-article. doi: 10.7554/eLife.56651.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85084700214&partnerID=MN8TOARS' target='_blank' class='bux-link'>The Role of Malnutrition and Muscle Wasting in Advanced Lung Cancer</a>, Current Oncology Reports. 2020 Jan | journal-article. doi: 10.1007/s11912-020-00916-9.

<a href='https://doi.org/10.1111/jphp.13154' target='_blank' class='bux-link'>Optimising time samples for determining area under the curve of pharmacokinetic data using non-compartmental analysis</a>, Journal of Pharmacy and Pharmacology. 2019 Oct | journal-article. doi: 10.1111/jphp.13154.

<a href='https://doi.org/10.1111/bcp.13873' target='_blank' class='bux-link'>Population pharmacokinetics of lenalidomide in patients with B‐cell malignancies</a>, British Journal of Clinical Pharmacology. 2019 May | journal-article. doi: 10.1111/bcp.13873.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85059237461&partnerID=MN8TOARS' target='_blank' class='bux-link'>A single nucleotide polymorphism in SLC7A5 was associated with clinical response in multiple myeloma patients</a>, Anticancer Research. 2019 Jan | journal-article. doi: 10.21873/anticanres.13080.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85073482100&partnerID=MN8TOARS' target='_blank' class='bux-link'>Development of a physiologically based pharmacokinetic model for intravenous lenalidomide in mice</a>, Cancer Chemotherapy and Pharmacology. 2019 Jan | journal-article. doi: 10.1007/s00280-019-03941-z.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85064389424&partnerID=MN8TOARS' target='_blank' class='bux-link'>Letter to the Editor: Exposure–response or clearance–response relationship in immune checkpoint therapy?—A comment on ‘correlation between nivolumab exposure and treatment outcomes in non-small-cell lung cancer’ by Basak et al</a>, European Journal of Cancer. 2019 Jan | journal-article. doi: 10.1016/j.ejca.2019.02.017.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85070773007&partnerID=MN8TOARS' target='_blank' class='bux-link'>ROR1-targeted delivery of miR-29b induces cell cycle arrest and therapeutic benefit in vivo in a CLL mouse model</a>, Blood. 2019 Jan | journal-article. doi: 10.1182/blood.2018882290.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85062265572&partnerID=MN8TOARS' target='_blank' class='bux-link'>SuV39H1 represses the expression of cytotoxic T-lymphocyte effector genes to promote colon tumor immune evasion</a>, Cancer Immunology Research. 2019 Jan | journal-article. doi: 10.1158/2326-6066.CIR-18-0126.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85063395528&partnerID=MN8TOARS' target='_blank' class='bux-link'>The Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research</a>, Cell. 2019 Jan | journal-article. doi: 10.1016/j.cell.2019.03.023.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85073963253&partnerID=MN8TOARS' target='_blank' class='bux-link'>XRCC1-mediated DNA repair is associated with progression-free survival of multiple myeloma patients after autologous stem cell transplant</a>, Molecular Carcinogenesis. 2019 Jan | journal-article. doi: 10.1002/mc.23121.

<a href='https://doi.org/10.1158/1078-0432.CCR-18-1847' target='_blank' class='bux-link'>Cachectic Cancer Patients: Immune to Checkpoint Inhibitor Therapy?</a>, Clinical Cancer Research. 2018 Dec | journal-article. doi: 10.1158/1078-0432.CCR-18-1847.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85047455960&partnerID=MN8TOARS' target='_blank' class='bux-link'>CD44 positive and sorafenib insensitive hepatocellular carcinomas respond to the ATP-competitive mTOR inhibitor INK128</a>, Oncotarget. 2018 Jan | journal-article. doi: 10.18632/oncotarget.25430.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85070451907&partnerID=MN8TOARS' target='_blank' class='bux-link'>Erratum: Author Correction: Nitric oxide mediated inhibition of antigen presentation from DCs to CD4+ T cells in cancer and measurement of STAT1 nitration (Scientific reports (2017) 7 1 (15424))</a>, Scientific reports. 2018 Jan | journal-article. doi: 10.1038/s41598-018-21306-z.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85047763191&partnerID=MN8TOARS' target='_blank' class='bux-link'>PRMT5 as a druggable target for glioblastoma therapy</a>, Neuro-Oncology. 2018 Jan | journal-article. doi: 10.1093/neuonc/nox206.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85055340839&partnerID=MN8TOARS' target='_blank' class='bux-link'>Pharmacokinetic-Pharmacodynamic Model of Neutropenia in Patients With Myeloma Receiving High-Dose Melphalan for Autologous Stem Cell Transplant</a>, CPT: Pharmacometrics and Systems Pharmacology. 2018 Jan | journal-article. doi: 10.1002/psp4.12345.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85077490229&partnerID=MN8TOARS' target='_blank' class='bux-link'>Phase I trial of dabrafenib and pazopanib in BRAF mutated advanced malignancies</a>, JCO Precision Oncology. 2018 Jan | journal-article. doi: 10.1200/PO.17.00247.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85054104554&partnerID=MN8TOARS' target='_blank' class='bux-link'>Phyllanthusmin derivatives induce apoptosis and reduce tumor burden in high-grade serous ovarian cancer by late-stage autophagy inhibition</a>, Molecular Cancer Therapeutics. 2018 Jan | journal-article. doi: 10.1158/1535-7163.MCT-17-1195.

<a href='https://doi.org/10.1182/blood-2017-03-772061' target='_blank' class='bux-link'>Rituximab immunotherapy: it’s getting personal</a>, Blood. 2017 May | journal-article. doi: 10.1182/blood-2017-03-772061.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85020740127&partnerID=MN8TOARS' target='_blank' class='bux-link'>A Phase I/II Trial of Panobinostat in Combination With Lenalidomide in Patients With Relapsed or Refractory Hodgkin Lymphoma</a>, Clinical Lymphoma, Myeloma and Leukemia. 2017 Jan | journal-article. doi: 10.1016/j.clml.2017.05.008.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85014613129&partnerID=MN8TOARS' target='_blank' class='bux-link'>A phase 1 trial of the HDAC inhibitor AR-42 in patients with multiple myeloma and T- and B-cell lymphomas</a>, Leukemia and Lymphoma. 2017 Jan | journal-article. doi: 10.1080/10428194.2017.1298751.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85015687439&partnerID=MN8TOARS' target='_blank' class='bux-link'>Achieving the Promise of Therapeutic Extracellular Vesicles: The Devil is in Details of Therapeutic Loading</a>, Pharmaceutical Research. 2017 Jan | journal-article. doi: 10.1007/s11095-017-2123-5.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85019750303&partnerID=MN8TOARS' target='_blank' class='bux-link'>Associations of High-Dose Melphalan Pharmacokinetics and Outcomes in the Setting of a Randomized Cryotherapy Trial</a>, Clinical Pharmacology and Therapeutics. 2017 Jan | journal-article. doi: 10.1002/cpt.644.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85034054886&partnerID=MN8TOARS' target='_blank' class='bux-link'>Comprehensive toxicity and immunogenicity studies reveal minimal effects in mice following sustained dosing of extracellular vesicles derived from HEK293T cells</a>, Journal of Extracellular Vesicles. 2017 Jan | journal-article. doi: 10.1080/20013078.2017.1324730.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85019226382&partnerID=MN8TOARS' target='_blank' class='bux-link'>G-CSF improves safety when you start the day after autologous transplant in multiple myeloma</a>, Leukemia and Lymphoma. 2017 Jan | journal-article. doi: 10.1080/10428194.2017.1318436.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85017165880&partnerID=MN8TOARS' target='_blank' class='bux-link'>Influence of OATP1B1 Function on the Disposition of Sorafenib-β-D-Glucuronide</a>, Clinical and Translational Science. 2017 Jan | journal-article. doi: 10.1111/cts.12458.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85033493022&partnerID=MN8TOARS' target='_blank' class='bux-link'>Low active loading of cargo into engineered extracellular vesicles results in inefficient miRNA mimic delivery</a>, Journal of Extracellular Vesicles. 2017 Jan | journal-article. doi: 10.1080/20013078.2017.1333882.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85034094984&partnerID=MN8TOARS' target='_blank' class='bux-link'>Nitric oxide mediated inhibition of antigen presentation from DCs to CD4+ T cells in cancer and measurement of STAT1 nitration</a>, Scientific Reports. 2017 Jan | journal-article. doi: 10.1038/s41598-017-14970-0.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85026902007&partnerID=MN8TOARS' target='_blank' class='bux-link'>Non-immunosuppressive FTY720-derivative OSU-2S mediates reactive oxygen species-mediated cytotoxicity in canine B-cell lymphoma</a>, Veterinary and Comparative Oncology. 2017 Jan | journal-article. doi: 10.1111/vco.12221.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85029668221&partnerID=MN8TOARS' target='_blank' class='bux-link'>Oral tetrahydrouridine and decitabine for non-cytotoxic epigenetic gene regulation in sickle cell disease: A randomized phase 1 study</a>, PLoS Medicine. 2017 Jan | journal-article. doi: 10.1371/journal.pmed.1002382.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85095633926&partnerID=MN8TOARS' target='_blank' class='bux-link'>Overcoming Resistance to Anabolic Selective Androgen Receptor Modulator (SARM) Therapy in Experimental Cancer Cachexia with Histone Deacetylase Inhibitor AR-42</a>, bioRxiv. 2017 Jan | other. doi: 10.1101/214155.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85014633606&partnerID=MN8TOARS' target='_blank' class='bux-link'>Plasma pharmacokinetics and bioavailability of verticillin A following different routes of administration in mice using liquid chromatography tandem mass spectrometry</a>, Journal of Pharmaceutical and Biomedical Analysis. 2017 Jan | journal-article. doi: 10.1016/j.jpba.2017.02.051.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85013271796&partnerID=MN8TOARS' target='_blank' class='bux-link'>Polymorphism in ANRIL is associated with relapse in patients with multiple myeloma after autologous stem cell transplant</a>, Molecular Carcinogenesis. 2017 Jan | journal-article. doi: 10.1002/mc.22626.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85026236990&partnerID=MN8TOARS' target='_blank' class='bux-link'>Target specificity, in vivo pharmacokinetics, and efficacy of the putative STAT3 inhibitor LY5 in osteosarcoma, Ewing’s sarcoma, and rhabdomyosarcoma</a>, PLoS ONE. 2017 Jan | journal-article. doi: 10.1371/journal.pone.0181885.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84954220961&partnerID=MN8TOARS' target='_blank' class='bux-link'>A phase I trial of the intravenous Hsp90 inhibitor alvespimycin (17-DMAG) in patients with relapsed chronic lymphocytic leukemia/small lymphocytic lymphoma</a>, Leukemia and Lymphoma. 2016 Jan | journal-article. doi: 10.3109/10428194.2015.1129536.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84969651106&partnerID=MN8TOARS' target='_blank' class='bux-link'>Discovery and Mechanism of Highly Efficient Cyclic Cell-Penetrating Peptides</a>, Biochemistry. 2016 Jan | journal-article. doi: 10.1021/acs.biochem.6b00226.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84993996126&partnerID=MN8TOARS' target='_blank' class='bux-link'>Discovery of anticancer agents of diverse natural origin</a>, Anticancer Research. 2016 Jan | journal-article. doi: 10.21873/anticanres.11146.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84963509872&partnerID=MN8TOARS' target='_blank' class='bux-link'>In vitro immunotoxicity assessment of culture-derived extracellular vesicles in human monocytes</a>, Journal of Immunotoxicology. 2016 Jan | journal-article. doi: 10.3109/1547691X.2016.1148089.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85016483007&partnerID=MN8TOARS' target='_blank' class='bux-link'>NK Cell-Mediated antitumor effects of a folate-conjugated immunoglobulin are enhanced by cytokines</a>, Cancer Immunology Research. 2016 Jan | journal-article. doi: 10.1158/2326-6066.CIR-15-0168.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84956633936&partnerID=MN8TOARS' target='_blank' class='bux-link'>Pharmacokinetics of intra-articular betamethasone sodium phosphate and betamethasone acetate and endogenous hydrocortisone suppression in exercising horses</a>, Journal of Veterinary Pharmacology and Therapeutics. 2016 Jan | journal-article. doi: 10.1111/jvp.12229.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85007543296&partnerID=MN8TOARS' target='_blank' class='bux-link'>Preclinical pharmacokinetics study of R- and S-Enantiomers of the histone deacetylase inhibitor, AR-42 (NSC 731438), in rodents</a>, AAPS Journal. 2016 Jan | journal-article. doi: 10.1208/s12248-016-9876-3.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84976339911&partnerID=MN8TOARS' target='_blank' class='bux-link'>Preferential delivery of an opioid antagonist to the fetal brain in pregnant mice</a>, Journal of Pharmacology and Experimental Therapeutics. 2016 Jan | journal-article. doi: 10.1124/jpet.115.231902.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84979498184&partnerID=MN8TOARS' target='_blank' class='bux-link'>Preparation and Evaluation of a Novel Class of Amphiphilic Amines as Antitumor Agents and Nanocarriers for Bioactive Molecules</a>, Pharmaceutical Research. 2016 Jan | journal-article. doi: 10.1007/s11095-016-1999-9.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84959266374&partnerID=MN8TOARS' target='_blank' class='bux-link'>Proteomic characterization of circulating extracellular vesicles identifies novel serum myeloma associated markers</a>, Journal of Proteomics. 2016 Jan | journal-article. doi: 10.1016/j.jprot.2015.12.016.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84961927582&partnerID=MN8TOARS' target='_blank' class='bux-link'>Registered report: Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs</a>, eLife. 2016 Jan | journal-article. doi: 10.7554/eLife.12470.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84928490666&partnerID=MN8TOARS' target='_blank' class='bux-link'>Decitabine priming enhances the antileukemic effects of exportin 1 (XPO1) selective inhibitor selinexor in acute myeloid leukemia</a>, Blood. 2015 Jan | journal-article. doi: 10.1182/blood-2014-10-607648.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84921412118&partnerID=MN8TOARS' target='_blank' class='bux-link'>Liquid chromatography-tandem mass spectrometry assay for the simultaneous quantification of simvastatin, lovastatin, atorvastatin, and their major metabolites in human plasma</a>, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 2015 Jan | journal-article. doi: 10.1016/j.jchromb.2014.12.029.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84920941596&partnerID=MN8TOARS' target='_blank' class='bux-link'>OSU-T315: A novel targeted therapeutic that antagonizes AKT membrane localization and activation of chronic lymphocytic leukemia cells</a>, Blood. 2015 Jan | journal-article. doi: 10.1182/blood-2014-06-583518.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84947560068&partnerID=MN8TOARS' target='_blank' class='bux-link'>Phase i dose escalation trial of the novel proteasome inhibitor carfilzomib in patients with relapsed chronic lymphocytic leukemia and small lymphocytic lymphoma</a>, Leukemia and Lymphoma. 2015 Jan | journal-article. doi: 10.3109/10428194.2015.1014368.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84940453671&partnerID=MN8TOARS' target='_blank' class='bux-link'>ROR1-targeted delivery of OSU-2S, a nonimmunosuppressive FTY720 derivative, exerts potent cytotoxicity in mantle-cell lymphoma in vitro and in vivo</a>, Experimental Hematology. 2015 Jan | journal-article. doi: 10.1016/j.exphem.2015.04.008.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84925348918&partnerID=MN8TOARS' target='_blank' class='bux-link'>Reduced occurrence of tumor flare with flavopiridol followed by combined flavopiridol and lenalidomide in patients with relapsed chronic lymphocytic leukemia (CLL)</a>, American Journal of Hematology. 2015 Jan | journal-article. doi: 10.1002/ajh.23946.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84937010435&partnerID=MN8TOARS' target='_blank' class='bux-link'>Results of an abbreviated phase-II study with the Akt Inhibitor MK-2206 in Patients with Advanced Biliary Cancer</a>, Scientific Reports. 2015 Jan | journal-article. doi: 10.1038/srep12122.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84929283967&partnerID=MN8TOARS' target='_blank' class='bux-link'>The combination of milatuzumab, a humanized anti-CD74 antibody, and veltuzumab, a humanized anti-CD20 antibody, demonstrates activity in patients with relapsed and refractory B-cell non-Hodgkin lymphoma</a>, British Journal of Haematology. 2015 Jan | journal-article. doi: 10.1111/bjh.13354.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84922460048&partnerID=MN8TOARS' target='_blank' class='bux-link'>Tumor antigen ROR1 targeted drug delivery mediated selective leukemic but not normal B-cell cytotoxicity in chronic lymphocytic leukemia</a>, Leukemia. 2015 Jan | journal-article. doi: 10.1038/leu.2014.199.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84906933911&partnerID=MN8TOARS' target='_blank' class='bux-link'>A dose escalation feasibility study of lenalidomide for treatment of symptomatic, relapsed chronic lymphocytic leukemia</a>, Leukemia Research. 2014 Jan | journal-article. doi: 10.1016/j.leukres.2014.05.011.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84895071225&partnerID=MN8TOARS' target='_blank' class='bux-link'>A novel liposomal formulation of FTY720 (Fingolimod) for promising enhanced targeted delivery</a>, Nanomedicine: Nanotechnology, Biology, and Medicine. 2014 Jan | journal-article. doi: 10.1016/j.nano.2013.08.001.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84896040809&partnerID=MN8TOARS' target='_blank' class='bux-link'>A phase I trial of flavopiridol in relapsed multiple myeloma</a>, Cancer Chemotherapy and Pharmacology. 2014 Jan | journal-article. doi: 10.1007/s00280-013-2347-y.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84897869476&partnerID=MN8TOARS' target='_blank' class='bux-link'>A snapshot of challenges and solutions in cancer drug development and therapy</a>, Clinical Pharmacology and Therapeutics. 2014 Jan | journal-article. doi: 10.1038/clpt.2014.15.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84944270933&partnerID=MN8TOARS' target='_blank' class='bux-link'>Comparison of high-dose intermittent and low-dose continuous oral artemisinin in dogs with naturally occurring tumors</a>, Journal of the American Animal Hospital Association. 2014 Jan | journal-article. doi: 10.5326/JAAHA-MS-6145.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84904855517&partnerID=MN8TOARS' target='_blank' class='bux-link'>Erlotinib in African Americans with advanced non-small cell lung cancer: A prospective randomized study with genetic and pharmacokinetic analyses</a>, Clinical Pharmacology and Therapeutics. 2014 Jan | journal-article. doi: 10.1038/clpt.2014.93.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84983031336&partnerID=MN8TOARS' target='_blank' class='bux-link'>Establishing a clinical pharmacology fellowship program for physicians, pharmacists, and pharmacologists: A newly accredited interdisciplinary training program at the Ohio State University</a>, Advances in Medical Education and Practice. 2014 Jan | journal-article. doi: 10.2147/AMEP.S60986.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84892853268&partnerID=MN8TOARS' target='_blank' class='bux-link'>Flavopiridol can be safely administered using a pharmacologically derived schedule and demonstrates activity in relapsed and refractory non-Hodgkin's lymphoma</a>, American Journal of Hematology. 2014 Jan | journal-article. doi: 10.1002/ajh.23568.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84905818955&partnerID=MN8TOARS' target='_blank' class='bux-link'>Irinotecan pharmacogenetics: A finished puzzle?</a>, Journal of Clinical Oncology. 2014 Jan | journal-article. doi: 10.1200/JCO.2014.56.3387.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84902135614&partnerID=MN8TOARS' target='_blank' class='bux-link'>Quantification of OSU-2S, a novel derivative of FTY720, in mouse plasma by liquid chromatography-tandem mass spectrometry</a>, Journal of Pharmaceutical and Biomedical Analysis. 2014 Jan | journal-article. doi: 10.1016/j.jpba.2014.05.022.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84897025767&partnerID=MN8TOARS' target='_blank' class='bux-link'>Race and ethnicity in cancer therapy: What have we learned?</a>, Clinical Pharmacology and Therapeutics. 2014 Jan | journal-article. doi: 10.1038/clpt.2014.5.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84884927672&partnerID=MN8TOARS' target='_blank' class='bux-link'>Sensitive liquid chromatography/mass spectrometry methods for quantification of pomalidomide in mouse plasma and brain tissue</a>, Journal of Pharmaceutical and Biomedical Analysis. 2014 Jan | journal-article. doi: 10.1016/j.jpba.2013.08.036.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84874825923&partnerID=MN8TOARS' target='_blank' class='bux-link'>A pharmacokinetic/pharmacodynamic model of tumor lysis syndrome in chronic lymphocytic leukemia patients treated with flavopiridol</a>, Clinical Cancer Research. 2013 Jan | journal-article. doi: 10.1158/1078-0432.CCR-12-1092.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84879105970&partnerID=MN8TOARS' target='_blank' class='bux-link'>A phase i study of prolonged infusion of triapine in combination with fixed dose rate gemcitabine in patients with advanced solid tumors</a>, Investigational New Drugs. 2013 Jan | journal-article. doi: 10.1007/s10637-012-9863-1.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84876551991&partnerID=MN8TOARS' target='_blank' class='bux-link'>CYP3A4/5 combined genotype analysis for predicting statin dose requirement for optimal lipid control</a>, Drug Metabolism and Drug Interactions. 2013 Jan | journal-article. doi: 10.1515/dmdi-2012-0031.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84876714850&partnerID=MN8TOARS' target='_blank' class='bux-link'>Comparative cellular pharmacokinetics and pharmacodynamics of siRNA delivery by SPANosomes and by cationic liposomes</a>, Nanomedicine: Nanotechnology, Biology, and Medicine. 2013 Jan | journal-article. doi: 10.1016/j.nano.2012.10.002.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84883557418&partnerID=MN8TOARS' target='_blank' class='bux-link'>Cyclophosphamide, alvocidib (flavopiridol), and rituximab, a novel feasible chemoimmunotherapy regimen for patients with high-risk chronic lymphocytic leukemia</a>, Leukemia Research. 2013 Jan | journal-article. doi: 10.1016/j.leukres.2013.06.006.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84872565342&partnerID=MN8TOARS' target='_blank' class='bux-link'>Milatuzumab-conjugated liposomes as targeted dexamethasone carriers for therapeutic delivery in CD74+ B-cell malignancies</a>, Clinical Cancer Research. 2013 Jan | journal-article. doi: 10.1158/1078-0432.CCR-12-2046.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84883006942&partnerID=MN8TOARS' target='_blank' class='bux-link'>Pharmacokinetics and dose escalation of the heat shock protein inhibitor 17-allyamino-17-demethoxygeldanamycin in combination with bortezomib in relapsed or refractory acute myeloid leukemia</a>, Leukemia and Lymphoma. 2013 Jan | journal-article. doi: 10.3109/10428194.2012.760733.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84888584556&partnerID=MN8TOARS' target='_blank' class='bux-link'>Site specific discrete PEGylation of 124I-labeled mCC49 Fab′ fragments improves tumor MicroPET/CT imaging in mice</a>, Bioconjugate Chemistry. 2013 Jan | journal-article. doi: 10.1021/bc400375f.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84880787367&partnerID=MN8TOARS' target='_blank' class='bux-link'>Standard pentostatin dose reductions in renal insufficiency are not adequate: Selected patients with steroid-refractory acute graft-versus-host disease</a>, Clinical Pharmacokinetics. 2013 Jan | journal-article. doi: 10.1007/s40262-013-0064-7.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84882384439&partnerID=MN8TOARS' target='_blank' class='bux-link'>Toxicology and biodistribution studies for MGH2.1, an oncolytic virus that expresses two prodrug-activating genes, in combination with prodrugs</a>, Molecular Therapy - Nucleic Acids. 2013 Jan | journal-article. doi: 10.1038/mtna.2013.38.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84860531850&partnerID=MN8TOARS' target='_blank' class='bux-link'>A dose-finding, pharmacokinetic and pharmacodynamic study of a novel schedule of flavopiridol in patients with advanced solid tumors</a>, Investigational New Drugs. 2012 Jan | journal-article. doi: 10.1007/s10637-010-9563-7.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84871755524&partnerID=MN8TOARS' target='_blank' class='bux-link'>Acetaminophen pediatric dose selection: Caregiver satisfaction regarding the antipyretic efficacy of acetaminophen in children</a>, Clinical Pediatrics. 2012 Jan | journal-article. doi: 10.1177/0009922812456592.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84870439326&partnerID=MN8TOARS' target='_blank' class='bux-link'>Analysis of the transport of and cytotoxic effects for nalbuphine solution in corneal cells</a>, American Journal of Veterinary Research. 2012 Jan | journal-article. doi: 10.2460/ajvr.73.12.1987.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84865786583&partnerID=MN8TOARS' target='_blank' class='bux-link'>Development and validation of sensitive liquid chromatography/tandem mass spectrometry method for quantification of bendamustine in mouse brain tissue</a>, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 2012 Jan | journal-article. doi: 10.1016/j.jchromb.2012.08.013.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84863393289&partnerID=MN8TOARS' target='_blank' class='bux-link'>Flavopiridol treatment of patients aged 70 or older with refractory or relapsed chronic lymphocytic leukemia is a feasible and active therapeutic approach</a>, Haematologica. 2012 Jan | journal-article. doi: 10.3324/haematol.2011.047324.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84857720364&partnerID=MN8TOARS' target='_blank' class='bux-link'>Influence of exercise on the distribution of technetium Tc 99m medronate following intra-articular injection in horses</a>, American Journal of Veterinary Research. 2012 Jan | journal-article. doi: 10.2460/ajvr.73.3.418.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84861170448&partnerID=MN8TOARS' target='_blank' class='bux-link'>Institutional profile: Program in pharmacogenomics at the ohio state university medical Center</a>, Pharmacogenomics. 2012 Jan | journal-article. doi: 10.2217/pgs.12.46.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84869106742&partnerID=MN8TOARS' target='_blank' class='bux-link'>Pharmacokinetics and tissue disposition of lenalidomide in mice</a>, AAPS Journal. 2012 Jan | journal-article. doi: 10.1208/s12248-012-9401-2.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84865798532&partnerID=MN8TOARS' target='_blank' class='bux-link'>Pharmacokinetics of methylprednisolone acetate after intra-articular administration and subsequent suppression of endogenous hydrocortisone secretion in exercising horses</a>, American Journal of Veterinary Research. 2012 Jan | journal-article. doi: 10.2460/ajvr.73.9.1453.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84866974959&partnerID=MN8TOARS' target='_blank' class='bux-link'>Reovirus-associated reduction of microRNA-let-7d is related to the increased apoptotic death of cancer cells in clinical samples</a>, Modern Pathology. 2012 Jan | journal-article. doi: 10.1038/modpathol.2012.95.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84862913262&partnerID=MN8TOARS' target='_blank' class='bux-link'>Reply to N. Chen et al</a>, Journal of Clinical Oncology. 2012 Jan | journal-article. doi: 10.1200/JCO.2011.39.6101.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84864996651&partnerID=MN8TOARS' target='_blank' class='bux-link'>Structurally modified curcumin analogs inhibit STAT3 phosphorylation and promote apoptosis of human renal cell carcinoma and melanoma cell lines</a>, PLoS ONE. 2012 Jan | journal-article. doi: 10.1371/journal.pone.0040724.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-83655203042&partnerID=MN8TOARS' target='_blank' class='bux-link'>6β-Naltrexol, a Peripherally Selective Opioid Antagonist that Inhibits Morphine-Induced Slowing of Gastrointestinal Transit: An Exploratory Study</a>, Pain Medicine. 2011 Jan | journal-article. doi: 10.1111/j.1526-4637.2011.01279.x.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-80052605911&partnerID=MN8TOARS' target='_blank' class='bux-link'>Characterization of silvestrol pharmacokinetics in mice using liquid chromatography-tandem mass spectrometry</a>, AAPS Journal. 2011 Jan | journal-article. doi: 10.1208/s12248-011-9273-x.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-79959283388&partnerID=MN8TOARS' target='_blank' class='bux-link'>Multi-institutional phase II study of selumetinib in patients with metastatic biliary cancers</a>, Journal of Clinical Oncology. 2011 Jan | journal-article. doi: 10.1200/JCO.2010.33.9473.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-79954514722&partnerID=MN8TOARS' target='_blank' class='bux-link'>Pharmacogenomic testing: Relevance in medical practice: Why drugs work in some patients but not in others</a>, Cleveland Clinic Journal of Medicine. 2011 Jan | journal-article. doi: 10.3949/ccjm.78a.10145.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-80052666885&partnerID=MN8TOARS' target='_blank' class='bux-link'>Pharmacokinetics of oral ivabradine in healthy cats</a>, Journal of Veterinary Pharmacology and Therapeutics. 2011 Jan | journal-article. doi: 10.1111/j.1365-2885.2010.01253.x.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-80052756653&partnerID=MN8TOARS' target='_blank' class='bux-link'>Phase I trial of lenalidomide and CCI-779 in patients with relapsed multiple myeloma: Evidence for lenalidomide-CCI-779 interaction via P-glycoprotein</a>, Journal of Clinical Oncology. 2011 Jan | journal-article. doi: 10.1200/JCO.2010.32.4962.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-80052575249&partnerID=MN8TOARS' target='_blank' class='bux-link'>Resistance to the translation initiation inhibitor silvestrol is mediated by ABCB1/P-glycoprotein overexpression in acute lymphoblastic leukemia cells</a>, AAPS Journal. 2011 Jan | journal-article. doi: 10.1208/s12248-011-9276-7.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-80052478669&partnerID=MN8TOARS' target='_blank' class='bux-link'>Risk factors for tumor lysis syndrome in patients with chronic lymphocytic leukemia treated with the cyclin-dependent kinase inhibitor, flavopiridol</a>, Leukemia. 2011 Jan | journal-article. doi: 10.1038/leu.2011.109.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84255192032&partnerID=MN8TOARS' target='_blank' class='bux-link'>miR-221 silencing blocks hepatocellular carcinoma and promotes survival</a>, Cancer Research. 2011 Jan | journal-article. doi: 10.1158/0008-5472.CAN-11-1144.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-79951908984&partnerID=MN8TOARS' target='_blank' class='bux-link'>Dose escalation of lenalidomide in relapsed or refractory acute leukemias</a>, Journal of Clinical Oncology. 2010 Jan | journal-article. doi: 10.1200/JCO.2010.30.3339.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-78249236222&partnerID=MN8TOARS' target='_blank' class='bux-link'>Flavopiridol Pharmacogenetics: Clinical and Functional Evidence for the Role of SLCO1B1/OATP1B1 in Flavopiridol Disposition</a>, PLoS ONE. 2010 Jan | journal-article. doi: 10.1371/journal.pone.0013792.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-77954499305&partnerID=MN8TOARS' target='_blank' class='bux-link'>Phase I clinical and pharmacokinetic study of a novel schedule of flavopiridol in relapsed or refractory acute leukemias</a>, Haematologica. 2010 Jan | journal-article. doi: 10.3324/haematol.2009.017103.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-78349299472&partnerID=MN8TOARS' target='_blank' class='bux-link'>REO-10: A phase I study of intravenous reovirus and docetaxel in patients with advanced cancer</a>, Clinical Cancer Research. 2010 Jan | journal-article. doi: 10.1158/1078-0432.CCR-10-1233.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-57049134722&partnerID=MN8TOARS' target='_blank' class='bux-link'>A novel liposomal formulation of flavopiridol</a>, International Journal of Pharmaceutics. 2009 Jan | journal-article. doi: 10.1016/j.ijpharm.2008.08.008.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-72949111820&partnerID=MN8TOARS' target='_blank' class='bux-link'>A phase I/II dose escalation study of Apolizumab (Hu1D10) using a stepped-up dosing schedule in patients with chronic lymphocytic leukemia and acute leukemia</a>, Leukemia and Lymphoma. 2009 Jan | journal-article. doi: 10.3109/10428190903186486.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-63849246351&partnerID=MN8TOARS' target='_blank' class='bux-link'>Clinical response and pharmacokinetics from a phase 1 study of an active dosing schedule of flavopiridol in relapsed chronic lymphocytic leukemia</a>, Blood. 2009 Jan | journal-article. doi: 10.1182/blood-2008-07-168583.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-73349096649&partnerID=MN8TOARS' target='_blank' class='bux-link'>Phase II study of flavopiridol in relapsed chronic lymphocytic leukemia demonstrating high response rates in genetically high-risk disease</a>, Journal of Clinical Oncology. 2009 Jan | journal-article. doi: 10.1200/JCO.2009.22.6944.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-55349093022&partnerID=MN8TOARS' target='_blank' class='bux-link'>Development and validation of a highly sensitive liquid chromatography/mass spectrometry method for simultaneous quantification of lenalidomide and flavopiridol in human plasma</a>, Therapeutic Drug Monitoring. 2008 Jan | journal-article. doi: 10.1097/FTD.0b013e318185813d.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-48049089816&partnerID=MN8TOARS' target='_blank' class='bux-link'>Development and validation of a rapid and sensitive high-performance liquid chromatography-mass spectroscopy assay for determination of 17-(allylamino)-17-demethoxygeldanamycin and 17-(amino)-17-demethoxygeldanamycin in human plasma</a>, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 2008 Jan | journal-article. doi: 10.1016/j.jchromb.2008.06.029.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-44449083839&partnerID=MN8TOARS' target='_blank' class='bux-link'>Development and validation of a sensitive liquid chromatography/mass spectrometry method for quantitation of flavopiridol in plasma enables accurate estimation of pharmacokinetic parameters with a clinically active dosing schedule</a>, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 2008 Jan | journal-article. doi: 10.1016/j.jchromb.2008.04.023.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-54249132485&partnerID=MN8TOARS' target='_blank' class='bux-link'>Flavopiridol (alvocidib) in chronic lymphocytic leukemia</a>, Haematologica Meeting Reports. 2008 Jan | journal-article. .

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-56649090952&partnerID=MN8TOARS' target='_blank' class='bux-link'>Inhibitors of tubulin assembly identified through screening a compound library</a>, Chemical Biology and Drug Design. 2008 Jan | journal-article. doi: 10.1111/j.1747-0285.2008.00729.x.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-56049123668&partnerID=MN8TOARS' target='_blank' class='bux-link'>Intracellular processing of riboflavin in human breast cancer cells</a>, Molecular Pharmaceutics. 2008 Jan | journal-article. doi: 10.1021/mp800046m.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-33846219417&partnerID=MN8TOARS' target='_blank' class='bux-link'>Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia</a>, Blood. 2007 Jan | journal-article. doi: 10.1182/blood-2006-05-020735.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-33745611775&partnerID=MN8TOARS' target='_blank' class='bux-link'>Antikinetoplastid antimitotic activity and metabolic stability of dinitroaniline sulfonamides and benzamides</a>, Bioorganic and Medicinal Chemistry. 2006 Jan | journal-article. doi: 10.1016/j.bmc.2006.04.017.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-33645889975&partnerID=MN8TOARS' target='_blank' class='bux-link'>Recognition, cointernalization, and recycling of an avian riboflavin carrier protein in human placental trophoblasts</a>, Journal of Pharmacology and Experimental Therapeutics. 2006 Jan | journal-article. doi: 10.1124/jpet.105.096149.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-26844496083&partnerID=MN8TOARS' target='_blank' class='bux-link'>Selective androgen receptor modulator treatment improves muscle strength and body composition and prevents bone loss in orchidectomized rats</a>, Endocrinology. 2005 Jan | journal-article. doi: 10.1210/en.2005-0572.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-22844436051&partnerID=MN8TOARS' target='_blank' class='bux-link'>A novel rhodamine-riboflavin conjugate probe exhibits distinct fluorescence resonance energy transfer that enables riboflavin trafficking and subcellular localization studies.</a>, Molecular pharmaceutics. 2004 Jan | journal-article. doi: 10.1021/mp0499510.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-0842327202&partnerID=MN8TOARS' target='_blank' class='bux-link'>Favorable Effects of Weak Acids on Negative-Ion Electrospray Ionization Mass Spectrometry</a>, Analytical Chemistry. 2004 Jan | journal-article. doi: 10.1021/ac0351670.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-4444299420&partnerID=MN8TOARS' target='_blank' class='bux-link'>Topology scanning and putative three-dimensional structure of the extracellular binding domains of the apical sodium-dependent bile acid transporter (SLC10A2)</a>, Biochemistry. 2004 Jan | journal-article. doi: 10.1021/bi049270a.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-0038686017&partnerID=MN8TOARS' target='_blank' class='bux-link'>Cytoskeletal motors and cargo in membrane trafficking: Opportunities for high specificity in drug intervention</a>, Drug Discovery Today. 2003 Jan | journal-article. doi: 10.1016/S1359-6446(03)02707-7.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-0038637155&partnerID=MN8TOARS' target='_blank' class='bux-link'>Involvement of endocytic organelles in the subcellular trafficking and localization of riboflavin</a>, Journal of Pharmacology and Experimental Therapeutics. 2003 Jan | journal-article. doi: 10.1124/jpet.103.051581.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-0037204542&partnerID=MN8TOARS' target='_blank' class='bux-link'>Modeling of active transport systems</a>, Advanced Drug Delivery Reviews. 2002 Jan | journal-article. doi: 10.1016/S0169-409X(02)00007-8.

Navjot Pabla

Associate Professor

Pharmaceutics and Pharmacology

Outcomes and Translational Sciences

Research Areas

Clinical & Pre-Clinical Pharmacology,

Pharmaceutics & Pharmacology

402 Riffe Building

pabla.2@osu.edu

(614) 292-1063

Our laboratory is focused on identifying therapeutic targets for kidney diseases. Acute kidney injury and renal cell carcinoma are the two major areas of interest. Our recent work has identified several protein kinases and membrane transporters as therapeutic targets for renal disorders. We utilize high throughput screening assays and functional genomics to identify molecular targets for renal diseases, followed by validation in in vivo animal models. The overall goal of these studies is to identify new therapeutic strategies to treat acute kidney injury and renal cell carcinoma, diseases for which no effective therapies are currently available.

2009, PhD (Biomedical Sciences), Medical College of Georgia

2003, M.Sc. (Biochemistry), Maharaja Sayajirao University of Baroda

2001, B.Sc. (Biotechnology), Sardar Patel University

<a href='http://europepmc.org/abstract/med/34614509' target='_blank' class='bux-link'>Gilteritinib-induced upregulation of S100A9 is mediated through BCL6 in Acute Myeloid Leukemia.</a>, Blood advances. 2021 Oct | journal-article. doi: 10.1182/bloodadvances.2021005614.

<a href='http://europepmc.org/abstract/med/34534550' target='_blank' class='bux-link'>Kidney toxicity of the BRAF-kinase inhibitor vemurafenib is driven by off-target ferrochelatase inhibition.</a>, Kidney international. 2021 Sep | journal-article. doi: 10.1016/j.kint.2021.08.022.

<a href='http://europepmc.org/abstract/med/33044867' target='_blank' class='bux-link'>Involvement of the CDKL5-SOX9 signaling axis in rhabdomyolysis-associated acute kidney injury.</a>, American journal of physiology. Renal physiology. 2020 Oct | journal-article. doi: 10.1152/ajprenal.00429.2020.

<a href='http://europepmc.org/abstract/med/32887795' target='_blank' class='bux-link'>SOX9 promotes stress-responsive transcription of VGF nerve growth factor inducible gene in renal tubular epithelial cells.</a>, The Journal of biological chemistry. 2020 Sep | journal-article. doi: 10.1074/jbc.ra120.015110.

<a href='http://europepmc.org/abstract/med/32484793' target='_blank' class='bux-link'>Neuronal uptake transporters contribute to oxaliplatin neurotoxicity in mice.</a>, The Journal of clinical investigation. 2020 Jun | journal-article. doi: 10.1172/jci136796.

<a href='http://europepmc.org/abstract/med/32317630' target='_blank' class='bux-link'>A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury.</a>, Nature communications. 2020 Apr | journal-article. doi: 10.1038/s41467-020-15638-6.

<a href='http://europepmc.org/abstract/med/32229099' target='_blank' class='bux-link'>Ribociclib mitigates cisplatin-associated kidney injury through retinoblastoma-1 dependent mechanisms.</a>, Biochemical pharmacology. 2020 Mar | journal-article. doi: 10.1016/j.bcp.2020.113939.

<a href='http://europepmc.org/abstract/med/30288751' target='_blank' class='bux-link'>FoxO1 is a critical regulator of M2-like macrophage activation in allergic asthma.</a>, Allergy. 2018 Nov | journal-article. doi: 10.1111/all.13626.

<a href='http://europepmc.org/abstract/med/29227282' target='_blank' class='bux-link'>Hypoxia-induced upregulation of BMX kinase mediates therapeutic resistance in acute myeloid leukemia.</a>, The Journal of clinical investigation. 2017 Dec | journal-article. doi: 10.1172/jci91893.

<a href='http://europepmc.org/abstract/med/28689374' target='_blank' class='bux-link'>Identification of OAT1/OAT3 as Contributors to Cisplatin Toxicity.</a>, Clinical and translational science. 2017 Jul | journal-article. doi: 10.1111/cts.12480.

<a href='http://europepmc.org/abstract/med/28209616' target='_blank' class='bux-link'>OCTN1 Is a High-Affinity Carrier of Nucleoside Analogues.</a>, Cancer research. 2017 Feb | journal-article. doi: 10.1158/0008-5472.can-16-2548.

<a href='http://europepmc.org/abstract/med/27804130' target='_blank' class='bux-link'>Role of Passive Diffusion, Transporters, and Membrane Trafficking-Mediated Processes in Cellular Drug Transport.</a>, Clinical pharmacology and therapeutics. 2016 Nov | journal-article. doi: 10.1002/cpt.545.

<a href='http://europepmc.org/abstract/med/26979622' target='_blank' class='bux-link'>A phosphotyrosine switch regulates organic cation transporters.</a>, Nature communications. 2016 Mar | journal-article. doi: 10.1038/ncomms10880.

<a href='http://europepmc.org/abstract/med/26564230' target='_blank' class='bux-link'>DNA damage response in cisplatin-induced nephrotoxicity.</a>, Archives of toxicology. 2015 Nov | journal-article. doi: 10.1007/s00204-015-1633-3.

<a href='http://europepmc.org/abstract/med/25848011' target='_blank' class='bux-link'>Mitigation of acute kidney injury by cell-cycle inhibitors that suppress both CDK4/6 and OCT2 functions.</a>, Proceedings of the National Academy of Sciences of the United States of America. 2015 Apr | journal-article. doi: 10.1073/pnas.1424313112.

<a href='http://europepmc.org/abstract/med/25770292' target='_blank' class='bux-link'>CCR 20th anniversary commentary: BMS-247550—microtubule stabilization as successful targeted therapy.</a>, Clinical cancer research : an official journal of the American Association for Cancer Research. 2015 Mar | journal-article. doi: 10.1158/1078-0432.ccr-14-2551.

<a href='http://europepmc.org/abstract/med/25587068' target='_blank' class='bux-link'>MicroRNA-687 Induced by Hypoxia-Inducible Factor-1 Targets Phosphatase and Tensin Homolog in Renal Ischemia-Reperfusion Injury.</a>, Journal of the American Society of Nephrology : JASN. 2015 Jan | journal-article. doi: 10.1681/asn.2014050463.

<a href='http://europepmc.org/abstract/med/24916697' target='_blank' class='bux-link'>Cisplatin-induced renal injury is independently mediated by OCT2 and p53.</a>, Clinical cancer research : an official journal of the American Association for Cancer Research. 2014 Jun | journal-article. doi: 10.1158/1078-0432.ccr-14-0319.

<a href='http://europepmc.org/abstract/med/23851348' target='_blank' class='bux-link'>Nek1 interacts with Ku80 to assist chromatin loading of replication factors and S-phase progression.</a>, Cell cycle (Georgetown, Tex.). 2013 Jul | journal-article. doi: 10.4161/cc.25624.

<a href='http://europepmc.org/abstract/med/23508805' target='_blank' class='bux-link'>Checkpoint kinase 1 in DNA damage response and cell cycle regulation.</a>, Cellular and molecular life sciences : CMLS. 2013 Mar | journal-article. doi: 10.1007/s00018-013-1307-3.

<a href='http://europepmc.org/abstract/med/23255108' target='_blank' class='bux-link'>Nek1 phosphorylates Von Hippel-Lindau tumor suppressor to promote its proteasomal degradation and ciliary destabilization.</a>, Cell cycle (Georgetown, Tex.). 2012 Dec | journal-article. doi: 10.4161/cc.23053.

<a href='http://europepmc.org/abstract/med/22544330' target='_blank' class='bux-link'>Sibling rivalry in checkpoint control of cell cycle and DNA damage response.</a>, Cell cycle (Georgetown, Tex.). 2012 May | journal-article. doi: 10.4161/cc.20416.

<a href='http://europepmc.org/abstract/med/22403741' target='_blank' class='bux-link'>Curtailing side effects in chemotherapy: a tale of PKCδ in cisplatin treatment.</a>, Oncotarget. 2012 Jan | journal-article. doi: 10.18632/oncotarget.439.

<a href='http://europepmc.org/abstract/med/22184239' target='_blank' class='bux-link'>Checkpoint kinase 1 (Chk1)-short is a splice variant and endogenous inhibitor of Chk1 that regulates cell cycle and DNA damage checkpoints.</a>, Proceedings of the National Academy of Sciences of the United States of America. 2011 Dec | journal-article. doi: 10.1073/pnas.1104767109.

<a href='http://europepmc.org/abstract/med/21633170' target='_blank' class='bux-link'>Inhibition of PKCδ reduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer.</a>, The Journal of clinical investigation. 2011 Jul | journal-article. doi: 10.1172/jci45586.

<a href='http://europepmc.org/abstract/med/21285353' target='_blank' class='bux-link'>hMSH2 recruits ATR to DNA damage sites for activation during DNA damage-induced apoptosis.</a>, The Journal of biological chemistry. 2011 Feb | journal-article. doi: 10.1074/jbc.m110.210989.

<a href='http://europepmc.org/abstract/med/20395372' target='_blank' class='bux-link'>PKC-delta promotes renal tubular cell apoptosis associated with proteinuria.</a>, Journal of the American Society of Nephrology : JASN. 2010 Apr | journal-article. doi: 10.1681/asn.2009070760.

<a href='http://europepmc.org/abstract/med/19144690' target='_blank' class='bux-link'>The copper transporter Ctr1 contributes to cisplatin uptake by renal tubular cells during cisplatin nephrotoxicity.</a>, American journal of physiology. Renal physiology. 2009 Jan | journal-article. doi: 10.1152/ajprenal.90545.2008.

<a href='http://europepmc.org/abstract/PMC/PMC3258876' target='_blank' class='bux-link'>ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis. VOLUME 283 (2008) PAGES 6572-6583</a>, The Journal of biological chemistry. 2008 May | journal-article. .

<a href='http://europepmc.org/abstract/med/18272962' target='_blank' class='bux-link'>Cisplatin nephrotoxicity: mechanisms and renoprotective strategies.</a>, Kidney international. 2008 Feb | journal-article. doi: 10.1038/sj.ki.5002786.

<a href='http://europepmc.org/abstract/med/18162465' target='_blank' class='bux-link'>ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis.</a>, The Journal of biological chemistry. 2007 Dec | journal-article. doi: 10.1074/jbc.m707568200.

<a href='http://europepmc.org/abstract/med/18160625' target='_blank' class='bux-link'>Effects of targeted Bcl-2 expression in mitochondria or endoplasmic reticulum on renal tubular cell apoptosis.</a>, American journal of physiology. Renal physiology. 2007 Dec | journal-article. doi: 10.1152/ajprenal.00415.2007.

<a href='http://europepmc.org/abstract/med/17291459' target='_blank' class='bux-link'>Effects of hydroxyl radical scavenging on cisplatin-induced p53 activation, tubular cell apoptosis and nephrotoxicity.</a>, Biochemical pharmacology. 2007 Jan | journal-article. doi: 10.1016/j.bcp.2007.01.010.

<a href='http://europepmc.org/abstract/med/17122151' target='_blank' class='bux-link'>Expression, subcellular localization, and regulation of sigma receptor in retinal muller cells.</a>, Investigative ophthalmology & visual science. 2006 Dec | journal-article. doi: 10.1167/iovs.06-0608.

<a href='http://europepmc.org/abstract/med/17130128' target='_blank' class='bux-link'>Nutlin-3 protects kidney cells during cisplatin therapy by suppressing Bax/Bak activation.</a>, The Journal of biological chemistry. 2006 Nov | journal-article. doi: 10.1074/jbc.m606928200.

<a href='http://europepmc.org/abstract/med/16849690' target='_blank' class='bux-link'>Caspase-mediated cleavage of ATM during cisplatin-induced tubular cell apoptosis: inactivation of its kinase activity toward p53.</a>, American journal of physiology. Renal physiology. 2006 Jul | journal-article. doi: 10.1152/ajprenal.00509.2005.

Robert Lee

Professor

Pharmaceutics and Pharmacology

Research Areas

Pharmaceutics & Pharmacology,

Nanotechnology & Drug Delivery Systems,

Cancer

lee.1339@osu.edu

(614) 292-4172

Dr. Lee's lab is focused on targeted drug delivery systems based on nanoparticles. Nanoparticles can serve as carriers of therapeutic agents, including nucleic acids such as siRNA, miRNA and anti-miRs, and facilitate their therapeutic delivery. The lab's effort is focused on improving nanoparticle composition based on rational design and directed at clinical applications. Ongoing projects include developing miR-targeting lipid nanoparticles and targeted chemotherapeutic drug formulations and bioconjugates for therapy of solid tumors, leukemias, diabetic wounds, and other diseases.

1994, PhD, Purdue University, Biological Sciences

1989, BS, Peking University, Biology

Yan C, Shi W, Gu J, Lee RJ, Zhang Y. Design of a Novel Nucleus-Targeted NLS- KALA-SA Nanocarrier to Delivery Poorly Water-Soluble Anti-Tumor Drug for Lung Cancer Treatment. J Pharm Sci. 2021 Jun;110(6):2432-2441. doi: 10.1016/j.xphs.2020.12.034. Epub 2021 Jan 5. PMID: 33412169.

Sun X, Yu K, Zhou Y, Dong S, Hu W, Sun Y, Li Y, Xie J, Lee RJ, Sun F, Ma Y, Wang S, Kim BYS, Wang Y, Yang Z, Jiang W, Li Y, Teng L. Self-Assembled pH- Sensitive Polymeric Nanoparticles for the Inflammation-Targeted Delivery of Cu/Zn-Superoxide Dismutase. ACS Appl Mater Interfaces. 2021 Apr 21;13(15):18152-18164. doi: 10.1021/acsami.1c03589. Epub 2021 Mar 25. PMID: 33764751.

He C, Zhang X, Chen C, Liu X, Chen Y, Yan R, Fan T, Gai Y, Lee RJ, Ma X, Luo J, Lu Y, Yang T, Xiang G. A solid lipid coated calcium peroxide nanocarrier enables combined cancer chemo/chemodynamic therapy with O2/H2O2 self-sufficiency. Acta Biomater. 2021 Mar 1;122:354-364. doi: 10.1016/j.actbio.2020.12.036. Epub 2021 Jan 6. PMID: 33359323.

Zhao M, Zhu T, Chen J, Cui Y, Zhang X, Lee RJ, Sun F, Li Y, Teng L. PLGA/PCADK composite microspheres containing hyaluronic acid-chitosan siRNA nanoparticles: A rational design for rheumatoid arthritis therapy. Int J Pharm. 2021 Mar 1;596:120204. doi: 10.1016/j.ijpharm.2021.120204. Epub 2021 Jan 23. PMID: 33493604.

Bobba CM, Fei Q, Shukla V, Lee H, Patel P, Putman RK, Spitzer C, Tsai M, Wewers MD, Lee RJ, Christman JW, Ballinger MN, Ghadiali SN, Englert JA. Nanoparticle delivery of microRNA-146a regulates mechanotransduction in lung macrophages and mitigates injury during mechanical ventilation. Nat Commun. 2021 Jan 12;12(1):289. doi: 10.1038/s41467-020-20449-w. PMID: 33436554; PMCID: PMC7804938.

Sugar SS, Heyob KM, Cheng X, Lee RJ, Rogers LK. Perinatal inflammation alters histone 3 and histone 4 methylation patterns: Effects of MiR-29b supplementation. Redox Biol. 2021 Jan;38:101783. doi: 10.1016/j.redox.2020.101783. Epub 2020 Nov 7. PMID: 33202301; PMCID: PMC7677713.

Kuo CT, Lee R, Garzon R. Methods Used to Make Lipid Nanoparticles to Deliver LNA Gapmers Against lncRNAs into Acute Myeloid Leukemia (AML) Blasts. Methods Mol Biol. 2021;2348:167-174. doi: 10.1007/978-1-0716-1581-2_11. PMID: 34160806.

Zhou X, Brown BA, Siegel AP, El Masry MS, Zeng X, Song W, Das A, Khandelwal P, Clark A, Singh K, Guda PR, Gorain M, Timsina L, Xuan Y, Jacobson SC, Novotny MV, Roy S, Agarwal M, Lee RJ, Sen CK, Clemmer DE, Ghatak S. Exosome-Mediated Crosstalk between Keratinocytes and Macrophages in Cutaneous Wound Healing. ACS Nano. 2020 Oct 27;14(10):12732-12748. doi: 10.1021/acsnano.0c03064. Epub 2020 Sep 25. PMID: 32931251; PMCID: PMC7970718.

Wang C, Hao J, Liu X, Li C, Yuan X, Lee RJ, Bai T, Wang D. Isoforsythiaside Attenuates Alzheimer's Disease via Regulating Mitochondrial Function Through the PI3K/AKT Pathway. Int J Mol Sci. 2020 Aug 8;21(16):5687. doi: 10.3390/ijms21165687. PMID: 32784451; PMCID: PMC7460834.

Papaioannou D, Petri A, Dovey OM, Terreri S, Wang E, Collins FA, Woodward LA, Walker AE, Nicolet D, Pepe F, Kumchala P, Bill M, Walker CJ, Karunasiri M, Mrózek K, Gardner ML, Camilotto V, Zitzer N, Cooper JL, Cai X, Rong-Mullins X, Kohlschmidt J, Archer KJ, Freitas MA, Zheng Y, Lee RJ, Aifantis I, Vassiliou G, Singh G, Kauppinen S, Bloomfield CD, Dorrance AM, Garzon R. Author Correction: The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia. Nat Commun. 2020 Jul 29;11(1):3878. doi: 10.1038/s41467-020-17746-9. Erratum for: Nat Commun. 2019 Nov 25;10(1):5351. PMID: 32728019; PMCID: PMC7391355.

Li Y, Ding J, Xu X, Shi R, Saw PE, Wang J, Chung S, Li W, Aljaeid BM, Lee RJ, Tao W, Teng L, Farokhzad OC, Shi J. Dual Hypoxia-Targeting RNAi Nanomedicine for Precision Cancer Therapy. Nano Lett. 2020 Jul 8;20(7):4857-4863. doi: 10.1021/acs.nanolett.0c00757. Epub 2020 Jun 8. PMID: 32479088; PMCID: PMC7405292.

Dou B, Hu W, Song M, Lee RJ, Zhang X, Wang D. Anti-inflammation of Erianin in dextran sulphate sodium-induced ulcerative colitis mice model via collaborative regulation of TLR4 and STAT3. Chem Biol Interact. 2020 Jun 1;324:109089. doi: 10.1016/j.cbi.2020.109089. Epub 2020 Apr 6. PMID: 32272095.

Zheng Z, Lang T, Huang X, Wang G, Lee RJ, Teng L, Yin Q, Li Y. Calcitriol- Loaded Dual-pH-Sensitive Micelle Counteracts Pro-Metastasis Effect of Paclitaxel in Triple-Negative Breast Cancer Therapy. Adv Healthc Mater. 2020 Jun;9(12):e2000392. doi: 10.1002/adhm.202000392. Epub 2020 May 17. PMID: 32419319.

Chen Y, Chen C, Zhang X, He C, Zhao P, Li M, Fan T, Yan R, Lu Y, Lee RJ, Khan MW, Sarfraz M, Ma X, Yang T, Xiang G. Platinum complexes of curcumin delivered by dual-responsive polymeric nanoparticles improve chemotherapeutic efficacy based on the enhanced anti-metastasis activity and reduce side effects. Acta Pharm Sin B. 2020 Jun;10(6):1106-1121. doi: 10.1016/j.apsb.2019.10.011. Epub 2019 Nov 1. PMID: 32642416; PMCID: PMC7332658.

Xie J, Bi Y, Zhang H, Dong S, Teng L, Lee RJ, Yang Z. Cell-Penetrating Peptides in Diagnosis and Treatment of Human Diseases: From Preclinical Research to Clinical Application. Front Pharmacol. 2020 May 20;11:697. doi: 10.3389/fphar.2020.00697. PMID: 32508641; PMCID: PMC7251059.

Chen Y, Lu Y, Lee RJ, Xiang G. Nano Encapsulated Curcumin: And Its Potential for Biomedical Applications. Int J Nanomedicine. 2020 May 1;15:3099-3120. doi: 10.2147/IJN.S210320. PMID: 32431504; PMCID: PMC7200256.

Sun Z, Xie Y, Lee RJ, Chen Y, Jin Q, Lv Q, Wang J, Yang Y, Li Y, Cai Y, Wang R, Han Z, Zhang L, Xie M. Myocardium-targeted transplantation of PHD2 shRNA- modified bone mesenchymal stem cells through ultrasound-targeted microbubble destruction protects the heart from acute myocardial infarction. Theranostics. 2020 Apr 6;10(11):4967-4982. doi: 10.7150/thno.43233. PMID: 32308762; PMCID: PMC7163444.

Zhang X, He C, Liu X, Chen Y, Zhao P, Chen C, Yan R, Li M, Fan T, Altine B, Yang T, Lu Y, Lee RJ, Gai Y, Xiang G. One-pot synthesis of a microporous organosilica-coated cisplatin nanoplatform for HIF-1-targeted combination cancer therapy. Theranostics. 2020 Feb 3;10(7):2918-2929. doi: 10.7150/thno.41077. PMID: 32194844; PMCID: PMC7053205.

Bi Y, Lv B, Li L, Lee RJ, Xie J, Qiu Z, Teng L. A Liposomal Formulation for Improving Solubility and Oral Bioavailability of Nifedipine. Molecules. 2020 Jan 14;25(2):338. doi: 10.3390/molecules25020338. PMID: 31947655; PMCID: PMC7024191.

Papaioannou D, Petri A, Dovey OM, Terreri S, Wang E, Collins FA, Woodward LA, Walker AE, Nicolet D, Pepe F, Kumchala P, Bill M, Walker CJ, Karunasiri M, Mrózek K, Gardner ML, Camilotto V, Zitzer N, Cooper JL, Cai X, Rong-Mullins X, Kohlschmidt J, Archer KJ, Freitas MA, Zheng Y, Lee RJ, Aifantis I, Vassiliou G, Singh G, Kauppinen S, Bloomfield CD, Dorrance AM, Garzon R. Publisher Correction: The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia. Nat Commun. 2020 Jan 7;11(1):204. doi: 10.1038/s41467-019-13969-7. Erratum for: Nat Commun. 2019 Nov 25;10(1):5351. PMID: 31911614; PMCID: PMC6946642.

Deanna L. Kroetz

Dean

Professor

College Administration

Pharmaceutics and Pharmacology

Research Areas

Cancer,

Pharmaceutics & Pharmacology,

Clinical & Pre-Clinical Pharmacology

kroetz.3@osu.edu

Professional Website

The overarching goal of the Kroetz laboratory is to understand the molecular basis of interindividual variability in drug response and toxicity. Genomic association studies are used to identify genes and pathways involved in common toxicities associated with cancer therapy, including taxane-induced peripheral neuropathy and bevacizumab-induced hypertension. Functional genomic studies are then used to define the role of these genes and pathways in the dose-limiting toxicities. A second area of research is on the role of ABC transporters in drug resistance and physiologic function. Ongoing efforts include cryo-EM studies of MRP4 and investigation of MRP4 in resistance to immunotherapy.

1990, PhD, University of Washington

1985, BS Pharm, The Ohio State University College of Pharmacy

2022, Rawls-Palmer Progress in Medicine Award, American Society for Clinical Pharmacology & Therapeutics ASCPT

2020, Jere E. Goyan Presidential Chair, Advancement of Pharmacy

2020, Bristol-Myers Squibb Mentorship in Clinical Pharmacology Award, American College of Clinical Pharmacology

2020, Deans Apple Award for Teaching, UCSF School of Pharmacy

2019, Mentor Award, American Society for Clinical Pharmacology and Therapeutics

2019, Deans Apple Award for Teaching, UCSF School of Pharmacy

2018, Elected Fellow, American Association for the Advancement of Science

2018, Deans Apple Award for Teaching, UCSF School of Pharmacy

2018, Distinguished Alumnus Award for Excellence in Pharmaceutical Sciences and Research, University of Washington School of Pharmacy

2016, Deans Apple Award for Teaching, UCSF School of Pharmacy

2014, Judith Pool Award for Mentoring, Northern California Association for Women in Science

2011, Deans Apple Award for Teaching, UCSF School of Pharmacy

2009, Deans Apple Award for Teaching, UCSF School of Pharmacy

2008, Elected Fellow, American Association of Pharmaceutical Scientists, American Association of Pharmaceutical Scientists

2008, Named to Faculty of 1000, Pharmacology, Pharmacology

2002, Elected Fellow, High Blood Pressure Research Council of the American Heart Association, American Heart Association

2002, Leon I. Goldberg Young Investigator Award, American Society for Clinical Pharmacology and Therapeutics

1996, American Association of Pharmaceutical Scientists Young Investigator Award in Pharmacokinetics, Phar, American Association of Pharmaceutical Scientists

1995, Josephine S. Failer Alumni Award, Ohio State University College of Pharmacy

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85147048381&partnerID=MN8TOARS' target='_blank' class='bux-link'>Host variation in type i interferon signaling genes (MX1), C-C chemokine receptor type 5 gene, and major histocompatibility complex class i alleles in treated HIV+ noncontrollers predict viral reservoir size</a>, AIDS. 2023 Jan | journal-article. doi: 10.1097/QAD.0000000000003428.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85159565525&partnerID=MN8TOARS' target='_blank' class='bux-link'>Inhibition of muscarinic receptor signaling protects human enteric inhibitory neurons against platin chemotherapy toxicity</a>, bioRxiv. 2023 Jan | other. doi: 10.1101/2023.03.08.531806.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85152127962&partnerID=MN8TOARS' target='_blank' class='bux-link'>Paclitaxel- and vincristine-induced neurotoxicity and drug transport in sensory neurons</a>, bioRxiv. 2023 Jan | other. doi: 10.1101/2023.02.07.527432.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85116427935&partnerID=MN8TOARS' target='_blank' class='bux-link'>Bevacizumab-induced hypertension and proteinuria: a genome-wide study of more than 1000 patients</a>, British Journal of Cancer. 2022 Jan | journal-article. doi: 10.1038/s41416-021-01557-w.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85120581731&partnerID=MN8TOARS' target='_blank' class='bux-link'>Correction: Bevacizumab-induced hypertension and proteinuria: a genome-wide study of more than 1000 patients (British Journal of Cancer, (2021), 10.1038/s41416-021-01557-w)</a>, British Journal of Cancer. 2022 Jan | journal-article. doi: 10.1038/s41416-021-01617-1.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85116050605&partnerID=MN8TOARS' target='_blank' class='bux-link'>Mechanistic insights into the pathogenesis of microtubule-targeting agent-induced peripheral neuropathy from pharmacogenetic and functional studies</a>, Basic and Clinical Pharmacology and Toxicology. 2022 Jan | journal-article. doi: 10.1111/bcpt.13654.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85130503206&partnerID=MN8TOARS' target='_blank' class='bux-link'>New and Emerging Research on Solute Carrier and ATP Binding Cassette Transporters in Drug Discovery and Development: Outlook From the International Transporter Consortium</a>, Clinical Pharmacology and Therapeutics. 2022 Jan | journal-article. doi: 10.1002/cpt.2627.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85151220233&partnerID=MN8TOARS' target='_blank' class='bux-link'>POLYMORPHISMS OF DRUG TRANSPORTERS AND CLINICAL RELEVANCE</a>, Drug Transporters: Molecular Characterization and Role in Drug Disposition: Third Edition. 2022 Jan | book-chapter. doi: 10.1002/9781119739883.ch18.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85147155757&partnerID=MN8TOARS' target='_blank' class='bux-link'>STRUCTURAL BASIS OF PROSTAGLANDIN EFFLUX BY MRP4</a>, bioRxiv. 2022 Jan | other. doi: 10.1101/2022.12.22.521501.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85097608526&partnerID=MN8TOARS' target='_blank' class='bux-link'>GSTP1 and ABCB1 Polymorphisms Predicting Toxicities and Clinical Management on Carboplatin and Paclitaxel-Based Chemotherapy in Ovarian Cancer</a>, Clinical and Translational Science. 2021 Jan | journal-article. doi: 10.1111/cts.12937.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85143916474&partnerID=MN8TOARS' target='_blank' class='bux-link'>Host variation in type I interferon signaling genes (MX1), CCR5Δ32, and MHC class I alleles in treated HIV+ non-controllers predict viral reservoir size</a>, bioRxiv. 2021 Jan | other. doi: 10.1101/2021.10.31.466670.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85097743565&partnerID=MN8TOARS' target='_blank' class='bux-link'>Human Induced Pluripotent Stem Cell Derived Sensory Neurons are Sensitive to the Neurotoxic Effects of Paclitaxel</a>, Clinical and Translational Science. 2021 Jan | journal-article. doi: 10.1111/cts.12912.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85114682494&partnerID=MN8TOARS' target='_blank' class='bux-link'>In-depth triacylglycerol profiling using MS3 Q-Trap mass spectrometry</a>, Analytica Chimica Acta. 2021 Jan | journal-article. doi: 10.1016/j.aca.2021.339023.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85115102718&partnerID=MN8TOARS' target='_blank' class='bux-link'>Interaction of Commonly Used Oral Molecular Excipients with P-glycoprotein</a>, AAPS Journal. 2021 Jan | journal-article. doi: 10.1208/s12248-021-00631-8.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85096713002&partnerID=MN8TOARS' target='_blank' class='bux-link'>Role for Drug Transporters in Chemotherapy-Induced Peripheral Neuropathy</a>, Clinical and Translational Science. 2021 Jan | journal-article. doi: 10.1111/cts.12915.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85099075473&partnerID=MN8TOARS' target='_blank' class='bux-link'>Genome-Wide Meta-Analysis Validates a Role for S1PR1 in Microtubule Targeting Agent-Induced Sensory Peripheral Neuropathy</a>, medRxiv. 2020 Jan | other. doi: 10.1101/2020.04.23.20076208.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85088096101&partnerID=MN8TOARS' target='_blank' class='bux-link'>Genomewide Meta-Analysis Validates a Role for S1PR1 in Microtubule Targeting Agent-Induced Sensory Peripheral Neuropathy</a>, Clinical Pharmacology and Therapeutics. 2020 Jan | journal-article. doi: 10.1002/cpt.1958.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85098838699&partnerID=MN8TOARS' target='_blank' class='bux-link'>Human induced pluripotent stem cell derived sensory neurons are sensitive to the neurotoxic effects of paclitaxel</a>, bioRxiv. 2020 Jan | other. doi: 10.1101/2020.06.04.134262.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85085571168&partnerID=MN8TOARS' target='_blank' class='bux-link'>P-Glycoprotein Inhibition Exacerbates Paclitaxel Neurotoxicity in Neurons and Patients With Cancer</a>, Clinical Pharmacology and Therapeutics. 2020 Jan | journal-article. doi: 10.1002/cpt.1847.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85055922262&partnerID=MN8TOARS' target='_blank' class='bux-link'>A Pharmacogenetic Prediction Model of Progression-Free Survival in Breast Cancer using Genome-Wide Genotyping Data from CALGB 40502 (Alliance)</a>, Clinical Pharmacology and Therapeutics. 2019 Jan | journal-article. doi: 10.1002/cpt.1241.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85104439797&partnerID=MN8TOARS' target='_blank' class='bux-link'>A practical first step using needs assessment and a survey approach to implementing a clinical pharmacogenomics consult service</a>, JACCP Journal of the American College of Clinical Pharmacy. 2019 Jan | journal-article. doi: 10.1002/jac5.1062.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85066351807&partnerID=MN8TOARS' target='_blank' class='bux-link'>Apical shear stress enhanced organic cation transport in Human OCT2/MATE1-transfected madin-darby canine kidney cells involves ciliary sensing</a>, Journal of Pharmacology and Experimental Therapeutics. 2019 Jan | journal-article. doi: 10.1124/jpet.118.255026.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85066312553&partnerID=MN8TOARS' target='_blank' class='bux-link'>Efficient estimation of grouped survival models</a>, BMC Bioinformatics. 2019 Jan | journal-article. doi: 10.1186/s12859-019-2899-x.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85064493982&partnerID=MN8TOARS' target='_blank' class='bux-link'>Organic Anion Transporter Polypeptide 1B1 Polymorphism Modulates the Extent of Drug–Drug Interaction and Associated Biomarker Levels in Healthy Volunteers</a>, Clinical and Translational Science. 2019 Jan | journal-article. doi: 10.1111/cts.12625.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85074214635&partnerID=MN8TOARS' target='_blank' class='bux-link'>Reversible inhibition of efflux transporters by hydrogel microdevices</a>, European Journal of Pharmaceutics and Biopharmaceutics. 2019 Jan | journal-article. doi: 10.1016/j.ejpb.2019.10.007.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85054505918&partnerID=MN8TOARS' target='_blank' class='bux-link'>Tumor Drug Penetration Measurements Could Be the Neglected Piece of the Personalized Cancer Treatment Puzzle</a>, Clinical Pharmacology and Therapeutics. 2019 Jan | journal-article. doi: 10.1002/cpt.1211.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84995480863&partnerID=MN8TOARS' target='_blank' class='bux-link'>ABC transporter polymorphisms are associated with irinotecan pharmacokinetics and neutropenia</a>, Pharmacogenomics Journal. 2018 Jan | journal-article. doi: 10.1038/tpj.2016.75.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85028986810&partnerID=MN8TOARS' target='_blank' class='bux-link'>Bevacizumab-induced hypertension: Clinical presentation and molecular understanding</a>, Pharmacology and Therapeutics. 2018 Jan | journal-article. doi: 10.1016/j.pharmthera.2017.08.012.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85056024433&partnerID=MN8TOARS' target='_blank' class='bux-link'>CYP2B6 Genetic Polymorphisms, Depression, and Viral Suppression in Adults Living with HIV Initiating Efavirenz-Containing Antiretroviral Therapy Regimens in Uganda: Pooled Analysis of Two Prospective Studies</a>, AIDS Research and Human Retroviruses. 2018 Jan | journal-article. doi: 10.1089/aid.2018.0062.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85020746663&partnerID=MN8TOARS' target='_blank' class='bux-link'>Clinical Pharmacokinetics of Paclitaxel Monotherapy: An Updated Literature Review</a>, Clinical Pharmacokinetics. 2018 Jan | journal-article. doi: 10.1007/s40262-017-0563-z.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85040200221&partnerID=MN8TOARS' target='_blank' class='bux-link'>Dicloxacillin induces CYP2C19, CYP2C9 and CYP3A4 in vivo and in vitro</a>, British Journal of Clinical Pharmacology. 2018 Jan | journal-article. doi: 10.1111/bcp.13467.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85043574037&partnerID=MN8TOARS' target='_blank' class='bux-link'>Genome-wide meta-analyses identifies novel taxane-induced peripheral neuropathy-associated loci</a>, Pharmacogenetics and Genomics. 2018 Jan | journal-article. doi: 10.1097/FPC.0000000000000318.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85054067794&partnerID=MN8TOARS' target='_blank' class='bux-link'>Identification of a genomic region between SLC29A1 and HsP90AB1 associated with risk of bevacizumab-induced hypertension: CALGB 80405 (Alliance)</a>, Clinical Cancer Research. 2018 Jan | journal-article. doi: 10.1158/1078-0432.CCR-17-1523.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85045852773&partnerID=MN8TOARS' target='_blank' class='bux-link'>Rare variants in the ABCG2 promoter modulate in vivo activity</a>, Drug Metabolism and Disposition. 2018 Jan | journal-article. doi: 10.1124/dmd.117.079541.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85032979833&partnerID=MN8TOARS' target='_blank' class='bux-link'>ABCG2 regulatory single-nucleotide polymorphisms alter in vivo enhancer activity and expression</a>, Pharmacogenetics and Genomics. 2017 Jan | journal-article. doi: 10.1097/FPC.0000000000000312.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85013460559&partnerID=MN8TOARS' target='_blank' class='bux-link'>Genetic advances uncover mechanisms of chemotherapy-induced peripheral neuropathy</a>, Clinical Pharmacology and Therapeutics. 2017 Jan | journal-article. doi: 10.1002/cpt.590.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85011004804&partnerID=MN8TOARS' target='_blank' class='bux-link'>In vivo hepatic enhancer elements in the human ABCG2 locus</a>, Drug Metabolism and Disposition. 2017 Jan | journal-article. doi: 10.1124/dmd.116.072033.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84957831292&partnerID=MN8TOARS' target='_blank' class='bux-link'>Transcriptomic variation of pharmacogenes in multiple human tissues and lymphoblastoid cell lines</a>, Pharmacogenomics Journal. 2017 Jan | journal-article. doi: 10.1038/tpj.2015.93.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84993940475&partnerID=MN8TOARS' target='_blank' class='bux-link'>Best Practices for Clinical and Translational Research and Implementation</a>, Clinical and Translational Science. 2016 Jan | journal-article. doi: 10.1111/cts.12411.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84963978909&partnerID=MN8TOARS' target='_blank' class='bux-link'>Host genetic predictors of the kynurenine pathway of tryptophan catabolism among treated HIV-infected Ugandans</a>, AIDS. 2016 Jan | journal-article. doi: 10.1097/QAD.0000000000001124.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-85027940504&partnerID=MN8TOARS' target='_blank' class='bux-link'>Metabolomic and Genome-wide Association Studies Reveal Potential Endogenous Biomarkers for OATP1B1</a>, Clinical Pharmacology and Therapeutics. 2016 Jan | journal-article. doi: 10.1002/cpt.434.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84954042047&partnerID=MN8TOARS' target='_blank' class='bux-link'>Multidrug resistance-associated protein 4 is a determinant of arsenite resistance</a>, Oncology Reports. 2016 Jan | journal-article. doi: 10.3892/or.2015.4343.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84990942803&partnerID=MN8TOARS' target='_blank' class='bux-link'>Pharmacogenetic discovery in CALGB (alliance) 90401 and mechanistic validation of a VAC14 polymorphism that increases risk of docetaxel-induced neuropathy</a>, Clinical Cancer Research. 2016 Jan | journal-article. doi: 10.1158/1078-0432.CCR-15-2823.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84958521776&partnerID=MN8TOARS' target='_blank' class='bux-link'>Transforming Translation: Impact of Clinical and Translational Science</a>, Clinical and Translational Science. 2016 Jan | journal-article. doi: 10.1111/cts.12380.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84925730519&partnerID=MN8TOARS' target='_blank' class='bux-link'>PharmGKB summary: Very important pharmacogene information for human leukocyte antigen B</a>, Pharmacogenetics and Genomics. 2015 Jan | journal-article. doi: 10.1097/FPC.0000000000000118.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84945539383&partnerID=MN8TOARS' target='_blank' class='bux-link'>Pharmacoethnicity in paclitaxel-induced sensory peripheral neuropathy</a>, Clinical Cancer Research. 2015 Jan | journal-article. doi: 10.1158/1078-0432.CCR-15-0133.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84925105193&partnerID=MN8TOARS' target='_blank' class='bux-link'>SOX11 identified by target gene evaluation of miRNAs differentially expressed in focal and non-focal brain tissue of therapy-resistant epilepsy patients</a>, Neurobiology of Disease. 2015 Jan | journal-article. doi: 10.1016/j.nbd.2015.02.025.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84892920396&partnerID=MN8TOARS' target='_blank' class='bux-link'>ABCC4 is regulated by microRNA-124a and microRNA-506</a>, Biochemical Pharmacology. 2014 Jan | journal-article. doi: 10.1016/j.bcp.2013.10.017.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84899417586&partnerID=MN8TOARS' target='_blank' class='bux-link'>Clinical pharmacogenetics implementation consortium guidelines for HLA-B genotype and abacavir dosing: 2014 update</a>, Clinical Pharmacology and Therapeutics. 2014 Jan | journal-article. doi: 10.1038/clpt.2014.38.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84898657998&partnerID=MN8TOARS' target='_blank' class='bux-link'>Expression of six drug transporters in vaginal, cervical, and colorectal tissues: Implications for drug disposition in HIV prevention</a>, Journal of Clinical Pharmacology. 2014 Jan | journal-article. doi: 10.1002/jcph.248.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84919784551&partnerID=MN8TOARS' target='_blank' class='bux-link'>Genomic architecture of pharmacological efficacy and adverse events</a>, Pharmacogenomics. 2014 Jan | journal-article. doi: 10.2217/pgs.14.144.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84898540382&partnerID=MN8TOARS' target='_blank' class='bux-link'>PharmGKB summary: Abacavir pathway</a>, Pharmacogenetics and Genomics. 2014 Jan | journal-article. doi: 10.1097/FPC.0000000000000040.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84904987626&partnerID=MN8TOARS' target='_blank' class='bux-link'>Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance)</a>, Pharmacogenomics Journal. 2014 Jan | journal-article. doi: 10.1038/tpj.2014.2.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84927153822&partnerID=MN8TOARS' target='_blank' class='bux-link'>Polymorphisms of Drug Transporters and Clinical Relevance</a>, Drug Transporters: Molecular Characterization and Role in Drug Disposition: Second Edition. 2014 Jan | book-chapter. doi: 10.1002/9781118705308.ch20.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84894422269&partnerID=MN8TOARS' target='_blank' class='bux-link'>Response to "cYP2C9 polymorphism is not a major determinant of bosentan exposure in healthy volunteers"</a>, Clinical Pharmacology and Therapeutics. 2014 Jan | journal-article. doi: 10.1038/clpt.2013.239.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84883192385&partnerID=MN8TOARS' target='_blank' class='bux-link'>Abacavir pharmacogenetics - From initial reports to standard of care</a>, Pharmacotherapy. 2013 Jan | journal-article. doi: 10.1002/phar.1278.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84887988640&partnerID=MN8TOARS' target='_blank' class='bux-link'>Association of cyp2c9*2 with bosentan-induced liver injury</a>, Clinical Pharmacology and Therapeutics. 2013 Jan | journal-article. doi: 10.1038/clpt.2013.143.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84888868447&partnerID=MN8TOARS' target='_blank' class='bux-link'>Epoxyeicosatrienoic acids prevent cisplatin-induced renal apoptosis through a p38 mitogen-activated protein kinase-regulated mitochondrial pathway</a>, Molecular Pharmacology. 2013 Jan | journal-article. doi: 10.1124/mol.113.088302.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84884591802&partnerID=MN8TOARS' target='_blank' class='bux-link'>Functional characterization of ABCC2 promoter polymorphisms and allele-specific expression</a>, Pharmacogenomics Journal. 2013 Jan | journal-article. doi: 10.1038/tpj.2012.20.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84872895907&partnerID=MN8TOARS' target='_blank' class='bux-link'>Genome-wide association studies in pharmacogenomics: Successes and lessons</a>, Pharmacogenetics and Genomics. 2013 Jan | journal-article. doi: 10.1097/FPC.0b013e32833d7b45.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84872549256&partnerID=MN8TOARS' target='_blank' class='bux-link'>Integration of cell line and clinical trial genome-wide analyses supports a polygenic architecture of paclitaxel-induced sensory peripheral neuropathy</a>, Clinical Cancer Research. 2013 Jan | journal-article. doi: 10.1158/1078-0432.CCR-12-2618.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84886583431&partnerID=MN8TOARS' target='_blank' class='bux-link'>Measuring the overall genetic component of nevirapine pharmacokinetics and the role of selected polymorphisms: Towards addressing the missing heritability in pharmacogenetic phenotypes?</a>, Pharmacogenetics and Genomics. 2013 Jan | journal-article. doi: 10.1097/FPC.0b013e32836533a5.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84879168884&partnerID=MN8TOARS' target='_blank' class='bux-link'>OATP1B1-related drug-drug and drug-gene interactions as potential risk factors for cerivastatin-induced rhabdomyolysis</a>, Pharmacogenetics and Genomics. 2013 Jan | journal-article. doi: 10.1097/FPC.0b013e3283620c3b.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84886131292&partnerID=MN8TOARS' target='_blank' class='bux-link'>The Pharmacogenomics of Membrane Transporters Project</a>, Pharmacogenomics of Human Drug Transporters: Clinical Impacts. 2013 Jan | book-chapter. doi: 10.1002/9781118353240.ch4.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84871918938&partnerID=MN8TOARS' target='_blank' class='bux-link'>The relationship of polymorphisms in ABCC2 and SLCO1B3 with docetaxel pharmacokinetics and neutropenia: CALGB 60805 (Alliance)</a>, Pharmacogenetics and Genomics. 2013 Jan | journal-article. doi: 10.1097/FPC.0b013e32835b16d8.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84866415102&partnerID=MN8TOARS' target='_blank' class='bux-link'>A genome-wide association study identifies novel loci for paclitaxel-induced sensory peripheral neuropathy in CALGB 40101</a>, Clinical Cancer Research. 2012 Jan | journal-article. doi: 10.1158/1078-0432.CCR-12-1590.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84861551890&partnerID=MN8TOARS' target='_blank' class='bux-link'>Attenuation of cisplatin-induced renal injury by inhibition of soluble epoxide hydrolase involves nuclear factor κB signaling</a>, Journal of Pharmacology and Experimental Therapeutics. 2012 Jan | journal-article. doi: 10.1124/jpet.111.191247.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84858798082&partnerID=MN8TOARS' target='_blank' class='bux-link'>Clinical pharmacogenetics implementation consortium guidelines for HLA-B genotype and abacavir dosing</a>, Clinical Pharmacology and Therapeutics. 2012 Jan | journal-article. doi: 10.1038/clpt.2011.355.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84861455911&partnerID=MN8TOARS' target='_blank' class='bux-link'>Discovery of regulatory elements in human ATP-binding cassette transporters through expression quantitative trait mapping</a>, Pharmacogenomics Journal. 2012 Jan | journal-article. doi: 10.1038/tpj.2011.8.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84867334155&partnerID=MN8TOARS' target='_blank' class='bux-link'>Ethical aspects of participation in the Database of Genotypes and Phenotypes of the National Center for Biotechnology Information: The Cancer and Leukemia Group B Experience</a>, Cancer. 2012 Jan | journal-article. doi: 10.1002/cncr.27515.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84867171279&partnerID=MN8TOARS' target='_blank' class='bux-link'>In vitro metabolism of piperaquine is primarily mediated by CYP3A4</a>, Xenobiotica. 2012 Jan | journal-article. doi: 10.3109/00498254.2012.693972.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84865486320&partnerID=MN8TOARS' target='_blank' class='bux-link'>Re: CYP2D6 genotype and tamoxifen response in postmenopausal women with endocrine-responsive breast cancer: The breast international group 1-98 trial</a>, Journal of the National Cancer Institute. 2012 Jan | journal-article. doi: 10.1093/jnci/djs304.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-79955477872&partnerID=MN8TOARS' target='_blank' class='bux-link'>Cerivastatin, genetic variants, and the risk of rhabdomyolysis</a>, Pharmacogenetics and Genomics. 2011 Jan | journal-article. doi: 10.1097/FPC.0b013e328343dd7d.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-81855194085&partnerID=MN8TOARS' target='_blank' class='bux-link'>Contribution of aquaporin 9 and multidrug resistance-associated protein 2 to differential sensitivity to arsenite between primary cultured chorion and amnion cells prepared from human fetal membranes</a>, Toxicology and Applied Pharmacology. 2011 Jan | journal-article. doi: 10.1016/j.taap.2011.09.006.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84857076391&partnerID=MN8TOARS' target='_blank' class='bux-link'>Exploiting the complexity of the genome and transcriptome using pharmacogenomics towards personalized medicine.</a>, Genome biology. 2011 Jan | journal-article. doi: 10.1186/gb-2011-12-1-301.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-79952988266&partnerID=MN8TOARS' target='_blank' class='bux-link'>Functional characterization of liver enhancers that regulate drug-associated transporters</a>, Clinical Pharmacology and Therapeutics. 2011 Jan | journal-article. doi: 10.1038/clpt.2010.353.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-78650790662&partnerID=MN8TOARS' target='_blank' class='bux-link'>Letter to the editor</a>, Protein Science. 2011 Jan | journal-article. doi: 10.1002/pro.555.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-79951677547&partnerID=MN8TOARS' target='_blank' class='bux-link'>Very important pharmacogene summary: ABCB1 (MDR1, P-glycoprotein)</a>, Pharmacogenetics and Genomics. 2011 Jan | journal-article. doi: 10.1097/FPC.0b013e3283385a1c.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-78349267919&partnerID=MN8TOARS' target='_blank' class='bux-link'>Functional hot spots in human ATP-binding cassette transporter nucleotide binding domains</a>, Protein Science. 2010 Jan | journal-article. doi: 10.1002/pro.491.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-73949091845&partnerID=MN8TOARS' target='_blank' class='bux-link'>Polymorphic variants in the human bile salt export pump (BSEP; ABCB11): Functional characterization and interindividual variability</a>, Pharmacogenetics and Genomics. 2010 Jan | journal-article. doi: 10.1097/FPC.0b013e3283349eb0.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-72849150876&partnerID=MN8TOARS' target='_blank' class='bux-link'>The pharmacogenomics of membrane transporters project: Research at the interface of genomics and transporter pharmacology</a>, Clinical Pharmacology and Therapeutics. 2010 Jan | journal-article. doi: 10.1038/clpt.2009.226.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-71049190929&partnerID=MN8TOARS' target='_blank' class='bux-link'>A survey of integral α-helical membrane proteins</a>, Journal of Structural and Functional Genomics. 2009 Jan | journal-article. doi: 10.1007/s10969-009-9069-8.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-66849111193&partnerID=MN8TOARS' target='_blank' class='bux-link'>Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics</a>, Journal of Clinical Oncology. 2009 Jan | journal-article. doi: 10.1200/JCO.2008.20.6300.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-63849265463&partnerID=MN8TOARS' target='_blank' class='bux-link'>Evolutionary conservation of vertebrate blood-brain barrier chemoprotective mechanisms in drosophila</a>, Journal of Neuroscience. 2009 Jan | journal-article. doi: 10.1523/JNEUROSCI.5564-08.2009.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84889295617&partnerID=MN8TOARS' target='_blank' class='bux-link'>Genetic Polymorphisms in ABC Transporters</a>, ABC Transporters and Multidrug Resistance. 2009 Jan | book-chapter. doi: 10.1002/9780470495131.ch15.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-70349091471&partnerID=MN8TOARS' target='_blank' class='bux-link'>Genetic variation in the proximal promoter of ABC and SLC superfamilies: Liver and kidney specific expression and promoter activity predict variation</a>, PLoS ONE. 2009 Jan | journal-article. doi: 10.1371/journal.pone.0006942.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-77950883639&partnerID=MN8TOARS' target='_blank' class='bux-link'>The University of California Pharmacogenomics Center: At the interface of genomics, biologicalmechanisms and drug therapy</a>, Pharmacogenomics. 2009 Jan | journal-article. doi: 10.2217/PGS.09.119.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-57349120615&partnerID=MN8TOARS' target='_blank' class='bux-link'>Inhibition of soluble epoxide hydrolase does not protect against endotoxin-mediated hepatic inflammation</a>, Journal of Pharmacology and Experimental Therapeutics. 2008 Jan | journal-article. doi: 10.1124/jpet.108.142398.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-49049102976&partnerID=MN8TOARS' target='_blank' class='bux-link'>Nicotine metabolism in pregnant and nonpregnant rabbits</a>, Nicotine and Tobacco Research. 2008 Jan | journal-article. doi: 10.1080/14622200802238878.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-58049204452&partnerID=MN8TOARS' target='_blank' class='bux-link'>Steady state bioequivalence of generic and innovator formulations of stavudine, lamivudine, and nevirapine in HIV-infected Ugandan adults</a>, PLoS ONE. 2008 Jan | journal-article. doi: 10.1371/journal.pone.0003981.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-42449087778&partnerID=MN8TOARS' target='_blank' class='bux-link'>Substrate-dependent effects of human ABCB1 coding polymorphisms</a>, Journal of Pharmacology and Experimental Therapeutics. 2008 Jan | journal-article. doi: 10.1124/jpet.107.135194.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-37549033138&partnerID=MN8TOARS' target='_blank' class='bux-link'>The effects of ABCB1 3′-untranslated region variants on mRNA stability</a>, Drug Metabolism and Disposition. 2008 Jan | journal-article. doi: 10.1124/dmd.107.017087.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-44249127017&partnerID=MN8TOARS' target='_blank' class='bux-link'>The human multidrug resistance protein 4 (MRP4, ABCC4): Functional analysis of a highly polymorphic gene</a>, Journal of Pharmacology and Experimental Therapeutics. 2008 Jan | journal-article. doi: 10.1124/jpet.108.136523.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-33846568546&partnerID=MN8TOARS' target='_blank' class='bux-link'>ABCB1 pharmacogenetics: Progress, pitfalls, and promise</a>, Clinical Pharmacology and Therapeutics. 2007 Jan | journal-article. doi: 10.1038/sj.clpt.6100052.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-34249341728&partnerID=MN8TOARS' target='_blank' class='bux-link'>Adherence-resistance relationships to combination HIV antiretroviral therapy</a>, Current HIV/AIDS Reports. 2007 Jan | journal-article. doi: 10.1007/s11904-007-0010-0.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-34447569316&partnerID=MN8TOARS' target='_blank' class='bux-link'>Amodiaquine metabolism is impaired by common polymorphisms in CYP2C8: Implications for malaria treatment in Africa</a>, Clinical Pharmacology and Therapeutics. 2007 Jan | journal-article. doi: 10.1038/sj.clpt.6100122.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-34250731775&partnerID=MN8TOARS' target='_blank' class='bux-link'>Cytochrome P450 eicosanoids are activators of peroxisome proliferator-activated receptor α</a>, Drug Metabolism and Disposition. 2007 Jan | journal-article. doi: 10.1124/dmd.106.013839.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-34047212776&partnerID=MN8TOARS' target='_blank' class='bux-link'>Function-altering SNPs in the human multidrug transporter gene ABCB1 identified using a Saccharomyces-based assay</a>, PLoS Genetics. 2007 Jan | journal-article. doi: 10.1371/journal.pgen.0030039.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-34447578816&partnerID=MN8TOARS' target='_blank' class='bux-link'>Interindividual variability in the effect of atazanavir and saquinavir on the expression of lymphocyte P-glycoprotein</a>, Journal of Antimicrobial Chemotherapy. 2007 Jan | journal-article. doi: 10.1093/jac/dkm135.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-33846012498&partnerID=MN8TOARS' target='_blank' class='bux-link'>Irinotecan-induced diarrhea: Functional significance of the polymorphic ABCC2 transporter protein</a>, Clinical Pharmacology and Therapeutics. 2007 Jan | journal-article. doi: 10.1038/sj.clpt.6100019.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-34247104934&partnerID=MN8TOARS' target='_blank' class='bux-link'>Lack of support for a role for RLIP76 (RALBP1) in response to treatment or predisposition to epilepsy</a>, Epilepsia. 2007 Jan | journal-article. doi: 10.1111/j.1528-1167.2007.00926.x.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-34249785088&partnerID=MN8TOARS' target='_blank' class='bux-link'>Response to Janigro et al. [4]</a>, Epilepsia. 2007 Jan | journal-article. doi: 10.1111/j.1528-1167.2007.01155_5.x.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-33847641458&partnerID=MN8TOARS' target='_blank' class='bux-link'>The Pharmacogenetics Research Network: From SNP discovery to clinical drug response</a>, Clinical Pharmacology and Therapeutics. 2007 Jan | journal-article. doi: 10.1038/sj.clpt.6100087.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-33745962817&partnerID=MN8TOARS' target='_blank' class='bux-link'>CYP4 isoform specificity in the ω-hydroxylation of phytanic acid, a potential route to elimination of the causative agent of Refsum's disease</a>, Journal of Pharmacology and Experimental Therapeutics. 2006 Jan | journal-article. doi: 10.1124/jpet.106.104976.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-33645876790&partnerID=MN8TOARS' target='_blank' class='bux-link'>Induction of renal cytochrome P450 arachidonic acid epoxygenase activity by dietary γ-linolenic acid</a>, Journal of Pharmacology and Experimental Therapeutics. 2006 Jan | journal-article. doi: 10.1124/jpet.105.098558.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-33750214897&partnerID=MN8TOARS' target='_blank' class='bux-link'>Inhibition of smooth muscle proliferation by urea-based alkanoic acids via peroxisome proliferator-activated receptor α-dependent repression of cyclin D1</a>, Arteriosclerosis, Thrombosis, and Vascular Biology. 2006 Jan | journal-article. doi: 10.1161/01.ATV.0000242013.29441.81.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-33744986097&partnerID=MN8TOARS' target='_blank' class='bux-link'>MDR1 haplotype frequencies in Japanese and Caucasian, and in Japanese patients with colorectal cancer and esophageal cancer.</a>, Drug metabolism and pharmacokinetics. 2006 Jan | journal-article. doi: 10.2133/dmpk.21.126.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-33644589982&partnerID=MN8TOARS' target='_blank' class='bux-link'>PharmGKB submission update: IV. PMT submissions of genetic variations in ATP-binding cassette transporters to the PharmGKB network</a>, Pharmacological Reviews. 2006 Jan | journal-article. doi: 10.1124/pr.58.1.1.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-33644593135&partnerID=MN8TOARS' target='_blank' class='bux-link'>PharmGKB submission update: V. PMT submissions of genetic variation in SLC22 family transporters</a>, Pharmacological Reviews. 2006 Jan | journal-article. doi: 10.1124/pr.58.1.2.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-33644597151&partnerID=MN8TOARS' target='_blank' class='bux-link'>PharmGKB submission update: VI. PMT submissions of genetic variations in neurotransmitter transporters (SLC6, SLC17, and SLC18) to the PharmGKB network</a>, Pharmacological Reviews. 2006 Jan | journal-article. doi: 10.1124/pr.58.1.3.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-84889376292&partnerID=MN8TOARS' target='_blank' class='bux-link'>Polymorphisms of Drug Transporters and Clinical Relevance</a>, Drug Transporters: Molecular Characterization and Role in Drug Disposition. 2006 Jan | book-chapter. doi: 10.1002/9780470140505.ch21.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-33748994272&partnerID=MN8TOARS' target='_blank' class='bux-link'>Role for drug transporters beyond tumor resistance: Hepatic functional imaging and genotyping of multidrug resistance transporters for the prediction of irinotecan toxicity</a>, Journal of Clinical Oncology. 2006 Jan | journal-article. doi: 10.1200/JCO.2006.07.2355.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-23944501007&partnerID=MN8TOARS' target='_blank' class='bux-link'>Differential renal gene expression in prehypertensive and hypertensive spontaneously hypertensive rats</a>, American Journal of Physiology - Renal Physiology. 2005 Jan | journal-article. doi: 10.1152/ajprenal.00354.2004.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-28844491802&partnerID=MN8TOARS' target='_blank' class='bux-link'>Drug-metabolizing enzymes: Evidence for clinical utility of pharmacogenomic tests</a>, Clinical Pharmacology and Therapeutics. 2005 Jan | journal-article. doi: 10.1016/j.clpt.2005.08.013.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-25144433260&partnerID=MN8TOARS' target='_blank' class='bux-link'>Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C>T affects mRNA stability</a>, Pharmacogenetics and Genomics. 2005 Jan | journal-article. doi: 10.1097/01.fpc.0000178311.02878.83.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-13844309746&partnerID=MN8TOARS' target='_blank' class='bux-link'>Regulation and inhibition of arachidonic acid ω-hydroxylases and 20-HETE formation</a>, Annual Review of Pharmacology and Toxicology. 2005 Jan | book. doi: 10.1146/annurev.pharmtox.45.120403.100045.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-1342323347&partnerID=MN8TOARS' target='_blank' class='bux-link'>Catalytic Activity and Isoform-Specific Inhibition of Rat Cytochrome P450 4F Enzymes</a>, Journal of Pharmacology and Experimental Therapeutics. 2004 Jan | journal-article. doi: 10.1124/jpet.103.059626.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-3042767682&partnerID=MN8TOARS' target='_blank' class='bux-link'>Functional implications of genetic polymorphisms in the multidrug resistance gene MDR1 (ABCB1)</a>, Pharmaceutical Research. 2004 Jan | journal-article. doi: 10.1023/B:PHAM.0000029276.21063.0b.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-1642384540&partnerID=MN8TOARS' target='_blank' class='bux-link'>Vascular localization of soluble epoxide hydrolase in the human kidney</a>, American Journal of Physiology - Renal Physiology. 2004 Jan | journal-article. doi: 10.1152/ajprenal.00165.2003.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-0038184179&partnerID=MN8TOARS' target='_blank' class='bux-link'>Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1</a>, Proceedings of the National Academy of Sciences of the United States of America. 2003 Jan | journal-article. doi: 10.1073/pnas.0730858100.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-0038612980&partnerID=MN8TOARS' target='_blank' class='bux-link'>Natural variation in human membrane transporter genes reveals evolutionary and functional constraints</a>, Proceedings of the National Academy of Sciences of the United States of America. 2003 Jan | journal-article. doi: 10.1073/pnas.0730857100.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-0242288066&partnerID=MN8TOARS' target='_blank' class='bux-link'>No effect of MDR1 C3435T variant on loperamide disposition and central nervous system effects</a>, Clinical Pharmacology and Therapeutics. 2003 Jan | journal-article. doi: 10.1016/S0009-9236(03)00234-0.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-0037255928&partnerID=MN8TOARS' target='_blank' class='bux-link'>Notes of the American Society for clinical pharmacology and therapeutics: A message from the ASCPT Membership Committee chairperson</a>, Clinical Pharmacology and Therapeutics. 2003 Jan | journal-article. .

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-10744222684&partnerID=MN8TOARS' target='_blank' class='bux-link'>Sequence diversity and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene</a>, Pharmacogenetics. 2003 Jan | journal-article. doi: 10.1097/00008571-200308000-00006.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-0036724493&partnerID=MN8TOARS' target='_blank' class='bux-link'>Antihypertensive effect of mechanism-based inhibition of renal arachidonic acid ω-hydroxylase activity</a>, American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 2002 Jan | journal-article. doi: 10.1152/ajpregu.00522.2001.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-0036209142&partnerID=MN8TOARS' target='_blank' class='bux-link'>Candidate gene approach for pharmacogenetic studies</a>, Pharmacogenomics. 2002 Jan | journal-article. doi: 10.1517/14622416.3.1.47.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-0037035545&partnerID=MN8TOARS' target='_blank' class='bux-link'>Covalent attachment of the heme prosthetic group in the CYP4F cytochrome P450 family</a>, Biochemistry. 2002 Jan | journal-article. doi: 10.1021/bi025527y.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-0035985704&partnerID=MN8TOARS' target='_blank' class='bux-link'>Cytochrome P450 pathways of arachidonic acid metabolism</a>, Current Opinion in Lipidology. 2002 Jan | journal-article. doi: 10.1097/00041433-200206000-00007.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-0036331858&partnerID=MN8TOARS' target='_blank' class='bux-link'>MDR1 reference sequence and reference function [1]</a>, Clinical Pharmacology and Therapeutics. 2002 Jan | journal-article. doi: 10.1067/mcp.2002.125561.

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-12444311660&partnerID=MN8TOARS' target='_blank' class='bux-link'>Antimalarial drugs are not substrates of human P-glycoprotein</a>, Clinical Pharmacology and Therapeutics. 2001 Jan | journal-article. .

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-33748985421&partnerID=MN8TOARS' target='_blank' class='bux-link'>Ethnic differences in the allele frequency of polymorphisms in the MDR1 gene</a>, Clinical Pharmacology and Therapeutics. 2001 Jan | journal-article. .

<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-33748978387&partnerID=MN8TOARS' target='_blank' class='bux-link'>Transport and disposition of nicotine in the human placenta</a>, Clinical Pharmacology and Therapeutics. 2001 Jan | journal-article. .

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<a href='http://www.scopus.com/inward/record.url?eid=2-s2.0-0028300816&partnerID=MN8TOARS' target='_blank' class='bux-link'>Human liver carbamazepine metabolism. Role of CYP3A4 and CYP2C8 in 10,11-epoxide formation</a>, Biochemical Pharmacology. 1994 Jan | journal-article. doi: 10.1016/0006-2952(94)90071-X.

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