Dale Hoyt, PhD
Associate Professor,
Division of Pharmacology
406 Riffe Building
496 West 12th Ave
Columbus, Ohio 43210
E-mail: hoyt.27@osu.edu
Office: (614) 292.6245, Fax: (614) 292.9083
Education
- PhD, Pharmacology, Oregon State University.
Areas of Interest
Research Interests: Our lab is interested in endothelial cell injury, dysfunction, and death. As endothelial cells line the inside of all blood vessels, damage to them impairs the normal operation of the circulatory system and leads to life-threatening diseases. Pulmonary fibrosis and atherosclerosis are examples. Conversely, endothelium in the tumor vasculature is a potentially important target for antitumor therapy.
One of our goals is to develop drugs to manipulate the sensitivity of endothelium to DNA damaging agents, including oxidants, in order to inhibit endothelial injury in normal tissue, or to enhance it in cancer. As an example, engagement of integrin cell adhesion receptors inhibits endothelial DNA breakage and cell death caused by several unrelated types of agents. We are pursuing this unexpected finding, investigating how nuclear structure is altered by integrins, and the signal transduction paths that are activated.
A second area involves the study and manipulation of endothelial gene expression associated with pro inflammatory stimuli. Here we are focusing on the role of chromatin structure in the endothelial response, linking this with signal transduction mechanisms from receptors on the endothelial cell surface.
Publications (link to search of US National Library of Medicine (NLM) and PubMed)
Teaching
Course Information coming soon...
Professional Experience
Professional Experience Information coming soon...
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