Distinguished Lecture to Feature Transporter Researcher
The Ohio State University College of Pharmacy is pleased to present John D. Schuetz, PhD on Tuesday, October 4, 1:00 p.m., Room L045, James Cancer Hospital, 460 West 10th Ave. Schuetz’s talk, “ABC Transporters as Modulators of Disease,” is part of the 2016 Distinguished Lecture series.
Schuetz is vice chair of the Pharmaceutical Sciences Department at St. Jude Children’s Hospital. He works with ATP-binding cassette (ABC) transporters: a protein super family that can move a wide variety of substrates across extra- and intracellular membranes, including metabolic products, lipids and sterols, and drugs.
Mutations in ABC transporters cause or contribute to Mendelian and complex disorders including cystic fibrosis, retinal degeneration, hypercholesteremia and cholestasis. They might also modify severity of disease or therapeutic response. Schuetz’s lab focuses on understanding how these transporters impact both normal physiology and pathophysiology. At his lecture, Schuetz will discuss two situations where ABC transporters have the ability to modify disease.
Schuetz received a BA in Physiology/Psychology from the University of Minnesota, St. Paul, and a PhD in Biochemical Pharmacology/Toxicology from the Medical College of Virginia, where he was later a postdoctoral fellow. He has written for a number of publications, including Nature Medicine, The Journal of Biological Chemistry and Cell, among others.