lee.5064@osu.edu

 Lee
Nam Lee
PhD
Associate Professor
Pharmacology
442 Riffe Building
Phone: 
614-292-8680

Specializations

  • Transforming growth factor beta signaling
  • Vascular biology and angiogenesis
  • Tumor vascularization

Professional Interests

Nam Lee’s research focuses on transforming growth factor b (TGF-b) signaling by endothelial-specific TGF-b receptors, endoglin (CD105) and ALK1, which have essential roles during embryonic development and conditions that require neovascularization- including wound healing, vascular remodeling, and tumor-induced angiogenesis. Mutations in these receptors give rise to hereditary hemorrhagic telangiectasia (HHT), a condition characterized by hemorrhagic arteriovenous malformations. He and his lab are interested in understanding how endoglin and ALK1 signal both, cooperatively and independently, to the canonical and non-canonical TGF-b signaling pathways in the vasculature. Their current work aims to define the mechanism of endoglin action during angiogenesis and vascular homeostasis/maintenance; novel roles of ALK1; prognostic and therapeutic applications for endoglin-associated disorders.

Honors

  • NIH NHLBI K99/R00 Career Development Award (2010-2014)
  • F32 NIH Ruth Kirschstein National Research Postdoctoral Fellowship, NCI (2008-2010)
  • Duke University Bell Award in Basic Cancer Research, Young Investigator of the Year (2009)
  • Department of Defense Breast Cancer Research Pre-doctoral Fellowship (2002-2004)

Education

  • Postdoctoral fellowship, 2005-2011, Duke University
  • PhD, 2005, University of Iowa, Molecular Biology/Biophysical Chemistry

Recent Publications