Dr. Larue’s research interests include identifying novel interactions between host and virally encoded proteins, elucidating the role of cellular cofactors in guiding integration site selection of retroviral integrases, discerning structural determinates for interactions between host proteins, retroviral integrases and select chromatin marks, and investigating methods to improve gammaretroviral based vectors for human gene-therapy. His laboratory utilizes a combination of molecular, biophysical and biochemical approaches coupled with collaborations with experts in structural biology to address these intriguing research interests.
Dr. Larue obtained his PhD degree in Microbiology at the Ohio State University, Columbus Ohio, USA in 2009. He then received postdoctoral training with Dr. Mamuka Kvaratskhelia, College of Pharmacy, Ohio State University (2010-2014). After his postdoctoral training, Dr. Larue joined the College of Pharmacy, Ohio State University as a research professor.
- Curr Top Microbiol Immunol. 2015;389:93-119
- J Biol Chem. 2014 Sep 19;289(38):26430-40
- Nucleic Acids Res. 2014 May;42(9):5917-28
- Nucleic Acids Res. 2014 Apr;42(8):4868-81
- Retrovirology. 2014;11:100
- Nucleic acids research. 2014; 42(16):10209-25
- Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):12036-41
- J Biol Chem. 2013 May 31;288(22):15813-20
- J Biol Chem. 2012 Oct 5;287(41):34044-58
- Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):1021-6