hoyt.27@osu.edu

 Hoyt
Dale G. Hoyt
PhD
Associate Professor
Pharmacology
406 Riffe Building
Phone: 
614-292-6245

Specializations

  • Endothelial Function and Injury
  • Inflammatory Signaling
  • DNA Damage and Repair
  • Cancer Pharmacology

Professional Interests

Dale Hoyt's lab is interested in endothelial cell injury, dysfunction, and death. As endothelial cells line the inside of all blood vessels, damage to them impairs the normal operation of the circulatory system and leads to life-threatening diseases. Pulmonary fibrosis and atherosclerosis are examples. Conversely, endothelium in the tumor vasculature is a potentially important target for antitumor therapy. One of the lab's goals is to develop drugs to manipulate the sensitivity of endothelium to DNA damaging agents, including oxidants, in order to inhibit endothelial injury in normal tissue, or to enhance it in cancer. As an example, engagement of integrin cell adhesion receptors inhibits endothelial DNA breakage and cell death caused by several unrelated types of agents. We are investigating how nuclear structure is altered by integrins, and the signal transduction paths that are activated. We are also interested in the phosphorylation signals that affect vascular stress responses and cancer.

Education

  • National Institute Environmental Health Sciences Postdoctoral Fellow in Environmental Physiology and Toxicology, 1985-1987, Department of Pharmacology and the John B. Pierce Foundation, Yale University, New Haven, CT
  • PhD, 1985, Pharmacology and Toxicology, Oregon State University, Corvallis, OR

Recent Publications