guo.1091@osu.edu

 Guo
Peixuan Guo
PhD
Professor and Sylvan G. Frank Chair
Pharmaceutics and Pharmaceutical Chemistry
912 Biomedical Research Tower
Phone: 
614-293-2114

Specializations

  • RNA nanotechnology for cancer therapy
  • Developed multifunctional RNA nanopartidevelopment of RNA nanoparticles for tumor specific delivery of therapeutics, image-guided drug delivery, and cancer immunotherapycles harboring RNA aptamer, siRNA, anti-miRNA, drugs or ribozymes

Professional Interests

Dr. Guo’s major research interest is to apply RNA nanotechnology for cancer therapy. His lab has developed multifunctional RNA nanoparticles harboring RNA aptamer, siRNA, anti-miRNA, drugs or ribozymes. RNA nanoparticles are envisioned to be a major breakthrough in cancer therapy as they are homogeneous in size and structure; thermodynamically and chemically stable; non-toxic; non-immunogenic; and display favorable pharmacological profiles. After systemic injection, the RNA nanoparticles specifically targeted tumors with little or no accumulation in healthy organs. Ongoing projects include development of RNA nanoparticles for tumor specific delivery of therapeutics, image-guided drug delivery, and cancer immunotherapy.

Education

  • 1989-1990: Postdoctoral Scientist, NIH/Institute of Infectious Diseases, Advisor: Bernard Moss (Member of the National Academy of Sciences)
  • 1988-1989: Postdoctoral Associate, Molecular Virology, New York State Department of Health, Advisor: Enzo Paoletti
  • 1987: PhD, Department of Microbiology, University of Minnesota, Minneapolis, MN

Honors

  • Distinguished Chinese Alumni of the 100 years of University of Minnesota, 2014
  • Distinguished Research Award, University of Cincinnati, 2010, 2011
  • Distinguished Alumni of the University of Minnesota, 2009
  • Lions Club Award for Cancer Research Excellence, 2006
  • One of five finalists for Feynman (Nobel Prize Laureate) Nanotechnology Award, 2005
  • Purdue Faculty Scholar, 1999-2004
  • Pfizer Distinguished Faculty Award for Research Excellence, 1995

Recent Publications